YOQW - BACSU - GREMLIN Contacts

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YOQW - Putative SOS response-associated peptidase YoqW

UniProt:	O31916	Sequences: MCGRFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTIINDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETLSEKPSFRKPLVSKRCIIPADSFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTPEGNPLYTCTIITTKPNELMEDIHDRMPVILTDENEKEWLNPKNTDPDYLQSLLQPYDADDMEAYQVSSLVNSPKNNSPELIESH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	224 (203)
Sequences:	3426 (2490)
Seq/√Len:	174.8

ECOLI - YEDK
BACSU - YOQW YOAM YOBE
HALSA - Q9HRI0 O51976

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_A	130_F	4.323	1.00
41_I	148_C	4.272	1.00
82_L	151_I	4.177	1.00
43_T	56_L	4.066	1.00
133_L	149_T	3.870	1.00
98_I	175_E	3.426	1.00
18_F	129_A	3.376	1.00
103_S	119_R	2.803	1.00
116_I	205_Q	2.713	1.00
171_T	174_N	2.646	1.00
97_C	132_G	2.479	1.00
79_A	151_I	2.452	1.00
91_P	135_E	2.411	1.00
130_F	150_I	2.369	1.00
45_I	54_G	2.332	1.00
121_K	202_E	2.287	1.00
121_K	204_Y	2.126	1.00
86_P	89_R	2.039	1.00
136_K	146_Y	1.991	1.00
98_I	129_A	1.911	1.00
76_N	163_H	1.903	1.00
120_I	162_I	1.874	1.00
106_E	163_H	1.860	1.00
83_S	92_L	1.847	1.00
51_N	176_K	1.808	1.00
74_M	87_S	1.721	1.00
5_F	41_I	1.697	1.00
95_K	135_E	1.696	1.00
77_A	149_T	1.692	1.00
10_E	13_D	1.674	1.00
17_Q	175_E	1.658	1.00
129_A	175_E	1.646	1.00
110_L	114_T	1.645	1.00
104_F	159_M	1.641	1.00
174_N	177_E	1.612	1.00
156_N	166_M	1.609	1.00
9_S	102_D	1.591	1.00
99_I	148_C	1.583	1.00
157_E	160_E	1.554	1.00
120_I	159_M	1.547	1.00
61_I	145_L	1.532	1.00
6_T	119_R	1.510	1.00
99_I	150_I	1.509	1.00
35_V	41_I	1.485	1.00
43_T	148_C	1.481	1.00
32_S	39_Q	1.476	1.00
7_L	35_V	1.472	1.00
196_Y	201_M	1.452	1.00
82_L	92_L	1.451	1.00
79_A	193_L	1.419	1.00
12_D	16_E	1.419	1.00
122_L	126_N	1.396	1.00
136_K	144_P	1.366	1.00
83_S	190_Q	1.363	1.00
34_N	117_P	1.351	1.00
138_N	144_P	1.321	1.00
128_F	201_M	1.321	1.00
107_W	115_K	1.279	1.00
45_I	52_R	1.278	1.00
169_I	201_M	1.244	1.00
153_T	195_P	1.243	1.00
158_L	199_D	1.242	1.00
108_K	118_M	1.234	1.00
5_F	101_A	1.233	1.00
122_L	128_F	1.224	1.00
114_T	208_S	1.210	1.00
43_T	97_C	1.193	1.00
81_T	85_K	1.191	1.00
20_I	53_L	1.190	1.00
90_K	93_V	1.176	1.00
47_D	50_N	1.163	1.00
45_I	134_Y	1.158	1.00
119_R	204_Y	1.151	1.00
91_P	95_K	1.149	1.00
170_L	174_N	1.146	1.00
32_S	35_V	1.144	1.00
123_K	202_E	1.142	1.00
118_M	205_Q	1.139	1.00
98_I	170_L	1.124	1.00
158_L	201_M	1.120	1.00
11_F	15_I	1.115	1.00
99_I	132_G	1.111	1.00
153_T	168_V	1.109	1.00
131_A	168_V	1.106	1.00
81_T	88_F	1.104	1.00
120_I	203_A	1.099	1.00
172_D	175_E	1.076	1.00
21_D	50_N	1.072	1.00
80_E	165_R	1.053	1.00
95_K	134_Y	1.048	1.00
76_N	106_E	1.032	0.99
9_S	127_L	1.025	0.99
137_W	140_P	1.020	0.99
42_L	53_L	1.019	0.99
65_A	70_I	1.018	0.99
198_A	201_M	1.016	0.99
43_T	99_I	1.014	0.99
56_L	146_Y	1.009	0.99
192_L	195_P	1.005	0.99
128_F	175_E	1.000	0.99
139_T	143_N	0.995	0.99
3_G	75_I	0.992	0.99
70_I	73_K	0.988	0.99
158_L	203_A	0.988	0.99
4_R	34_N	0.987	0.99
109_R	115_K	0.982	0.99
154_K	164_D	0.981	0.99
41_I	99_I	0.974	0.99
44_I	51_N	0.964	0.99
97_C	134_Y	0.953	0.99
153_T	156_N	0.949	0.99
153_T	166_M	0.948	0.99
180_N	183_N	0.946	0.99
157_E	161_D	0.939	0.99
122_L	171_T	0.932	0.99
60_L	147_T	0.931	0.99
61_I	74_M	0.922	0.99
38_S	72_Y	0.912	0.99
61_I	147_T	0.910	0.99
5_F	42_L	0.908	0.99
132_G	149_T	0.904	0.99
36_A	39_Q	0.904	0.99
177_E	191_S	0.904	0.99
111_D	114_T	0.904	0.99
4_R	107_W	0.892	0.98
54_G	146_Y	0.882	0.98
34_N	107_W	0.880	0.98
74_M	88_F	0.880	0.98
8_F	102_D	0.879	0.98
158_L	161_D	0.866	0.98
59_G	75_I	0.866	0.98
38_S	57_R	0.865	0.98
138_N	143_N	0.863	0.98
107_W	117_P	0.861	0.98
121_K	125_S	0.857	0.98
104_F	156_N	0.851	0.98
110_L	113_K	0.845	0.98
177_E	188_Y	0.836	0.98
60_L	135_E	0.826	0.97
150_I	167_P	0.826	0.97
110_L	116_I	0.824	0.97
2_C	76_N	0.824	0.97
122_L	201_M	0.823	0.97
188_Y	191_S	0.820	0.97
85_K	88_F	0.815	0.97
177_E	180_N	0.815	0.97
67_D	71_G	0.791	0.97
82_L	133_L	0.778	0.96
89_R	93_V	0.775	0.96
67_D	73_K	0.772	0.96
171_T	200_D	0.769	0.96
15_I	22_Q	0.768	0.96
187_D	191_S	0.763	0.96
17_Q	126_N	0.763	0.96
90_K	135_E	0.757	0.96
36_A	107_W	0.752	0.95
77_A	88_F	0.746	0.95
104_F	161_D	0.740	0.95
155_P	164_D	0.739	0.95
58_W	96_R	0.737	0.95
18_F	175_E	0.736	0.95
33_Y	117_P	0.735	0.95
46_N	51_N	0.733	0.95
90_K	94_S	0.733	0.95
40_N	55_K	0.732	0.95
122_L	200_D	0.731	0.95
79_A	153_T	0.725	0.95
5_F	35_V	0.725	0.95
174_N	194_Q	0.725	0.95
168_V	195_P	0.725	0.95
109_R	114_T	0.723	0.94
42_L	55_K	0.720	0.94
154_K	157_E	0.716	0.94
151_I	168_V	0.716	0.94
58_W	167_P	0.714	0.94
155_P	160_E	0.709	0.94
108_K	115_K	0.707	0.94
156_N	161_D	0.706	0.94
174_N	192_L	0.703	0.94
7_L	42_L	0.702	0.94
3_G	37_P	0.701	0.93
6_T	103_S	0.697	0.93
189_L	192_L	0.696	0.93
104_F	169_I	0.695	0.93
139_T	144_P	0.695	0.93
63_P	90_K	0.690	0.93
9_S	13_D	0.686	0.93
176_K	180_N	0.686	0.93
63_P	135_E	0.683	0.93
2_C	163_H	0.676	0.92
138_N	142_G	0.673	0.92
197_D	200_D	0.668	0.92
5_F	148_C	0.667	0.92
45_I	146_Y	0.665	0.92
128_F	169_I	0.663	0.91
196_Y	200_D	0.663	0.91
61_I	67_D	0.662	0.91
103_S	121_K	0.661	0.91
189_L	193_L	0.660	0.91
15_I	20_I	0.655	0.91
122_L	127_L	0.653	0.91
181_P	189_L	0.648	0.91
183_N	188_Y	0.647	0.90
78_R	106_E	0.647	0.90
106_E	165_R	0.644	0.90
137_W	145_L	0.644	0.90
71_G	74_M	0.641	0.90
70_I	74_M	0.637	0.90
5_F	100_P	0.635	0.90
41_I	58_W	0.634	0.90
13_D	16_E	0.632	0.89
44_I	100_P	0.632	0.89
60_L	74_M	0.630	0.89
9_S	14_I	0.627	0.89
84_E	141_E	0.624	0.89
81_T	84_E	0.622	0.89
104_F	158_L	0.621	0.89
5_F	36_A	0.620	0.89
101_A	150_I	0.620	0.89
5_F	99_I	0.620	0.89
108_K	116_I	0.617	0.88
155_P	158_L	0.616	0.88
118_M	162_I	0.616	0.88
67_D	70_I	0.615	0.88
36_A	117_P	0.614	0.88
132_G	150_I	0.613	0.88
12_D	21_D	0.612	0.88
57_R	145_L	0.609	0.88
130_F	167_P	0.609	0.88
37_P	75_I	0.609	0.88
3_G	107_W	0.606	0.87
34_N	103_S	0.603	0.87
14_I	22_Q	0.601	0.87
126_N	172_D	0.599	0.87
75_I	149_T	0.596	0.87
60_L	72_Y	0.595	0.86
110_L	118_M	0.593	0.86
92_L	189_L	0.591	0.86
94_S	135_E	0.589	0.86
57_R	68_E	0.585	0.85
114_T	199_D	0.583	0.85
108_K	111_D	0.582	0.85
2_C	106_E	0.581	0.85
158_L	200_D	0.579	0.85
60_L	87_S	0.577	0.85
74_M	149_T	0.576	0.85
25_P	28_E	0.574	0.84
9_S	12_D	0.573	0.84
122_L	125_S	0.572	0.84
130_F	169_I	0.567	0.84
169_I	195_P	0.567	0.84
156_N	195_P	0.567	0.84
56_L	148_C	0.566	0.84
19_N	176_K	0.566	0.84
151_I	193_L	0.562	0.83
78_R	163_H	0.560	0.83
18_F	44_I	0.560	0.83
196_Y	199_D	0.560	0.83
65_A	71_G	0.559	0.83
109_R	164_D	0.558	0.83
162_I	203_A	0.558	0.83
68_E	145_L	0.558	0.83
33_Y	36_A	0.557	0.83
72_Y	87_S	0.555	0.82
205_Q	208_S	0.555	0.82
80_E	154_K	0.553	0.82
108_K	161_D	0.552	0.82
49_S	98_I	0.549	0.82
69_K	72_Y	0.549	0.82
77_A	82_L	0.547	0.81
17_Q	172_D	0.547	0.81
191_S	194_Q	0.541	0.81
29_Y	42_L	0.539	0.81
159_M	162_I	0.537	0.80
61_I	68_E	0.537	0.80
80_E	151_I	0.537	0.80
105_Y	206_V	0.532	0.80
156_N	198_A	0.529	0.79
38_S	75_I	0.527	0.79
120_I	164_D	0.527	0.79
4_R	37_P	0.526	0.79
46_N	49_S	0.523	0.79
105_Y	117_P	0.522	0.78
105_Y	165_R	0.522	0.78
51_N	179_L	0.521	0.78
158_L	169_I	0.519	0.78
64_W	67_D	0.514	0.77
5_F	132_G	0.513	0.77
14_I	18_F	0.512	0.77
83_S	93_V	0.511	0.77
16_E	22_Q	0.511	0.77
137_W	147_T	0.510	0.77
109_R	113_K	0.509	0.77
7_L	14_I	0.508	0.77
79_A	85_K	0.508	0.77
64_W	85_K	0.507	0.76
6_T	102_D	0.507	0.76
40_N	57_R	0.506	0.76
18_F	21_D	0.503	0.76
79_A	168_V	0.503	0.76
22_Q	25_P	0.503	0.76
42_L	148_C	0.501	0.76
43_T	132_G	0.500	0.75
50_N	144_P	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2icuA	1	0.9241	100	0.09	Contact Map
2bdvA	1	0.9241	100	0.093	Contact Map
2f20A	1	0.9732	100	0.101	Contact Map
2aegA	1	0.9062	100	0.135	Contact Map
1zn6A	1	0.8839	100	0.146	Contact Map
2jd3A	2	0.3839	17.4	0.955	Contact Map
2gs0B	1	0.0625	16.7	0.955	Contact Map
3bsuA	1	0.2188	9.6	0.96	Contact Map
2b3gB	2	0.1071	6.6	0.963	Contact Map
2iiiA	2	0.1741	5.9	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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