GREMLIN Database
YONF - SPBc2 prophage-derived uncharacterized protein YonF
UniProt: O31952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 589 (470)
Sequences: 177 (143)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_R290_E6.3881.00
102_A110_I4.0340.95
348_N397_I3.8340.94
56_K68_C3.6760.92
226_S359_D3.5330.91
182_E349_D3.2980.87
166_S304_F3.2430.86
346_V365_V3.1850.85
365_V400_I2.9030.79
290_E359_D2.8620.78
226_S290_E2.8160.77
67_Q89_G2.7400.75
180_V365_V2.7170.74
91_T225_L2.6380.72
273_V276_E2.5550.69
386_V483_K2.4940.67
171_R359_D2.4770.67
171_R226_S2.4200.65
159_S224_Y2.4180.65
269_D479_K2.3410.62
348_N363_Y2.3330.62
273_V277_M2.3240.62
157_N417_G2.3020.61
130_L350_I2.2930.60
172_S348_N2.2840.60
541_N545_K2.2670.60
171_R344_R2.2400.59
61_I436_E2.2390.59
255_C291_M2.2300.58
239_F254_V2.1830.57
527_L531_M2.1720.56
67_Q182_E2.1300.55
67_Q349_D2.1300.55
199_L410_V2.0930.53
179_I225_L2.0750.53
67_Q86_R2.0630.52
55_V71_I2.0340.51
412_D466_G2.0170.50
63_L67_Q2.0030.50
51_P352_G1.9750.49
51_P181_D1.9750.49
203_R266_G1.9180.47
112_I299_S1.8990.46
344_R365_V1.8970.46
239_F295_W1.8720.45
86_R182_E1.8500.44
86_R349_D1.8500.44
63_L74_M1.8310.43
92_W295_W1.8260.43
90_K181_D1.7970.42
495_E498_E1.7920.42
87_G412_D1.7510.41
159_S417_G1.7480.40
181_D256_G1.7440.40
61_I298_E1.7250.40
181_D293_A1.7140.39
89_G359_D1.7140.39
380_V414_Q1.7120.39
100_V123_V1.7060.39
330_D335_Y1.6980.39
471_N506_Y1.6720.38
89_G181_D1.6560.37
336_E378_H1.6520.37
102_A155_F1.6400.37
168_D286_G1.6380.37
185_M289_M1.6350.36
175_A178_L1.6330.36
180_V311_K1.6280.36
66_F258_P1.6220.36
349_D417_G1.6200.36
182_E417_G1.6200.36
276_E279_E1.6200.36
229_W289_M1.6180.36
106_P444_N1.6140.36
473_E523_Q1.5870.35
412_D415_S1.5730.34
515_G519_S1.5720.34
181_D266_G1.5690.34
361_S416_I1.5640.34
161_I226_S1.5580.34
87_G295_W1.5530.34
172_S182_E1.5500.34
172_S349_D1.5500.34
361_S401_Y1.5210.33
184_R188_F1.5190.33
541_N544_V1.5020.32
270_K274_R1.4940.32
361_S393_Q1.4880.32
373_N378_H1.4870.32
226_S390_T1.4850.31
84_A90_K1.4850.31
254_V412_D1.4830.31
89_G168_D1.4800.31
287_W291_M1.4670.31
109_K160_W1.4670.31
157_N221_K1.4620.31
330_D333_F1.4530.30
316_A320_F1.4290.30
55_V61_I1.4250.30
331_S336_E1.4250.30
86_R290_E1.4060.29
227_S290_E1.4010.29
152_K347_S1.3950.29
295_W414_Q1.3910.29
181_D359_D1.3870.28
181_D186_V1.3800.28
158_G417_G1.3780.28
56_K96_V1.3780.28
47_Y53_R1.3690.28
85_S251_K1.3660.28
66_F197_K1.3650.28
542_G545_K1.3550.27
135_P227_S1.3540.27
242_Y254_V1.3480.27
99_C393_Q1.3410.27
174_R412_D1.3340.27
337_G503_F1.3300.27
482_F489_I1.3280.27
121_R226_S1.3270.27
87_G227_S1.3230.26
110_I177_L1.3130.26
332_N336_E1.3110.26
330_D336_E1.3110.26
86_R171_R1.3020.26
67_Q359_D1.3020.26
87_G92_W1.2980.26
158_G351_A1.2980.26
181_D225_L1.2880.25
47_Y57_E1.2720.25
459_K479_K1.2710.25
229_W233_H1.2690.25
242_Y412_D1.2640.25
90_K287_W1.2540.25
320_F346_V1.2470.24
318_P321_P1.2460.24
412_D534_L1.2440.24
230_Y471_N1.2400.24
463_S467_N1.2360.24
263_I268_L1.2300.24
86_R135_P1.2300.24
123_V169_G1.2260.24
181_D228_C1.2250.24
522_A526_L1.2240.24
512_E516_K1.2220.24
91_T251_K1.2170.24
539_S543_Q1.2140.23
66_F90_K1.2090.23
47_Y104_L1.2060.23
109_K155_F1.2050.23
189_E499_Y1.2040.23
289_M518_L1.1980.23
70_L391_G1.1940.23
268_L273_V1.1890.23
90_K293_A1.1830.23
166_S497_K1.1810.23
165_A184_R1.1800.23
99_C363_Y1.1770.22
397_I477_L1.1720.22
404_Y516_K1.1700.22
193_K467_N1.1660.22
120_A365_V1.1660.22
89_G235_S1.1650.22
62_T276_E1.1640.22
259_Y515_G1.1640.22
351_A362_V1.1630.22
226_S299_S1.1610.22
86_R227_S1.1590.22
47_Y50_N1.1570.22
91_T363_Y1.1560.22
290_E344_R1.1510.22
81_M226_S1.1510.22
86_R157_N1.1510.22
61_I84_A1.1470.22
487_I527_L1.1450.22
244_N519_S1.1400.22
90_K197_K1.1390.22
497_K501_K1.1380.21
347_S366_F1.1350.21
344_R404_Y1.1350.21
126_K157_N1.1310.21
183_F224_Y1.1180.21
126_K174_R1.1170.21
412_D463_S1.1090.21
366_F379_I1.1080.21
227_S259_Y1.1040.21
185_M229_W1.1010.21
86_R91_T1.0990.21
258_P293_A1.0990.21
344_R516_K1.0970.20
470_L497_K1.0920.20
344_R414_Q1.0910.20
149_N159_S1.0900.20
283_D427_P1.0840.20
172_S287_W1.0820.20
284_P510_S1.0820.20
141_I189_E1.0820.20
50_N55_V1.0760.20
478_L522_A1.0750.20
44_T249_G1.0730.20
102_A127_I1.0720.20
172_S195_L1.0670.20
134_S228_C1.0640.20
97_Y393_Q1.0610.20
107_G168_D1.0600.20
487_I500_L1.0600.20
344_R367_R1.0570.20
97_Y226_S1.0500.19
87_G515_G1.0490.19
91_T121_R1.0470.19
89_G230_Y1.0430.19
364_T379_I1.0410.19
70_L84_A1.0380.19
266_G294_L1.0340.19
397_I424_L1.0320.19
171_R227_S1.0300.19
70_L153_V1.0270.19
362_V365_V1.0260.19
227_S230_Y1.0260.19
251_K419_G1.0240.19
86_R159_S1.0220.19
463_S466_G1.0200.19
188_F192_S1.0200.19
496_G502_R1.0160.19
66_F179_I1.0150.19
240_I409_I1.0140.19
55_V153_V1.0130.19
131_R334_K1.0080.18
163_I201_A1.0080.18
102_A161_I1.0060.18
317_S397_I0.9990.18
349_D412_D0.9990.18
182_E412_D0.9990.18
348_N361_S0.9980.18
488_K519_S0.9980.18
386_V389_H0.9950.18
331_S337_G0.9920.18
99_C140_E0.9910.18
330_D334_K0.9910.18
47_Y58_Y0.9900.18
261_I415_S0.9840.18
221_K455_Q0.9830.18
61_I65_L0.9790.18
201_A257_L0.9770.18
304_F394_A0.9750.18
67_Q290_E0.9740.18
48_R111_V0.9740.18
463_S497_K0.9730.18
34_E38_D0.9730.18
241_T252_Y0.9710.18
91_T263_I0.9680.18
172_S299_S0.9680.18
178_L502_R0.9660.17
172_S303_Y0.9660.17
420_V424_L0.9600.17
171_R252_Y0.9590.17
157_N287_W0.9590.17
530_E533_N0.9580.17
87_G259_Y0.9580.17
350_I420_V0.9570.17
276_E480_D0.9570.17
536_A544_V0.9550.17
53_R519_S0.9540.17
124_I478_L0.9540.17
89_G226_S0.9540.17
419_G423_A0.9530.17
81_M348_N0.9530.17
381_Y412_D0.9520.17
361_S390_T0.9510.17
479_K483_K0.9510.17
115_G119_Q0.9460.17
475_A478_L0.9460.17
172_S483_K0.9430.17
235_S318_P0.9420.17
351_A358_N0.9420.17
278_A363_Y0.9410.17
230_Y361_S0.9400.17
71_I93_L0.9400.17
76_H398_R0.9390.17
412_D515_G0.9360.17
225_L314_K0.9330.17
42_A45_S0.9330.17
67_Q424_L0.9320.17
84_A225_L0.9310.17
51_P225_L0.9300.17
120_A163_I0.9300.17
401_Y407_D0.9300.17
268_L281_D0.9270.17
112_I471_N0.9270.17
114_S281_D0.9260.17
67_Q91_T0.9260.17
168_D445_D0.9250.17
412_D509_L0.9250.17
379_I415_S0.9240.17
50_N224_Y0.9240.17
172_S297_G0.9230.17
31_S45_S0.9200.17
116_T347_S0.9170.16
438_E445_D0.9160.16
169_G228_C0.9150.16
149_N236_F0.9150.16
363_Y427_P0.9140.16
447_R456_N0.9110.16
135_P414_Q0.9100.16
76_H298_E0.9070.16
312_N482_F0.9040.16
344_R509_L0.9010.16
230_Y289_M0.9010.16
460_V465_K0.9010.16
397_I417_G0.9000.16
91_T171_R0.8990.16
87_G174_R0.8980.16
267_L270_K0.8980.16
178_L195_L0.8970.16
334_K337_G0.8960.16
63_L351_A0.8960.16
122_E172_S0.8960.16
84_A256_G0.8940.16
130_L233_H0.8930.16
48_R445_D0.8930.16
221_K253_F0.8930.16
232_V289_M0.8910.16
159_S286_G0.8900.16
184_R226_S0.8900.16
228_C293_A0.8900.16
305_K397_I0.8900.16
67_Q226_S0.8870.16
344_R407_D0.8860.16
47_Y228_C0.8860.16
316_A488_K0.8840.16
85_S308_D0.8840.16
66_F225_L0.8830.16
66_F123_V0.8820.16
182_E359_D0.8810.16
349_D359_D0.8810.16
414_Q466_G0.8810.16
237_N279_E0.8810.16
186_V359_D0.8790.16
380_V404_Y0.8790.16
67_Q227_S0.8770.16
345_L438_E0.8750.16
105_F351_A0.8740.16
366_F503_F0.8730.16
83_L412_D0.8730.16
241_T267_L0.8720.16
350_I441_S0.8720.16
481_G521_Y0.8700.16
36_L39_G0.8700.16
383_E394_A0.8700.16
91_T349_D0.8690.15
91_T182_E0.8690.15
155_F161_I0.8690.15
70_L226_S0.8680.15
534_L537_E0.8670.15
282_F311_K0.8670.15
73_M468_A0.8660.15
107_G128_D0.8600.15
228_C291_M0.8590.15
539_S542_G0.8570.15
114_S257_L0.8570.15
333_F336_E0.8560.15
54_F108_T0.8550.15
118_G418_L0.8550.15
74_M161_I0.8540.15
185_M249_G0.8500.15
348_N401_Y0.8490.15
261_I397_I0.8480.15
512_E515_G0.8440.15
405_D438_E0.8400.15
420_V490_P0.8400.15
89_G182_E0.8400.15
89_G349_D0.8400.15
71_I528_I0.8390.15
186_V275_D0.8390.15
96_V184_R0.8330.15
436_E487_I0.8320.15
351_A527_L0.8320.15
60_G187_D0.8310.15
526_L530_E0.8310.15
118_G147_S0.8290.15
74_M103_I0.8280.15
163_I295_W0.8270.15
224_Y238_R0.8270.15
317_S416_I0.8220.15
351_A417_G0.8210.15
87_G463_S0.8210.15
281_D448_M0.8180.15
91_T139_R0.8170.14
473_E500_L0.8140.14
417_G424_L0.8140.14
71_I130_L0.8120.14
346_V398_R0.8110.14
40_I469_Q0.8100.14
290_E471_N0.8100.14
171_R185_M0.8090.14
228_C295_W0.8080.14
61_I91_T0.8080.14
176_N291_M0.8060.14
352_G422_D0.8050.14
226_S349_D0.8050.14
182_E226_S0.8050.14
98_C142_E0.8040.14
63_L86_R0.8030.14
37_M44_T0.8000.14
483_K487_I0.7990.14
398_R402_E0.7980.14
94_T226_S0.7960.14
521_Y524_I0.7940.14
290_E386_V0.7930.14
134_S517_F0.7920.14
82_Y112_I0.7870.14
312_N487_I0.7870.14
70_L485_G0.7870.14
39_G62_T0.7860.14
90_K417_G0.7860.14
227_S414_Q0.7830.14
344_R512_E0.7820.14
266_G272_Q0.7790.14
277_M394_A0.7780.14
220_N484_R0.7780.14
153_V460_V0.7760.14
525_T529_N0.7750.14
54_F355_G0.7740.14
86_R417_G0.7740.14
42_A144_L0.7730.14
495_E501_K0.7720.14
502_R521_Y0.7720.14
104_L474_I0.7700.14
64_K96_V0.7680.14
102_A351_A0.7670.14
227_S411_L0.7660.14
496_G499_Y0.7650.14
77_N85_S0.7650.14
70_L236_F0.7640.14
48_R203_R0.7640.14
227_S298_E0.7630.14
330_D438_E0.7620.14
66_F88_Q0.7610.13
154_E223_I0.7560.13
67_Q114_S0.7560.13
305_K399_Q0.7550.13
348_N393_Q0.7540.13
92_W516_K0.7510.13
250_S288_S0.7500.13
166_S470_L0.7500.13
90_K424_L0.7500.13
171_R420_V0.7490.13
123_V265_E0.7490.13
240_I243_Y0.7480.13
464_I528_I0.7460.13
93_L225_L0.7410.13
114_S361_S0.7400.13
452_C455_Q0.7390.13
271_D274_R0.7380.13
361_S383_E0.7380.13
184_R471_N0.7380.13
332_N505_G0.7370.13
95_S186_V0.7360.13
125_E180_V0.7360.13
83_L256_G0.7340.13
91_T290_E0.7310.13
32_K495_E0.7300.13
82_Y362_V0.7290.13
495_E502_R0.7280.13
230_Y519_S0.7270.13
509_L516_K0.7260.13
81_M97_Y0.7260.13
109_K351_A0.7230.13
227_S381_Y0.7210.13
239_F407_D0.7210.13
236_F496_G0.7190.13
30_K40_I0.7170.13
235_S295_W0.7170.13
309_I355_G0.7160.13
118_G357_D0.7160.13
99_C130_L0.7160.13
188_F250_S0.7150.13
128_D447_R0.7120.13
360_A509_L0.7120.13
184_R229_W0.7100.13
288_S427_P0.7090.13
61_I83_L0.7080.13
58_Y503_F0.7070.13
57_E102_A0.7050.13
393_Q412_D0.7050.13
53_R104_L0.7040.13
115_G412_D0.7010.12
71_I346_V0.7010.12
90_K225_L0.6990.12
40_I154_E0.6980.12
87_G220_N0.6960.12
373_N527_L0.6960.12
83_L226_S0.6960.12
347_S537_E0.6960.12
83_L294_L0.6950.12
463_S516_K0.6930.12
91_T173_K0.6920.12
342_E367_R0.6910.12
59_L95_S0.6870.12
125_E252_Y0.6870.12
436_E545_K0.6860.12
290_E295_W0.6860.12
172_S222_E0.6860.12
127_I178_L0.6850.12
181_D191_I0.6850.12
495_E531_M0.6840.12
334_K400_I0.6840.12
184_R289_M0.6820.12
308_D348_N0.6820.12
344_R380_V0.6820.12
128_D146_T0.6810.12
389_H483_K0.6790.12
274_R489_I0.6780.12
224_Y430_D0.6780.12
235_S359_D0.6780.12
38_D180_V0.6760.12
120_A306_F0.6750.12
135_P517_F0.6740.12
330_D345_L0.6740.12
70_L528_I0.6730.12
273_V278_A0.6730.12
345_L458_E0.6700.12
91_T310_E0.6690.12
40_I50_N0.6680.12
51_P254_V0.6680.12
93_L187_D0.6670.12
445_D449_A0.6660.12
153_V518_L0.6640.12
396_R399_Q0.6640.12
319_L344_R0.6630.12
30_K347_S0.6600.12
259_Y483_K0.6590.12
130_L229_W0.6580.12
343_I493_E0.6580.12
71_I96_V0.6580.12
80_F255_C0.6570.12
74_M299_S0.6490.12
180_V244_N0.6470.12
505_G508_G0.6450.12
304_F437_Y0.6440.12
115_G172_S0.6430.12
155_F417_G0.6420.12
71_I153_V0.6420.12
142_E388_G0.6420.12
315_L320_F0.6410.12
192_S196_R0.6390.12
135_P259_Y0.6380.11
336_E503_F0.6380.11
304_F410_V0.6380.11
412_D523_Q0.6370.11
223_I426_Q0.6370.11
140_E158_G0.6350.11
444_N448_M0.6350.11
161_I359_D0.6350.11
317_S320_F0.6340.11
117_K405_D0.6340.11
67_Q171_R0.6330.11
157_N290_E0.6330.11
176_N282_F0.6320.11
127_I155_F0.6310.11
277_M480_D0.6310.11
250_S308_D0.6300.11
135_P515_G0.6290.11
87_G113_A0.6280.11
114_S352_G0.6270.11
271_D363_Y0.6270.11
489_I497_K0.6260.11
98_C186_V0.6260.11
293_A362_V0.6250.11
116_T181_D0.6250.11
93_L122_E0.6230.11
193_K200_T0.6220.11
68_C71_I0.6210.11
239_F404_Y0.6180.11
71_I118_G0.6180.11
70_L102_A0.6170.11
295_W360_A0.6170.11
50_N54_F0.6170.11
161_I527_L0.6170.11
42_A47_Y0.6150.11
87_G512_E0.6150.11
537_E544_V0.6140.11
51_P55_V0.6100.11
518_L530_E0.6100.11
173_K265_E0.6100.11
295_W298_E0.6090.11
342_E521_Y0.6080.11
336_E356_K0.6080.11
175_A199_L0.6070.11
285_I300_E0.6070.11
85_S225_L0.6060.11
404_Y515_G0.6030.11
50_N94_T0.6030.11
54_F520_S0.6010.11
195_L292_E0.6010.11
366_F445_D0.6000.11
181_D412_D0.6000.11
131_R156_H0.5990.11
59_L141_I0.5980.11
268_L415_S0.5940.11
304_F481_G0.5900.11
381_Y404_Y0.5890.11
250_S448_M0.5880.11
31_S34_E0.5870.11
90_K393_Q0.5870.11
75_V441_S0.5870.11
463_S515_G0.5850.11
230_Y298_E0.5850.11
141_I254_V0.5850.11
68_C110_I0.5850.11
173_K466_G0.5840.11
509_L512_E0.5830.11
394_A518_L0.5820.11
72_Y76_H0.5820.11
119_Q268_L0.5820.11
243_Y337_G0.5820.11
52_H467_N0.5800.11
38_D474_I0.5770.11
82_Y415_S0.5760.11
73_M102_A0.5750.11
102_A347_S0.5750.11
172_S355_G0.5740.11
267_L275_D0.5730.11
50_N463_S0.5730.11
181_D417_G0.5710.11
146_T366_F0.5700.11
225_L256_G0.5690.10
380_V465_K0.5690.10
123_V175_A0.5680.10
90_K174_R0.5680.10
85_S171_R0.5650.10
347_S371_N0.5640.10
133_E393_Q0.5630.10
111_V422_D0.5630.10
68_C482_F0.5630.10
29_K33_S0.5630.10
347_S495_E0.5620.10
115_G166_S0.5620.10
382_M459_K0.5620.10
74_M94_T0.5610.10
341_G400_I0.5610.10
266_G319_L0.5590.10
87_G533_N0.5570.10
90_K464_I0.5560.10
244_N305_K0.5550.10
274_R277_M0.5550.10
337_G409_I0.5550.10
135_P298_E0.5550.10
494_N528_I0.5550.10
90_K119_Q0.5530.10
106_P187_D0.5520.10
194_V232_V0.5520.10
43_W178_L0.5510.10
56_K97_Y0.5470.10
220_N439_P0.5470.10
321_P493_E0.5440.10
120_A497_K0.5430.10
195_L201_A0.5420.10
227_S344_R0.5420.10
88_Q197_K0.5420.10
314_K440_F0.5410.10
237_N317_S0.5410.10
110_I234_W0.5400.10
47_Y181_D0.5370.10
124_I174_R0.5370.10
36_L45_S0.5370.10
103_I490_P0.5360.10
65_L167_N0.5350.10
223_I359_D0.5350.10
60_G495_E0.5340.10
31_S50_N0.5330.10
42_A106_P0.5320.10
171_R249_G0.5310.10
315_L495_E0.5310.10
284_P288_S0.5280.10
383_E424_L0.5280.10
429_Y474_I0.5280.10
273_V279_E0.5270.10
242_Y250_S0.5260.10
69_I316_A0.5220.10
126_K417_G0.5210.10
259_Y289_M0.5200.10
93_L175_A0.5180.10
443_I453_T0.5180.10
181_D294_L0.5180.10
181_D474_I0.5160.10
135_P230_Y0.5150.10
227_S466_G0.5150.10
45_S50_N0.5150.10
153_V227_S0.5130.10
237_N336_E0.5130.10
331_S334_K0.5130.10
56_K278_A0.5120.10
74_M222_E0.5120.10
535_E538_Y0.5120.10
78_H221_K0.5090.10
380_V427_P0.5070.10
169_G332_N0.5070.10
255_C356_K0.5060.10
320_F520_S0.5050.10
114_S500_L0.5040.10
311_K402_E0.5040.10
288_S340_P0.5030.10
53_R222_E0.5020.10
355_G383_E0.5010.10
177_L223_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cpeA 1 0.8048 100 0.645 Contact Map
4idhA 1 0.7284 100 0.733 Contact Map
2o0jA 1 0.4618 100 0.739 Contact Map
4bijA 3 0.6842 100 0.774 Contact Map
4znkA 1 0.3939 100 0.793 Contact Map
3c6aA 1 0.3345 100 0.822 Contact Map
1vecA 2 0.3328 98.6 0.929 Contact Map
3iuyA 1 0.3447 98.5 0.932 Contact Map
2pl3A 1 0.3684 98.4 0.935 Contact Map
3fe2A 1 0.3684 98.4 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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