GREMLIN Database
SUNS - SPBc2 prophage-derived glycosyltransferase SunS
UniProt: O31986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (332)
Sequences: 623 (586)
Seq/√Len: 32.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_V109_Y5.3901.00
306_N309_D4.5001.00
64_N91_T4.2731.00
66_S93_D4.0061.00
113_K118_Y3.8001.00
115_D118_Y3.7791.00
266_K269_E3.7531.00
69_I98_I3.7431.00
93_D96_D3.5051.00
122_K126_Y3.4681.00
59_G127_A3.4151.00
70_K100_C3.2221.00
382_N385_R3.0271.00
58_C80_F2.9251.00
70_K74_N2.8841.00
110_E113_K2.8641.00
252_K256_F2.8171.00
219_H222_Y2.7171.00
374_I390_S2.6741.00
58_C76_V2.6421.00
342_K345_S2.6371.00
140_L220_N2.3500.99
215_L219_H2.3270.99
254_L273_Y2.3080.99
127_A132_I2.2890.99
332_S350_I2.2860.99
124_I184_F2.2720.99
370_K389_I2.2290.99
259_R274_L2.1900.99
198_E236_N2.1470.99
122_K125_E2.1150.98
339_M343_L2.0790.98
366_K369_F2.0600.98
114_N242_E2.0110.98
310_L334_I1.9890.98
57_T82_E1.9720.97
76_V135_I1.9690.97
55_T129_S1.9570.97
146_K150_A1.9530.97
258_G274_L1.9510.97
60_I72_C1.8380.96
114_N238_N1.8370.96
74_N102_F1.8260.96
108_K126_Y1.8250.96
271_I304_R1.7970.96
71_K140_L1.7620.95
98_I107_I1.7590.95
82_E106_E1.7420.95
123_I134_F1.7310.94
87_D90_S1.7300.94
377_N385_R1.7230.94
195_K246_L1.7190.94
182_R197_H1.7060.94
62_V137_A1.7020.94
237_I257_F1.6850.94
162_D168_Y1.6820.94
352_E355_T1.6770.93
61_I119_A1.6710.93
135_I217_V1.6650.93
55_T130_E1.6530.93
335_L345_S1.6270.92
301_L309_D1.6100.92
165_V168_Y1.6040.92
58_C135_I1.5970.92
57_T129_S1.5780.91
110_E122_K1.5780.91
162_D166_S1.5760.91
62_V73_L1.5660.91
58_C81_N1.5480.90
62_V94_T1.5450.90
269_E272_D1.5420.90
60_I85_V1.5410.90
107_I112_W1.5360.90
171_E174_G1.5330.90
262_H267_D1.5310.90
65_E137_A1.5270.90
163_C167_P1.5120.89
247_E250_N1.5070.89
298_C314_L1.5070.89
162_D165_V1.5020.89
98_I105_V1.5010.89
261_L269_E1.4870.88
271_I297_L1.4770.88
221_G232_K1.4650.88
61_I65_E1.4640.88
87_D92_D1.4490.87
385_R388_E1.4450.87
68_R71_K1.4370.87
347_S373_L1.4170.86
347_S377_N1.4150.86
182_R192_F1.4040.85
192_F197_H1.3900.85
69_I73_L1.3690.84
346_L376_L1.3540.83
90_S94_T1.3520.83
62_V85_V1.3520.83
164_V167_P1.3400.83
195_K243_M1.3400.83
174_G179_D1.3190.82
69_I94_T1.3070.81
69_I97_I1.3060.81
153_A156_L1.2990.81
378_I390_S1.2930.80
164_V168_Y1.2910.80
95_V99_K1.2860.80
133_Y183_M1.2820.80
268_E304_R1.2820.80
354_L373_L1.2750.79
63_Y88_S1.2730.79
315_D331_R1.2710.79
61_I123_I1.2690.79
196_V240_T1.2660.79
59_G132_I1.2530.78
199_E252_K1.2500.78
257_F261_L1.2360.77
318_E328_D1.2250.76
62_V69_I1.2250.76
311_T331_R1.2240.76
258_G313_Y1.2070.75
270_A300_L1.1970.75
215_L221_G1.1910.74
182_R236_N1.1880.74
120_R136_D1.1810.74
86_L110_E1.1760.73
110_E118_Y1.1720.73
105_V112_W1.1670.73
170_E174_G1.1590.72
88_S136_D1.1490.72
163_C166_S1.1370.71
180_T192_F1.1370.71
88_S197_H1.1360.71
333_A350_I1.1150.69
58_C83_I1.1020.68
299_T330_F1.0910.68
56_I59_G1.0900.68
57_T127_A1.0900.68
232_K235_R1.0810.67
114_N195_K1.0700.66
58_C72_C1.0690.66
325_V353_A1.0690.66
162_D167_P1.0610.65
57_T128_T1.0570.65
65_E88_S1.0500.65
86_L122_K1.0500.65
112_W182_R1.0480.64
272_D276_K1.0370.64
332_S353_A1.0300.63
82_E128_T1.0300.63
378_I386_V1.0300.63
112_W115_D1.0260.63
61_I88_S1.0260.63
199_E256_F1.0240.63
254_L276_K1.0240.63
134_F192_F1.0150.62
57_T84_I1.0110.62
60_I80_F1.0060.61
65_E116_F1.0040.61
259_R263_L0.9780.59
88_S116_F0.9740.59
277_S293_A0.9660.58
256_F259_R0.9640.58
83_I237_I0.9610.58
124_I127_A0.9530.57
124_I132_I0.9530.57
222_Y232_K0.9490.57
86_L123_I0.9480.57
163_C168_Y0.9470.56
152_V156_L0.9450.56
267_D303_Q0.9440.56
196_V236_N0.9390.56
275_K309_D0.9380.56
366_K370_K0.9340.55
136_D197_H0.9330.55
309_D312_L0.9280.55
70_K96_D0.9200.54
146_K152_V0.9160.54
184_F192_F0.9120.54
55_T58_C0.9080.53
275_K279_N0.9040.53
271_I275_K0.8960.52
252_K258_G0.8950.52
234_R264_L0.8870.52
132_I184_F0.8850.51
248_P322_P0.8840.51
233_T260_E0.8830.51
87_D94_T0.8780.51
142_S218_Y0.8750.51
110_E119_A0.8730.50
72_C75_S0.8710.50
61_I137_A0.8650.50
102_F105_V0.8620.50
141_Y217_V0.8610.49
311_T334_I0.8590.49
88_S139_N0.8580.49
328_D349_M0.8580.49
371_R378_I0.8500.49
373_L377_N0.8480.48
81_N124_I0.8480.48
96_D100_C0.8440.48
301_L306_N0.8420.48
297_L301_L0.8400.48
116_F120_R0.8400.48
193_H201_M0.8350.47
103_P107_I0.8310.47
60_I123_I0.8300.47
125_E191_K0.8300.47
68_R140_L0.8290.47
60_I137_A0.8250.46
72_C133_Y0.8230.46
162_D169_I0.8230.46
74_N77_K0.8210.46
301_L367_D0.8190.46
103_P108_K0.8130.46
142_S145_N0.8130.46
123_I126_Y0.8110.45
234_R238_N0.8100.45
255_F259_R0.8100.45
73_L103_P0.8090.45
85_V103_P0.8080.45
358_R361_A0.8030.45
254_L277_S0.7980.44
164_V169_I0.7970.44
131_W185_R0.7960.44
236_N260_E0.7930.44
237_I241_E0.7900.44
274_L297_L0.7850.43
394_K397_N0.7840.43
329_Y372_I0.7840.43
120_R123_I0.7810.43
105_V110_E0.7780.43
350_I369_F0.7770.43
331_R335_L0.7690.42
288_R375_S0.7660.42
351_D385_R0.7650.42
56_I195_K0.7650.42
161_I164_V0.7620.41
69_I114_N0.7620.41
104_D107_I0.7600.41
240_T257_F0.7590.41
241_E257_F0.7580.41
72_C80_F0.7580.41
372_I375_S0.7570.41
288_R324_C0.7550.41
65_E94_T0.7520.41
182_R235_R0.7520.41
99_K109_Y0.7510.41
343_L376_L0.7480.40
72_C346_L0.7470.40
65_E197_H0.7460.40
252_K260_E0.7450.40
196_V239_L0.7450.40
338_D342_K0.7440.40
196_V264_L0.7410.40
59_G350_I0.7390.40
275_K297_L0.7390.40
60_I73_L0.7340.39
93_D97_I0.7320.39
263_L274_L0.7300.39
92_D136_D0.7290.39
195_K239_L0.7270.39
388_E392_E0.7250.38
300_L304_R0.7230.38
69_I137_A0.7220.38
146_K156_L0.7210.38
271_I300_L0.7180.38
109_Y126_Y0.7170.38
317_L327_V0.7160.38
289_H294_L0.7140.38
252_K372_I0.7120.37
105_V108_K0.7120.37
139_N221_G0.7110.37
88_S120_R0.7110.37
65_E136_D0.7110.37
133_Y141_Y0.7070.37
88_S115_D0.7050.37
332_S373_L0.7040.37
245_R276_K0.7020.37
329_Y369_F0.7010.37
165_V169_I0.6980.36
371_R374_I0.6920.36
89_Y92_D0.6920.36
327_V331_R0.6920.36
274_L390_S0.6880.36
97_I102_F0.6880.36
134_F180_T0.6870.36
66_S335_L0.6860.35
99_K148_K0.6840.35
166_S169_I0.6830.35
351_D389_I0.6830.35
197_H235_R0.6820.35
89_Y94_T0.6810.35
243_M246_L0.6770.35
252_K263_L0.6760.35
148_K151_K0.6760.35
190_V199_E0.6750.35
392_E395_N0.6740.35
227_N230_K0.6690.34
252_K259_R0.6670.34
270_A298_C0.6670.34
88_S112_W0.6650.34
276_K280_N0.6640.34
61_I116_F0.6640.34
216_K220_N0.6590.33
374_I378_I0.6570.33
282_K319_T0.6560.33
85_V95_V0.6560.33
70_K104_D0.6540.33
313_Y316_I0.6520.33
143_K147_G0.6520.33
179_D345_S0.6510.33
349_M353_A0.6510.33
199_E222_Y0.6500.33
161_I225_S0.6500.33
199_E263_L0.6470.33
184_F200_P0.6450.32
314_L327_V0.6440.32
256_F263_L0.6400.32
64_N280_N0.6390.32
183_M188_G0.6390.32
259_R296_L0.6360.32
194_G198_E0.6340.32
200_P292_D0.6320.32
119_A122_K0.6320.32
367_D370_K0.6300.31
351_D377_N0.6290.31
241_E261_L0.6290.31
84_I127_A0.6280.31
210_N374_I0.6270.31
159_F166_S0.6270.31
58_C85_V0.6270.31
56_I147_G0.6210.31
317_L322_P0.6210.31
76_V80_F0.6200.31
154_R157_E0.6200.31
82_E86_L0.6200.31
114_N118_Y0.6190.31
244_L253_W0.6170.30
89_Y136_D0.6160.30
267_D300_L0.6140.30
271_I317_L0.6140.30
237_I260_E0.6140.30
274_L296_L0.6120.30
346_L350_I0.6110.30
60_I105_V0.6110.30
256_F324_C0.6090.30
159_F165_V0.6090.30
69_I136_D0.6080.30
80_F83_I0.6080.30
81_N130_E0.6070.30
185_R252_K0.6060.30
115_D195_K0.6040.30
182_R196_V0.6040.30
337_V342_K0.6040.30
76_V120_R0.6030.30
84_I334_I0.6030.30
60_I135_I0.6030.30
347_S351_D0.6020.29
187_N307_Y0.6010.29
268_E303_Q0.6000.29
220_N223_N0.6000.29
84_I105_V0.5990.29
84_I107_I0.5970.29
353_A356_D0.5970.29
255_F296_L0.5940.29
241_E245_R0.5940.29
253_W274_L0.5940.29
68_R220_N0.5920.29
159_F168_Y0.5920.29
245_R279_N0.5910.29
97_I190_V0.5910.29
197_H200_P0.5900.29
240_T261_L0.5880.28
86_L108_K0.5870.28
326_D329_Y0.5850.28
98_I112_W0.5850.28
84_I108_K0.5830.28
56_I79_D0.5830.28
58_C133_Y0.5830.28
262_H299_T0.5830.28
110_E236_N0.5820.28
197_H219_H0.5800.28
256_F353_A0.5790.28
256_F372_I0.5790.28
253_W259_R0.5790.28
83_I103_P0.5780.28
139_N222_Y0.5770.28
184_F296_L0.5760.28
323_R349_M0.5760.28
371_R390_S0.5760.28
358_R362_I0.5750.28
261_L266_K0.5740.28
76_V217_V0.5720.27
69_I78_D0.5720.27
111_K125_E0.5720.27
260_E298_C0.5710.27
236_N239_L0.5700.27
182_R194_G0.5690.27
58_C61_I0.5680.27
332_S349_M0.5680.27
159_F163_C0.5670.27
283_K286_D0.5660.27
73_L112_W0.5650.27
253_W260_E0.5650.27
88_S137_A0.5620.27
258_G277_S0.5620.27
350_I367_D0.5600.27
266_K344_T0.5590.27
108_K122_K0.5590.27
120_R140_L0.5580.27
82_E119_A0.5580.27
199_E235_R0.5570.26
85_V345_S0.5560.26
231_S234_R0.5550.26
246_L354_L0.5540.26
269_E273_Y0.5510.26
76_V81_N0.5500.26
57_T350_I0.5500.26
86_L106_E0.5500.26
195_K242_E0.5500.26
56_I308_V0.5480.26
59_G192_F0.5470.26
263_L297_L0.5460.26
117_S356_D0.5450.26
134_F256_F0.5440.26
94_T116_F0.5430.26
90_S137_A0.5420.26
134_F296_L0.5420.26
115_D136_D0.5410.25
240_T253_W0.5410.25
163_C169_I0.5410.25
219_H223_N0.5400.25
331_R349_M0.5400.25
70_K142_S0.5400.25
182_R198_E0.5400.25
253_W256_F0.5380.25
298_C310_L0.5380.25
297_L313_Y0.5370.25
116_F235_R0.5360.25
134_F198_E0.5350.25
243_M253_W0.5340.25
69_I83_I0.5340.25
72_C85_V0.5340.25
241_E269_E0.5340.25
227_N256_F0.5340.25
232_K236_N0.5330.25
115_D120_R0.5330.25
199_E277_S0.5330.25
240_T243_M0.5300.25
61_I136_D0.5290.25
190_V289_H0.5280.25
69_I102_F0.5260.25
386_V390_S0.5250.24
180_T183_M0.5250.24
109_Y122_K0.5240.24
173_T312_L0.5230.24
56_I143_K0.5220.24
67_K99_K0.5210.24
140_L374_I0.5210.24
120_R139_N0.5190.24
184_F274_L0.5190.24
332_S346_L0.5180.24
152_V155_V0.5180.24
200_P204_N0.5180.24
244_L254_L0.5170.24
165_V172_Y0.5160.24
112_W136_D0.5160.24
73_L270_A0.5160.24
259_R292_D0.5160.24
187_N192_F0.5150.24
311_T335_L0.5150.24
381_E384_E0.5150.24
123_I127_A0.5140.24
149_I152_V0.5120.24
60_I88_S0.5120.24
213_V217_V0.5120.24
130_E293_A0.5110.24
119_A200_P0.5110.24
94_T147_G0.5110.24
115_D386_V0.5110.24
194_G197_H0.5110.24
241_E354_L0.5100.24
337_V343_L0.5090.24
302_L337_V0.5090.24
215_L222_Y0.5080.23
265_D383_W0.5070.23
309_D345_S0.5060.23
371_R375_S0.5060.23
112_W137_A0.5050.23
76_V141_Y0.5050.23
170_E173_T0.5040.23
181_R259_R0.5040.23
263_L295_V0.5030.23
374_I386_V0.5030.23
90_S138_D0.5030.23
347_S380_L0.5020.23
199_E232_K0.5020.23
244_L319_T0.5010.23
85_V104_D0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qg8A 1 0.4455 99.9 0.769 Contact Map
3bcvA 2 0.3483 99.9 0.78 Contact Map
2z86A 2 0.6114 99.9 0.782 Contact Map
3l7iA 4 0.1754 99.9 0.783 Contact Map
3f1yA 2 0.6114 99.9 0.796 Contact Map
2nxvA 4 0.4787 99.9 0.806 Contact Map
3q7aA 1 0.5237 99.9 0.807 Contact Map
3ckjA 2 0.5735 99.9 0.808 Contact Map
4l9pA 1 0.5379 99.8 0.809 Contact Map
1xhbA 1 0.7891 99.8 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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