MTNN - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MTNN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

UniProt:	O32028	Sequences: MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVILLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDVTAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVEEVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVHSTELVLKVIKRIH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (216)
Sequences:	5464 (3950)
Seq/√Len:	268.8

ECOLI - MTNN DEOD UDP
BACSU - MTNN DEOD
HALSA - Q9HP14 Q9HR25
SULSO - PNPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_N	37_E	3.361	1.00
147_A	169_L	3.105	1.00
77_A	196_L	3.083	1.00
52_K	150_D	2.763	1.00
122_D	189_P	2.748	1.00
4_A	62_L	2.693	1.00
130_E	143_K	2.524	1.00
63_L	188_T	2.417	1.00
176_A	192_V	2.399	1.00
93_T	143_K	2.384	1.00
94_D	145_T	2.230	1.00
98_H	149_G	2.225	1.00
94_D	120_A	2.174	1.00
158_R	161_E	2.154	1.00
161_E	165_R	2.120	1.00
5_V	16_L	2.113	1.00
70_Y	189_P	2.083	1.00
90_V	171_A	2.073	1.00
27_T	32_E	2.069	1.00
37_E	42_E	2.064	1.00
94_D	118_A	2.034	1.00
7_G	13_V	2.033	1.00
24_K	35_T	1.987	1.00
61_L	64_D	1.967	1.00
81_H	170_Y	1.952	1.00
60_T	186_F	1.909	1.00
144_G	170_Y	1.879	1.00
173_E	176_A	1.859	1.00
127_S	131_E	1.849	1.00
77_A	171_A	1.823	1.00
160_E	164_A	1.797	1.00
60_T	64_D	1.786	1.00
129_T	191_V	1.753	1.00
126_I	143_K	1.746	1.00
69_D	188_T	1.672	1.00
123_E	127_S	1.640	1.00
64_D	186_F	1.620	1.00
171_A	196_L	1.587	1.00
55_A	179_V	1.585	1.00
52_K	148_T	1.571	1.00
92_S	146_I	1.569	1.00
52_K	178_A	1.569	1.00
126_I	191_V	1.510	1.00
63_L	71_V	1.509	1.00
59_T	71_V	1.481	1.00
71_V	183_C	1.470	1.00
97_H	181_Q	1.470	1.00
25_T	32_E	1.465	1.00
85_N	88_D	1.460	1.00
90_V	170_Y	1.450	1.00
92_S	121_A	1.450	1.00
155_D	158_R	1.442	1.00
142_A	170_Y	1.435	1.00
207_S	210_Q	1.433	1.00
8_A	73_N	1.422	1.00
59_T	182_V	1.420	1.00
63_L	68_P	1.417	1.00
10_E	47_K	1.417	1.00
97_H	177_A	1.409	1.00
80_F	172_V	1.376	1.00
160_E	163_R	1.358	1.00
26_E	66_Y	1.358	1.00
91_I	126_I	1.351	1.00
95_V	192_V	1.349	1.00
10_E	14_T	1.347	1.00
46_L	58_S	1.346	1.00
146_I	171_A	1.332	1.00
24_K	42_E	1.327	1.00
90_V	196_L	1.325	1.00
84_L	142_A	1.325	1.00
79_G	196_L	1.323	1.00
20_L	36_G	1.321	1.00
206_V	209_D	1.293	1.00
52_K	99_D	1.254	1.00
59_T	179_V	1.252	1.00
146_I	194_R	1.251	1.00
147_A	162_V	1.228	1.00
111_Q	116_P	1.219	1.00
57_I	182_V	1.216	1.00
14_T	18_N	1.214	1.00
73_N	179_V	1.212	1.00
127_S	130_E	1.204	1.00
98_H	151_S	1.202	1.00
26_E	35_T	1.199	1.00
183_C	190_F	1.197	1.00
31_C	47_K	1.192	1.00
79_G	199_I	1.184	1.00
96_R	118_A	1.176	1.00
79_G	84_L	1.166	1.00
17_R	34_T	1.164	1.00
95_V	180_A	1.164	1.00
21_E	37_E	1.157	1.00
208_F	212_L	1.155	1.00
77_A	90_V	1.154	1.00
180_A	190_F	1.154	1.00
159_V	163_R	1.151	1.00
37_E	40_G	1.149	1.00
33_F	44_I	1.122	1.00
95_V	176_A	1.120	1.00
70_Y	125_L	1.119	1.00
217_V	221_E	1.115	1.00
96_R	147_A	1.109	1.00
113_P	116_P	1.103	1.00
211_F	215_A	1.097	1.00
89_V	195_A	1.092	1.00
213_E	217_V	1.092	1.00
17_R	23_A	1.085	1.00
78_G	200_A	1.084	1.00
91_I	141_V	1.072	1.00
80_F	169_L	1.044	1.00
93_T	145_T	1.024	1.00
83_T	142_A	1.014	1.00
97_H	100_V	1.011	1.00
13_V	34_T	1.010	1.00
195_A	211_F	1.009	1.00
124_K	128_I	1.007	1.00
28_I	65_R	1.004	1.00
20_L	45_L	0.996	1.00
77_A	194_R	0.995	1.00
13_V	45_L	0.985	1.00
53_V	150_D	0.969	1.00
51_G	174_M	0.969	1.00
57_I	60_T	0.966	1.00
33_F	66_Y	0.956	1.00
99_D	150_D	0.955	1.00
20_L	23_A	0.954	1.00
208_F	211_F	0.949	1.00
78_G	172_V	0.940	1.00
153_M	172_V	0.938	1.00
216_A	220_T	0.938	1.00
127_S	135_E	0.935	1.00
157_K	160_E	0.933	1.00
214_Q	218_H	0.923	1.00
91_I	130_E	0.920	1.00
156_P	160_E	0.911	1.00
80_F	200_A	0.910	1.00
19_K	224_L	0.906	1.00
46_L	62_L	0.901	1.00
81_H	84_L	0.900	1.00
124_K	189_P	0.899	1.00
119_Y	181_Q	0.896	1.00
166_F	169_L	0.890	1.00
152_F	174_M	0.885	1.00
38_Y	224_L	0.876	1.00
26_E	46_L	0.869	1.00
151_S	158_R	0.867	1.00
126_I	130_E	0.862	1.00
201_G	204_S	0.852	1.00
157_K	161_E	0.851	1.00
80_F	163_R	0.841	1.00
199_I	202_K	0.835	0.99
23_A	34_T	0.832	0.99
148_T	176_A	0.821	0.99
118_A	145_T	0.821	0.99
85_N	199_I	0.819	0.99
91_I	191_V	0.818	0.99
214_Q	217_V	0.816	0.99
212_L	216_A	0.814	0.99
125_L	129_T	0.812	0.99
49_G	126_I	0.812	0.99
44_I	66_Y	0.803	0.99
85_N	204_S	0.800	0.99
17_R	45_L	0.796	0.99
215_A	219_S	0.795	0.99
72_I	220_T	0.794	0.99
76_S	212_L	0.790	0.99
63_L	186_F	0.786	0.99
55_A	178_A	0.785	0.99
11_E	210_Q	0.782	0.99
36_G	43_V	0.780	0.99
91_I	219_S	0.778	0.99
32_E	47_K	0.775	0.99
212_L	217_V	0.768	0.99
80_F	159_V	0.767	0.99
15_I	220_T	0.765	0.99
76_S	198_D	0.764	0.99
10_E	17_R	0.762	0.99
219_S	222_L	0.760	0.99
29_A	65_R	0.756	0.99
121_A	126_I	0.752	0.99
33_F	61_L	0.750	0.99
172_V	198_D	0.746	0.99
53_V	57_I	0.745	0.99
56_A	178_A	0.741	0.99
62_L	68_P	0.739	0.99
101_D	105_F	0.738	0.99
56_A	60_T	0.738	0.99
76_S	208_F	0.734	0.99
145_T	169_L	0.732	0.99
173_E	192_V	0.731	0.99
133_V	141_V	0.731	0.99
219_S	223_V	0.728	0.99
70_Y	124_K	0.727	0.99
124_K	127_S	0.726	0.99
178_A	182_V	0.725	0.99
85_N	202_K	0.724	0.99
29_A	61_L	0.723	0.99
71_V	188_T	0.718	0.98
99_D	151_S	0.718	0.98
55_A	59_T	0.718	0.98
92_S	191_V	0.718	0.98
88_D	142_A	0.709	0.98
126_I	129_T	0.709	0.98
38_Y	43_V	0.694	0.98
172_V	200_A	0.694	0.98
89_V	219_S	0.693	0.98
162_V	165_R	0.686	0.98
220_T	224_L	0.684	0.98
92_S	95_V	0.684	0.98
110_G	114_G	0.681	0.98
102_V	112_V	0.680	0.98
200_A	204_S	0.680	0.98
100_V	112_V	0.677	0.98
176_A	194_R	0.676	0.98
57_I	61_L	0.675	0.98
84_L	90_V	0.675	0.98
104_A	113_P	0.673	0.98
149_G	153_M	0.671	0.98
132_A	136_L	0.666	0.97
101_D	182_V	0.664	0.97
89_V	139_I	0.662	0.97
89_V	193_I	0.657	0.97
14_T	17_R	0.654	0.97
209_D	212_L	0.652	0.97
174_M	204_S	0.652	0.97
103_T	151_S	0.651	0.97
161_E	164_A	0.648	0.97
13_V	17_R	0.647	0.97
25_T	34_T	0.647	0.97
98_H	172_V	0.645	0.97
15_I	18_N	0.645	0.97
8_A	12_E	0.645	0.97
114_G	166_F	0.644	0.97
155_D	185_Q	0.640	0.97
60_T	182_V	0.639	0.97
110_G	113_P	0.636	0.97
121_A	180_A	0.636	0.97
209_D	213_E	0.636	0.97
95_V	190_F	0.635	0.97
206_V	210_Q	0.634	0.97
110_G	166_F	0.633	0.97
197_S	206_V	0.629	0.96
9_M	50_I	0.629	0.96
149_G	162_V	0.629	0.96
120_A	123_E	0.628	0.96
153_M	158_R	0.622	0.96
112_V	115_L	0.621	0.96
104_A	111_Q	0.620	0.96
120_A	186_F	0.620	0.96
162_V	166_F	0.616	0.96
7_G	15_I	0.612	0.96
147_A	172_V	0.611	0.96
93_T	126_I	0.610	0.96
4_A	71_V	0.609	0.96
218_H	221_E	0.609	0.96
21_E	36_G	0.607	0.96
81_H	142_A	0.607	0.96
50_I	174_M	0.607	0.96
6_I	179_V	0.603	0.96
156_P	202_K	0.602	0.95
101_D	112_V	0.602	0.95
16_L	19_K	0.600	0.95
193_I	223_V	0.599	0.95
125_L	191_V	0.599	0.95
111_Q	117_A	0.598	0.95
103_T	158_R	0.591	0.95
8_A	174_M	0.589	0.95
152_F	204_S	0.586	0.95
102_V	111_Q	0.586	0.95
122_D	125_L	0.586	0.95
52_K	97_H	0.585	0.95
101_D	152_F	0.582	0.95
156_P	201_G	0.582	0.95
28_I	64_D	0.581	0.95
21_E	24_K	0.581	0.95
90_V	146_I	0.580	0.94
6_I	73_N	0.578	0.94
98_H	147_A	0.578	0.94
35_T	66_Y	0.577	0.94
29_A	33_F	0.577	0.94
102_V	113_P	0.573	0.94
174_M	198_D	0.570	0.94
30_H	61_L	0.570	0.94
4_A	68_P	0.568	0.94
159_V	202_K	0.562	0.93
7_G	74_T	0.559	0.93
103_T	110_G	0.557	0.93
199_I	204_S	0.556	0.93
159_V	162_V	0.555	0.93
180_A	192_V	0.553	0.93
87_G	206_V	0.553	0.93
99_D	149_G	0.550	0.93
12_E	194_R	0.545	0.92
154_N	204_S	0.545	0.92
15_I	19_K	0.543	0.92
50_I	197_S	0.539	0.92
212_L	220_T	0.536	0.92
22_N	25_T	0.535	0.92
27_T	30_H	0.533	0.92
31_C	58_S	0.531	0.91
84_L	196_L	0.530	0.91
89_V	215_A	0.525	0.91
7_G	45_L	0.524	0.91
117_A	181_Q	0.523	0.91
221_E	224_L	0.522	0.91
86_V	199_I	0.521	0.91
63_L	69_D	0.518	0.90
20_L	38_Y	0.516	0.90
51_G	175_E	0.514	0.90
44_I	68_P	0.513	0.90
51_G	150_D	0.512	0.90
32_E	127_S	0.510	0.90
145_T	167_S	0.510	0.90
146_I	173_E	0.508	0.90
128_I	132_A	0.507	0.90
16_L	38_Y	0.506	0.89
127_S	143_K	0.505	0.89
15_I	217_V	0.505	0.89
111_Q	115_L	0.504	0.89
182_V	186_F	0.504	0.89
23_A	37_E	0.501	0.89
128_I	131_E	0.501	0.89
48_S	59_T	0.500	0.89
5_V	72_I	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qezB	2	0.974	100	0.19	Contact Map
1zosA	2	0.9957	100	0.197	Contact Map
3bl6A	2	0.9913	100	0.202	Contact Map
3dp9A	2	0.9957	100	0.205	Contact Map
4josA	2	0.9827	100	0.209	Contact Map
3eeiA	2	0.9913	100	0.212	Contact Map
4oy3A	2	0.987	100	0.218	Contact Map
4l0mA	2	0.987	100	0.218	Contact Map
4g41A	2	0.9957	100	0.221	Contact Map
4jwtA	2	0.9913	100	0.228	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.