GREMLIN Database
MTNN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
UniProt: O32028 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (216)
Sequences: 5464 (3950)
Seq/√Len: 268.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_N37_E3.3611.00
147_A169_L3.1051.00
77_A196_L3.0831.00
52_K150_D2.7631.00
122_D189_P2.7481.00
4_A62_L2.6931.00
130_E143_K2.5241.00
63_L188_T2.4171.00
176_A192_V2.3991.00
93_T143_K2.3841.00
94_D145_T2.2301.00
98_H149_G2.2251.00
94_D120_A2.1741.00
158_R161_E2.1541.00
161_E165_R2.1201.00
5_V16_L2.1131.00
70_Y189_P2.0831.00
90_V171_A2.0731.00
27_T32_E2.0691.00
37_E42_E2.0641.00
94_D118_A2.0341.00
7_G13_V2.0331.00
24_K35_T1.9871.00
61_L64_D1.9671.00
81_H170_Y1.9521.00
60_T186_F1.9091.00
144_G170_Y1.8791.00
173_E176_A1.8591.00
127_S131_E1.8491.00
77_A171_A1.8231.00
160_E164_A1.7971.00
60_T64_D1.7861.00
129_T191_V1.7531.00
126_I143_K1.7461.00
69_D188_T1.6721.00
123_E127_S1.6401.00
64_D186_F1.6201.00
171_A196_L1.5871.00
55_A179_V1.5851.00
52_K148_T1.5711.00
92_S146_I1.5691.00
52_K178_A1.5691.00
126_I191_V1.5101.00
63_L71_V1.5091.00
59_T71_V1.4811.00
71_V183_C1.4701.00
97_H181_Q1.4701.00
25_T32_E1.4651.00
85_N88_D1.4601.00
90_V170_Y1.4501.00
92_S121_A1.4501.00
155_D158_R1.4421.00
142_A170_Y1.4351.00
207_S210_Q1.4331.00
8_A73_N1.4221.00
59_T182_V1.4201.00
63_L68_P1.4171.00
10_E47_K1.4171.00
97_H177_A1.4091.00
80_F172_V1.3761.00
160_E163_R1.3581.00
26_E66_Y1.3581.00
91_I126_I1.3511.00
95_V192_V1.3491.00
10_E14_T1.3471.00
46_L58_S1.3461.00
146_I171_A1.3321.00
24_K42_E1.3271.00
90_V196_L1.3251.00
84_L142_A1.3251.00
79_G196_L1.3231.00
20_L36_G1.3211.00
206_V209_D1.2931.00
52_K99_D1.2541.00
59_T179_V1.2521.00
146_I194_R1.2511.00
147_A162_V1.2281.00
111_Q116_P1.2191.00
57_I182_V1.2161.00
14_T18_N1.2141.00
73_N179_V1.2121.00
127_S130_E1.2041.00
98_H151_S1.2021.00
26_E35_T1.1991.00
183_C190_F1.1971.00
31_C47_K1.1921.00
79_G199_I1.1841.00
96_R118_A1.1761.00
79_G84_L1.1661.00
17_R34_T1.1641.00
95_V180_A1.1641.00
21_E37_E1.1571.00
208_F212_L1.1551.00
77_A90_V1.1541.00
180_A190_F1.1541.00
159_V163_R1.1511.00
37_E40_G1.1491.00
33_F44_I1.1221.00
95_V176_A1.1201.00
70_Y125_L1.1191.00
217_V221_E1.1151.00
96_R147_A1.1091.00
113_P116_P1.1031.00
211_F215_A1.0971.00
89_V195_A1.0921.00
213_E217_V1.0921.00
17_R23_A1.0851.00
78_G200_A1.0841.00
91_I141_V1.0721.00
80_F169_L1.0441.00
93_T145_T1.0241.00
83_T142_A1.0141.00
97_H100_V1.0111.00
13_V34_T1.0101.00
195_A211_F1.0091.00
124_K128_I1.0071.00
28_I65_R1.0041.00
20_L45_L0.9961.00
77_A194_R0.9951.00
13_V45_L0.9851.00
53_V150_D0.9691.00
51_G174_M0.9691.00
57_I60_T0.9661.00
33_F66_Y0.9561.00
99_D150_D0.9551.00
20_L23_A0.9541.00
208_F211_F0.9491.00
78_G172_V0.9401.00
153_M172_V0.9381.00
216_A220_T0.9381.00
127_S135_E0.9351.00
157_K160_E0.9331.00
214_Q218_H0.9231.00
91_I130_E0.9201.00
156_P160_E0.9111.00
80_F200_A0.9101.00
19_K224_L0.9061.00
46_L62_L0.9011.00
81_H84_L0.9001.00
124_K189_P0.8991.00
119_Y181_Q0.8961.00
166_F169_L0.8901.00
152_F174_M0.8851.00
38_Y224_L0.8761.00
26_E46_L0.8691.00
151_S158_R0.8671.00
126_I130_E0.8621.00
201_G204_S0.8521.00
157_K161_E0.8511.00
80_F163_R0.8411.00
199_I202_K0.8350.99
23_A34_T0.8320.99
148_T176_A0.8210.99
118_A145_T0.8210.99
85_N199_I0.8190.99
91_I191_V0.8180.99
214_Q217_V0.8160.99
212_L216_A0.8140.99
125_L129_T0.8120.99
49_G126_I0.8120.99
44_I66_Y0.8030.99
85_N204_S0.8000.99
17_R45_L0.7960.99
215_A219_S0.7950.99
72_I220_T0.7940.99
76_S212_L0.7900.99
63_L186_F0.7860.99
55_A178_A0.7850.99
11_E210_Q0.7820.99
36_G43_V0.7800.99
91_I219_S0.7780.99
32_E47_K0.7750.99
212_L217_V0.7680.99
80_F159_V0.7670.99
15_I220_T0.7650.99
76_S198_D0.7640.99
10_E17_R0.7620.99
219_S222_L0.7600.99
29_A65_R0.7560.99
121_A126_I0.7520.99
33_F61_L0.7500.99
172_V198_D0.7460.99
53_V57_I0.7450.99
56_A178_A0.7410.99
62_L68_P0.7390.99
101_D105_F0.7380.99
56_A60_T0.7380.99
76_S208_F0.7340.99
145_T169_L0.7320.99
173_E192_V0.7310.99
133_V141_V0.7310.99
219_S223_V0.7280.99
70_Y124_K0.7270.99
124_K127_S0.7260.99
178_A182_V0.7250.99
85_N202_K0.7240.99
29_A61_L0.7230.99
71_V188_T0.7180.98
99_D151_S0.7180.98
55_A59_T0.7180.98
92_S191_V0.7180.98
88_D142_A0.7090.98
126_I129_T0.7090.98
38_Y43_V0.6940.98
172_V200_A0.6940.98
89_V219_S0.6930.98
162_V165_R0.6860.98
220_T224_L0.6840.98
92_S95_V0.6840.98
110_G114_G0.6810.98
102_V112_V0.6800.98
200_A204_S0.6800.98
100_V112_V0.6770.98
176_A194_R0.6760.98
57_I61_L0.6750.98
84_L90_V0.6750.98
104_A113_P0.6730.98
149_G153_M0.6710.98
132_A136_L0.6660.97
101_D182_V0.6640.97
89_V139_I0.6620.97
89_V193_I0.6570.97
14_T17_R0.6540.97
209_D212_L0.6520.97
174_M204_S0.6520.97
103_T151_S0.6510.97
161_E164_A0.6480.97
13_V17_R0.6470.97
25_T34_T0.6470.97
98_H172_V0.6450.97
15_I18_N0.6450.97
8_A12_E0.6450.97
114_G166_F0.6440.97
155_D185_Q0.6400.97
60_T182_V0.6390.97
110_G113_P0.6360.97
121_A180_A0.6360.97
209_D213_E0.6360.97
95_V190_F0.6350.97
206_V210_Q0.6340.97
110_G166_F0.6330.97
197_S206_V0.6290.96
9_M50_I0.6290.96
149_G162_V0.6290.96
120_A123_E0.6280.96
153_M158_R0.6220.96
112_V115_L0.6210.96
104_A111_Q0.6200.96
120_A186_F0.6200.96
162_V166_F0.6160.96
7_G15_I0.6120.96
147_A172_V0.6110.96
93_T126_I0.6100.96
4_A71_V0.6090.96
218_H221_E0.6090.96
21_E36_G0.6070.96
81_H142_A0.6070.96
50_I174_M0.6070.96
6_I179_V0.6030.96
156_P202_K0.6020.95
101_D112_V0.6020.95
16_L19_K0.6000.95
193_I223_V0.5990.95
125_L191_V0.5990.95
111_Q117_A0.5980.95
103_T158_R0.5910.95
8_A174_M0.5890.95
152_F204_S0.5860.95
102_V111_Q0.5860.95
122_D125_L0.5860.95
52_K97_H0.5850.95
101_D152_F0.5820.95
156_P201_G0.5820.95
28_I64_D0.5810.95
21_E24_K0.5810.95
90_V146_I0.5800.94
6_I73_N0.5780.94
98_H147_A0.5780.94
35_T66_Y0.5770.94
29_A33_F0.5770.94
102_V113_P0.5730.94
174_M198_D0.5700.94
30_H61_L0.5700.94
4_A68_P0.5680.94
159_V202_K0.5620.93
7_G74_T0.5590.93
103_T110_G0.5570.93
199_I204_S0.5560.93
159_V162_V0.5550.93
180_A192_V0.5530.93
87_G206_V0.5530.93
99_D149_G0.5500.93
12_E194_R0.5450.92
154_N204_S0.5450.92
15_I19_K0.5430.92
50_I197_S0.5390.92
212_L220_T0.5360.92
22_N25_T0.5350.92
27_T30_H0.5330.92
31_C58_S0.5310.91
84_L196_L0.5300.91
89_V215_A0.5250.91
7_G45_L0.5240.91
117_A181_Q0.5230.91
221_E224_L0.5220.91
86_V199_I0.5210.91
63_L69_D0.5180.90
20_L38_Y0.5160.90
51_G175_E0.5140.90
44_I68_P0.5130.90
51_G150_D0.5120.90
32_E127_S0.5100.90
145_T167_S0.5100.90
146_I173_E0.5080.90
128_I132_A0.5070.90
16_L38_Y0.5060.89
127_S143_K0.5050.89
15_I217_V0.5050.89
111_Q115_L0.5040.89
182_V186_F0.5040.89
23_A37_E0.5010.89
128_I131_E0.5010.89
48_S59_T0.5000.89
5_V72_I0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qezB 2 0.974 100 0.19 Contact Map
1zosA 2 0.9957 100 0.197 Contact Map
3bl6A 2 0.9913 100 0.202 Contact Map
3dp9A 2 0.9957 100 0.205 Contact Map
4josA 2 0.9827 100 0.209 Contact Map
3eeiA 2 0.9913 100 0.212 Contact Map
4oy3A 2 0.987 100 0.218 Contact Map
4l0mA 2 0.987 100 0.218 Contact Map
4g41A 2 0.9957 100 0.221 Contact Map
4jwtA 2 0.9913 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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