GREMLIN Database
YORI - SPBc2 prophage-derived uncharacterized protein YorI
UniProt: O31905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 504 (428)
Sequences: 3788 (2530)
Seq/√Len: 122.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
396_D399_E4.2351.00
34_D109_S3.5931.00
328_I340_V3.4341.00
200_E483_D3.3851.00
211_K384_D3.3061.00
120_D157_K3.1551.00
285_K295_E3.0841.00
197_L209_S3.0581.00
257_S338_E2.9641.00
32_S45_F2.9211.00
256_E338_E2.8801.00
213_K269_E2.7801.00
409_A425_A2.7761.00
228_N232_D2.6361.00
236_L339_Y2.6111.00
406_V454_V2.5301.00
471_F484_C2.4561.00
259_T331_N2.3921.00
205_I466_D2.3491.00
179_G268_E2.2641.00
66_Y69_D2.2581.00
428_I455_T2.2471.00
233_A341_Y2.2421.00
171_S267_A2.2261.00
196_P203_T2.2071.00
373_S421_K2.2031.00
340_V385_V2.1891.00
452_N469_K2.1271.00
400_A411_Y2.1171.00
219_S428_I2.0881.00
257_S310_N2.0861.00
53_Q66_Y2.0861.00
440_D469_K2.0751.00
206_F424_A2.0681.00
202_L426_M2.0621.00
438_A442_I2.0341.00
216_L422_T2.0261.00
314_E327_T2.0211.00
222_G462_G1.9931.00
328_I383_Y1.9841.00
472_S476_M1.9751.00
312_W335_N1.9741.00
321_I375_K1.9641.00
427_I458_F1.9271.00
214_F376_L1.9001.00
49_N70_Y1.8901.00
324_I352_F1.8901.00
109_S113_E1.8791.00
173_G271_Q1.8741.00
364_R367_Q1.8671.00
475_N482_K1.8571.00
217_R388_M1.8391.00
16_L63_I1.8381.00
364_R414_G1.8261.00
431_L435_E1.8161.00
282_E285_K1.8081.00
223_G433_K1.8011.00
223_G434_K1.7941.00
199_S470_V1.7881.00
29_K102_Y1.7831.00
216_L418_I1.7801.00
47_M57_V1.7621.00
172_V175_Q1.7211.00
49_N66_Y1.7161.00
234_C278_I1.7121.00
238_A309_S1.7091.00
219_S223_G1.7031.00
66_Y70_Y1.6981.00
198_N203_T1.6921.00
438_A441_P1.6751.00
22_L48_S1.6321.00
280_S478_N1.6161.00
237_S311_I1.6071.00
43_L85_Y1.5951.00
185_D189_E1.5931.00
170_E259_T1.5891.00
275_L299_V1.5881.00
279_S478_N1.5881.00
195_V236_L1.5871.00
124_I153_A1.5821.00
15_I22_L1.5811.00
46_A66_Y1.5761.00
424_A460_N1.5751.00
257_S336_N1.5751.00
341_Y388_M1.5741.00
205_I457_V1.5701.00
108_F111_L1.5641.00
452_N484_C1.5591.00
11_V105_L1.5591.00
12_L40_H1.5551.00
294_K298_L1.5421.00
15_I47_M1.5301.00
64_D86_I1.5181.00
332_V336_N1.5061.00
115_D125_Y1.4871.00
229_M341_Y1.4841.00
460_N464_E1.4841.00
217_R228_N1.4811.00
211_K338_E1.4711.00
118_G121_I1.4531.00
65_G69_D1.4521.00
278_I305_V1.4361.00
146_S149_E1.4311.00
370_L417_A1.4281.00
227_R273_L1.4231.00
212_K266_M1.4201.00
32_S48_S1.4201.00
34_D106_K1.4201.00
373_S389_S1.4121.00
46_A63_I1.4111.00
33_D41_S1.4081.00
456_H467_K1.4021.00
222_G465_Y1.4001.00
73_Q81_K1.3931.00
11_V30_I1.3921.00
227_R479_M1.3811.00
432_S442_I1.3771.00
113_E116_G1.3721.00
287_L460_N1.3721.00
259_T328_I1.3711.00
44_F48_S1.3711.00
182_E186_S1.3661.00
183_L187_F1.3641.00
156_M160_D1.3571.00
209_S339_Y1.3481.00
38_R41_S1.3431.00
237_S258_S1.3431.00
29_K103_K1.3391.00
193_I210_R1.3361.00
37_S40_H1.3321.00
99_D103_K1.3281.00
9_I85_Y1.3271.00
339_Y388_M1.3241.00
453_F481_I1.3241.00
304_K308_E1.3231.00
201_M204_S1.3211.00
350_T391_T1.3181.00
209_S232_D1.3131.00
259_T340_V1.3081.00
365_E370_L1.3081.00
276_A286_I1.3031.00
21_I98_F1.3021.00
233_A260_V1.2991.00
201_M483_D1.2951.00
454_V467_K1.2891.00
332_V384_D1.2861.00
5_K37_S1.2811.00
234_C277_Y1.2751.00
7_A105_L1.2751.00
324_I342_F1.2711.00
426_M455_T1.2681.00
118_G125_Y1.2671.00
106_K110_L1.2641.00
14_S98_F1.2621.00
429_L434_K1.2571.00
460_N463_N1.2551.00
121_I154_Y1.2541.00
210_R213_K1.2430.99
332_V337_V1.2410.99
413_R420_D1.2350.99
93_A101_H1.2350.99
4_D65_G1.2340.99
42_I72_I1.2270.99
213_K462_G1.2250.99
260_V311_I1.2240.99
115_D126_D1.2240.99
118_G122_K1.2200.99
475_N478_N1.2170.99
40_H85_Y1.2020.99
45_F49_N1.2020.99
362_N366_D1.1950.99
64_D68_K1.1890.99
363_L366_D1.1860.99
119_F122_K1.1810.99
157_K160_D1.1790.99
222_G459_K1.1770.99
228_N455_T1.1720.99
98_F102_Y1.1690.99
282_E477_G1.1680.99
406_V467_K1.1670.99
394_N397_W1.1560.99
212_K384_D1.1510.99
281_V299_V1.1510.99
176_G267_A1.1470.99
184_L299_V1.1400.99
7_A104_R1.1400.99
153_A157_K1.1380.99
312_W331_N1.1370.99
232_D236_L1.1350.99
230_V274_A1.1330.99
35_F44_F1.1330.99
292_N295_E1.1300.99
183_L268_E1.1270.99
235_R254_W1.1240.99
328_I387_M1.1240.99
325_E382_K1.1210.99
186_S190_S1.1140.99
379_L383_Y1.1120.99
196_P254_W1.1080.99
233_A258_S1.1070.99
475_N480_R1.0980.99
285_K292_N1.0970.99
280_S480_R1.0950.99
153_A156_M1.0780.98
236_L256_E1.0780.98
229_M390_A1.0770.98
111_L150_I1.0770.98
397_W433_K1.0740.98
180_I272_S1.0730.98
471_F475_N1.0710.98
127_E144_K1.0580.98
200_E204_S1.0560.98
9_I40_H1.0350.98
362_N365_E1.0350.98
344_Y350_T1.0310.98
319_F324_I1.0300.98
72_I79_D1.0290.98
171_S176_G1.0290.98
171_S179_G1.0180.98
406_V456_H1.0150.98
345_I418_I1.0140.98
471_F482_K1.0100.98
394_N433_K1.0080.98
116_G120_D1.0060.98
83_L87_E1.0050.98
295_E298_L1.0010.98
19_P57_V1.0010.98
230_V260_V1.0000.98
430_P434_K0.9920.97
222_G409_A0.9900.97
394_N425_A0.9830.97
291_I299_V0.9820.97
60_D64_D0.9820.97
186_S189_E0.9810.97
259_T385_V0.9800.97
379_L387_M0.9800.97
342_F376_L0.9720.97
397_W405_Q0.9710.97
104_R108_F0.9670.97
9_I88_K0.9660.97
395_G419_A0.9600.97
431_L438_A0.9570.97
120_D124_I0.9570.97
413_R416_K0.9560.97
103_K107_K0.9550.97
180_I275_L0.9510.97
428_I453_F0.9500.97
170_E331_N0.9490.97
316_L319_F0.9450.97
220_I398_K0.9430.96
223_G453_F0.9420.96
34_D113_E0.9400.96
226_T270_L0.9390.96
276_A282_E0.9380.96
65_G68_K0.9370.96
13_G92_L0.9330.96
106_K109_S0.9330.96
210_R287_L0.9290.96
199_S231_A0.9270.96
117_L157_K0.9250.96
206_F457_V0.9240.96
12_L89_I0.9230.96
237_S309_S0.9200.96
202_L455_T0.9180.96
6_Q9_I0.9170.96
439_I442_I0.9150.96
65_G104_R0.9140.96
180_I184_L0.9110.96
188_E296_K0.9100.96
145_K149_E0.9090.96
228_N428_I0.9080.96
405_Q434_K0.9070.96
38_R42_I0.9060.96
220_I419_A0.9050.96
215_Y424_A0.9030.95
171_S175_Q0.9020.95
400_A408_D0.9010.95
284_K288_R0.9000.95
22_L51_F0.8960.95
207_R288_R0.8950.95
279_S302_A0.8930.95
67_L73_Q0.8930.95
84_E87_E0.8920.95
217_R229_M0.8900.95
177_G303_A0.8890.95
376_L389_S0.8880.95
280_S482_K0.8880.95
33_D113_E0.8840.95
110_L151_L0.8780.95
263_T319_F0.8760.95
230_V270_L0.8700.94
183_L186_S0.8700.94
24_E99_D0.8680.94
294_K297_Q0.8670.94
365_E414_G0.8640.94
398_K405_Q0.8620.94
345_I350_T0.8620.94
26_N98_F0.8600.94
373_S417_A0.8570.94
469_K486_T0.8570.94
435_E438_A0.8560.94
284_K464_E0.8550.94
176_G271_Q0.8520.94
22_L27_K0.8480.94
42_I80_N0.8470.94
301_K305_V0.8370.93
328_I337_V0.8370.93
432_S476_M0.8370.93
155_E159_V0.8360.93
73_Q82_G0.8330.93
227_R230_V0.8310.93
233_A311_I0.8300.93
259_T337_V0.8260.93
278_I302_A0.8260.93
377_K423_D0.8170.92
124_I157_K0.8170.92
365_E394_N0.8130.92
234_C274_A0.8080.92
179_G182_E0.8070.92
214_F389_S0.8040.92
221_T419_A0.8020.92
214_F373_S0.8010.92
212_K269_E0.8000.92
14_S95_V0.7990.92
30_I35_F0.7980.92
23_S51_F0.7970.91
97_N101_H0.7970.91
370_L374_D0.7970.91
395_G416_K0.7960.91
88_K91_E0.7940.91
18_D95_V0.7930.91
49_N53_Q0.7930.91
19_P63_I0.7930.91
15_I26_N0.7920.91
378_G381_N0.7890.91
409_A427_I0.7860.91
117_L158_I0.7830.91
438_A452_N0.7780.90
60_D87_E0.7770.90
46_A49_N0.7770.90
409_A458_F0.7760.90
455_T470_V0.7740.90
26_N102_Y0.7720.90
232_D339_Y0.7720.90
310_N338_E0.7710.90
202_L209_S0.7710.90
187_F272_S0.7670.90
15_I19_P0.7650.90
169_S327_T0.7640.90
233_A237_S0.7640.90
117_L161_I0.7620.90
119_F123_E0.7600.89
43_L86_I0.7580.89
97_N100_Y0.7580.89
234_C238_A0.7570.89
4_D108_F0.7540.89
258_S339_Y0.7530.89
202_L457_V0.7520.89
222_G424_A0.7500.89
191_P290_T0.7490.89
255_S308_E0.7470.89
469_K484_C0.7450.88
283_E479_M0.7450.88
209_S236_L0.7440.88
351_I421_K0.7430.88
59_N101_H0.7380.88
46_A70_Y0.7350.88
111_L125_Y0.7350.88
205_I460_N0.7340.88
78_H81_K0.7340.88
416_K419_A0.7320.88
321_I352_F0.7320.88
338_E385_V0.7300.87
261_I340_V0.7290.87
60_D86_I0.7280.87
353_S371_L0.7280.87
319_F323_E0.7270.87
59_N97_N0.7270.87
321_I354_E0.7260.87
197_L203_T0.7230.87
159_V163_E0.7230.87
369_L415_S0.7190.87
332_V338_E0.7190.87
218_S393_L0.7190.87
417_A421_K0.7180.87
454_V469_K0.7160.86
436_K441_P0.7140.86
339_Y386_Y0.7130.86
42_I45_F0.7110.86
319_F327_T0.7100.86
365_E417_A0.7100.86
100_Y103_K0.7100.86
84_E88_K0.7100.86
221_T398_K0.7100.86
107_K146_S0.7090.86
282_E295_E0.7080.86
182_E185_D0.7070.86
236_L258_S0.7050.86
50_L55_T0.7030.85
350_T414_G0.7020.85
177_G180_I0.7010.85
149_E153_A0.7010.85
269_E462_G0.6990.85
5_K9_I0.6970.85
432_S453_F0.6930.85
207_R210_R0.6910.84
201_M484_C0.6910.84
117_L121_I0.6870.84
337_V383_Y0.6870.84
441_P452_N0.6840.84
363_L367_Q0.6830.84
51_F57_V0.6810.84
220_I395_G0.6800.83
17_K93_A0.6770.83
342_F389_S0.6770.83
31_T34_D0.6760.83
317_P382_K0.6760.83
398_K410_S0.6730.83
21_I24_E0.6720.83
183_L272_S0.6720.83
433_K465_Y0.6710.83
149_E152_T0.6710.83
300_R304_K0.6670.82
17_K95_V0.6670.82
285_K290_T0.6660.82
120_D153_A0.6660.82
213_K460_N0.6660.82
194_G289_N0.6650.82
238_A278_I0.6630.82
226_T230_V0.6610.82
17_K92_L0.6610.82
65_G108_F0.6600.82
183_L211_K0.6590.82
380_C387_M0.6580.81
184_L286_I0.6570.81
210_R460_N0.6570.81
255_S310_N0.6560.81
209_S388_M0.6540.81
258_S341_Y0.6540.81
64_D73_Q0.6530.81
399_E408_D0.6520.81
302_A305_V0.6510.81
152_T322_Q0.6470.80
221_T416_K0.6450.80
223_G412_L0.6440.80
160_D163_E0.6430.80
3_Q36_P0.6430.80
262_S315_H0.6430.80
263_T351_I0.6420.80
43_L89_I0.6420.80
68_K73_Q0.6420.80
48_S52_H0.6410.80
49_N52_H0.6390.80
201_M468_V0.6380.79
55_T103_K0.6370.79
231_A277_Y0.6360.79
114_M118_G0.6340.79
430_P433_K0.6340.79
14_S101_H0.6310.79
119_F126_D0.6300.79
432_S438_A0.6300.79
26_N44_F0.6290.78
32_S41_S0.6260.78
225_K343_D0.6260.78
206_F210_R0.6250.78
232_D388_M0.6250.78
7_A61_V0.6240.78
297_Q301_K0.6230.78
432_S435_E0.6230.78
176_G180_I0.6230.78
263_T413_R0.6220.78
26_N29_K0.6210.78
332_V383_Y0.6210.78
229_M388_M0.6210.78
22_L57_V0.6210.78
16_L47_M0.6190.77
221_T422_T0.6180.77
315_H381_N0.6150.77
430_P453_F0.6150.77
64_D83_L0.6130.77
354_E361_V0.6120.77
13_G94_V0.6100.76
27_K51_F0.6100.76
453_F476_M0.6090.76
85_Y89_I0.6070.76
416_K420_D0.6040.76
110_L147_I0.6000.75
45_F70_Y0.5990.75
359_S371_L0.5960.75
50_L62_E0.5960.75
460_N466_D0.5960.75
202_L206_F0.5940.74
404_G429_L0.5920.74
122_K125_Y0.5920.74
238_A305_V0.5910.74
11_V101_H0.5910.74
318_D353_S0.5900.74
374_D378_G0.5900.74
412_L427_I0.5890.74
422_T425_A0.5890.74
43_L46_A0.5890.74
328_I332_V0.5880.74
231_A234_C0.5880.74
201_M486_T0.5880.74
354_E367_Q0.5870.74
262_S270_L0.5860.73
454_V483_D0.5830.73
328_I379_L0.5830.73
221_T393_L0.5830.73
391_T417_A0.5820.73
180_I271_Q0.5810.73
184_L187_F0.5800.73
412_L425_A0.5800.73
437_D441_P0.5800.73
266_M269_E0.5770.72
457_V460_N0.5770.72
152_T156_M0.5770.72
365_E373_S0.5750.72
222_G433_K0.5720.72
117_L154_Y0.5720.72
340_V379_L0.5710.72
210_R462_G0.5710.72
379_L382_K0.5700.71
46_A67_L0.5700.71
365_E381_N0.5680.71
397_W429_L0.5660.71
46_A50_L0.5660.71
114_M158_I0.5660.71
442_I452_N0.5650.71
225_K264_E0.5650.71
429_L456_H0.5650.71
10_Q59_N0.5640.71
111_L147_I0.5630.70
31_T48_S0.5630.70
221_T420_D0.5620.70
227_R472_S0.5620.70
429_L433_K0.5620.70
99_D102_Y0.5610.70
321_I376_L0.5590.70
4_D7_A0.5590.70
297_Q300_R0.5590.70
432_S436_K0.5580.70
344_Y369_L0.5570.70
455_T468_V0.5570.70
218_S397_W0.5530.69
234_C309_S0.5520.69
41_S45_F0.5520.69
303_A307_Q0.5500.69
351_I393_L0.5500.69
57_V62_E0.5490.69
214_F427_I0.5490.69
431_L434_K0.5490.69
369_L373_S0.5480.68
280_S475_N0.5480.68
93_A105_L0.5470.68
45_F72_I0.5460.68
127_E143_D0.5450.68
276_A283_E0.5440.68
470_V483_D0.5430.68
275_L303_A0.5430.68
310_N335_N0.5420.68
321_I379_L0.5420.68
23_S333_I0.5420.68
353_S378_G0.5410.67
15_I44_F0.5410.67
206_F215_Y0.5410.67
18_D116_G0.5410.67
371_L375_K0.5410.67
220_I420_D0.5380.67
340_V382_K0.5370.67
471_F485_F0.5370.67
18_D21_I0.5370.67
15_I21_I0.5360.67
78_H82_G0.5360.67
47_M63_I0.5340.66
120_D123_E0.5340.66
122_K126_D0.5330.66
174_I178_E0.5330.66
215_Y388_M0.5320.66
374_D421_K0.5320.66
10_Q93_A0.5320.66
276_A281_V0.5310.66
115_D119_F0.5310.66
358_K361_V0.5310.66
399_E403_K0.5310.66
359_S362_N0.5310.66
460_N468_V0.5300.66
205_I468_V0.5290.66
375_K379_L0.5280.66
218_S412_L0.5280.66
211_K386_Y0.5270.65
24_E28_Y0.5250.65
400_A434_K0.5240.65
196_P256_E0.5240.65
11_V98_F0.5240.65
178_E307_Q0.5230.65
353_S374_D0.5230.65
224_G264_E0.5220.65
199_S228_N0.5220.65
274_A311_I0.5210.65
174_I308_E0.5210.65
285_K291_I0.5200.64
225_K392_Q0.5200.64
199_S235_R0.5190.64
154_Y158_I0.5190.64
217_R426_M0.5190.64
238_A255_S0.5180.64
179_G267_A0.5170.64
219_S409_A0.5170.64
212_K381_N0.5160.64
42_I46_A0.5160.64
46_A72_I0.5150.64
92_L95_V0.5150.64
323_E458_F0.5150.64
316_L327_T0.5140.64
176_G313_F0.5140.64
59_N62_E0.5140.64
260_V390_A0.5130.63
233_A270_L0.5130.63
197_L388_M0.5120.63
373_S420_D0.5120.63
375_K378_G0.5110.63
393_L413_R0.5100.63
224_G343_D0.5100.63
36_P112_R0.5090.63
67_L81_K0.5090.63
291_I295_E0.5070.62
210_R222_G0.5060.62
124_I150_I0.5040.62
483_D486_T0.5040.62
118_G158_I0.5030.62
218_S415_S0.5030.62
10_Q61_V0.5030.62
265_M461_R0.5030.62
94_V122_K0.5020.62
30_I44_F0.5020.62
176_G179_G0.5020.62
228_N481_I0.5010.62
106_K164_K0.5010.62
325_E379_L0.5010.62
193_I207_R0.5000.61
400_A405_Q0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q6tA 1 0.8294 100 0.286 Contact Map
4nmnA 3 0.8452 100 0.289 Contact Map
3bgwA 3 0.8214 100 0.296 Contact Map
2r6aA 5 0.8234 100 0.322 Contact Map
3bh0A 1 0.5556 100 0.556 Contact Map
4a1fA 2 0.5833 100 0.563 Contact Map
1cr0A 3 0.4623 100 0.633 Contact Map
1q57A 3 0.8254 100 0.637 Contact Map
3io5A 2 0.4067 100 0.706 Contact Map
1nlfA 3 0.504 100 0.727 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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