GREMLIN Database
UVRX - Putative UV-damage repair protein UvrX
UniProt: O31990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (356)
Sequences: 8748 (6159)
Seq/√Len: 326.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_R136_S3.9461.00
136_S140_E2.9651.00
190_S200_E2.9241.00
273_K333_L2.9131.00
102_R140_E2.8421.00
268_R271_E2.8151.00
40_V79_I2.7321.00
294_G352_L2.6431.00
28_T88_L2.5801.00
204_N209_S2.3921.00
92_V95_E2.3461.00
257_G351_T2.3441.00
17_M145_C2.3381.00
70_L81_I2.3081.00
138_W169_S2.3011.00
273_K337_N2.2461.00
85_Q88_L2.2301.00
135_S139_R2.2251.00
132_A136_S2.1631.00
209_S213_Q2.1571.00
190_S204_N2.1511.00
36_C57_A2.1401.00
103_F136_S2.1121.00
206_M225_K2.1001.00
110_H153_M2.0961.00
26_A55_S2.0541.00
212_G216_K2.0221.00
137_M145_C2.0221.00
104_V119_L2.0171.00
235_Y240_I2.0001.00
234_Y238_H1.9931.00
208_I214_L1.9921.00
37_Y80_H1.9651.00
223_E231_N1.9651.00
269_S337_N1.9321.00
184_W215_A1.9241.00
184_W212_G1.9051.00
17_M96_I1.9001.00
208_I217_F1.8921.00
283_V352_L1.8871.00
28_T85_Q1.8751.00
13_L121_A1.8681.00
134_Q169_S1.8591.00
17_M143_L1.8361.00
287_A352_L1.8041.00
97_T117_S1.7621.00
175_R178_D1.7551.00
296_T354_N1.7521.00
219_L231_N1.7421.00
232_Q236_H1.7151.00
101_Y109_V1.6541.00
277_L329_Y1.6491.00
324_I327_D1.6401.00
364_S367_E1.6291.00
180_P184_W1.6211.00
298_S353_S1.6191.00
88_L91_R1.6081.00
40_V51_V1.5921.00
316_K334_M1.5741.00
127_E131_K1.5731.00
300_G349_S1.5731.00
112_Y118_F1.5611.00
280_C328_I1.5591.00
27_V92_V1.5541.00
323_S358_D1.5451.00
57_A61_D1.5411.00
134_Q171_I1.5261.00
155_L174_W1.5241.00
22_A39_A1.5241.00
200_E204_N1.5151.00
125_D128_E1.5131.00
178_D181_N1.5041.00
316_K338_K1.4991.00
258_K283_V1.4821.00
151_D179_V1.4741.00
266_Y272_I1.4711.00
210_T213_Q1.4571.00
217_F221_L1.4561.00
91_R95_E1.4561.00
296_T353_S1.4561.00
206_M226_F1.4551.00
129_M133_I1.4511.00
201_R205_R1.4471.00
15_V145_C1.4331.00
40_V64_I1.4181.00
13_L147_V1.4121.00
40_V81_I1.4021.00
131_K135_S1.4021.00
103_F132_A1.4011.00
31_L34_L1.4011.00
230_G234_Y1.4001.00
284_A325_T1.3911.00
25_S89_F1.3891.00
332_C350_V1.3841.00
231_N235_Y1.3821.00
24_V88_L1.3801.00
219_L235_Y1.3731.00
130_A147_V1.3681.00
26_A35_T1.3631.00
69_R72_E1.3621.00
280_C350_V1.3591.00
130_A149_I1.3541.00
62_F78_R1.3441.00
281_E325_T1.3431.00
149_I171_I1.3381.00
264_R271_E1.3321.00
287_A294_G1.3291.00
100_F119_L1.3251.00
293_V356_E1.3221.00
219_L234_Y1.3211.00
217_F222_L1.3171.00
222_L234_Y1.3071.00
284_A328_I1.3041.00
24_V92_V1.3041.00
19_S23_S1.3031.00
295_R354_N1.3011.00
127_E173_R1.2981.00
259_S349_S1.2921.00
269_S273_K1.2911.00
99_L140_E1.2871.00
318_I331_C1.2821.00
13_L130_A1.2801.00
131_K134_Q1.2791.00
98_K101_Y1.2671.00
180_P215_A1.2571.00
267_T344_T1.2561.00
118_F193_W1.2491.00
288_R381_D1.2451.00
302_G311_G1.2451.00
22_A26_A1.2451.00
258_K286_R1.2431.00
72_E75_E1.2411.00
256_F290_H1.2351.00
331_C334_M1.2271.00
150_G155_L1.2261.00
329_Y333_L1.2161.00
262_L275_V1.2111.00
159_A174_W1.2101.00
34_L39_A1.2071.00
26_A57_A1.2051.00
15_V100_F1.2021.00
25_S85_Q1.1991.00
202_N225_K1.1851.00
62_F76_D1.1821.00
198_R201_R1.1791.00
88_L92_V1.1761.00
258_K282_E1.1761.00
99_L136_S1.1751.00
327_D331_C1.1691.00
56_P61_D1.1681.00
213_Q216_K1.1641.00
87_K91_R1.1601.00
99_L141_F1.1541.00
298_S315_S1.1501.00
219_L223_E1.1481.00
266_Y271_E1.1461.00
316_K331_C1.1431.00
218_P221_L1.1401.00
280_C284_A1.1321.00
31_L82_V1.1321.00
333_L337_N1.1301.00
100_F117_S1.1281.00
221_L225_K1.1281.00
262_L266_Y1.1261.00
27_V88_L1.1251.00
39_A82_V1.1231.00
162_L172_A1.1151.00
302_G347_S1.1131.00
265_D304_S1.1121.00
318_I322_T1.1081.00
14_C160_L1.1071.00
330_R334_M1.1061.00
108_C247_A1.1021.00
121_A129_M1.0931.00
296_T315_S1.0841.00
51_V54_A1.0801.00
51_V64_I1.0781.00
259_S300_G1.0731.00
272_I336_F1.0701.00
376_L379_V1.0571.00
51_V73_I1.0561.00
280_C329_Y1.0501.00
192_M211_I1.0501.00
362_Q365_L1.0491.00
47_Q74_P1.0491.00
26_A36_C1.0481.00
215_A238_H1.0471.00
97_T111_T1.0461.00
103_F133_I1.0441.00
54_A66_T1.0371.00
295_R356_E1.0321.00
371_E375_K1.0301.00
150_G156_S1.0261.00
27_V142_G1.0251.00
275_V278_E1.0231.00
296_T317_T1.0201.00
322_T327_D1.0141.00
128_E132_A1.0061.00
295_R321_P1.0011.00
284_A288_R0.9991.00
15_V119_L0.9981.00
52_L84_P0.9951.00
201_R204_N0.9941.00
161_D191_K0.9831.00
265_D346_R0.9821.00
299_L335_L0.9821.00
227_G230_G0.9821.00
124_E129_M0.9791.00
71_F75_E0.9771.00
292_K357_D0.9771.00
163_E172_A0.9751.00
96_I141_F0.9751.00
293_V323_S0.9741.00
19_S56_P0.9731.00
22_A53_A0.9701.00
158_L186_V0.9691.00
28_T92_V0.9591.00
295_R317_T0.9571.00
280_C332_C0.9491.00
334_M338_K0.9471.00
288_R323_S0.9461.00
20_F24_V0.9461.00
64_I79_I0.9451.00
42_G70_L0.9411.00
317_T354_N0.9411.00
112_Y193_W0.9361.00
11_N126_P0.9341.00
303_Y343_K0.9341.00
86_M90_I0.9311.00
68_S72_E0.9301.00
260_Q275_V0.9241.00
325_T377_G0.9241.00
326_M330_R0.9221.00
226_F230_G0.9211.00
298_S351_T0.9161.00
131_K171_I0.9141.00
97_T101_Y0.9051.00
130_A171_I0.9031.00
301_I348_V0.9021.00
265_D344_T0.9011.00
105_P108_C0.8971.00
276_L299_L0.8971.00
276_L348_V0.8881.00
138_W142_G0.8851.00
229_M232_Q0.8801.00
65_K68_S0.8771.00
214_L222_L0.8751.00
202_N205_R0.8721.00
100_F133_I0.8701.00
293_V358_D0.8651.00
42_G49_S0.8631.00
26_A39_A0.8581.00
19_S26_A0.8571.00
21_Y86_M0.8561.00
276_L336_F0.8551.00
276_L332_C0.8551.00
379_V383_I0.8531.00
283_V350_V0.8511.00
221_L224_K0.8501.00
185_K212_G0.8491.00
95_E98_K0.8491.00
154_L236_H0.8421.00
215_A237_A0.8391.00
40_V76_D0.8341.00
222_L226_F0.8321.00
90_I94_T0.8301.00
189_L204_N0.8271.00
153_M245_I0.8221.00
358_D374_R0.8181.00
138_W144_M0.8171.00
178_D182_K0.8161.00
297_I331_C0.8161.00
321_P356_E0.8161.00
374_R378_F0.8151.00
325_T329_Y0.8151.00
208_I213_Q0.8131.00
259_S347_S0.8121.00
37_Y78_R0.8101.00
298_S313_H0.8091.00
326_M373_R0.8091.00
68_S73_I0.8071.00
375_K378_F0.8071.00
110_H245_I0.8061.00
292_K355_I0.8061.00
195_I230_G0.8051.00
235_Y242_L0.8041.00
132_A135_S0.8031.00
168_K172_A0.8011.00
220_E224_K0.7971.00
188_P204_N0.7961.00
316_K335_L0.7931.00
276_L329_Y0.7881.00
199_M202_N0.7851.00
314_R339_F0.7831.00
149_I173_R0.7781.00
202_N226_F0.7781.00
331_C335_L0.7771.00
109_V117_S0.7761.00
126_P130_A0.7741.00
152_N155_L0.7721.00
212_G215_A0.7711.00
97_T109_V0.7691.00
280_C325_T0.7691.00
182_K186_V0.7691.00
99_L137_M0.7631.00
314_R338_K0.7590.99
312_F339_F0.7590.99
303_Y312_F0.7580.99
104_V109_V0.7580.99
54_A64_I0.7580.99
188_P191_K0.7570.99
95_E141_F0.7560.99
76_D79_I0.7550.99
121_A130_A0.7540.99
378_F382_G0.7540.99
314_R335_L0.7520.99
93_S97_T0.7510.99
127_E171_I0.7480.99
274_A278_E0.7480.99
277_L333_L0.7410.99
269_S336_F0.7350.99
301_I339_F0.7340.99
58_L79_I0.7280.99
286_R290_H0.7280.99
199_M226_F0.7250.99
189_L208_I0.7250.99
174_W182_K0.7220.99
99_L103_F0.7200.99
111_T114_I0.7180.99
206_M217_F0.7170.99
218_P238_H0.7160.99
38_L76_D0.7140.99
17_M20_F0.7140.99
147_V171_I0.7130.99
74_P81_I0.7120.99
195_I233_L0.7110.99
43_N49_S0.7110.99
51_V81_I0.7100.99
52_L66_T0.7100.99
273_K277_L0.7090.99
22_A55_S0.7090.99
41_V82_V0.7090.99
270_E273_K0.7090.99
54_A60_K0.7060.99
42_G81_I0.7050.99
99_L102_R0.7050.99
214_L234_Y0.7050.99
282_E285_R0.7050.99
281_E285_R0.7040.99
241_D244_E0.7040.99
297_I328_I0.7030.99
260_Q282_E0.7030.99
118_F153_M0.7020.99
108_C120_D0.7000.99
108_C244_E0.7000.99
136_S139_R0.7000.99
73_I76_D0.6990.99
12_I245_I0.6970.99
328_I332_C0.6970.99
21_Y84_P0.6960.99
53_A60_K0.6960.99
103_F129_M0.6930.99
272_I348_V0.6890.99
320_L327_D0.6890.99
34_L80_H0.6870.99
21_Y114_I0.6860.99
12_I120_D0.6820.99
44_T83_N0.6820.99
134_Q147_V0.6810.99
56_P60_K0.6810.99
135_S138_W0.6740.99
44_T47_Q0.6740.99
18_K146_T0.6730.99
92_V141_F0.6730.99
128_E131_K0.6720.99
266_Y275_V0.6710.99
325_T381_D0.6660.99
92_V143_L0.6660.99
206_M221_L0.6640.99
180_P216_K0.6630.99
322_T328_I0.6620.99
37_Y57_A0.6610.99
274_A277_L0.6600.99
226_F233_L0.6580.99
87_K90_I0.6540.99
36_C55_S0.6530.98
71_F74_P0.6530.98
189_L203_L0.6520.98
279_I348_V0.6520.98
98_K102_R0.6520.98
129_M132_A0.6510.98
253_Q290_H0.6500.98
108_C123_K0.6500.98
43_N83_N0.6490.98
257_G349_S0.6420.98
375_K379_V0.6410.98
288_R325_T0.6390.98
371_E374_R0.6390.98
32_N35_T0.6390.98
74_P79_I0.6350.98
181_N184_W0.6350.98
151_D155_L0.6350.98
277_L281_E0.6320.98
74_P77_P0.6310.98
293_V355_I0.6300.98
121_A124_E0.6290.98
219_L230_G0.6290.98
73_I79_I0.6290.98
160_L163_E0.6260.98
328_I352_L0.6260.98
327_D330_R0.6240.98
256_F286_R0.6230.98
186_V191_K0.6160.98
261_I347_S0.6150.98
269_S340_Y0.6140.98
40_V70_L0.6100.98
301_I345_V0.6090.98
50_V66_T0.6070.98
155_L179_V0.6060.98
271_E274_A0.6060.98
256_F292_K0.6060.98
367_E370_N0.6060.98
357_D360_N0.6060.98
285_R289_T0.6050.98
272_I345_V0.6040.98
189_L200_E0.6030.97
303_Y307_E0.6030.97
144_M163_E0.6030.97
95_E140_E0.6030.97
283_V297_I0.6020.97
179_V182_K0.6020.97
300_G313_H0.6010.97
336_F340_Y0.6000.97
223_E230_G0.6000.97
84_P89_F0.5990.97
318_I321_P0.5980.97
270_E274_A0.5980.97
214_L226_F0.5960.97
303_Y345_V0.5950.97
185_K210_T0.5930.97
25_S31_L0.5910.97
304_S343_K0.5890.97
193_W236_H0.5890.97
276_L333_L0.5880.97
34_L82_V0.5870.97
163_E170_G0.5860.97
25_S28_T0.5860.97
352_L355_I0.5860.97
277_L325_T0.5830.97
197_G201_R0.5820.97
236_H241_D0.5810.97
312_F315_S0.5780.97
316_K319_D0.5780.97
324_I373_R0.5750.97
24_V28_T0.5740.97
100_F109_V0.5740.97
23_S53_A0.5740.97
223_E228_I0.5730.97
275_V348_V0.5720.97
18_K163_E0.5700.96
126_P129_M0.5670.96
113_S116_E0.5650.96
104_V129_M0.5620.96
233_L236_H0.5610.96
90_I114_I0.5600.96
179_V183_L0.5600.96
24_V27_V0.5600.96
304_S346_R0.5570.96
291_N358_D0.5550.96
327_D370_N0.5540.96
180_P238_H0.5530.96
116_E157_K0.5530.96
214_L237_A0.5500.96
158_L193_W0.5470.96
184_W216_K0.5470.96
284_A332_C0.5470.96
53_A66_T0.5450.95
294_G355_I0.5430.95
154_L233_L0.5430.95
27_V95_E0.5430.95
94_T98_K0.5430.95
362_Q366_F0.5430.95
19_S60_K0.5430.95
294_G297_I0.5430.95
70_L76_D0.5420.95
13_L149_I0.5390.95
70_L74_P0.5390.95
211_I237_A0.5380.95
137_M141_F0.5370.95
104_V108_C0.5360.95
219_L238_H0.5360.95
15_V147_V0.5350.95
18_K56_P0.5350.95
152_N241_D0.5340.95
54_A68_S0.5340.95
231_N234_Y0.5340.95
326_M329_Y0.5330.95
58_L76_D0.5320.95
202_N227_G0.5310.95
301_I336_F0.5310.95
100_F104_V0.5270.95
324_I377_G0.5250.94
271_E275_V0.5220.94
51_V79_I0.5210.94
162_L191_K0.5200.94
100_F111_T0.5180.94
13_L126_P0.5170.94
235_Y238_H0.5160.94
256_F287_A0.5160.94
52_L86_M0.5150.94
228_I232_Q0.5130.94
258_K279_I0.5120.94
299_L336_F0.5120.94
181_N185_K0.5110.94
154_L158_L0.5100.94
134_Q145_C0.5100.94
86_M114_I0.5090.94
195_I214_L0.5080.93
336_F339_F0.5080.93
17_M24_V0.5070.93
38_L42_G0.5070.93
97_T100_F0.5060.93
60_K66_T0.5060.93
273_K329_Y0.5060.93
230_G233_L0.5060.93
43_N47_Q0.5050.93
373_R376_L0.5050.93
26_A31_L0.5030.93
210_T215_A0.5030.93
356_E359_V0.5030.93
20_F96_I0.5010.93
65_K72_E0.5000.93
144_M169_S0.5000.93
261_I265_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f50A 1 0.7861 100 0.178 Contact Map
4dezA 2 0.5457 100 0.186 Contact Map
3gqcA 3 0.8197 100 0.199 Contact Map
4q45F 1 0.8029 100 0.199 Contact Map
3pzpA 1 0.8149 100 0.204 Contact Map
4tqrA 1 0.7933 100 0.208 Contact Map
1t94A 1 0.8005 100 0.209 Contact Map
3osnA 1 0.8029 100 0.217 Contact Map
4ecqA 1 0.8221 100 0.221 Contact Map
2aq4A 1 0.8365 100 0.223 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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