GREMLIN Database
YOKA - Resolvase homolog YokA
UniProt: O32006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 545 (471)
Sequences: 4619 (4062)
Seq/√Len: 187.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_L223_L4.8671.00
58_K79_D4.8101.00
285_D288_Q4.5991.00
177_Q188_V4.0571.00
72_V75_E3.6321.00
201_I219_H3.4961.00
286_K290_Q3.3351.00
203_L288_Q3.2931.00
219_H223_L3.2771.00
416_K451_E3.0451.00
197_L201_I2.9411.00
17_G44_M2.8941.00
188_V191_E2.7481.00
409_M458_A2.7231.00
56_E75_E2.7181.00
319_T507_D2.6781.00
410_S459_K2.6281.00
80_L85_Y2.5411.00
417_E452_F2.5391.00
179_N186_D2.5341.00
46_K50_A2.5101.00
203_L292_S2.5061.00
14_N86_Q2.4871.00
319_T326_P2.4511.00
321_S511_N2.4471.00
19_L41_K2.4201.00
177_Q186_D2.4031.00
41_K45_N2.4021.00
251_T277_Q2.2961.00
413_L455_L2.2801.00
41_K57_L2.2571.00
200_N288_Q2.2361.00
413_L459_K2.1501.00
79_D84_K2.1461.00
146_E153_R2.1291.00
417_E455_L2.1101.00
246_E251_T2.1041.00
325_E350_S2.0521.00
200_N204_N2.0071.00
192_A196_Q1.9951.00
197_L219_H1.9831.00
240_K244_Q1.9791.00
251_T286_K1.9691.00
363_Y367_E1.9441.00
133_M148_E1.9381.00
45_N57_L1.9361.00
289_F293_Q1.9311.00
249_I286_K1.9261.00
244_Q297_A1.9251.00
414_S463_N1.9191.00
60_E72_V1.8861.00
199_F292_S1.8751.00
420_L452_F1.8451.00
421_K452_F1.8021.00
414_S459_K1.7941.00
423_K433_S1.7911.00
16_L85_Y1.7791.00
191_E228_P1.7661.00
317_V502_R1.7631.00
15_I53_I1.7581.00
81_E110_L1.7511.00
420_L448_L1.7191.00
187_P283_I1.7131.00
146_E150_T1.7061.00
244_Q296_I1.6761.00
42_E46_K1.6451.00
214_T218_S1.6431.00
432_E444_R1.6381.00
161_Y166_K1.6291.00
102_S109_N1.6181.00
277_Q286_K1.6181.00
90_V118_I1.6141.00
76_C88_I1.6081.00
120_T123_K1.6021.00
282_P286_K1.5951.00
425_N447_A1.5901.00
498_N502_R1.5801.00
199_F284_I1.5661.00
73_F76_C1.5581.00
203_L291_Q1.5511.00
202_F243_L1.5501.00
198_I216_I1.5501.00
217_A239_I1.5391.00
179_N182_T1.5371.00
23_R26_M1.5321.00
454_E458_A1.5271.00
48_L89_A1.5201.00
65_E147_F1.5101.00
219_H222_N1.5081.00
174_Y194_V1.4891.00
290_Q294_V1.4831.00
201_I223_L1.4731.00
446_A450_E1.4571.00
243_L292_S1.4541.00
429_D444_R1.4521.00
41_K59_M1.4391.00
493_S496_K1.4391.00
437_S440_L1.4381.00
199_F248_Y1.4331.00
108_V136_I1.4191.00
192_A283_I1.4171.00
189_E196_Q1.4161.00
16_L76_C1.4151.00
447_A451_E1.4131.00
75_E79_D1.4101.00
246_E275_V1.4081.00
137_R141_F1.4061.00
452_F456_Q1.4051.00
149_M153_R1.4031.00
212_S215_A1.4031.00
373_Y376_S1.4011.00
198_I242_I1.3961.00
246_E249_I1.3931.00
213_Y240_K1.3911.00
314_L367_E1.3901.00
144_R148_E1.3891.00
104_A140_L1.3821.00
198_I220_L1.3801.00
246_E253_K1.3801.00
421_K456_Q1.3671.00
129_N132_D1.3601.00
45_N49_T1.3561.00
187_P192_A1.3541.00
47_I51_I1.3501.00
322_K359_T1.3481.00
312_S329_K1.3481.00
96_L107_I1.3471.00
80_L88_I1.3401.00
221_T234_W1.3301.00
295_K299_K1.3301.00
416_K419_E1.3251.00
14_N54_P1.3231.00
101_Y137_R1.3191.00
217_A221_T1.3091.00
417_E459_K1.3061.00
134_R145_E1.3031.00
444_R447_A1.3001.00
441_F445_K1.3001.00
410_S463_N1.2981.00
80_L116_L1.2931.00
151_R155_T1.2811.00
21_R26_M1.2791.00
147_F150_T1.2771.00
235_N238_T1.2671.00
44_M89_A1.2671.00
159_Y163_A1.2671.00
269_P273_Q1.2641.00
318_C366_V1.2621.00
19_L37_L1.2601.00
78_K82_E1.2591.00
147_F151_R1.2581.00
90_V120_T1.2571.00
249_I289_F1.2571.00
77_L107_I1.2551.00
456_Q460_N1.2541.00
252_V279_A1.2471.00
425_N443_K1.2411.00
458_A461_E1.2401.00
418_K421_K1.2401.00
94_T143_A1.2291.00
410_S414_S1.2181.00
130_P152_E1.2171.00
459_K463_N1.2151.00
92_E153_R1.2141.00
251_T275_V1.2091.00
218_S222_N1.2051.00
179_N184_K1.2041.00
424_E452_F1.1991.00
420_L455_L1.1931.00
406_K462_L1.1921.00
194_V225_I1.1901.00
16_L58_K1.1841.00
270_E273_Q1.1821.00
368_N372_D1.1741.00
17_G57_L1.1731.00
18_Y60_E1.1631.00
81_E114_K1.1591.00
160_T164_Q1.1591.00
202_F296_I1.1491.00
198_I239_I1.1491.00
431_Y438_D1.1481.00
451_E454_E1.1481.00
284_I292_S1.1481.00
226_P234_W1.1461.00
78_K81_E1.1451.00
199_F289_F1.1431.00
176_Y248_Y1.1391.00
93_I143_A1.1361.00
251_T278_D1.1351.00
409_M412_H1.1331.00
346_Y363_Y1.1291.00
58_K76_C1.1251.00
134_R141_F1.1241.00
217_A236_Q1.1231.00
417_E456_Q1.1181.00
201_I204_N1.1131.00
134_R142_M1.1121.00
177_Q189_E1.1121.00
193_K196_Q1.1071.00
101_Y105_G1.1071.00
362_R365_D1.1061.00
420_L451_E1.1041.00
99_G144_R1.1031.00
426_F431_Y1.0981.00
426_F434_G1.0961.00
268_R272_E1.0961.00
167_W185_L1.0941.00
410_S462_L1.0931.00
227_T230_G1.0911.00
19_L57_L1.0901.00
93_I136_I1.0901.00
243_L293_Q1.0891.00
94_T153_R1.0851.00
505_L508_V1.0841.00
202_F295_K1.0841.00
453_K457_N1.0831.00
413_L458_A1.0801.00
288_Q292_S1.0791.00
91_K156_G1.0761.00
423_K432_E1.0761.00
216_I239_I1.0751.00
330_Y347_H1.0711.00
453_K456_Q1.0701.00
190_D193_K1.0631.00
321_S509_I1.0581.00
97_S104_A1.0571.00
146_E149_M1.0521.00
213_Y217_A1.0481.00
123_K139_E1.0431.00
258_E268_R1.0421.00
105_G137_R1.0421.00
195_V199_F1.0391.00
194_V198_I1.0381.00
444_R448_L1.0371.00
450_E454_E1.0311.00
269_P272_E1.0261.00
344_S363_Y1.0251.00
117_I126_D1.0241.00
249_I290_Q1.0241.00
15_I87_A1.0231.00
46_K49_T1.0211.00
64_G97_S1.0191.00
73_F107_I1.0181.00
288_Q291_Q1.0080.99
201_I216_I1.0040.99
93_I120_T1.0010.99
345_V362_R0.9980.99
414_S418_K0.9930.99
112_Q133_M0.9910.99
150_T157_A0.9890.99
431_Y441_F0.9870.99
295_K298_N0.9850.99
158_K161_Y0.9850.99
202_F216_I0.9850.99
413_L417_E0.9840.99
80_L111_L0.9830.99
424_E445_K0.9800.99
343_E362_R0.9800.99
43_L91_K0.9800.99
411_E414_S0.9790.99
455_L459_K0.9780.99
440_L449_D0.9760.99
226_P233_R0.9760.99
253_K275_V0.9680.99
327_L510_V0.9670.99
73_F96_L0.9650.99
196_Q288_Q0.9620.99
433_S438_D0.9550.99
133_M144_R0.9550.99
289_F292_S0.9530.99
418_K422_N0.9530.99
16_L79_D0.9520.99
195_V283_I0.9510.99
93_I123_K0.9490.99
483_K486_D0.9460.99
253_K256_V0.9450.99
458_A462_L0.9450.99
194_V197_L0.9430.99
356_N359_T0.9400.99
88_I111_L0.9370.99
73_F103_D0.9340.99
351_L358_C0.9290.99
314_L363_Y0.9270.99
249_I282_P0.9250.99
249_I285_D0.9240.99
449_D453_K0.9240.99
87_A119_I0.9210.99
160_T163_A0.9210.99
312_S315_A0.9170.99
157_A161_Y0.9170.99
131_V134_R0.9150.99
197_L200_N0.9140.99
457_N461_E0.9140.99
199_F203_L0.9130.99
203_L295_K0.9100.99
318_C346_Y0.9100.99
371_L375_S0.9080.99
200_N203_L0.9070.99
195_V248_Y0.9070.99
424_E448_L0.9070.99
90_V96_L0.9070.99
424_E449_D0.9060.99
314_L370_I0.9040.99
205_G216_I0.9040.99
291_Q294_V0.9030.99
19_L59_M0.9010.99
101_Y140_L0.9000.99
153_R156_G0.8950.99
185_L247_V0.8920.99
176_Y282_P0.8910.99
501_L505_L0.8870.99
294_V298_N0.8840.99
15_I48_L0.8790.99
44_M121_P0.8780.99
312_S346_Y0.8760.99
166_K183_S0.8750.99
110_L114_K0.8740.99
294_V297_A0.8740.99
77_L110_L0.8730.99
48_L53_I0.8720.99
136_I140_L0.8710.99
53_I89_A0.8700.99
21_R36_T0.8670.98
162_A254_Y0.8640.98
442_L446_A0.8620.98
77_L81_E0.8610.98
213_Y239_I0.8600.98
317_V501_L0.8600.98
313_E501_L0.8580.98
248_Y284_I0.8580.98
409_M462_L0.8550.98
430_K435_I0.8540.98
101_Y144_R0.8530.98
195_V242_I0.8520.98
104_A136_I0.8500.98
220_L234_W0.8500.98
26_M34_E0.8480.98
154_M158_K0.8480.98
135_Q139_E0.8480.98
416_K420_L0.8450.98
150_T154_M0.8430.98
245_N248_Y0.8410.98
27_E34_E0.8410.98
419_E433_S0.8400.98
201_I205_G0.8400.98
59_M72_V0.8390.98
202_F299_K0.8370.98
14_N55_Y0.8350.98
107_I111_L0.8330.98
174_Y234_W0.8320.98
322_K512_M0.8320.98
424_E440_L0.8280.98
324_G509_I0.8250.98
338_N341_G0.8250.98
320_C323_C0.8240.98
151_R154_M0.8200.98
423_K448_L0.8200.98
172_A178_L0.8180.98
17_G41_K0.8180.98
47_I89_A0.8140.98
68_D97_S0.8120.98
460_N463_N0.8100.98
424_E428_F0.8090.98
457_N460_N0.8090.98
79_D85_Y0.8070.98
420_L423_K0.8060.98
426_F432_E0.8030.98
137_R140_L0.7980.97
189_E193_K0.7960.97
138_F141_F0.7950.97
102_S106_Q0.7940.97
134_R137_R0.7930.97
92_E149_M0.7930.97
313_E346_Y0.7920.97
174_Y191_E0.7890.97
187_P281_A0.7880.97
193_K200_N0.7880.97
35_D38_T0.7870.97
162_A274_I0.7870.97
435_I442_L0.7860.97
92_E123_K0.7850.97
87_A117_I0.7850.97
215_A218_S0.7840.97
445_K449_D0.7820.97
80_L114_K0.7820.97
406_K466_Q0.7810.97
213_Y296_I0.7810.97
53_I87_A0.7780.97
313_E367_E0.7750.97
227_T234_W0.7730.97
175_G248_Y0.7730.97
63_S66_S0.7700.97
327_L360_Y0.7670.97
288_Q295_K0.7660.97
58_K84_K0.7630.97
134_R138_F0.7580.96
26_M33_G0.7580.96
237_Y241_A0.7580.96
194_V220_L0.7560.96
426_F430_K0.7550.96
440_L445_K0.7540.96
193_K197_L0.7530.96
438_D442_L0.7500.96
239_I242_I0.7490.96
244_Q293_Q0.7490.96
407_K466_Q0.7490.96
154_M157_A0.7470.96
293_Q296_I0.7460.96
329_K344_S0.7450.96
375_S489_H0.7450.96
419_E423_K0.7440.96
412_H416_K0.7400.96
36_T40_Q0.7390.96
448_L452_F0.7390.96
15_I89_A0.7380.96
101_Y141_F0.7380.96
96_L104_A0.7370.96
199_F288_Q0.7370.96
126_D129_N0.7360.96
37_L61_I0.7340.96
426_F429_D0.7320.96
92_E139_E0.7320.96
220_L239_I0.7310.96
21_R34_E0.7300.96
192_A195_V0.7280.96
225_I234_W0.7270.96
364_N368_N0.7260.95
221_T233_R0.7250.95
512_M515_K0.7240.95
176_Y187_P0.7240.95
19_L44_M0.7220.95
132_D139_E0.7190.95
455_L458_A0.7180.95
99_G109_N0.7170.95
64_G103_D0.7160.95
172_A185_L0.7150.95
42_E160_T0.7150.95
248_Y292_S0.7140.95
39_E160_T0.7110.95
194_V234_W0.7110.95
58_K75_E0.7080.95
69_G74_K0.7080.95
354_K357_K0.7070.95
390_N394_S0.7070.95
420_L424_E0.7070.95
213_Y236_Q0.7070.95
41_K44_M0.7050.95
56_E79_D0.7050.95
104_A108_V0.7030.95
251_T279_A0.7000.95
39_E156_G0.6990.94
253_K273_Q0.6950.94
85_Y116_L0.6930.94
249_I253_K0.6920.94
323_C348_V0.6910.94
39_E91_K0.6900.94
287_E291_Q0.6880.94
314_L318_C0.6880.94
217_A234_W0.6840.94
297_A300_V0.6840.94
215_A219_H0.6820.94
255_K273_Q0.6810.94
488_Y497_K0.6810.94
135_Q142_M0.6810.94
135_Q141_F0.6800.94
314_L508_V0.6800.94
337_K342_T0.6800.94
150_T153_R0.6800.94
198_I234_W0.6780.94
47_I53_I0.6780.94
428_F440_L0.6770.93
427_I441_F0.6750.93
461_E465_L0.6740.93
318_C508_V0.6740.93
202_F212_S0.6730.93
494_S497_K0.6720.93
145_E148_E0.6720.93
24_Q61_I0.6700.93
91_K122_Y0.6700.93
44_M48_L0.6690.93
68_D73_F0.6690.93
329_K363_Y0.6680.93
196_Q200_N0.6660.93
372_D376_S0.6640.93
48_L52_E0.6610.93
177_Q191_E0.6600.93
421_K425_N0.6600.93
481_I488_Y0.6590.93
74_K77_L0.6590.93
429_D438_D0.6590.93
320_C348_V0.6590.93
161_Y168_I0.6590.93
111_L116_L0.6580.93
417_E420_L0.6570.92
427_I432_E0.6570.92
428_F432_E0.6560.92
313_E494_S0.6550.92
329_K346_Y0.6540.92
137_R142_M0.6540.92
174_Y195_V0.6520.92
96_L118_I0.6510.92
228_P234_W0.6510.92
39_E43_L0.6480.92
242_I248_Y0.6470.92
202_F213_Y0.6470.92
268_R273_Q0.6470.92
406_K465_L0.6470.92
278_D281_A0.6460.92
108_V118_I0.6460.92
56_E84_K0.6440.92
131_V145_E0.6410.92
416_K455_L0.6400.91
102_S105_G0.6400.91
76_C79_D0.6390.91
91_K153_R0.6390.91
252_V280_H0.6390.91
459_K466_Q0.6370.91
197_L220_L0.6370.91
240_K296_I0.6370.91
247_V281_A0.6360.91
480_N485_I0.6360.91
16_L55_Y0.6350.91
319_T509_I0.6320.91
423_K429_D0.6310.91
96_L111_L0.6300.91
406_K410_S0.6290.91
138_F142_M0.6280.91
64_G94_T0.6280.91
414_S417_E0.6270.91
258_E266_T0.6240.90
256_V273_Q0.6240.90
221_T227_T0.6240.90
159_Y162_A0.6220.90
500_L504_V0.6220.90
133_M138_F0.6210.90
202_F292_S0.6180.90
407_K411_E0.6170.90
443_K447_A0.6170.90
142_M149_M0.6150.90
143_A153_R0.6140.90
367_E371_L0.6130.90
481_I485_I0.6130.90
79_D82_E0.6120.90
411_E415_Q0.6110.89
430_K433_S0.6070.89
427_I445_K0.6070.89
158_K162_A0.6050.89
145_E149_M0.6040.89
64_G98_R0.6040.89
339_K342_T0.6020.89
17_G45_N0.6000.89
311_L315_A0.6000.89
213_Y243_L0.6000.89
492_S496_K0.5990.89
34_E61_I0.5990.89
167_W173_P0.5990.89
413_L416_K0.5980.88
199_F242_I0.5960.88
410_S466_Q0.5940.88
212_S218_S0.5920.88
346_Y367_E0.5910.88
374_L504_V0.5910.88
124_V139_E0.5910.88
174_Y228_P0.5900.88
255_K258_E0.5880.88
317_V505_L0.5860.87
246_E256_V0.5860.87
422_N426_F0.5860.87
350_S355_K0.5850.87
227_T231_K0.5840.87
465_L468_T0.5840.87
99_G103_D0.5840.87
200_N205_G0.5830.87
135_Q138_F0.5820.87
125_Y139_E0.5770.87
415_Q419_E0.5760.87
318_C327_L0.5750.86
284_I288_Q0.5720.86
291_Q295_K0.5720.86
328_S349_K0.5710.86
97_S107_I0.5710.86
186_D189_E0.5710.86
370_I373_Y0.5700.86
236_Q240_K0.5700.86
450_E453_K0.5700.86
437_S449_D0.5690.86
35_D157_A0.5690.86
21_R27_E0.5660.86
435_I438_D0.5650.86
313_E498_N0.5640.85
429_D432_E0.5640.85
417_E421_K0.5640.85
105_G141_F0.5640.85
384_T388_H0.5630.85
89_A119_I0.5630.85
25_D33_G0.5630.85
195_V292_S0.5630.85
188_V193_K0.5620.85
137_R144_R0.5610.85
149_M156_G0.5610.85
290_Q293_Q0.5590.85
139_E142_M0.5580.85
108_V140_L0.5560.85
493_S497_K0.5560.85
178_L183_S0.5550.85
43_L156_G0.5540.84
159_Y255_K0.5540.84
276_V279_A0.5540.84
479_N483_K0.5540.84
21_R62_G0.5540.84
513_T518_G0.5530.84
481_I484_I0.5520.84
143_A146_E0.5510.84
120_T147_F0.5510.84
213_Y244_Q0.5490.84
439_E453_K0.5490.84
21_R39_E0.5480.84
167_W170_G0.5480.84
104_A127_P0.5480.84
338_N342_T0.5470.84
162_A168_I0.5470.84
203_L289_F0.5470.84
27_E61_I0.5460.84
477_V485_I0.5460.84
361_V366_V0.5450.83
186_D281_A0.5450.83
511_N515_K0.5440.83
53_I86_Q0.5430.83
187_P191_E0.5430.83
75_E78_K0.5430.83
422_N425_N0.5420.83
427_I431_Y0.5420.83
462_L469_Q0.5420.83
47_I119_I0.5410.83
36_T39_E0.5400.83
93_I140_L0.5380.83
97_S103_D0.5380.83
196_Q283_I0.5370.83
16_L88_I0.5370.83
142_M145_E0.5370.83
406_K409_M0.5370.83
197_L225_I0.5340.82
185_L279_A0.5340.82
350_S353_C0.5330.82
45_N55_Y0.5330.82
123_K149_M0.5320.82
93_I104_A0.5320.82
381_N384_T0.5310.82
132_D145_E0.5300.82
214_T236_Q0.5300.82
493_S500_L0.5290.82
37_L59_M0.5280.82
456_Q459_K0.5280.82
247_V280_H0.5280.82
92_E152_E0.5270.81
139_E149_M0.5260.81
176_Y280_H0.5260.81
249_I292_S0.5260.81
430_K444_R0.5260.81
252_V278_D0.5260.81
283_I292_S0.5250.81
106_Q110_L0.5250.81
48_L55_Y0.5250.81
109_N113_S0.5240.81
134_R139_E0.5240.81
23_R147_F0.5230.81
74_K78_K0.5230.81
73_F77_L0.5230.81
134_R144_R0.5220.81
83_G116_L0.5210.81
168_I254_Y0.5210.81
27_E62_G0.5210.81
195_V284_I0.5200.81
192_A292_S0.5200.81
388_H391_S0.5200.81
142_M150_T0.5200.81
88_I141_F0.5190.80
131_V135_Q0.5190.80
463_N466_Q0.5190.80
255_K268_R0.5170.80
259_K265_R0.5170.80
118_I127_P0.5160.80
136_I141_F0.5150.80
387_K390_N0.5150.80
132_D137_R0.5140.80
427_I444_R0.5120.80
174_Y198_I0.5110.79
118_I147_F0.5100.79
27_E35_D0.5100.79
422_N434_G0.5090.79
21_R25_D0.5090.79
407_K410_S0.5080.79
219_H224_Q0.5070.79
314_L366_V0.5070.79
369_A372_D0.5070.79
79_D83_G0.5070.79
125_Y132_D0.5060.79
452_F459_K0.5060.79
77_L139_E0.5050.79
469_Q472_I0.5050.79
133_M137_R0.5040.78
18_Y76_C0.5040.78
421_K424_E0.5030.78
391_S394_S0.5020.78
70_R175_G0.5020.78
167_W172_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bqqA 2 0.5321 100 0.426 Contact Map
4kisA 2 0.5908 100 0.527 Contact Map
2r0qC 3 0.3394 100 0.651 Contact Map
1gdtA 2 0.3339 100 0.686 Contact Map
3guvA 2 0.2661 100 0.691 Contact Map
3g13A 2 0.2862 100 0.691 Contact Map
3uj3X 2 0.2275 100 0.698 Contact Map
3lhkA 2 0.2679 100 0.741 Contact Map
3bvpA 4 0.244 100 0.743 Contact Map
2gm5A 4 0.2257 100 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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