GREMLIN Database
YORJ - SPBc2 prophage-derived uncharacterized protein YorJ
UniProt: O31904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (333)
Sequences: 3906 (2676)
Seq/√Len: 146.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_D80_R4.4331.00
143_N146_V3.2301.00
329_A333_P3.1401.00
190_D194_R3.0221.00
33_Q38_I2.9791.00
26_S101_I2.9241.00
199_R254_E2.7771.00
196_I231_N2.7171.00
14_I17_I2.6531.00
41_T68_C2.5571.00
38_I54_Y2.5221.00
159_L165_H2.4831.00
152_P156_Q2.4681.00
143_N147_L2.4101.00
167_T262_D2.4051.00
351_D359_E2.3581.00
62_F80_R2.3491.00
48_G66_T2.3311.00
18_H102_A2.3281.00
329_A337_V2.2981.00
273_V298_L2.1591.00
35_G58_E2.1361.00
127_G130_K2.1241.00
158_W184_I2.0881.00
89_I97_Y2.0861.00
44_H68_C2.0781.00
82_K97_Y2.0531.00
63_H69_G2.0451.00
21_L37_P2.0451.00
189_R236_H2.0361.00
247_K269_F2.0161.00
124_E130_K2.0091.00
90_S93_Q2.0071.00
302_R306_E2.0071.00
41_T44_H1.9731.00
18_H23_D1.9441.00
156_Q160_G1.9371.00
96_E108_F1.9311.00
248_V286_L1.9291.00
292_E321_Q1.8801.00
230_M281_F1.8271.00
242_I248_V1.8141.00
48_G53_L1.8071.00
36_N54_Y1.7901.00
30_L55_Y1.7791.00
163_I255_K1.7671.00
241_S268_N1.7511.00
11_S107_G1.7411.00
197_G217_L1.7361.00
199_R274_C1.7331.00
76_E80_R1.7241.00
340_L344_E1.7071.00
126_M130_K1.6981.00
147_L151_V1.6971.00
170_E268_N1.6951.00
27_E82_K1.6861.00
189_R237_K1.6821.00
172_E189_R1.6711.00
28_N39_Y1.6661.00
63_H71_N1.6661.00
334_Y338_Y1.6591.00
226_H274_C1.6501.00
15_E73_D1.6381.00
127_G225_N1.6201.00
73_D76_E1.6131.00
165_H168_L1.6091.00
64_C68_C1.6051.00
202_S206_E1.5991.00
78_V97_Y1.5971.00
19_K57_H1.5881.00
165_H169_K1.5721.00
295_F325_L1.5671.00
123_W130_K1.5651.00
124_E127_G1.5541.00
27_E81_A1.5401.00
154_P184_I1.5401.00
39_Y55_Y1.5241.00
23_D74_V1.5161.00
292_E323_K1.4911.00
251_F270_T1.4911.00
56_Y59_A1.4901.00
164_S262_D1.4891.00
186_I233_Y1.4851.00
41_T64_C1.4791.00
36_N56_Y1.4681.00
62_F70_D1.4651.00
217_L223_L1.4651.00
164_S167_T1.4561.00
41_T66_T1.4541.00
44_H66_T1.4441.00
91_F95_I1.4351.00
344_E348_D1.4271.00
247_K292_E1.4041.00
300_K329_A1.3821.00
168_L173_I1.3791.00
345_G349_Y1.3771.00
56_Y61_Q1.3721.00
13_T16_D1.3701.00
338_Y346_L1.3661.00
229_M281_F1.3611.00
21_L57_H1.3591.00
153_Y182_E1.3561.00
222_I227_Q1.3531.00
15_E74_V1.3361.00
89_I94_A1.3201.00
339_V342_D1.3151.00
123_W225_N1.2971.00
212_Y215_M1.2961.00
283_R314_Q1.2941.00
273_V282_H1.2911.00
234_G261_Q1.2861.00
15_E75_F1.2851.00
170_E237_K1.2801.00
11_S104_R1.2511.00
327_L346_L1.2471.00
19_K22_K1.2421.00
297_A343_Y1.2401.00
251_F260_C1.2371.00
131_K195_L1.2351.00
297_A327_L1.2331.00
163_I168_L1.2321.00
306_E310_E1.2271.00
204_I207_E1.2251.00
332_T336_R1.2161.00
155_H165_H1.2151.00
123_W127_G1.2091.00
227_Q230_M1.2041.00
283_R315_E1.1941.00
50_S66_T1.1901.00
323_K350_K1.1871.00
254_E274_C1.1851.00
30_L39_Y1.1841.00
143_N151_V1.1781.00
158_W168_L1.1771.00
155_H168_L1.1611.00
234_G257_V1.1541.00
325_L346_L1.1471.00
122_D125_W1.1461.00
92_N96_E1.1410.99
218_K222_I1.1290.99
171_F261_Q1.1290.99
158_W173_I1.1270.99
98_V101_I1.1270.99
312_K353_P1.1210.99
234_G237_K1.1200.99
148_D151_V1.1180.99
131_K172_E1.1180.99
96_E100_K1.1140.99
155_H159_L1.1130.99
287_L320_Y1.1120.99
309_T357_G1.1110.99
27_E77_L1.1020.99
44_H64_C1.0980.99
97_Y101_I1.0950.99
40_R48_G1.0910.99
345_G348_D1.0790.99
48_G52_K1.0740.99
128_K172_E1.0720.99
342_D345_G1.0700.99
18_H74_V1.0660.99
121_D125_W1.0570.99
335_V343_Y1.0540.99
144_E172_E1.0510.99
341_W345_G1.0360.99
329_A338_Y1.0290.99
53_L66_T1.0230.99
50_S53_L1.0230.99
159_L168_L1.0180.99
128_K194_R1.0180.99
18_H98_V1.0170.99
189_R195_L1.0170.99
341_W344_E1.0150.99
246_K291_V1.0150.99
166_K169_K1.0080.99
193_N236_H1.0050.99
11_S106_F0.9990.99
129_F132_K0.9970.99
156_Q159_L0.9940.99
12_L95_I0.9850.99
175_Y181_T0.9760.98
144_E148_D0.9750.98
78_V89_I0.9730.98
62_F71_N0.9700.98
39_Y53_L0.9700.98
173_I258_L0.9680.98
152_P155_H0.9660.98
44_H52_K0.9640.98
25_G29_N0.9630.98
207_E212_Y0.9630.98
144_E169_K0.9520.98
18_H101_I0.9490.98
145_T149_V0.9480.98
75_F98_V0.9430.98
246_K292_E0.9380.98
366_R369_I0.9380.98
202_S207_E0.9350.98
17_I104_R0.9320.98
19_K60_K0.9280.98
60_K74_V0.9250.98
250_I296_I0.9250.98
128_K132_K0.9220.98
267_S344_E0.9090.97
32_D37_P0.9090.97
338_Y342_D0.9080.97
229_M282_H0.9050.97
27_E97_Y0.9050.97
142_F146_V0.9030.97
20_I23_D0.9010.97
37_P57_H0.8990.97
260_C270_T0.8980.97
153_Y156_Q0.8960.97
247_K348_D0.8960.97
10_E14_I0.8960.97
186_I255_K0.8860.97
352_S355_D0.8850.97
97_Y100_K0.8810.97
124_E131_K0.8800.97
76_E79_I0.8780.97
36_N61_Q0.8770.97
351_D355_D0.8750.97
170_E261_Q0.8730.97
61_Q71_N0.8730.97
180_H185_T0.8660.97
247_K295_F0.8630.97
260_C343_Y0.8630.97
247_K290_G0.8610.97
18_H22_K0.8590.96
291_V320_Y0.8560.96
125_W130_K0.8540.96
300_K328_A0.8520.96
232_L271_C0.8490.96
235_L289_L0.8470.96
48_G51_Y0.8450.96
298_L311_E0.8430.96
278_I311_E0.8410.96
362_E367_R0.8410.96
249_L260_C0.8370.96
294_V315_E0.8370.96
75_F95_I0.8370.96
334_Y343_Y0.8320.96
242_I290_G0.8280.96
63_H70_D0.8270.96
49_G66_T0.8230.95
188_H199_R0.8220.95
45_N48_G0.8220.95
123_W129_F0.8210.95
146_V149_V0.8200.95
202_S205_K0.8150.95
168_L184_I0.8140.95
126_M129_F0.8130.95
125_W128_K0.8100.95
99_A106_F0.8080.95
128_K131_K0.8080.95
124_E194_R0.8070.95
229_M279_S0.8060.95
315_E322_K0.8050.95
162_G336_R0.8030.95
24_L55_Y0.8030.95
40_R66_T0.8020.95
309_T360_T0.8010.95
182_E204_I0.7930.94
260_C335_V0.7930.94
146_V151_V0.7920.94
305_K326_K0.7910.94
360_T363_E0.7890.94
259_K263_F0.7860.94
241_S245_F0.7850.94
245_F344_E0.7840.94
177_F218_K0.7810.94
166_K170_E0.7800.94
36_N59_A0.7790.94
280_N314_Q0.7780.94
280_N317_L0.7770.94
185_T200_R0.7750.94
273_V311_E0.7740.94
33_Q54_Y0.7690.94
93_Q96_E0.7690.94
251_F257_V0.7690.94
188_H231_N0.7680.94
81_A88_N0.7630.93
233_Y254_E0.7610.93
231_N274_C0.7580.93
40_R51_Y0.7570.93
202_S212_Y0.7560.93
273_V296_I0.7540.93
287_L318_V0.7540.93
176_Y181_T0.7520.93
163_I186_I0.7460.93
296_I315_E0.7450.92
79_I91_F0.7440.92
24_L28_N0.7360.92
183_G200_R0.7310.92
259_K262_D0.7310.92
227_Q281_F0.7300.92
54_Y61_Q0.7300.92
278_I283_R0.7300.92
263_F340_L0.7270.92
333_P336_R0.7240.91
143_N149_V0.7240.91
287_L291_V0.7230.91
120_I124_E0.7230.91
249_L267_S0.7230.91
313_Y357_G0.7220.91
286_L320_Y0.7210.91
305_K360_T0.7170.91
11_S14_I0.7160.91
120_I127_G0.7150.91
277_N310_E0.7120.91
88_N243_E0.7110.91
171_F258_L0.7080.90
362_E365_M0.7000.90
359_E363_E0.6980.90
206_E212_Y0.6960.90
123_W126_M0.6920.89
325_L347_L0.6880.89
249_L347_L0.6880.89
271_C286_L0.6870.89
44_H70_D0.6870.89
127_G131_K0.6850.89
241_S244_R0.6830.89
111_R114_Y0.6830.89
58_E243_E0.6800.89
154_P158_W0.6790.89
215_M226_H0.6790.89
269_F344_E0.6790.89
73_D79_I0.6760.88
177_F215_M0.6720.88
257_V270_T0.6700.88
49_G53_L0.6700.88
80_R88_N0.6690.88
78_V81_A0.6680.88
199_R215_M0.6670.88
145_T150_F0.6670.88
261_Q268_N0.6660.88
249_L297_A0.6660.88
145_T148_D0.6590.87
38_I51_Y0.6580.87
256_S304_P0.6570.87
154_P157_L0.6570.87
112_E115_I0.6560.87
20_I62_F0.6560.87
120_I123_W0.6530.87
355_D359_E0.6530.87
14_I104_R0.6500.86
260_C297_A0.6470.86
63_H66_T0.6460.86
116_N119_L0.6440.86
285_I289_L0.6430.86
359_E362_E0.6420.86
148_D168_L0.6410.86
143_N150_F0.6400.85
188_H197_G0.6340.85
78_V82_K0.6330.85
216_P228_T0.6330.85
24_L81_A0.6280.84
44_H51_Y0.6270.84
273_V277_N0.6270.84
249_L295_F0.6260.84
346_L349_Y0.6240.84
247_K350_K0.6240.84
125_W129_F0.6230.84
246_K290_G0.6210.84
41_T70_D0.6200.84
29_N40_R0.6190.83
186_I258_L0.6170.83
257_V272_A0.6170.83
332_T335_V0.6160.83
99_A102_A0.6120.83
52_K66_T0.6110.83
40_R49_G0.6110.83
161_E174_G0.6080.82
252_E299_D0.6070.82
21_L25_G0.6040.82
361_L364_L0.6040.82
276_S307_H0.6020.82
261_Q270_T0.6000.82
297_A325_L0.5990.81
148_D155_H0.5970.81
171_F233_Y0.5970.81
17_I102_A0.5970.81
98_V102_A0.5970.81
18_H78_V0.5960.81
184_I203_M0.5940.81
122_D127_G0.5940.81
44_H48_G0.5940.81
334_Y342_D0.5920.81
66_T70_D0.5920.81
240_N244_R0.5910.81
308_E312_K0.5900.80
197_G231_N0.5900.80
356_K360_T0.5890.80
278_I298_L0.5870.80
361_L365_M0.5870.80
124_E128_K0.5860.80
23_D77_L0.5850.80
100_K105_T0.5850.80
43_C77_L0.5840.80
172_E195_L0.5840.80
283_R320_Y0.5820.80
247_K344_E0.5800.79
197_G227_Q0.5800.79
161_E255_K0.5790.79
197_G226_H0.5770.79
180_H215_M0.5770.79
285_I288_S0.5770.79
30_L34_Q0.5770.79
354_A371_I0.5760.79
226_H254_E0.5760.79
338_Y345_G0.5760.79
282_H298_L0.5750.79
267_S335_V0.5750.79
365_M369_I0.5740.79
143_N148_D0.5730.79
233_Y257_V0.5730.79
115_I118_D0.5720.78
82_K239_K0.5720.78
226_H282_H0.5720.78
188_H254_E0.5700.78
245_F269_F0.5690.78
61_Q73_D0.5690.78
281_F284_D0.5690.78
279_S282_H0.5660.78
191_L239_K0.5630.77
167_T170_E0.5620.77
218_K223_L0.5620.77
360_T364_L0.5620.77
300_K331_F0.5610.77
183_G228_T0.5600.77
157_L161_E0.5600.77
148_D165_H0.5600.77
183_G216_P0.5600.77
113_T117_N0.5600.77
147_L158_W0.5590.77
171_F174_G0.5560.76
267_S347_L0.5520.76
308_E326_K0.5490.76
368_K371_I0.5480.75
77_L81_A0.5460.75
188_H274_C0.5450.75
130_K225_N0.5440.75
280_N284_D0.5420.75
144_E147_L0.5410.75
62_F76_E0.5400.74
238_T242_I0.5400.74
309_T313_Y0.5390.74
114_Y117_N0.5380.74
259_K332_T0.5370.74
180_H217_L0.5370.74
326_K359_E0.5360.74
124_E129_F0.5340.74
173_I186_I0.5300.73
131_K144_E0.5300.73
237_K261_Q0.5290.73
62_F72_F0.5290.73
43_C72_F0.5280.73
334_Y346_L0.5280.73
160_G205_K0.5260.72
200_R254_E0.5260.72
148_D169_K0.5260.72
122_D126_M0.5250.72
78_V98_V0.5220.72
352_S371_I0.5220.72
123_W131_K0.5210.72
154_P174_G0.5210.72
248_V290_G0.5210.72
147_L169_K0.5200.72
240_N268_N0.5190.71
114_Y118_D0.5190.71
180_H200_R0.5180.71
251_F282_H0.5180.71
249_L269_F0.5180.71
40_R50_S0.5180.71
40_R53_L0.5170.71
10_E13_T0.5170.71
294_V320_Y0.5150.71
245_F268_N0.5140.71
183_G214_Y0.5120.70
216_P254_E0.5110.70
24_L77_L0.5110.70
213_K228_T0.5100.70
146_V150_F0.5100.70
125_W131_K0.5090.70
196_I235_L0.5090.70
191_L289_L0.5090.70
255_K332_T0.5080.70
308_E324_I0.5070.70
278_I314_Q0.5070.70
40_R52_K0.5070.70
14_I107_G0.5060.70
23_D101_I0.5050.69
79_I92_N0.5040.69
190_D231_N0.5030.69
257_V300_K0.5020.69
242_I245_F0.5020.69
75_F89_I0.5020.69
249_L325_L0.5020.69
120_I125_W0.5010.69
111_R115_I0.5000.69
45_N49_G0.5000.69
53_L70_D0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2au3A 1 0.8836 100 0.262 Contact Map
1dd9A 1 0.627 100 0.518 Contact Map
4edgA 1 0.6429 100 0.534 Contact Map
1nuiA 1 0.627 100 0.622 Contact Map
1q57A 3 0.5688 100 0.667 Contact Map
1d0qA 2 0.2619 99.9 0.727 Contact Map
1t6t1 2 0.2857 99.5 0.813 Contact Map
2fcjA 2 0.3042 98.3 0.886 Contact Map
3vdpA 2 0.4868 83.5 0.945 Contact Map
1vddA 7 0.4921 82.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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