GREMLIN Database
YOKL - SPBc2 prophage-derived uncharacterized N-acetyltransferase YokL
UniProt: O31995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (163)
Sequences: 19792 (15296)
Seq/√Len: 1198.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_T138_H2.9401.00
104_K140_K2.7961.00
14_R20_D2.4611.00
146_E166_G2.4271.00
127_V135_I2.3621.00
10_N105_E2.2901.00
145_K163_I2.2861.00
87_F120_Y2.2761.00
77_T114_F2.2761.00
145_K148_Q2.1801.00
8_G109_M2.1781.00
127_V138_H2.1151.00
135_I139_E2.0461.00
8_G105_E2.0191.00
89_Y107_I1.9761.00
136_R139_E1.9751.00
111_L143_F1.8811.00
112_R116_L1.8671.00
23_I71_I1.8001.00
148_Q163_I1.7861.00
121_Q151_K1.7691.00
75_I106_M1.7541.00
111_L123_V1.7311.00
135_I163_I1.7261.00
14_R65_V1.6961.00
107_I141_L1.6891.00
44_A48_R1.6581.00
21_I48_R1.6571.00
154_F159_Y1.6491.00
30_E95_E1.6051.00
135_I145_K1.5941.00
22_V44_A1.5561.00
109_M112_R1.5511.00
129_S161_D1.5381.00
18_P52_E1.5301.00
94_F97_Y1.4961.00
93_V103_A1.4881.00
50_W54_Q1.4651.00
139_E145_K1.4491.00
7_T67_S1.4201.00
121_Q159_Y1.4191.00
43_S46_N1.4161.00
132_N135_I1.4131.00
6_W109_M1.3961.00
7_T12_T1.3791.00
152_I162_G1.3631.00
104_K137_L1.3621.00
122_K166_G1.3551.00
135_I165_F1.3551.00
75_I110_V1.3361.00
113_F117_E1.3301.00
72_V97_Y1.3131.00
129_S148_Q1.3101.00
130_F160_Y1.2951.00
23_I70_N1.2871.00
63_I67_S1.2871.00
91_L138_H1.2811.00
149_L164_C1.2491.00
70_N97_Y1.2001.00
48_R52_E1.1991.00
114_F123_V1.1981.00
74_M92_A1.1821.00
103_A137_L1.1721.00
63_I66_E1.1721.00
27_L92_A1.1521.00
98_R133_P1.1331.00
127_V165_F1.1311.00
88_G126_T1.1131.00
25_D44_A1.1071.00
6_W113_F1.1031.00
145_K165_F1.0991.00
104_K108_L1.0981.00
70_N96_P1.0951.00
6_W13_L1.0921.00
114_F118_L1.0871.00
27_L94_F1.0801.00
21_I51_V1.0681.00
8_G11_L1.0671.00
148_Q161_D1.0611.00
113_F118_L1.0601.00
95_E98_R1.0591.00
86_T124_N1.0571.00
125_T143_F1.0571.00
81_D84_N1.0551.00
41_P47_M1.0541.00
111_L167_M1.0471.00
151_K161_D1.0321.00
65_V69_N1.0321.00
42_R46_N1.0261.00
128_Y160_Y1.0101.00
49_E53_E1.0101.00
21_I44_A1.0091.00
23_I26_S0.9911.00
18_P48_R0.9911.00
91_L134_S0.9871.00
134_S138_H0.9821.00
16_I63_I0.9651.00
150_R161_D0.9561.00
129_S163_I0.9531.00
111_L141_L0.9521.00
137_L141_L0.9451.00
77_T110_V0.9431.00
122_K146_E0.9421.00
108_L112_R0.9411.00
30_E94_F0.9351.00
132_N136_R0.9221.00
150_R166_G0.9211.00
16_I74_M0.9191.00
25_D29_D0.9131.00
11_L102_F0.9071.00
33_R36_D0.9051.00
30_E96_P0.9051.00
91_L103_A0.9041.00
138_H143_F0.9031.00
104_K141_L0.8981.00
143_F167_M0.8951.00
32_L98_R0.8871.00
86_T122_K0.8851.00
99_G133_P0.8841.00
12_T69_N0.8801.00
26_S94_F0.8721.00
108_L141_L0.8701.00
11_L106_M0.8651.00
114_F120_Y0.8451.00
105_E109_M0.8311.00
85_G159_Y0.8251.00
18_P21_I0.8251.00
22_V26_S0.8191.00
12_T67_S0.8191.00
149_L152_I0.8181.00
21_I25_D0.8131.00
97_Y100_K0.8081.00
85_G154_F0.8041.00
63_I71_I0.8031.00
86_T152_I0.7971.00
150_R168_T0.7861.00
64_A71_I0.7771.00
132_N139_E0.7741.00
18_P55_L0.7711.00
88_G124_N0.7641.00
93_V102_F0.7571.00
154_F158_A0.7571.00
49_E52_E0.7561.00
64_A67_S0.7511.00
23_I94_F0.7431.00
26_S70_N0.7411.00
128_Y155_T0.7401.00
126_T162_G0.7351.00
70_N94_F0.7351.00
126_T149_L0.7281.00
47_M50_W0.7271.00
107_I137_L0.7271.00
25_D47_M0.7221.00
99_G104_K0.7181.00
139_E165_F0.7171.00
10_N101_G0.7161.00
127_V134_S0.7151.00
26_S96_P0.7111.00
62_F65_V0.7061.00
122_K168_T0.7051.00
127_V163_I0.7011.00
146_E150_R0.7001.00
151_K159_Y0.6961.00
91_L107_I0.6921.00
93_V98_R0.6911.00
66_E72_V0.6911.00
9_E105_E0.6861.00
8_G13_L0.6851.00
12_T65_V0.6831.00
12_T66_E0.6811.00
77_T87_F0.6711.00
42_R47_M0.6711.00
28_D92_A0.6691.00
58_D62_F0.6641.00
130_F158_A0.6561.00
87_F114_F0.6531.00
44_A47_M0.6421.00
99_G136_R0.6371.00
133_P136_R0.6291.00
136_R140_K0.6281.00
125_T134_S0.6271.00
45_N49_E0.6251.00
62_F110_V0.6241.00
104_K133_P0.6181.00
14_R66_E0.6171.00
45_N48_R0.6171.00
35_M130_F0.6141.00
155_T158_A0.6121.00
17_Q20_D0.6111.00
102_F105_E0.6101.00
124_N149_L0.6081.00
103_A107_I0.6071.00
111_L115_F0.6061.00
46_N49_E0.6041.00
71_I74_M0.6031.00
153_I162_G0.6021.00
11_L105_E0.6021.00
35_M128_Y0.6011.00
85_G121_Q0.6001.00
125_T165_F0.6001.00
14_R64_A0.5991.00
26_S30_E0.5941.00
72_V102_F0.5911.00
51_V55_L0.5901.00
141_L167_M0.5891.00
32_L36_D0.5891.00
151_K168_T0.5881.00
33_R38_L0.5841.00
126_T164_C0.5831.00
76_E90_Y0.5821.00
28_D31_I0.5801.00
7_T66_E0.5791.00
75_I107_I0.5791.00
58_D61_R0.5721.00
80_C87_F0.5701.00
14_R17_Q0.5661.00
93_V97_Y0.5651.00
129_S135_I0.5601.00
27_L71_I0.5511.00
30_E98_R0.5501.00
15_A55_L0.5481.00
32_L92_A0.5451.00
115_F167_M0.5441.00
154_F157_G0.5421.00
93_V106_M0.5411.00
64_A93_V0.5391.00
138_H165_F0.5381.00
124_N152_I0.5371.00
66_E70_N0.5341.00
27_L31_I0.5331.00
122_K152_I0.5311.00
78_F88_G0.5301.00
144_M150_R0.5291.00
67_S102_F0.5291.00
99_G137_L0.5291.00
131_N134_S0.5281.00
89_Y123_V0.5271.00
155_T160_Y0.5251.00
21_I47_M0.5201.00
66_E69_N0.5201.00
62_F113_F0.5051.00
22_V25_D0.5031.00
24_F74_M0.5011.00
47_M51_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pzjA 2 0.9774 100 0.304 Contact Map
2vzyA 3 0.9096 100 0.309 Contact Map
2z10A 2 1 100 0.316 Contact Map
1yreA 2 0.9548 100 0.316 Contact Map
3r9fA 1 0.9548 100 0.333 Contact Map
1nslA 3 0.9661 100 0.34 Contact Map
2fckA 2 0.9379 100 0.353 Contact Map
3tcvA 2 1 100 0.362 Contact Map
1s7kA 2 0.8757 100 0.362 Contact Map
4r9mA 5 0.9435 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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