GREMLIN Database
YOMM - SPBc2 prophage-derived recombinase-like protein YomM
UniProt: O31971 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (273)
Sequences: 36599 (29584)
Seq/√Len: 1790.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_I306_V5.3011.00
219_L307_A3.4131.00
77_S80_D3.3721.00
189_T235_H3.3311.00
178_G287_C2.9211.00
279_N282_L2.8651.00
174_A280_P2.7981.00
181_R281_H2.7401.00
287_C305_Y2.7131.00
88_L101_K2.6001.00
71_K80_D2.5431.00
188_K256_Q2.2881.00
188_K244_Y2.2531.00
174_A184_L2.2371.00
197_P228_L2.1551.00
169_A234_W2.1411.00
308_H315_T2.1191.00
148_T151_D2.0791.00
285_A320_D2.0421.00
176_N224_N2.0031.00
56_S100_L1.9931.00
85_Q102_K1.9601.00
188_K243_E1.9551.00
298_K301_L1.9551.00
183_E219_L1.8971.00
228_L232_R1.8961.00
292_L302_I1.8631.00
59_Q101_K1.8401.00
56_S104_G1.8151.00
300_E303_S1.7941.00
54_Y58_R1.7841.00
222_M305_Y1.7651.00
193_D196_V1.7591.00
291_L297_V1.7131.00
217_K309_H1.7051.00
306_V315_T1.6901.00
194_Y197_P1.6691.00
179_G184_L1.6551.00
36_V57_L1.6541.00
287_C291_L1.6511.00
167_G265_F1.6481.00
149_Y290_Y1.6281.00
299_I316_I1.6071.00
81_F130_T1.5591.00
168_M172_A1.5511.00
223_I228_L1.5351.00
291_L302_I1.5291.00
72_K75_K1.5271.00
170_W262_A1.5101.00
188_K191_I1.5011.00
175_F290_Y1.4971.00
76_I109_N1.4951.00
181_R185_I1.4941.00
194_Y232_R1.4701.00
96_S100_L1.4571.00
147_V286_S1.4401.00
292_L319_Y1.4321.00
181_R259_E1.4291.00
189_T245_L1.4291.00
172_A230_Y1.4201.00
36_V108_L1.4161.00
108_L112_I1.4031.00
49_T53_Y1.3991.00
152_Y175_F1.3961.00
40_L54_Y1.3851.00
303_S312_V1.3821.00
209_F212_G1.3811.00
38_E42_A1.3731.00
294_V325_E1.3691.00
48_K51_K1.3651.00
35_L112_I1.3481.00
176_N227_A1.3431.00
169_A233_L1.3251.00
289_T320_D1.3241.00
47_D51_K1.3211.00
314_T317_K1.3181.00
151_D154_L1.3091.00
33_R37_Q1.3081.00
156_M172_A1.3071.00
300_E304_K1.3061.00
182_A186_Q1.2981.00
89_K98_I1.2901.00
244_Y256_Q1.2851.00
170_W184_L1.2771.00
259_E263_D1.2741.00
160_K168_M1.2661.00
84_Y101_K1.2651.00
159_L269_V1.2561.00
147_V278_I1.2371.00
152_Y290_Y1.2361.00
190_E243_E1.2331.00
169_A230_Y1.2261.00
44_S50_R1.2251.00
288_I302_I1.2211.00
51_K55_S1.2181.00
312_V316_I1.2171.00
102_K106_S1.2131.00
85_Q89_K1.2121.00
84_Y88_L1.2091.00
181_R263_D1.2091.00
265_F268_D1.1771.00
303_S315_T1.1751.00
180_R281_H1.1741.00
175_F283_F1.1651.00
35_L111_Y1.1641.00
313_S316_I1.1631.00
97_G101_K1.1621.00
286_S290_Y1.1591.00
146_K286_S1.1541.00
153_K157_D1.1521.00
270_L278_I1.1481.00
113_E125_K1.1261.00
258_S261_W1.1261.00
123_Y127_R1.1241.00
82_I86_S1.1241.00
263_D267_S1.1201.00
170_W246_F1.1191.00
260_S263_D1.1101.00
261_W264_Y1.1091.00
94_S97_G1.1051.00
147_V155_M1.0991.00
110_N131_R1.0941.00
39_F43_H1.0941.00
266_C270_L1.0941.00
33_R70_G1.0921.00
193_D202_Y1.0911.00
154_L158_A1.0871.00
197_P225_T1.0851.00
52_Q55_S1.0701.00
158_A273_I1.0671.00
287_C306_V1.0631.00
224_N227_A1.0591.00
158_A272_D1.0521.00
207_K210_G1.0511.00
190_E242_H1.0501.00
149_Y295_K1.0481.00
56_S101_K1.0441.00
52_Q56_S1.0421.00
50_R54_Y1.0381.00
173_T246_F1.0371.00
93_M101_K1.0371.00
35_L73_L1.0331.00
311_D314_T1.0321.00
202_Y220_E1.0261.00
63_W83_R1.0231.00
193_D197_P1.0231.00
67_S87_F1.0221.00
176_N226_E1.0161.00
185_I259_E1.0151.00
175_F286_S1.0131.00
225_T229_E1.0091.00
39_F107_S1.0031.00
189_T238_R0.9971.00
45_F50_R0.9941.00
172_A226_E0.9911.00
78_K82_I0.9851.00
234_W238_R0.9811.00
147_V151_D0.9761.00
71_K75_K0.9751.00
294_V322_R0.9701.00
89_K95_S0.9691.00
168_M230_Y0.9651.00
33_R65_H0.9601.00
149_Y153_K0.9601.00
48_K52_Q0.9571.00
288_I319_Y0.9551.00
109_N129_F0.9521.00
226_E229_E0.9341.00
289_T319_Y0.9331.00
40_L50_R0.9321.00
53_Y104_G0.9321.00
55_S59_Q0.9321.00
208_V211_K0.9301.00
297_V301_L0.9231.00
88_L93_M0.9221.00
110_N128_N0.9211.00
46_R49_T0.9211.00
47_D50_R0.9201.00
78_K114_N0.9201.00
52_Q100_L0.9191.00
31_E34_N0.9191.00
173_T227_A0.9121.00
114_N134_P0.9041.00
288_I292_L0.8981.00
209_F218_P0.8961.00
165_Y233_L0.8951.00
290_Y294_V0.8901.00
194_Y228_L0.8891.00
45_F53_Y0.8841.00
149_Y294_V0.8791.00
263_D280_P0.8781.00
112_I124_E0.8751.00
100_L103_A0.8741.00
109_N125_K0.8671.00
93_M97_G0.8661.00
106_S110_N0.8651.00
209_F216_G0.8651.00
304_K326_E0.8611.00
46_R211_K0.8601.00
111_Y122_N0.8601.00
33_R69_N0.8601.00
169_A246_F0.8561.00
35_L39_F0.8501.00
244_Y247_T0.8501.00
159_L171_L0.8461.00
187_L192_L0.8461.00
88_L98_I0.8401.00
63_W84_Y0.8281.00
165_Y237_K0.8261.00
145_V282_L0.8241.00
146_K320_D0.8221.00
300_E316_I0.8181.00
151_D276_R0.8181.00
36_V43_H0.8161.00
99_A137_P0.8141.00
114_N132_G0.8121.00
37_Q41_D0.8111.00
285_A317_K0.8061.00
227_A230_Y0.8051.00
60_F109_N0.8041.00
177_V221_Y0.8011.00
223_I227_A0.7991.00
269_V272_D0.7981.00
39_F42_A0.7971.00
93_M98_I0.7911.00
40_L44_S0.7901.00
268_D272_D0.7901.00
36_V40_L0.7891.00
83_R87_F0.7891.00
212_G217_K0.7841.00
113_E128_N0.7801.00
38_E124_E0.7791.00
102_K130_T0.7781.00
265_F269_V0.7761.00
233_L237_K0.7731.00
109_N130_T0.7711.00
267_S277_R0.7701.00
261_W265_F0.7651.00
181_R262_A0.7621.00
165_Y168_M0.7621.00
80_D83_R0.7611.00
158_A269_V0.7601.00
63_W87_F0.7601.00
181_R280_P0.7581.00
264_Y268_D0.7541.00
165_Y169_A0.7511.00
178_G306_V0.7511.00
187_L245_L0.7511.00
288_I315_T0.7491.00
197_P202_Y0.7481.00
128_N131_R0.7421.00
185_I262_A0.7411.00
173_T184_L0.7401.00
267_S271_S0.7401.00
37_Q54_Y0.7391.00
208_V212_G0.7361.00
173_T179_G0.7321.00
43_H107_S0.7301.00
96_S99_A0.7291.00
113_E127_R0.7241.00
232_R235_H0.7211.00
303_S316_I0.7181.00
81_F105_V0.7141.00
260_S267_S0.7121.00
288_I308_H0.7091.00
112_I125_K0.7091.00
262_A280_P0.7071.00
278_I282_L0.7041.00
301_L305_Y0.7031.00
99_A103_A0.7021.00
123_Y132_G0.6981.00
238_R247_T0.6971.00
108_L111_Y0.6931.00
86_S89_K0.6921.00
248_T252_G0.6911.00
82_I85_Q0.6901.00
79_R83_R0.6881.00
292_L322_R0.6851.00
76_I81_F0.6811.00
159_L168_M0.6801.00
113_E131_R0.6791.00
171_L283_F0.6781.00
189_T239_G0.6761.00
150_D154_L0.6761.00
87_F91_R0.6721.00
38_E41_D0.6711.00
235_H239_G0.6711.00
85_Q98_I0.6681.00
299_I312_V0.6681.00
235_H238_R0.6651.00
55_S58_R0.6621.00
155_M171_L0.6611.00
154_L157_D0.6561.00
146_K289_T0.6551.00
232_R236_E0.6551.00
266_C283_F0.6541.00
323_D326_E0.6541.00
84_Y87_F0.6491.00
174_A181_R0.6481.00
37_Q65_H0.6481.00
32_H36_V0.6471.00
67_S83_R0.6441.00
44_S54_Y0.6441.00
187_L203_V0.6401.00
82_I122_N0.6361.00
166_L234_W0.6351.00
177_V224_N0.6331.00
78_K123_Y0.6331.00
229_E233_L0.6321.00
160_K172_A0.6321.00
106_S130_T0.6311.00
32_H108_L0.6291.00
282_L285_A0.6291.00
167_G269_V0.6281.00
172_A227_A0.6261.00
59_Q84_Y0.6241.00
88_L91_R0.6241.00
87_F90_N0.6231.00
145_V276_R0.6231.00
58_R61_F0.6221.00
179_G183_E0.6181.00
155_M270_L0.6171.00
110_N113_E0.6171.00
229_E232_R0.6131.00
41_D44_S0.6131.00
152_Y156_M0.6131.00
267_S270_L0.6111.00
266_C280_P0.6101.00
35_L108_L0.6091.00
169_A227_A0.6081.00
59_Q91_R0.6041.00
230_Y233_L0.6021.00
186_Q256_Q0.6011.00
149_Y286_S0.6001.00
113_E132_G0.5991.00
147_V282_L0.5971.00
305_Y326_E0.5961.00
79_R122_N0.5911.00
292_L298_K0.5881.00
34_N38_E0.5861.00
207_K218_P0.5841.00
311_D316_I0.5841.00
196_V202_Y0.5831.00
109_N113_E0.5811.00
180_R209_F0.5811.00
95_S99_A0.5781.00
155_M266_C0.5771.00
322_R325_E0.5751.00
169_A173_T0.5731.00
169_A231_L0.5701.00
210_G219_L0.5701.00
60_F105_V0.5701.00
294_V324_F0.5691.00
152_Y286_S0.5691.00
324_F327_E0.5691.00
84_Y105_V0.5681.00
260_S264_Y0.5671.00
172_A176_N0.5661.00
39_F111_Y0.5631.00
35_L38_E0.5621.00
158_A161_E0.5621.00
53_Y56_S0.5611.00
171_L266_C0.5601.00
34_N37_Q0.5601.00
60_F64_V0.5591.00
60_F63_W0.5551.00
297_V302_I0.5541.00
156_M168_M0.5511.00
303_S314_T0.5511.00
316_I319_Y0.5511.00
183_E307_A0.5501.00
147_V152_Y0.5501.00
166_L265_F0.5501.00
281_H285_A0.5471.00
269_V273_I0.5461.00
188_K242_H0.5441.00
192_L231_L0.5441.00
248_T251_G0.5441.00
105_V130_T0.5431.00
150_D153_K0.5421.00
231_L245_L0.5421.00
160_K164_N0.5411.00
234_W237_K0.5411.00
166_L169_A0.5391.00
78_K132_G0.5391.00
40_L43_H0.5371.00
292_L300_E0.5361.00
302_I319_Y0.5351.00
173_T231_L0.5331.00
58_R62_W0.5321.00
38_E111_Y0.5321.00
189_T231_L0.5291.00
57_L108_L0.5281.00
292_L299_I0.5281.00
99_A135_A0.5261.00
57_L61_F0.5221.00
57_L104_G0.5211.00
73_L109_N0.5211.00
107_S110_N0.5191.00
60_F91_R0.5141.00
179_G187_L0.5121.00
144_K279_N0.5111.00
174_A283_F0.5101.00
191_I208_V0.5101.00
106_S131_R0.5071.00
192_L245_L0.5061.00
107_S111_Y0.5061.00
60_F84_Y0.5021.00
102_K133_L0.5021.00
300_E312_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.7718 100 0.242 Contact Map
2a3vA 3 0.8288 100 0.257 Contact Map
1z1bA 3 0.9009 100 0.261 Contact Map
1xo0A 3 0.8649 100 0.276 Contact Map
1z19A 3 0.8138 100 0.284 Contact Map
4a8eA 2 0.7808 100 0.3 Contact Map
3nkhA 2 0.5526 100 0.435 Contact Map
1ae9A 4 0.4835 100 0.501 Contact Map
1aihA 2 0.4805 99.9 0.532 Contact Map
4e0gA 2 0.8048 99.9 0.568 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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