GREMLIN Database
YRRT - Uncharacterized methyltransferase YrrT
UniProt: O32029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (183)
Sequences: 27342 (20763)
Seq/√Len: 1534.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_H69_T2.9231.00
77_P95_D2.7591.00
133_G194_F2.7291.00
54_P72_G2.7281.00
126_R191_A2.4291.00
53_G116_A2.3851.00
71_F108_A2.3821.00
109_D137_H2.2301.00
71_F94_V2.1941.00
73_I96_G2.1761.00
83_A93_I2.1721.00
132_Y142_I2.1711.00
50_L108_A2.1231.00
136_L140_D2.1211.00
131_Q134_K2.0981.00
61_A87_L2.0931.00
80_R93_I2.0821.00
60_T70_V2.0081.00
103_E108_A1.9751.00
69_T92_E1.9651.00
52_F132_Y1.9441.00
77_P81_K1.9401.00
44_K47_T1.9321.00
80_R95_D1.9281.00
111_I132_Y1.9101.00
126_R130_K1.8091.00
111_I136_L1.7491.00
82_L85_D1.7441.00
48_H71_F1.7311.00
47_T110_T1.7111.00
126_R188_M1.6961.00
52_F98_F1.6741.00
75_P97_D1.6621.00
131_Q135_Y1.6491.00
10_E76_S1.6341.00
87_L93_I1.6281.00
186_K190_T1.6021.00
74_E80_R1.5631.00
136_L142_I1.5551.00
116_A120_L1.5391.00
61_A86_K1.5271.00
48_H137_H1.5141.00
96_G102_P1.4961.00
10_E78_A1.4721.00
123_E126_R1.4641.00
71_F92_E1.4561.00
48_H109_D1.4551.00
49_V110_T1.4521.00
54_P60_T1.4471.00
78_A81_K1.4301.00
49_V63_L1.4281.00
60_T72_G1.4241.00
123_E188_M1.4151.00
181_T184_A1.3771.00
80_R84_S1.3731.00
187_E191_A1.3711.00
122_D127_A1.3421.00
113_S116_A1.3211.00
62_K65_D1.3201.00
129_I189_F1.3091.00
48_H108_A1.3081.00
105_P134_K1.3011.00
126_R192_E1.2771.00
98_F116_A1.2681.00
118_H146_D1.2651.00
120_L128_A1.2341.00
30_A33_G1.2001.00
94_V103_E1.1991.00
87_L91_T1.1971.00
111_I135_Y1.1941.00
130_K192_E1.1881.00
136_L194_F1.1761.00
47_T68_K1.1511.00
97_D100_T1.1491.00
81_K84_S1.1481.00
64_L90_R1.1461.00
104_P107_Q1.1291.00
127_A130_K1.1201.00
62_K66_A1.1161.00
51_E54_P1.1141.00
98_F120_L1.1131.00
101_F131_Q1.1101.00
48_H107_Q1.1031.00
133_G192_E1.0971.00
61_A65_D1.0941.00
102_P131_Q1.0821.00
72_G93_I1.0801.00
43_R47_T1.0781.00
36_H40_A1.0651.00
27_Y34_Y1.0341.00
115_Y118_H1.0331.00
50_L111_I1.0211.00
17_D56_T1.0191.00
17_D86_K1.0131.00
46_G68_K1.0071.00
101_F135_Y0.9911.00
35_D66_A0.9881.00
31_F35_D0.9851.00
59_L112_V0.9841.00
53_G113_S0.9811.00
187_E190_T0.9731.00
54_P83_A0.9701.00
71_F103_E0.9701.00
128_A132_Y0.9691.00
9_F119_H0.9571.00
36_H39_D0.9461.00
107_Q137_H0.9331.00
103_E135_Y0.9311.00
184_A187_E0.9281.00
76_S79_M0.9231.00
63_L112_V0.9211.00
74_E79_M0.9211.00
59_L114_S0.9211.00
47_T109_D0.9191.00
82_L86_K0.9191.00
73_I101_F0.9151.00
35_D39_D0.9121.00
115_Y119_H0.9061.00
30_A34_Y0.8981.00
29_E33_G0.8971.00
72_G83_A0.8971.00
27_Y31_F0.8941.00
129_I192_E0.8871.00
73_I94_V0.8841.00
110_T141_K0.8831.00
117_F120_L0.8821.00
81_K85_D0.8771.00
27_Y30_A0.8681.00
15_T18_Q0.8581.00
115_Y145_A0.8461.00
27_Y33_G0.8401.00
38_L66_A0.8361.00
28_K32_R0.8331.00
49_V112_V0.8321.00
37_I143_V0.8301.00
119_H146_D0.8281.00
182_L186_K0.8221.00
60_T93_I0.8171.00
31_F34_Y0.8161.00
132_Y136_L0.8101.00
117_F128_A0.8061.00
9_F118_H0.8041.00
127_A131_Q0.8041.00
114_S145_A0.8031.00
14_A82_L0.8021.00
60_T91_T0.8021.00
54_P80_R0.8011.00
118_H147_T0.8001.00
32_R35_D0.7941.00
28_K31_F0.7931.00
49_V70_V0.7891.00
84_S88_S0.7851.00
117_F129_I0.7751.00
100_T127_A0.7731.00
57_G83_A0.7711.00
58_N86_K0.7671.00
56_T79_M0.7561.00
54_P74_E0.7511.00
50_L135_Y0.7501.00
52_F73_I0.7461.00
159_I163_R0.7441.00
130_K134_K0.7381.00
35_D62_K0.7291.00
105_P131_Q0.7171.00
110_T140_D0.7141.00
61_A64_L0.7121.00
33_G36_H0.7111.00
129_I188_M0.7081.00
103_E107_Q0.7071.00
49_V68_K0.7031.00
108_A135_Y0.6991.00
84_S92_E0.6951.00
117_F144_F0.6891.00
99_L128_A0.6891.00
40_A199_T0.6851.00
99_L120_L0.6841.00
57_G93_I0.6791.00
96_G101_F0.6781.00
58_N62_K0.6781.00
113_S132_Y0.6741.00
129_I185_L0.6731.00
48_H106_F0.6721.00
149_F181_T0.6721.00
85_D88_S0.6691.00
64_L91_T0.6651.00
67_G70_V0.6651.00
34_Y38_L0.6611.00
46_G67_G0.6601.00
59_L63_L0.6591.00
78_A82_L0.6581.00
52_F111_I0.6501.00
146_D185_L0.6491.00
142_I189_F0.6481.00
54_P93_I0.6441.00
49_V67_G0.6411.00
60_T64_L0.6361.00
51_E112_V0.6351.00
80_R83_A0.6351.00
100_T131_Q0.6341.00
28_K34_Y0.6341.00
36_H199_T0.6281.00
183_D186_K0.6271.00
48_H68_K0.6261.00
115_Y147_T0.6241.00
188_M192_E0.6221.00
29_E32_R0.6221.00
113_S144_F0.6211.00
105_P135_Y0.6201.00
122_D126_R0.6171.00
89_G92_E0.6151.00
117_F146_D0.6131.00
77_P84_S0.6111.00
61_A88_S0.6091.00
59_L62_K0.6051.00
161_K164_S0.6041.00
107_Q134_K0.6031.00
99_L122_D0.6021.00
10_E77_P0.6021.00
119_H175_E0.5991.00
152_A155_Y0.5981.00
158_A162_A0.5961.00
113_S120_L0.5941.00
56_T86_K0.5941.00
183_D187_E0.5931.00
30_A37_I0.5911.00
53_G75_P0.5891.00
107_Q135_Y0.5891.00
160_D164_S0.5861.00
157_Q160_D0.5851.00
84_S93_I0.5841.00
159_I162_A0.5841.00
99_L127_A0.5831.00
44_K68_K0.5821.00
113_S142_I0.5801.00
144_F189_F0.5751.00
186_K198_F0.5721.00
29_E34_Y0.5691.00
61_A93_I0.5681.00
15_T19_T0.5671.00
147_T177_E0.5661.00
51_E119_H0.5651.00
188_M191_A0.5651.00
39_D66_A0.5621.00
98_F128_A0.5611.00
51_E70_V0.5611.00
14_A78_A0.5581.00
158_A161_K0.5561.00
75_P95_D0.5561.00
47_T141_K0.5531.00
45_S67_G0.5521.00
106_F134_K0.5491.00
134_K137_H0.5481.00
87_L90_R0.5471.00
43_R46_G0.5431.00
41_I110_T0.5371.00
160_D163_R0.5361.00
17_D20_V0.5321.00
75_P80_R0.5321.00
170_L173_D0.5301.00
158_A163_R0.5281.00
50_L73_I0.5251.00
180_P185_L0.5241.00
106_F137_H0.5231.00
37_I41_I0.5211.00
56_T82_L0.5191.00
106_F138_L0.5181.00
142_I194_F0.5171.00
17_D82_L0.5121.00
13_A78_A0.5121.00
75_P98_F0.5041.00
69_T90_R0.5031.00
115_Y146_D0.5011.00
189_F194_F0.5001.00
20_V23_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hnrA 1 0.8873 100 0.318 Contact Map
4obxA 2 0.9343 100 0.336 Contact Map
3ou2A 1 0.9108 100 0.365 Contact Map
4kdcA 1 0.9343 100 0.368 Contact Map
2o57A 2 0.9484 100 0.369 Contact Map
4pneA 2 0.939 100 0.369 Contact Map
2yqzA 1 0.9437 100 0.378 Contact Map
3dtnA 2 0.9765 100 0.38 Contact Map
4krgA 1 0.9671 100 0.383 Contact Map
4fsdA 1 0.831 100 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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