GREMLIN Database
YOKD - SPBc2 prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD
UniProt: O32003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (244)
Sequences: 789 (625)
Seq/√Len: 40.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L32_V5.5061.00
30_M169_Y4.9121.00
116_E119_R4.3801.00
59_V65_I3.5311.00
69_S135_V3.4511.00
14_K57_D3.1081.00
67_M118_F3.0331.00
164_Y256_D3.0041.00
118_F124_V2.9071.00
167_E250_S2.8691.00
86_P89_W2.7031.00
175_A179_S2.4261.00
74_L201_P2.3661.00
171_L248_L2.3651.00
168_S251_L2.2601.00
56_I137_W2.2521.00
36_S114_I2.2181.00
91_D95_E2.1530.99
163_L168_S2.1440.99
38_L48_A2.0650.99
167_E252_T2.0610.99
240_K245_N2.0540.99
182_C251_L2.0000.99
124_V137_W1.9760.99
53_Q121_Y1.9390.99
24_L239_G1.9160.99
118_F137_W1.8720.98
26_L58_V1.8300.98
51_V173_L1.7570.97
140_H143_K1.7420.97
64_T140_H1.7410.97
177_F231_E1.7090.97
140_H166_R1.6880.97
67_M124_V1.6610.96
172_L175_A1.6460.96
156_E161_G1.6240.96
157_Q161_G1.6100.96
183_F254_A1.5900.95
199_G212_E1.5860.95
66_V144_I1.5740.95
44_V51_V1.5630.95
172_L179_S1.5430.94
177_F180_S1.5310.94
18_T57_D1.4950.93
12_R16_S1.4900.93
147_Q162_K1.4890.93
186_A258_A1.4850.93
14_K18_T1.4830.93
118_F135_V1.4830.93
126_R133_S1.4790.93
56_I121_Y1.4750.93
229_A257_F1.4600.93
162_K165_I1.4560.92
28_K62_E1.4520.92
18_T22_K1.4100.91
239_G246_C1.4070.91
20_D239_G1.4070.91
204_V211_K1.3970.91
66_V136_A1.3820.90
40_S244_A1.3700.90
250_S253_E1.3630.90
204_V207_K1.3410.89
52_I115_V1.3400.89
35_H68_P1.3340.89
170_V251_L1.3300.89
238_V245_N1.3290.88
111_M115_V1.3260.88
43_W89_W1.3240.88
33_L134_F1.3210.88
136_A145_L1.3000.87
127_S136_A1.2970.87
154_L188_Y1.2970.87
44_V47_G1.2910.87
113_Q117_L1.2800.87
32_V171_L1.2740.86
18_T58_V1.2720.86
183_F258_A1.2710.86
149_P157_Q1.2670.86
107_T115_V1.2490.85
249_F254_A1.2430.85
59_V64_T1.2380.85
52_I114_I1.2320.84
15_Q96_S1.2230.84
31_T140_H1.2200.84
12_R243_S1.2100.83
230_F235_N1.2080.83
148_H159_P1.2070.83
37_S40_S1.1970.83
201_P208_R1.1950.82
20_D246_C1.1920.82
25_G29_G1.1910.82
170_V249_F1.1730.81
69_S111_M1.1710.81
41_I244_A1.1710.81
136_A141_K1.1670.81
197_N214_K1.1530.80
35_H181_T1.1520.80
73_E109_R1.1450.80
189_R193_Q1.1450.80
35_H170_V1.1180.78
22_K28_K1.1170.78
20_D41_I1.1170.78
41_I246_C1.1140.78
14_K53_Q1.1090.77
231_E247_R1.1050.77
233_E257_F1.0980.77
75_S131_N1.0980.77
125_K142_N1.0960.77
60_T139_K1.0940.76
34_V55_L1.0900.76
42_G242_G1.0890.76
142_N146_N1.0880.76
87_E90_W1.0770.75
152_F188_Y1.0680.75
176_D224_Q1.0670.75
230_F257_F1.0650.74
53_Q56_I1.0530.74
197_N212_E1.0470.73
41_I44_V1.0450.73
45_N96_S1.0440.73
156_E189_R1.0390.73
134_F145_L1.0270.72
67_M114_I1.0150.71
125_K145_L1.0140.71
36_S51_V1.0100.70
49_V53_Q1.0080.70
22_K58_V0.9970.69
71_S100_Y0.9960.69
131_N153_G0.9910.69
241_V246_C0.9910.69
70_Q154_L0.9830.68
229_A261_W0.9800.68
71_S172_L0.9770.68
177_F183_F0.9770.68
19_E22_K0.9640.67
189_R192_Y0.9640.67
20_D23_A0.9610.67
66_V168_S0.9590.66
231_E238_V0.9590.66
29_G60_T0.9580.66
52_I117_L0.9560.66
164_Y252_T0.9550.66
29_G63_G0.9510.66
53_Q57_D0.9480.66
32_V65_I0.9440.65
163_L251_L0.9360.65
188_Y218_F0.9320.64
41_I173_L0.9310.64
134_F160_L0.9240.64
164_Y182_C0.9220.63
249_F253_E0.9210.63
143_K166_R0.9200.63
25_G63_G0.9170.63
67_M135_V0.9150.63
60_T137_W0.9080.62
14_K50_A0.9070.62
35_H187_E0.9050.62
227_G231_E0.9030.62
200_A213_Y0.9020.62
38_L42_G0.9000.61
16_S20_D0.8980.61
36_S115_V0.8860.60
71_S133_S0.8840.60
127_S159_P0.8810.60
51_V114_I0.8720.59
17_I20_D0.8660.58
144_I166_R0.8630.58
190_I193_Q0.8610.58
124_V135_V0.8540.57
68_P176_D0.8530.57
74_L200_A0.8480.57
62_E139_K0.8460.57
228_Q232_A0.8450.57
145_L166_R0.8440.56
177_F227_G0.8430.56
183_F249_F0.8320.55
41_I239_G0.8270.55
172_L177_F0.8260.55
102_S128_N0.8240.55
180_S249_F0.8220.54
47_G50_A0.8140.54
31_T64_T0.8140.54
92_I96_S0.8140.54
90_W93_I0.8110.53
183_F186_A0.8100.53
20_D241_V0.8080.53
169_Y250_S0.8070.53
160_L185_L0.8000.52
31_T168_S0.7990.52
188_Y215_E0.7870.51
41_I51_V0.7860.51
67_M137_W0.7820.51
36_S109_R0.7820.51
180_S251_L0.7810.51
36_S43_W0.7800.51
91_D96_S0.7730.50
260_K264_N0.7700.50
161_G165_I0.7700.50
127_S148_H0.7640.49
153_G188_Y0.7640.49
61_E237_K0.7520.48
164_Y255_V0.7480.48
43_W50_A0.7380.47
115_V223_F0.7380.47
57_D91_D0.7350.47
72_V132_Y0.7330.46
39_S86_P0.7330.46
47_G174_G0.7310.46
24_L122_P0.7290.46
165_I252_T0.7250.46
89_W93_I0.7230.45
15_Q19_E0.7210.45
131_N200_A0.7200.45
132_Y215_E0.7180.45
112_G184_H0.7170.45
232_A257_F0.7140.45
37_S174_G0.7120.44
27_K250_S0.7080.44
204_V209_V0.7070.44
99_A208_R0.7030.44
117_L262_F0.6990.43
41_I245_N0.6980.43
44_V54_A0.6950.43
26_L30_M0.6880.42
161_G185_L0.6880.42
227_G247_R0.6810.42
107_T124_V0.6800.42
119_R163_L0.6780.41
37_S51_V0.6770.41
107_T116_E0.6760.41
201_P210_W0.6750.41
28_K57_D0.6750.41
24_L246_C0.6700.41
68_P111_M0.6690.41
132_Y153_G0.6680.40
28_K60_T0.6660.40
222_L262_F0.6630.40
239_G244_A0.6600.40
141_K145_L0.6580.40
238_V247_R0.6560.39
71_S105_T0.6510.39
86_P90_W0.6510.39
17_I21_L0.6500.39
195_I214_K0.6460.39
32_V248_L0.6450.38
37_S181_T0.6430.38
230_F253_E0.6420.38
94_R210_W0.6360.38
21_L26_L0.6360.38
241_V244_A0.6350.38
36_S100_Y0.6330.37
193_Q202_I0.6300.37
29_G62_E0.6230.37
154_L185_L0.6220.36
58_V241_V0.6190.36
43_W86_P0.6190.36
151_E161_G0.6160.36
155_G187_E0.6150.36
24_L262_F0.6140.36
129_H153_G0.6120.36
199_G210_W0.6110.36
16_S40_S0.6110.36
241_V248_L0.6080.35
42_G244_A0.6060.35
37_S46_G0.6040.35
66_V251_L0.6040.35
13_T16_S0.6030.35
100_Y195_I0.6030.35
56_I60_T0.6030.35
50_A71_S0.6010.35
101_N104_Y0.6010.35
121_Y124_V0.6010.35
149_P238_V0.5990.35
23_A123_E0.5960.34
86_P93_I0.5950.34
172_L249_F0.5950.34
51_V260_K0.5900.34
131_N215_E0.5900.34
71_S180_S0.5890.34
226_V235_N0.5870.34
15_Q61_E0.5870.34
104_Y120_S0.5860.33
17_I246_C0.5850.33
177_F236_M0.5850.33
67_M119_R0.5850.33
36_S68_P0.5840.33
30_M250_S0.5780.33
19_E23_A0.5780.33
100_Y175_A0.5770.33
28_K61_E0.5670.32
252_T256_D0.5660.32
146_N240_K0.5660.32
100_Y240_K0.5660.32
22_K202_I0.5660.32
65_I97_M0.5660.32
203_I208_R0.5660.32
37_S48_A0.5640.32
73_E262_F0.5640.32
153_G200_A0.5610.31
16_S92_I0.5600.31
41_I242_G0.5600.31
132_Y154_L0.5590.31
41_I59_V0.5570.31
72_V153_G0.5570.31
26_L63_G0.5560.31
188_Y216_L0.5560.31
127_S134_F0.5510.31
23_A232_A0.5500.31
203_I206_G0.5500.31
180_S227_G0.5500.31
135_V168_S0.5490.31
39_S44_V0.5480.30
101_N181_T0.5470.30
153_G215_E0.5450.30
213_Y256_D0.5440.30
71_S111_M0.5430.30
34_V171_L0.5430.30
122_P252_T0.5410.30
90_W94_R0.5410.30
74_L131_N0.5410.30
66_V134_F0.5400.30
146_N244_A0.5370.30
161_G226_V0.5360.30
33_L251_L0.5350.29
26_L223_F0.5340.29
68_P135_V0.5330.29
152_F218_F0.5330.29
88_E92_I0.5310.29
172_L223_F0.5300.29
16_S89_W0.5290.29
155_G158_S0.5290.29
109_R197_N0.5280.29
43_W114_I0.5270.29
71_S126_R0.5260.29
168_S177_F0.5250.29
12_R60_T0.5240.29
98_P129_H0.5230.29
100_Y189_R0.5220.28
57_D146_N0.5210.28
205_E232_A0.5210.28
48_A65_I0.5200.28
45_N49_V0.5200.28
230_F254_A0.5190.28
164_Y180_S0.5190.28
144_I231_E0.5180.28
223_F254_A0.5170.28
190_I262_F0.5160.28
125_K154_L0.5150.28
155_G161_G0.5110.28
69_S133_S0.5100.28
42_G201_P0.5090.28
258_A261_W0.5080.27
61_E125_K0.5070.27
213_Y217_E0.5050.27
192_Y218_F0.5050.27
171_L226_V0.5040.27
166_R195_I0.5040.27
161_G255_V0.5040.27
177_F247_R0.5040.27
184_H187_E0.5030.27
149_P156_E0.5030.27
115_V233_E0.5030.27
86_P109_R0.5030.27
103_N122_P0.5010.27
34_V57_D0.5000.27
153_G172_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nygA 2 0.9926 100 0.054 Contact Map
3ijwA 2 0.9706 100 0.066 Contact Map
3smaA 2 0.9743 100 0.1 Contact Map
3dr5A 2 0.4265 44.8 0.955 Contact Map
3lk7A 1 0.2243 35.3 0.958 Contact Map
1rhsA 1 0.3015 29 0.959 Contact Map
1sqgA 1 0.4081 27.8 0.96 Contact Map
2ki8A 1 0.3713 27.3 0.96 Contact Map
4kdlB 1 0.1176 25.9 0.96 Contact Map
3dh0A 1 0.4118 25.9 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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