GREMLIN Database
BLYA - N-acetylmuramoyl-L-alanine amidase BlyA
UniProt: O31982 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (327)
Sequences: 394 (297)
Seq/√Len: 16.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_I74_A5.6191.00
59_V107_V5.5271.00
56_H70_L3.9621.00
293_S297_V3.8061.00
293_S299_K3.3590.99
297_V300_I3.1620.99
293_S300_I3.0880.99
76_H106_G3.0230.99
345_N360_S2.7550.97
34_N41_N2.7540.97
345_N362_Q2.7420.97
293_S301_K2.7360.97
34_N42_H2.7100.97
293_S296_S2.5470.96
300_I303_V2.5460.96
297_V301_K2.5010.95
309_A316_D2.4970.95
324_G330_S2.4850.95
288_S291_S2.4540.95
293_S303_V2.4370.94
293_S302_I2.3710.93
58_F67_I2.3500.93
316_D320_S2.3250.93
28_V150_I2.2880.92
310_I316_D2.2490.91
299_K303_V2.2200.91
297_V302_I2.1830.90
287_T290_S2.1830.90
299_K302_I2.0870.88
125_T169_F2.0310.87
16_R19_L1.9920.85
219_S222_D1.9890.85
287_T291_S1.9850.85
8_Y17_P1.9170.83
296_S300_I1.9150.83
226_V269_V1.9150.83
53_A74_A1.9060.83
54_S68_I1.8960.82
310_I313_D1.8900.82
297_V303_V1.8890.82
288_S293_S1.8890.82
300_I304_G1.8850.82
55_A67_I1.8660.81
46_F55_A1.8410.80
310_I314_K1.8020.79
54_S74_A1.7990.79
305_V308_A1.7920.79
324_G328_L1.7680.78
34_N58_F1.7490.77
231_K239_V1.7050.75
311_V316_D1.7030.75
330_S333_S1.6860.74
304_G308_A1.6800.74
324_G329_G1.6690.73
8_Y12_N1.6650.73
188_T191_T1.6590.73
40_D44_R1.6500.72
320_S323_I1.6480.72
311_V317_R1.6100.70
188_T193_S1.6060.70
288_S297_V1.5890.69
29_L105_I1.5850.69
55_A58_F1.5670.68
321_K324_G1.5660.68
323_I329_G1.5440.67
39_A60_D1.5340.67
44_R250_Y1.5200.66
320_S330_S1.5040.65
326_V332_I1.5010.65
309_A313_D1.4920.64
109_M125_T1.4780.64
323_I330_S1.4780.64
306_S315_P1.4570.62
311_V314_K1.4400.62
296_S299_K1.4230.61
330_S336_G1.4110.60
322_N329_G1.4040.60
348_W361_G1.3840.58
327_K330_S1.3740.58
306_S309_A1.3730.58
309_A324_G1.3610.57
320_S331_T1.3490.56
46_F58_F1.3360.56
313_D316_D1.3330.55
25_K103_L1.3310.55
217_K223_K1.3270.55
219_S223_K1.3140.54
326_V330_S1.3130.54
309_A320_S1.3060.54
307_S310_I1.3000.54
74_A106_G1.2970.53
291_S300_I1.2890.53
314_K326_V1.2850.53
167_V246_S1.2770.52
78_N101_N1.2740.52
329_G336_G1.2740.52
293_S304_G1.2670.52
215_Y223_K1.2600.51
53_A68_I1.2520.51
308_A311_V1.2320.50
119_S168_D1.2280.49
18_G25_K1.2180.49
237_T241_K1.2170.49
309_A312_M1.2140.48
60_D110_C1.2140.48
30_H108_E1.2140.48
296_S302_I1.2120.48
320_S324_G1.2060.48
26_K138_L1.2030.48
205_L209_V1.2020.48
30_H147_H1.1960.47
9_I12_N1.1830.47
56_H59_V1.1800.46
309_A330_S1.1750.46
237_T240_E1.1730.46
309_A315_P1.1720.46
352_Y357_G1.1700.46
126_E172_R1.1600.45
311_V315_P1.1600.45
9_I17_P1.1580.45
149_D351_I1.1580.45
310_I315_P1.1520.45
26_K104_S1.1490.45
58_F107_V1.1460.45
210_D213_R1.1420.44
27_C105_I1.1390.44
321_K330_S1.1350.44
301_K329_G1.1340.44
301_K304_G1.1330.44
323_I336_G1.1290.44
314_K335_S1.1280.43
296_S303_V1.1250.43
8_Y16_R1.1250.43
274_S279_S1.1240.43
109_M121_T1.1160.43
195_P198_S1.1150.43
330_S335_S1.1120.43
289_S296_S1.1120.43
307_S313_D1.1060.42
46_F67_I1.1010.42
59_V63_E1.0930.41
35_P41_N1.0910.41
31_Y106_G1.0840.41
313_D335_S1.0740.40
15_T18_G1.0720.40
314_K320_S1.0690.40
187_P190_P1.0660.40
105_I136_F1.0660.40
57_I128_V1.0650.40
310_I322_N1.0650.40
193_S198_S1.0570.39
248_Y351_I1.0520.39
111_L157_A1.0490.39
45_Y65_I1.0420.39
309_A328_L1.0390.38
154_N236_P1.0380.38
41_N45_Y1.0330.38
186_S193_S1.0330.38
323_I328_L1.0270.38
145_V356_R1.0210.37
305_V330_S1.0100.37
111_L146_R1.0100.37
46_F107_V1.0080.37
35_P42_H0.9950.36
201_V358_Y0.9950.36
34_N124_R0.9930.36
307_S316_D0.9920.36
9_I16_R0.9910.36
211_G242_V0.9820.35
316_D330_S0.9780.35
146_R155_C0.9720.35
311_V321_K0.9690.35
288_S299_K0.9690.35
146_R157_A0.9660.34
205_L208_K0.9630.34
247_A253_K0.9620.34
288_S292_S0.9610.34
329_G333_S0.9530.34
315_P337_S0.9500.34
202_S215_Y0.9490.34
305_V324_G0.9440.33
137_G284_T0.9400.33
316_D324_G0.9390.33
203_G222_D0.9350.33
122_V157_A0.9340.33
114_D154_N0.9330.33
41_N44_R0.9310.33
361_G364_G0.9310.33
212_L242_V0.9310.33
126_E155_C0.9280.32
339_K365_S0.9280.32
231_K238_V0.9280.32
311_V330_S0.9270.32
58_F124_R0.9210.32
150_I356_R0.9180.32
328_L335_S0.9150.32
296_S301_K0.9120.32
346_G362_Q0.9090.31
320_S336_G0.9070.31
185_A282_P0.9030.31
114_D181_S0.8970.31
311_V318_N0.8940.31
149_D248_Y0.8930.31
27_C64_A0.8900.31
289_S299_K0.8870.30
168_D172_R0.8820.30
311_V329_G0.8820.30
187_P193_S0.8770.30
144_I167_V0.8760.30
109_M160_V0.8710.30
64_A276_K0.8690.30
316_D321_K0.8690.30
108_E147_H0.8640.29
311_V324_G0.8580.29
254_N268_Y0.8550.29
312_M315_P0.8550.29
292_S365_S0.8500.29
232_G237_T0.8460.28
11_V46_F0.8450.28
296_S325_T0.8420.28
170_K177_M0.8420.28
350_V361_G0.8400.28
324_G331_T0.8360.28
309_A329_G0.8290.28
238_V241_K0.8290.28
271_V279_S0.8280.28
309_A318_N0.8220.27
308_A316_D0.8210.27
187_P191_T0.8200.27
215_Y281_A0.8190.27
328_L332_I0.8150.27
272_T276_K0.8140.27
304_G316_D0.8130.27
29_L63_E0.8110.27
306_S311_V0.8050.26
106_G109_M0.8020.26
314_K333_S0.8000.26
14_Y17_P0.7960.26
231_K235_F0.7960.26
309_A321_K0.7950.26
329_G335_S0.7950.26
289_S293_S0.7950.26
186_S191_T0.7940.26
310_I330_S0.7930.26
287_T292_S0.7930.26
262_I271_V0.7900.26
208_K213_R0.7880.26
187_P195_P0.7880.26
310_I320_S0.7860.26
39_A110_C0.7810.25
129_F173_V0.7790.25
329_G332_I0.7780.25
66_C140_P0.7780.25
311_V335_S0.7720.25
130_V134_N0.7710.25
220_W272_T0.7700.25
304_G330_S0.7690.25
298_G363_F0.7690.25
53_A59_V0.7660.25
53_A80_I0.7640.25
196_S202_S0.7620.25
265_S353_K0.7620.25
331_T336_G0.7610.25
53_A159_W0.7580.24
42_H103_L0.7530.24
309_A314_K0.7500.24
31_Y146_R0.7490.24
103_L211_G0.7480.24
201_V206_K0.7480.24
305_V311_V0.7470.24
321_K336_G0.7440.24
64_A118_H0.7330.23
312_M316_D0.7310.23
66_C78_N0.7270.23
311_V320_S0.7240.23
202_S233_I0.7230.23
31_Y111_L0.7220.23
216_S223_K0.7190.23
305_V359_I0.7170.23
12_N17_P0.7160.23
32_T124_R0.7150.23
280_S287_T0.7150.23
323_I326_V0.7150.23
312_M317_R0.7130.22
34_N46_F0.7130.22
146_R153_K0.7100.22
33_A111_L0.7080.22
304_G311_V0.7080.22
261_Y268_Y0.7080.22
213_R238_V0.7070.22
234_G238_V0.7060.22
169_F172_R0.7040.22
42_H45_Y0.7020.22
113_K154_N0.7020.22
40_D134_N0.7000.22
184_K358_Y0.7000.22
323_I335_S0.6980.22
259_T270_D0.6970.22
23_G347_Y0.6960.22
345_N365_S0.6950.22
22_Q103_L0.6940.22
101_N147_H0.6930.22
111_L125_T0.6930.22
328_L331_T0.6920.22
150_I153_K0.6900.22
155_C160_V0.6890.22
331_T334_I0.6880.21
326_V331_T0.6870.21
311_V336_G0.6850.21
323_I331_T0.6840.21
311_V322_N0.6830.21
324_G333_S0.6800.21
310_I324_G0.6790.21
113_K213_R0.6770.21
127_D213_R0.6750.21
153_K160_V0.6710.21
188_T192_T0.6700.21
333_S336_G0.6700.21
121_T125_T0.6690.21
78_N152_H0.6690.21
42_H46_F0.6690.21
73_V80_I0.6680.21
75_Y80_I0.6660.21
111_L153_K0.6650.21
56_H65_I0.6640.21
307_S311_V0.6630.21
25_K171_N0.6620.20
305_V309_A0.6580.20
55_A74_A0.6570.20
118_H146_R0.6560.20
322_N328_L0.6560.20
320_S333_S0.6550.20
303_V307_S0.6550.20
52_Y138_L0.6520.20
72_E173_V0.6520.20
324_G332_I0.6510.20
147_H156_P0.6480.20
226_V275_V0.6440.20
277_T288_S0.6420.20
154_N238_V0.6400.20
206_K242_V0.6390.20
309_A322_N0.6390.20
111_L117_F0.6380.20
326_V336_G0.6380.20
228_T237_T0.6350.19
136_F153_K0.6330.19
289_S304_G0.6330.19
111_L160_V0.6320.19
14_Y19_L0.6270.19
334_I340_G0.6270.19
28_V158_P0.6270.19
23_G115_G0.6260.19
334_I339_K0.6240.19
46_F54_S0.6230.19
114_D236_P0.6190.19
41_N358_Y0.6190.19
311_V331_T0.6180.19
307_S318_N0.6170.19
322_N330_S0.6160.19
167_V179_G0.6140.19
62_A122_V0.6140.19
155_C172_R0.6130.19
26_K69_P0.6130.19
30_H101_N0.6130.19
141_I355_K0.6120.19
250_Y338_V0.6100.19
75_Y108_E0.6080.18
153_K172_R0.6070.18
314_K324_G0.6070.18
202_S205_L0.6060.18
8_Y19_L0.6050.18
287_T293_S0.6050.18
307_S320_S0.6040.18
259_T266_D0.6010.18
167_V177_M0.6000.18
111_L122_V0.6000.18
217_K256_K0.6000.18
271_V274_S0.5970.18
133_C143_D0.5970.18
189_K197_S0.5950.18
321_K331_T0.5950.18
304_G307_S0.5930.18
27_C129_F0.5930.18
57_I68_I0.5920.18
109_M169_F0.5920.18
55_A170_K0.5910.18
42_H138_L0.5900.18
114_D208_K0.5900.18
335_S341_K0.5890.18
179_G184_K0.5880.18
304_G335_S0.5880.18
24_V70_L0.5870.18
316_D322_N0.5860.18
56_H69_P0.5860.18
229_V239_V0.5850.18
320_S328_L0.5830.18
289_S292_S0.5810.18
309_A317_R0.5810.18
53_A123_E0.5800.18
106_G132_L0.5790.17
322_N335_S0.5790.17
260_Y264_A0.5770.17
231_K240_E0.5770.17
31_Y122_V0.5760.17
31_Y155_C0.5750.17
321_K326_V0.5740.17
304_G324_G0.5740.17
283_K351_I0.5740.17
32_T42_H0.5700.17
31_Y153_K0.5680.17
107_V128_V0.5680.17
8_Y14_Y0.5680.17
187_P204_S0.5670.17
253_K260_Y0.5660.17
212_L215_Y0.5660.17
146_R160_V0.5660.17
45_Y120_D0.5650.17
57_I111_L0.5620.17
70_L131_E0.5600.17
127_D145_V0.5590.17
108_E155_C0.5580.17
336_G339_K0.5580.17
242_V245_G0.5580.17
10_P16_R0.5570.17
30_H156_P0.5570.17
294_I365_S0.5560.17
64_A284_T0.5540.17
324_G335_S0.5530.17
226_V240_E0.5520.17
296_S313_D0.5510.17
326_V329_G0.5490.16
31_Y157_A0.5490.16
215_Y218_P0.5490.16
287_T301_K0.5480.16
288_S300_I0.5480.16
32_T172_R0.5470.16
314_K321_K0.5470.16
312_M320_S0.5460.16
175_A179_G0.5440.16
132_L140_P0.5430.16
286_S344_S0.5430.16
215_Y224_D0.5420.16
215_Y219_S0.5420.16
297_V308_A0.5370.16
304_G329_G0.5370.16
306_S326_V0.5370.16
211_G238_V0.5360.16
300_I329_G0.5350.16
217_K231_K0.5350.16
232_G239_V0.5350.16
326_V333_S0.5350.16
311_V323_I0.5300.16
315_P318_N0.5300.16
259_T264_A0.5300.16
284_T287_T0.5300.16
328_L333_S0.5300.16
138_L143_D0.5280.16
15_T40_D0.5270.16
76_H104_S0.5270.16
10_P14_Y0.5250.16
128_V143_D0.5250.16
46_F51_V0.5230.16
55_A146_R0.5220.16
61_K117_F0.5220.16
314_K331_T0.5200.16
357_G365_S0.5190.16
116_S160_V0.5180.16
217_K230_N0.5160.15
58_F65_I0.5150.15
55_A59_V0.5130.15
301_K306_S0.5110.15
179_G182_V0.5110.15
183_S194_S0.5100.15
235_F241_K0.5090.15
325_T330_S0.5080.15
111_L141_I0.5070.15
246_S254_N0.5070.15
15_T73_V0.5070.15
186_S198_S0.5070.15
232_G235_F0.5020.15
339_K358_Y0.5020.15
204_S209_V0.5020.15
117_F160_V0.5020.15
126_E143_D0.5010.15
125_T162_N0.5010.15
229_V237_T0.5010.15
106_G146_R0.5010.15
215_Y251_K0.5010.15
55_A68_I0.5000.15
330_S334_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4knkA 1 0.4632 100 0.581 Contact Map
4ivvA 1 0.4169 100 0.597 Contact Map
3rdrA 4 0.4114 100 0.633 Contact Map
1yb0A 3 0.4278 100 0.645 Contact Map
4olsA 2 0.4305 100 0.646 Contact Map
4x36A 2 0.7793 100 0.656 Contact Map
1j3gA 1 0.4469 100 0.677 Contact Map
4bxjA 4 0.624 100 0.697 Contact Map
3d2yA 3 0.624 100 0.699 Contact Map
4bolA 2 0.5967 100 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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