GREMLIN Database
YOKF - SPBc2 prophage-derived endonuclease YokF
UniProt: O32001 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (244)
Sequences: 184 (171)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_L270_Y3.0170.94
266_L269_K2.8470.93
123_L156_V2.7830.92
235_P241_T2.6320.89
79_D101_E2.6220.89
83_V131_L2.5280.87
270_Y273_G2.5020.86
266_L271_P2.4930.86
82_K91_T2.4350.85
266_L273_G2.2620.80
202_Y207_G2.2520.80
94_Y157_Q2.2380.79
72_L126_S2.2190.79
155_S182_F2.2000.78
93_R142_Y2.1710.77
96_L196_I2.1510.77
271_P274_V2.1290.76
263_C273_G2.1110.75
131_L149_V2.0370.72
90_D139_R2.0170.72
101_E144_R2.0130.71
72_L129_L2.0080.71
9_A21_S1.9830.70
102_T113_G1.9340.68
101_E142_Y1.9290.68
263_C267_R1.8570.65
93_R101_E1.8310.64
231_Q235_P1.7870.62
262_N270_Y1.7840.62
126_S129_L1.7610.61
119_R123_L1.7530.60
67_L130_Q1.7390.60
159_T162_K1.7180.59
79_D98_D1.7130.58
187_Q190_K1.7020.58
231_Q234_T1.7000.58
72_L127_G1.6500.55
10_A16_S1.6470.55
96_L171_V1.6460.55
103_K117_S1.6360.55
98_D101_E1.6230.54
120_N156_V1.6210.54
260_F271_P1.6050.53
109_V114_E1.6050.53
124_V129_L1.5570.51
75_A126_S1.5340.50
93_R98_D1.5060.49
44_K52_K1.4950.48
126_S157_Q1.4930.48
204_T207_G1.4670.47
263_C266_L1.4600.46
75_A129_L1.4400.45
266_L272_N1.4270.45
92_V143_G1.4100.44
166_A197_W1.3940.43
92_V147_A1.3900.43
111_P168_V1.3850.43
242_S251_S1.3740.42
234_T254_T1.3680.42
257_T263_C1.3570.42
113_G142_Y1.3520.41
102_T109_V1.3500.41
11_F19_A1.3400.41
244_T266_L1.3370.41
269_K273_G1.3350.40
104_K108_C1.3320.40
13_L16_S1.3130.39
79_D144_R1.3000.39
263_C274_V1.3000.39
148_Y178_Y1.2900.38
119_R165_L1.2800.38
242_S272_N1.2790.38
119_R163_E1.2790.38
120_N178_Y1.2730.38
251_S272_N1.2720.38
99_T102_T1.2630.37
262_N266_L1.2630.37
93_R140_D1.2550.37
262_N271_P1.2520.37
164_G189_A1.2320.36
95_L153_G1.2220.35
161_L182_F1.2130.35
243_T263_C1.2130.35
237_A240_E1.2120.35
237_A257_T1.2120.35
243_T251_S1.2100.35
266_L274_V1.2090.35
14_S24_D1.2060.35
264_T270_Y1.2040.35
262_N267_R1.1990.34
148_Y168_V1.1960.34
267_R273_G1.1940.34
232_P257_T1.1910.34
120_N124_V1.1890.34
112_Y195_S1.1800.34
232_P235_P1.1770.33
270_Y274_V1.1760.33
226_K229_A1.1750.33
104_K107_S1.1730.33
167_R196_I1.1690.33
109_V118_K1.1690.33
161_L185_D1.1620.33
15_L60_K1.1600.33
244_T251_S1.1580.33
186_E190_K1.1560.33
148_Y197_W1.1510.32
264_T271_P1.1390.32
99_T109_V1.1390.32
50_S53_E1.1260.31
263_C275_P1.1210.31
147_A169_A1.1150.31
85_Y133_F1.1150.31
9_A12_T1.1100.31
148_Y174_P1.1050.30
262_N273_G1.1000.30
54_K58_K1.0980.30
124_V156_V1.0940.30
231_Q241_T1.0930.30
246_E270_Y1.0880.30
112_Y178_Y1.0870.30
165_L175_N1.0870.30
11_F76_V1.0860.30
262_N272_N1.0840.30
96_L197_W1.0830.30
235_P257_T1.0800.29
14_S20_C1.0770.29
242_S245_T1.0730.29
243_T247_K1.0720.29
187_Q191_S1.0680.29
97_I163_E1.0550.28
83_V129_L1.0550.28
271_P275_P1.0550.28
115_D124_V1.0400.28
94_Y108_C1.0350.28
96_L148_Y1.0340.28
82_K172_Y1.0260.27
94_Y159_T1.0250.27
78_G101_E1.0210.27
264_T273_G1.0190.27
97_I160_L1.0140.27
260_F265_E1.0140.27
243_T266_L1.0060.27
82_K89_V1.0040.26
245_T248_E0.9950.26
70_V124_V0.9850.26
267_R271_P0.9800.26
107_S165_L0.9750.25
241_T251_S0.9660.25
237_A256_G0.9660.25
270_Y275_P0.9650.25
263_C272_N0.9600.25
14_S22_S0.9580.25
132_E177_K0.9580.25
267_R274_V0.9470.24
113_G144_R0.9440.24
105_P109_V0.9420.24
104_K112_Y0.9410.24
263_C271_P0.9410.24
79_D93_R0.9410.24
98_D142_Y0.9350.24
133_F147_A0.9340.24
234_T257_T0.9340.24
171_V196_I0.9290.24
260_F270_Y0.9260.24
158_E196_I0.9260.24
203_V207_G0.9180.23
167_R202_Y0.9170.23
231_Q257_T0.9140.23
11_F21_S0.9130.23
96_L198_S0.9080.23
10_A46_E0.9020.23
77_D101_E0.9010.23
111_P148_Y0.9010.23
264_T267_R0.8980.23
113_G117_S0.8970.23
46_E49_E0.8950.23
111_P132_E0.8920.23
233_T257_T0.8830.22
247_K251_S0.8810.22
244_T272_N0.8780.22
263_C269_K0.8770.22
101_E113_G0.8760.22
94_Y162_K0.8670.22
14_S19_A0.8660.22
101_E140_D0.8640.22
9_A13_L0.8630.22
167_R207_G0.8620.22
186_E197_W0.8580.21
262_N274_V0.8510.21
134_D146_L0.8480.21
244_T270_Y0.8450.21
152_D165_L0.8450.21
243_T248_E0.8450.21
97_I188_E0.8430.21
182_F197_W0.8420.21
264_T268_K0.8420.21
132_E148_Y0.8390.21
124_V157_Q0.8330.21
96_L202_Y0.8320.21
243_T272_N0.8300.21
95_L138_R0.8210.20
10_A24_D0.8180.20
240_E256_G0.8160.20
103_K107_S0.8150.20
72_L124_V0.8110.20
96_L169_A0.8110.20
49_E53_E0.8040.20
10_A13_L0.8020.20
242_S248_E0.7990.20
94_Y120_N0.7980.20
148_Y166_A0.7890.19
92_V123_L0.7880.19
93_R144_R0.7850.19
245_T251_S0.7800.19
96_L168_V0.7790.19
232_P241_T0.7730.19
76_V103_K0.7720.19
244_T253_T0.7690.19
168_V186_E0.7680.19
139_R161_L0.7680.19
10_A14_S0.7660.19
133_F175_N0.7640.19
130_Q152_D0.7630.18
155_S161_L0.7590.18
77_D144_R0.7590.18
96_L179_I0.7530.18
241_T257_T0.7530.18
15_L23_N0.7490.18
225_S230_T0.7470.18
110_Q167_R0.7460.18
98_D144_R0.7440.18
175_N200_N0.7420.18
93_R113_G0.7370.18
45_T51_T0.7320.18
272_N275_P0.7300.18
24_D42_E0.7170.17
251_S254_T0.7160.17
196_I203_V0.7150.17
179_I183_K0.7120.17
129_L195_S0.7020.17
169_A179_I0.7020.17
79_D142_Y0.6990.17
233_T251_S0.6970.17
124_V127_G0.6960.17
226_K230_T0.6920.17
233_T236_K0.6900.16
140_D144_R0.6890.16
77_D142_Y0.6890.16
48_K51_T0.6870.16
233_T239_S0.6870.16
96_L203_V0.6840.16
72_L75_A0.6840.16
242_S246_E0.6790.16
51_T57_D0.6770.16
17_L20_C0.6740.16
10_A17_L0.6730.16
112_Y186_E0.6670.16
133_F138_R0.6650.16
110_Q176_T0.6630.16
239_S245_T0.6620.16
47_Q55_T0.6620.16
105_P174_P0.6600.16
258_E263_C0.6590.16
86_N158_E0.6560.16
96_L138_R0.6540.16
70_V119_R0.6540.16
98_D147_A0.6530.16
99_T113_G0.6480.15
175_N180_D0.6460.15
94_Y141_K0.6430.15
120_N155_S0.6430.15
139_R186_E0.6400.15
72_L92_V0.6390.15
241_T269_K0.6390.15
157_Q161_L0.6380.15
167_R203_V0.6360.15
43_K47_Q0.6300.15
243_T262_N0.6290.15
129_L157_Q0.6280.15
102_T105_P0.6250.15
236_K251_S0.6210.15
135_K176_T0.6210.15
13_L19_A0.6210.15
43_K48_K0.6200.15
243_T270_Y0.6200.15
49_E58_K0.6160.15
151_V154_K0.6150.15
10_A21_S0.6080.14
173_E176_T0.6080.14
92_V145_L0.6080.14
91_T120_N0.6070.14
161_L166_A0.6010.14
9_A14_S0.5960.14
76_V178_Y0.5960.14
181_Q184_K0.5950.14
44_K47_Q0.5940.14
236_K247_K0.5940.14
56_A63_D0.5930.14
148_Y182_F0.5910.14
95_L152_D0.5890.14
261_K265_E0.5840.14
152_D158_E0.5830.14
95_L151_V0.5830.14
140_D149_V0.5830.14
108_C186_E0.5810.14
124_V269_K0.5810.14
97_I102_T0.5810.14
125_N190_K0.5780.14
239_S257_T0.5750.14
131_L134_D0.5750.14
100_P164_G0.5730.14
50_S57_D0.5720.14
254_T272_N0.5710.14
110_Q208_F0.5690.14
132_E178_Y0.5660.13
256_G271_P0.5650.13
117_S121_K0.5590.13
110_Q153_G0.5590.13
155_S174_P0.5590.13
13_L18_A0.5580.13
95_L182_F0.5570.13
102_T176_T0.5570.13
130_Q175_N0.5530.13
257_T266_L0.5530.13
15_L21_S0.5530.13
242_S254_T0.5520.13
100_P115_D0.5520.13
167_R186_E0.5510.13
44_K49_E0.5500.13
92_V149_V0.5500.13
16_S19_A0.5490.13
49_E56_A0.5480.13
158_E181_Q0.5480.13
150_Y155_S0.5430.13
92_V169_A0.5420.13
72_L95_L0.5360.13
15_L45_T0.5360.13
83_V161_L0.5360.13
87_G100_P0.5350.13
81_I145_L0.5350.13
72_L157_Q0.5340.13
19_A162_K0.5330.13
240_E259_T0.5320.13
120_N126_S0.5310.13
147_A208_F0.5280.13
19_A215_K0.5270.13
248_E273_G0.5260.13
243_T271_P0.5250.13
44_K48_K0.5240.13
269_K274_V0.5240.13
147_A163_E0.5210.12
46_E51_T0.5180.12
254_T260_F0.5170.12
137_D185_D0.5150.12
119_R122_E0.5150.12
70_V81_I0.5140.12
42_E49_E0.5100.12
74_R82_K0.5090.12
130_Q155_S0.5090.12
169_A202_Y0.5080.12
250_S274_V0.5070.12
132_E168_V0.5070.12
153_G183_K0.5050.12
129_L194_L0.5040.12
141_K145_L0.5030.12
103_K108_C0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eqpA 1 0.4324 100 0.597 Contact Map
4qmgA 3 0.6622 100 0.639 Contact Map
3bdlA 2 0.7365 100 0.643 Contact Map
2wacA 1 0.6284 99.9 0.752 Contact Map
2hqxA 2 0.2027 99.9 0.753 Contact Map
4b9wA 2 0.5304 97 0.92 Contact Map
4q5yA 2 0.5304 86.9 0.946 Contact Map
4b9xA 1 0.5507 85.5 0.947 Contact Map
3zbiC 1 0.0912 81.8 0.95 Contact Map
3ntkA 1 0.5236 77.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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