GREMLIN Database
YRRS - Uncharacterized membrane protein YrrS
UniProt: O32031 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (210)
Sequences: 140 (116)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_I201_G6.6391.00
154_G220_D4.8270.99
188_L204_L4.3370.98
156_H166_D3.6910.96
22_N28_V3.3750.93
158_A170_M3.2450.91
18_N28_V2.9770.87
205_D209_G2.5770.78
33_V36_A2.5450.77
171_L187_V2.4900.75
136_V228_K2.4820.75
24_L160_Y2.3500.71
42_N188_L2.3380.70
213_Q232_L2.3150.69
25_I32_I2.2520.67
179_G185_M2.1390.63
184_N220_D2.1200.62
167_W190_L2.0810.61
18_N22_N2.0480.59
164_S179_G2.0160.58
21_L25_I1.9910.57
21_L177_A1.9870.57
28_V32_I1.9730.56
193_N216_I1.8880.53
136_V213_Q1.8750.53
145_W226_P1.8670.52
67_T222_K1.8500.51
22_N32_I1.8400.51
135_D211_K1.8300.51
167_W170_M1.7840.49
20_V40_F1.7780.49
18_N32_I1.7050.46
157_A210_N1.6940.45
148_V173_A1.6860.45
18_N21_L1.6670.44
15_R158_A1.6560.44
170_M199_A1.6410.43
28_V36_A1.6380.43
149_G176_Y1.5830.41
170_M229_V1.5760.40
155_E220_D1.5650.40
128_T203_I1.5400.39
160_Y229_V1.5330.39
18_N25_I1.5160.38
22_N25_I1.5050.38
18_N36_A1.4970.37
25_I31_L1.4800.37
15_R170_M1.4150.34
160_Y170_M1.4000.34
186_T208_T1.3890.33
167_W199_A1.3880.33
22_N36_A1.3880.33
117_S120_D1.3700.33
170_M216_I1.3590.32
15_R34_V1.3440.32
69_K72_D1.3180.31
184_N221_E1.2810.29
21_L26_A1.2670.29
117_S183_D1.2590.29
39_L221_E1.2460.28
142_N176_Y1.2450.28
166_D211_K1.2430.28
45_S57_Q1.2190.27
33_V74_D1.2110.27
21_L178_T1.2080.27
171_L182_T1.2030.27
155_E221_E1.2000.27
162_S167_W1.1940.27
163_S168_A1.1920.27
149_G173_A1.1700.26
40_F68_E1.1670.26
25_I28_V1.1530.25
16_K31_L1.1520.25
180_V217_T1.1390.25
180_V208_T1.1380.25
142_N213_Q1.1250.24
192_N204_L1.1160.24
133_S213_Q1.0930.23
42_N204_L1.0910.23
150_T169_E1.0830.23
136_V156_H1.0650.23
180_V193_N1.0620.23
189_W222_K1.0610.23
159_T189_W1.0590.22
118_A212_Y1.0550.22
192_N200_K1.0480.22
136_V166_D1.0470.22
96_D108_D1.0420.22
223_G226_P1.0300.22
99_K111_S1.0280.22
151_E165_Q1.0270.22
148_V195_S1.0150.21
200_K207_A1.0010.21
25_I36_A0.9970.21
24_L230_E0.9960.21
202_K207_A0.9950.21
37_A42_N0.9860.20
26_A183_D0.9810.20
158_A211_K0.9710.20
172_K194_G0.9700.20
98_K108_D0.9700.20
127_V216_I0.9690.20
180_V188_L0.9690.20
124_D183_D0.9680.20
26_A171_L0.9650.20
23_I39_L0.9610.20
182_T187_V0.9540.20
171_L227_T0.9540.20
145_W150_T0.9500.20
24_L166_D0.9500.20
27_I231_K0.9470.19
55_T183_D0.9430.19
152_Q170_M0.9420.19
153_T184_N0.9390.19
178_T199_A0.9320.19
149_G152_Q0.9300.19
104_S109_S0.9260.19
32_I170_M0.9250.19
135_D158_A0.9190.19
204_L213_Q0.9160.19
43_S202_K0.9130.19
156_H178_T0.9090.18
17_A230_E0.9050.18
125_A196_P0.9050.18
27_I115_S0.9010.18
160_Y186_T0.9000.18
22_N176_Y0.8980.18
36_A40_F0.8890.18
16_K156_H0.8840.18
72_D77_D0.8780.18
21_L27_I0.8760.18
152_Q169_E0.8700.18
158_A191_G0.8670.17
192_N196_P0.8610.17
22_N201_G0.8540.17
160_Y199_A0.8520.17
154_G228_K0.8480.17
171_L175_S0.8470.17
131_G170_M0.8410.17
159_T167_W0.8380.17
22_N35_V0.8330.17
153_T203_I0.8300.17
66_K227_T0.8270.17
36_A167_W0.8210.16
153_T196_P0.8200.16
16_K202_K0.8070.16
136_V145_W0.8050.16
34_V153_T0.8040.16
48_D219_V0.8020.16
15_R216_I0.8000.16
198_D203_I0.7990.16
175_S185_M0.7990.16
15_R172_K0.7920.16
66_K182_T0.7910.16
39_L205_D0.7900.16
144_D203_I0.7860.16
32_I185_M0.7860.16
220_D228_K0.7840.16
109_S183_D0.7840.16
22_N31_L0.7830.16
76_K146_K0.7830.16
21_L32_I0.7820.16
7_R15_R0.7800.16
158_A202_K0.7750.15
200_K208_T0.7700.15
175_S213_Q0.7690.15
164_S168_A0.7670.15
67_T75_I0.7640.15
213_Q228_K0.7640.15
16_K215_T0.7630.15
40_F55_T0.7600.15
52_D183_D0.7590.15
125_A130_G0.7580.15
193_N212_Y0.7550.15
11_R28_V0.7540.15
29_S36_A0.7490.15
189_W202_K0.7440.15
11_R177_A0.7320.14
28_V225_K0.7310.14
67_T71_S0.7290.14
176_Y201_G0.7290.14
140_Y228_K0.7280.14
57_Q109_S0.7270.14
163_S209_G0.7260.14
178_T216_I0.7260.14
174_I191_G0.7190.14
28_V31_L0.7190.14
228_K232_L0.7170.14
39_L213_Q0.7170.14
101_D162_S0.7170.14
58_K181_S0.7150.14
11_R18_N0.7150.14
10_N165_Q0.7150.14
128_T216_I0.7140.14
68_E73_E0.7130.14
65_G182_T0.6990.14
18_N139_T0.6980.14
60_E182_T0.6950.14
176_Y196_P0.6950.14
50_S107_D0.6910.14
166_D193_N0.6730.13
109_S119_G0.6700.13
199_A206_K0.6700.13
142_N159_T0.6690.13
67_T144_D0.6680.13
129_E139_T0.6670.13
150_T223_G0.6660.13
192_N199_A0.6660.13
71_S75_I0.6610.13
9_E138_K0.6580.13
155_E225_K0.6550.13
8_Y34_V0.6550.13
96_D100_D0.6530.13
47_K52_D0.6470.13
52_D73_E0.6440.13
193_N196_P0.6440.13
12_D16_K0.6430.13
153_T207_A0.6430.13
180_V205_D0.6420.13
77_D118_A0.6420.13
158_A193_N0.6420.13
159_T199_A0.6410.13
8_Y39_L0.6400.13
122_L212_Y0.6400.13
5_Q53_S0.6370.13
46_S59_Q0.6320.13
73_E116_D0.6320.13
51_K71_S0.6290.13
147_A219_V0.6260.12
125_A216_I0.6210.12
158_A199_A0.6170.12
156_H211_K0.6150.12
163_S167_W0.6140.12
48_D68_E0.6120.12
108_D114_S0.6110.12
157_A230_E0.6090.12
78_S113_S0.6090.12
207_A217_T0.6080.12
148_V169_E0.6060.12
102_S117_S0.6020.12
39_L155_E0.6020.12
39_L168_A0.6010.12
140_Y208_T0.6010.12
22_N199_A0.6010.12
8_Y193_N0.6010.12
18_N31_L0.5980.12
156_H228_K0.5910.12
23_I28_V0.5870.12
20_V200_K0.5840.12
108_D183_D0.5840.12
203_I208_T0.5820.12
118_A140_Y0.5810.12
164_S202_K0.5810.12
20_V34_V0.5790.12
189_W193_N0.5770.12
71_S77_D0.5740.12
134_S221_E0.5720.12
21_L36_A0.5710.12
22_N190_L0.5690.11
18_N24_L0.5680.11
174_I182_T0.5680.11
11_R35_V0.5670.11
43_S178_T0.5650.11
149_G170_M0.5630.11
145_W152_Q0.5620.11
153_T156_H0.5600.11
136_V200_K0.5590.11
74_D109_S0.5590.11
142_N228_K0.5590.11
59_Q74_D0.5580.11
191_G206_K0.5580.11
156_H207_A0.5560.11
145_W228_K0.5560.11
110_D115_S0.5520.11
64_S67_T0.5520.11
29_S37_A0.5520.11
14_R43_S0.5510.11
55_T99_K0.5510.11
190_L208_T0.5500.11
188_L208_T0.5490.11
60_E110_D0.5450.11
166_D215_T0.5430.11
111_S134_S0.5420.11
30_I44_P0.5410.11
99_K102_S0.5410.11
36_A146_K0.5400.11
76_K189_W0.5400.11
58_K76_K0.5390.11
134_S225_K0.5380.11
156_H215_T0.5380.11
16_K228_K0.5360.11
52_D68_E0.5350.11
167_W216_I0.5340.11
158_A224_W0.5330.11
55_T67_T0.5330.11
51_K60_E0.5320.11
33_V58_K0.5300.11
99_K182_T0.5290.11
149_G201_G0.5270.11
24_L136_V0.5240.11
135_D218_W0.5220.11
22_N153_T0.5220.11
145_W203_I0.5210.11
27_I69_K0.5200.11
21_L28_V0.5180.11
107_D112_D0.5170.11
101_D183_D0.5140.11
104_S122_L0.5140.11
136_V220_D0.5130.11
122_L183_D0.5110.11
160_Y195_S0.5090.11
104_S107_D0.5050.10
190_L199_A0.5050.10
65_G121_G0.5020.10
151_E172_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kogA 1 0.1803 91.5 0.933 Contact Map
3hd7A 1 0.1803 87 0.938 Contact Map
2m8rA 1 0.1803 86.9 0.939 Contact Map
4u7aA 1 0 84.2 0.941 Contact Map
3fymA 1 0 75.9 0.945 Contact Map
5a2fA 1 0 44.2 0.956 Contact Map
4fp9B 2 0.2189 37.3 0.957 Contact Map
1n7lA 1 0.1717 31.3 0.959 Contact Map
2e6xA 2 0.206 18.4 0.963 Contact Map
4kytB 2 0.1245 17.8 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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