GREMLIN Database
YOPK - SPBc2 prophage-derived uncharacterized protein YopK
UniProt: O31927 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (357)
Sequences: 253 (189)
Seq/√Len: 10.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_E195_R4.3930.99
125_L163_S3.8170.98
214_R241_L3.6840.98
214_R240_S3.5620.97
276_F337_L3.3530.96
85_L97_E3.3290.96
86_E119_Y3.1230.94
339_G351_S2.9530.92
21_K234_Y2.8760.91
305_F310_E2.7640.89
306_I337_L2.7510.89
310_E313_K2.6740.88
315_K342_E2.6360.87
306_I318_L2.5580.85
250_Q274_L2.5360.85
162_L371_L2.4910.83
208_N365_R2.4780.83
246_Y283_K2.4420.82
105_I120_K2.3860.81
112_S116_G2.2360.76
318_L337_L2.2280.76
307_N348_F2.2230.75
119_Y195_R2.1660.73
197_H219_K2.1250.72
234_Y252_N2.1230.72
10_K13_E2.1190.72
221_L274_L2.1100.71
245_N248_L2.0630.70
336_Y348_F2.0500.69
238_G277_L2.0240.68
205_L240_S2.0230.68
197_H363_L2.0120.68
204_K212_E2.0090.67
136_V161_Y1.9810.66
85_L148_E1.9750.66
297_D333_M1.9630.66
246_Y360_D1.9460.65
204_K213_C1.9340.64
11_D59_Y1.9320.64
146_T149_M1.9050.63
300_E303_H1.8560.61
306_I314_A1.8480.61
299_Q334_H1.8350.60
95_E127_N1.8030.59
34_L38_L1.7940.58
246_Y339_G1.7920.58
45_F274_L1.7840.58
337_L341_L1.7830.58
275_C295_I1.7630.57
22_W32_N1.7600.57
92_M300_E1.7500.56
340_R348_F1.7380.56
122_H156_L1.7320.56
351_S367_P1.7260.55
182_I189_R1.7130.55
80_A198_V1.7040.54
283_K360_D1.6840.53
179_L310_E1.6780.53
370_E373_K1.6740.53
305_F309_N1.6590.52
82_R146_T1.6540.52
159_Y195_R1.6510.52
125_L300_E1.6360.51
187_Y238_G1.6330.51
300_E331_L1.6140.50
335_Y354_Y1.6090.50
260_S363_L1.5970.49
299_Q337_L1.5910.49
4_I166_N1.5890.49
118_V181_E1.5840.49
95_E222_E1.5830.49
276_F300_E1.5750.48
218_K222_E1.5720.48
84_A87_Y1.5490.47
26_A35_Y1.5440.47
70_Y74_L1.5250.46
314_A337_L1.5200.46
177_I308_F1.5170.46
67_M177_I1.5000.45
189_R205_L1.4900.44
318_L339_G1.4900.44
352_I368_L1.4840.44
144_I182_I1.4660.43
237_I362_F1.4600.43
15_D54_I1.4420.42
273_A363_L1.4320.42
237_I244_S1.4310.42
273_A368_L1.4260.42
20_N30_N1.4240.42
276_F314_A1.4170.41
82_R238_G1.4140.41
8_M237_I1.4020.41
147_P151_S1.3980.40
80_A125_L1.3970.40
155_L159_Y1.3920.40
85_L101_I1.3840.40
339_G367_P1.3730.39
16_N38_L1.3710.39
245_N301_Q1.3580.39
51_I79_K1.3530.38
118_V253_F1.3490.38
342_E347_C1.3480.38
34_L54_I1.3360.38
70_Y281_W1.3330.38
231_V256_G1.3330.38
101_I319_D1.3290.37
77_K210_L1.3190.37
91_N360_D1.3120.37
92_M125_L1.3110.37
4_I9_K1.2910.36
122_H152_F1.2800.35
280_V303_H1.2770.35
117_K258_S1.2660.35
319_D323_L1.2630.35
218_K237_I1.2600.34
246_Y367_P1.2500.34
82_R112_S1.2500.34
118_V132_E1.2420.34
240_S350_S1.2390.34
4_I34_L1.2250.33
175_K320_K1.2210.33
10_K336_Y1.2200.33
45_F48_F1.2130.33
170_M210_L1.2060.32
331_L336_Y1.2000.32
12_L70_Y1.1970.32
356_K368_L1.1960.32
233_S363_L1.1950.32
255_K258_S1.1830.31
241_L248_L1.1830.31
333_M337_L1.1800.31
121_I314_A1.1800.31
38_L54_I1.1760.31
120_K177_I1.1750.31
55_V341_L1.1710.31
94_F182_I1.1580.30
352_I364_I1.1550.30
201_S205_L1.1470.30
97_E278_N1.1400.30
59_Y213_C1.1300.29
206_N360_D1.1290.29
154_R238_G1.1230.29
361_K364_I1.1230.29
86_E371_L1.1090.28
50_S54_I1.1070.28
22_W50_S1.1070.28
106_S316_E1.1020.28
114_E170_M1.1010.28
351_S366_L1.1000.28
368_L371_L1.0970.28
233_S250_Q1.0920.28
81_A112_S1.0890.28
331_L334_H1.0890.28
234_Y348_F1.0880.28
21_K26_A1.0870.28
68_K189_R1.0820.27
300_E341_L1.0780.27
54_I242_L1.0750.27
167_F318_L1.0740.27
302_A309_N1.0740.27
86_E159_Y1.0680.27
10_K18_L1.0640.27
115_Y149_M1.0590.27
282_R307_N1.0570.27
217_S233_S1.0570.27
85_L88_A1.0540.26
17_S21_K1.0500.26
189_R320_K1.0490.26
274_L353_E1.0490.26
9_K19_M1.0440.26
302_A317_V1.0400.26
352_I356_K1.0330.26
251_E255_K1.0310.26
210_L214_R1.0300.26
118_V158_L1.0290.26
71_C100_L1.0230.25
55_V92_M1.0210.25
80_A217_S1.0150.25
75_D238_G1.0100.25
52_V159_Y1.0070.25
350_S365_R1.0050.25
152_F240_S1.0040.25
205_L233_S1.0020.25
189_R218_K1.0000.25
315_K341_L1.0000.25
273_A356_K1.0000.25
4_I8_M0.9980.25
186_M192_Y0.9900.24
74_L210_L0.9870.24
201_S233_S0.9850.24
23_A67_M0.9840.24
183_S237_I0.9820.24
45_F79_K0.9770.24
92_M235_L0.9740.24
321_L334_H0.9710.24
52_V187_Y0.9660.23
8_M19_M0.9640.23
309_N314_A0.9640.23
170_M362_F0.9590.23
102_D350_S0.9580.23
122_H159_Y0.9560.23
29_K369_L0.9560.23
275_C285_N0.9550.23
7_A11_D0.9510.23
69_D245_N0.9480.23
114_E340_R0.9440.23
142_L248_L0.9430.23
110_M186_M0.9420.23
22_W307_N0.9420.23
6_I213_C0.9420.23
199_L235_L0.9420.23
322_D338_K0.9410.23
113_K211_E0.9390.23
346_A350_S0.9370.23
142_L301_Q0.9360.22
97_E152_F0.9350.22
217_S220_A0.9340.22
210_L222_E0.9280.22
119_Y148_E0.9270.22
88_A96_I0.9250.22
209_S214_R0.9200.22
29_K346_A0.9190.22
258_S316_E0.9180.22
321_L337_L0.9140.22
35_Y45_F0.9140.22
119_Y200_M0.9090.22
215_E219_K0.9080.22
337_L363_L0.9060.22
161_Y253_F0.9020.21
116_G192_Y0.8970.21
83_S163_S0.8950.21
115_Y177_I0.8950.21
8_M28_L0.8830.21
8_M139_L0.8800.21
141_K307_N0.8740.21
65_E230_Q0.8720.20
5_R8_M0.8700.20
114_E119_Y0.8690.20
173_L298_L0.8690.20
113_K238_G0.8680.20
339_G355_F0.8660.20
88_A144_I0.8660.20
22_W35_Y0.8630.20
249_A254_L0.8590.20
69_D103_S0.8550.20
144_I218_K0.8540.20
116_G149_M0.8540.20
39_N177_I0.8520.20
58_Q244_S0.8510.20
342_E348_F0.8500.20
192_Y196_V0.8480.20
125_L239_N0.8480.20
61_D282_R0.8480.20
35_Y152_F0.8470.20
19_M28_L0.8440.20
38_L118_V0.8420.20
302_A341_L0.8410.20
167_F215_E0.8380.20
209_S286_K0.8370.19
331_L335_Y0.8360.19
262_Q286_K0.8360.19
176_Q220_A0.8330.19
270_F274_L0.8320.19
86_E339_G0.8310.19
82_R148_E0.8290.19
279_N363_L0.8280.19
78_T197_H0.8160.19
123_R162_L0.8150.19
279_N285_N0.8140.19
186_M232_F0.8100.19
138_R316_E0.8070.19
340_R367_P0.8030.19
87_Y119_Y0.8000.18
83_S288_I0.7960.18
90_A177_I0.7960.18
163_S359_N0.7950.18
237_I241_L0.7930.18
80_A249_A0.7920.18
276_F321_L0.7890.18
357_K364_I0.7880.18
39_N64_Y0.7880.18
116_G246_Y0.7870.18
4_I32_N0.7850.18
70_Y188_I0.7830.18
151_S213_C0.7820.18
216_Y259_I0.7770.18
35_Y339_G0.7750.18
279_N307_N0.7740.18
139_L199_L0.7730.18
254_L258_S0.7700.18
110_M118_V0.7680.18
262_Q320_K0.7680.18
311_N323_L0.7680.18
41_D97_E0.7670.18
182_I186_M0.7640.17
124_E132_E0.7630.17
131_T314_A0.7630.17
352_I361_K0.7620.17
119_Y213_C0.7620.17
85_L194_T0.7590.17
341_L347_C0.7590.17
306_I341_L0.7590.17
86_E114_E0.7560.17
89_D122_H0.7540.17
156_L184_E0.7520.17
119_Y371_L0.7520.17
66_L179_L0.7520.17
71_C250_Q0.7520.17
135_A356_K0.7500.17
39_N59_Y0.7480.17
305_F313_K0.7460.17
220_A233_S0.7460.17
139_L242_L0.7400.17
304_C308_F0.7400.17
5_R22_W0.7380.17
123_R239_N0.7380.17
282_R301_Q0.7370.17
11_D17_S0.7370.17
117_K181_E0.7360.17
26_A34_L0.7360.17
45_F155_L0.7300.17
312_S351_S0.7300.17
34_L100_L0.7260.16
148_E277_L0.7250.16
138_R262_Q0.7240.16
226_I336_Y0.7240.16
233_S263_N0.7220.16
65_E95_E0.7190.16
149_M335_Y0.7180.16
64_Y93_F0.7120.16
251_E333_M0.7090.16
88_A101_I0.7060.16
90_A155_L0.7050.16
82_R277_L0.7030.16
130_I151_S0.7000.16
15_D21_K0.6980.16
251_E319_D0.6970.16
23_A26_A0.6970.16
14_N38_L0.6950.16
316_E320_K0.6950.16
171_A189_R0.6940.16
60_P199_L0.6940.16
60_P234_Y0.6940.16
94_F277_L0.6930.16
89_D123_R0.6900.16
114_E195_R0.6900.16
276_F341_L0.6900.16
81_A304_C0.6900.16
281_W318_L0.6870.16
95_E313_K0.6850.15
71_C88_A0.6810.15
19_M35_Y0.6810.15
330_E334_H0.6810.15
70_Y274_L0.6790.15
67_M238_G0.6790.15
256_G270_F0.6770.15
167_F339_G0.6760.15
187_Y193_Q0.6760.15
109_N332_A0.6750.15
16_N170_M0.6740.15
202_N280_V0.6710.15
286_K328_D0.6700.15
204_K207_E0.6690.15
101_I373_K0.6680.15
106_S120_K0.6670.15
189_R216_Y0.6650.15
70_Y77_K0.6640.15
246_Y334_H0.6640.15
259_I362_F0.6620.15
198_V363_L0.6590.15
60_P266_Y0.6580.15
55_V88_A0.6560.15
165_G169_P0.6550.15
198_V220_A0.6540.15
276_F318_L0.6520.15
336_Y370_E0.6510.15
12_L16_N0.6500.15
249_A318_L0.6500.15
27_G100_L0.6490.15
17_S330_E0.6440.15
98_D102_D0.6430.14
28_L34_L0.6430.14
123_R149_M0.6410.14
163_S332_A0.6410.14
12_L95_E0.6400.14
142_L245_N0.6400.14
51_I273_A0.6390.14
27_G261_V0.6370.14
245_N311_N0.6370.14
240_S277_L0.6360.14
48_F86_E0.6360.14
205_L238_G0.6350.14
45_F159_Y0.6340.14
151_S249_A0.6320.14
92_M239_N0.6320.14
95_E250_Q0.6300.14
238_G295_I0.6260.14
4_I12_L0.6250.14
67_M119_Y0.6210.14
148_E182_I0.6200.14
55_V69_D0.6200.14
86_E367_P0.6190.14
241_L311_N0.6150.14
60_P105_I0.6140.14
60_P289_N0.6140.14
80_A273_A0.6140.14
311_N343_Q0.6140.14
121_I371_L0.6130.14
12_L54_I0.6130.14
62_R65_E0.6110.14
249_A277_L0.6090.14
88_A112_S0.6090.14
132_E360_D0.6080.14
108_S283_K0.6080.14
130_I302_A0.6060.14
102_D221_L0.6040.14
307_N313_K0.6030.14
355_F371_L0.6000.14
80_A173_L0.6000.14
85_L177_I0.5980.13
139_L362_F0.5970.13
44_T48_F0.5950.13
169_P274_L0.5940.13
118_V149_M0.5930.13
119_Y191_T0.5930.13
300_E337_L0.5920.13
211_E289_N0.5920.13
130_I206_N0.5920.13
186_M350_S0.5920.13
128_S138_R0.5920.13
148_E231_V0.5900.13
192_Y352_I0.5890.13
119_Y202_N0.5880.13
119_Y217_S0.5880.13
159_Y296_M0.5870.13
124_E138_R0.5870.13
239_N279_N0.5850.13
81_A104_M0.5840.13
189_R233_S0.5830.13
80_A163_S0.5830.13
19_M26_A0.5800.13
8_M175_K0.5780.13
366_L371_L0.5780.13
84_A167_F0.5780.13
114_E149_M0.5780.13
29_K71_C0.5720.13
100_L123_R0.5720.13
9_K38_L0.5720.13
189_R220_A0.5680.13
155_L220_A0.5680.13
56_K60_P0.5660.13
60_P305_F0.5660.13
29_K146_T0.5650.13
102_D319_D0.5630.13
231_V260_S0.5620.13
196_V271_Q0.5620.13
71_C367_P0.5600.13
85_L367_P0.5590.13
314_A341_L0.5580.13
188_I265_N0.5580.13
302_A314_A0.5520.13
156_L239_N0.5520.13
273_A349_Y0.5520.13
18_L120_K0.5520.13
35_Y38_L0.5510.13
87_Y140_G0.5510.13
98_D315_K0.5510.13
281_W334_H0.5500.12
193_Q209_S0.5500.12
48_F255_K0.5460.12
20_N23_A0.5460.12
182_I261_V0.5450.12
67_M158_L0.5440.12
339_G348_F0.5430.12
8_M84_A0.5430.12
149_M193_Q0.5420.12
4_I28_L0.5400.12
123_R312_S0.5390.12
57_S61_D0.5380.12
53_N140_G0.5370.12
84_A339_G0.5360.12
81_A100_L0.5360.12
222_E230_Q0.5360.12
158_L205_L0.5360.12
92_M199_L0.5340.12
213_C236_T0.5330.12
164_T276_F0.5330.12
7_A18_L0.5320.12
32_N165_G0.5320.12
146_T321_L0.5310.12
69_D121_I0.5310.12
338_K352_I0.5300.12
215_E265_N0.5290.12
110_M145_K0.5280.12
89_D152_F0.5260.12
62_R169_P0.5240.12
225_N336_Y0.5240.12
304_C340_R0.5230.12
73_N213_C0.5230.12
245_N353_E0.5200.12
8_M365_R0.5190.12
38_L302_A0.5190.12
262_Q301_Q0.5180.12
200_M207_E0.5180.12
11_D19_M0.5180.12
330_E362_F0.5170.12
28_L310_E0.5170.12
39_N281_W0.5160.12
10_K32_N0.5160.12
274_L289_N0.5160.12
210_L329_N0.5130.12
71_C86_E0.5130.12
5_R37_F0.5130.12
194_T336_Y0.5130.12
149_M268_M0.5130.12
152_F206_N0.5120.12
20_N24_T0.5120.12
137_K289_N0.5110.12
5_R26_A0.5110.12
79_K194_T0.5100.12
203_I211_E0.5100.12
85_L170_M0.5090.12
246_Y297_D0.5090.12
219_K240_S0.5080.12
276_F302_A0.5080.12
355_F366_L0.5060.12
101_I277_L0.5040.12
224_T359_N0.5040.12
121_I270_F0.5040.12
12_L18_L0.5030.12
125_L331_L0.5020.12
22_W41_D0.5020.12
370_E374_M0.5010.12
239_N273_A0.5010.12
39_N332_A0.5010.12
311_N322_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u3wA 2 0.6891 99.1 0.879 Contact Map
4yv9A 3 0.671 98.7 0.895 Contact Map
4rykA 2 0.6943 98.3 0.906 Contact Map
3q15A 2 0.7383 97.9 0.915 Contact Map
4gyoA 2 0.7358 97.8 0.918 Contact Map
2awiA 3 0.715 97.6 0.921 Contact Map
4i1aA 2 0.7202 97.5 0.923 Contact Map
3ulqA 1 0.7383 97.4 0.924 Contact Map
3zpjA 1 0.7306 97.3 0.925 Contact Map
4houA 1 0.614 97.1 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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