GREMLIN Database
YORM - SPBc2 prophage-derived uncharacterized protein YorM
UniProt: O31901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (219)
Sequences: 804 (726)
Seq/√Len: 49.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_Y205_I4.8521.00
144_V231_R4.5551.00
178_I191_V4.2441.00
222_S225_E3.7431.00
143_V236_V2.8411.00
106_K109_K2.7291.00
152_C156_C2.7171.00
192_Q237_S2.6561.00
144_V215_R2.6431.00
143_V178_I2.6311.00
196_E202_A2.5031.00
140_S237_S2.2641.00
142_E235_R2.0921.00
180_V204_A2.0881.00
166_V219_L2.0781.00
145_A229_F2.0331.00
150_A166_V2.0261.00
194_S235_R1.9780.99
164_Y177_I1.9200.99
161_R207_T1.9140.99
167_S177_I1.9030.99
196_E218_I1.8800.99
161_R187_L1.8600.99
149_T223_E1.8080.99
187_L207_T1.7830.99
86_A124_N1.7810.99
223_E227_N1.7620.99
93_L114_K1.7490.99
210_D215_R1.7340.99
152_C158_G1.7290.99
151_F219_L1.7060.98
147_A229_F1.6910.98
150_A219_L1.6560.98
177_I219_L1.6520.98
218_I229_F1.5840.97
78_L81_E1.5750.97
204_A207_T1.5660.97
70_D122_K1.5580.97
229_F234_V1.5310.97
149_T152_C1.5080.96
99_Y109_K1.4910.96
88_S91_K1.4860.96
145_A220_M1.4850.96
137_A237_S1.4820.96
218_I232_K1.4700.96
33_L102_E1.4690.96
147_A220_M1.4670.96
229_F232_K1.4570.96
152_C157_T1.4430.95
150_A158_G1.4410.95
55_Y98_T1.4390.95
64_K90_K1.4130.95
220_M226_A1.4050.95
182_P185_I1.3650.94
99_Y106_K1.3620.94
184_V214_N1.3480.93
151_F167_S1.3480.93
150_A155_G1.3390.93
177_I205_I1.3350.93
14_Y24_A1.3140.93
84_K88_S1.3070.92
202_A234_V1.3020.92
164_Y203_Y1.3000.92
89_R118_K1.2950.92
98_T110_H1.2870.92
138_V237_S1.2820.92
196_E234_V1.2750.91
143_V234_V1.2740.91
168_N176_R1.2700.91
140_S235_R1.2680.91
145_A234_V1.2650.91
143_V229_F1.2600.91
167_S219_L1.2540.91
149_T156_C1.2520.91
144_V233_N1.2470.90
152_C155_G1.2350.90
169_T176_R1.2090.89
211_I215_R1.2080.89
215_R231_R1.2060.89
185_I204_A1.2050.89
168_N225_E1.1880.88
140_S143_V1.1780.88
190_L201_Q1.1670.87
21_A32_G1.1610.87
209_G231_R1.1570.87
34_V38_K1.1490.86
143_V218_I1.1440.86
32_G52_K1.1390.86
176_R221_D1.1340.86
165_D169_T1.1340.86
180_V207_T1.1270.85
180_V185_I1.1230.85
185_I216_I1.1160.85
164_Y167_S1.1140.85
178_I216_I1.1020.84
26_I50_I1.0960.84
190_L203_Y1.0920.83
145_A216_I1.0910.83
145_A196_E1.0880.83
161_R209_G1.0840.83
149_T158_G1.0610.82
152_C219_L1.0580.81
202_A218_I1.0580.81
224_Q228_A1.0570.81
77_R80_S1.0490.81
195_Y229_F1.0300.80
14_Y19_K1.0290.80
181_D211_I1.0240.79
94_N115_K1.0230.79
20_M24_A1.0190.79
193_V221_D1.0140.79
156_C226_A1.0060.78
167_S176_R1.0050.78
34_V50_I1.0000.78
74_I77_R0.9870.77
28_L52_K0.9860.77
145_A202_A0.9850.77
158_G166_V0.9820.76
183_E212_K0.9820.76
152_C166_V0.9810.76
169_T203_Y0.9720.76
97_I111_T0.9710.76
15_H20_M0.9680.75
178_I236_V0.9680.75
182_P204_A0.9660.75
223_E226_A0.9660.75
194_S202_A0.9650.75
14_Y23_F0.9500.74
87_E123_R0.9500.74
14_Y18_N0.9470.74
165_D177_I0.9330.73
151_F158_G0.9210.72
94_N101_T0.9210.72
143_V202_A0.9200.71
142_E233_N0.9120.71
166_V169_T0.9120.71
190_L202_A0.9050.70
154_T223_E0.9050.70
74_I80_S0.9020.70
184_V204_A0.9020.70
75_L78_L0.9010.70
92_Y118_K0.8990.70
187_L204_A0.8960.69
95_A111_T0.8960.69
149_T155_G0.8940.69
12_Y189_S0.8910.69
181_D184_V0.8900.69
162_T187_L0.8890.69
166_V177_I0.8800.68
145_A215_R0.8760.68
91_K103_E0.8730.67
75_L81_E0.8680.67
160_T226_A0.8670.67
152_C223_E0.8630.67
211_I214_N0.8630.67
85_Q88_S0.8620.66
120_N123_R0.8610.66
178_I218_I0.8590.66
180_V184_V0.8520.66
197_G207_T0.8520.66
132_S137_A0.8470.65
14_Y20_M0.8410.65
193_V237_S0.8400.64
21_A28_L0.8350.64
119_T218_I0.8340.64
67_H91_K0.8330.64
193_V229_F0.8310.64
67_H88_S0.8290.63
145_A189_S0.8240.63
97_I109_K0.8130.62
165_D237_S0.8070.61
91_K104_N0.8000.61
82_E85_Q0.7980.60
9_H25_T0.7880.59
53_S103_E0.7870.59
155_G159_K0.7720.58
96_T113_T0.7720.58
150_A156_C0.7690.58
166_V205_I0.7660.57
220_M229_F0.7590.57
155_G158_G0.7570.56
132_S135_A0.7500.56
193_V234_V0.7490.56
166_V193_V0.7450.55
194_S234_V0.7440.55
184_V213_N0.7440.55
143_V196_E0.7410.55
11_K20_M0.7410.55
181_D212_K0.7390.55
80_S91_K0.7350.54
193_V196_E0.7350.54
67_H73_R0.7330.54
196_E205_I0.7320.54
205_I219_L0.7280.53
166_V221_D0.7240.53
192_Q201_Q0.7220.53
32_G53_S0.7180.52
180_V187_L0.7180.52
80_S88_S0.7170.52
152_C226_A0.7170.52
192_Q205_I0.7150.52
165_D221_D0.7130.52
181_D187_L0.7100.52
128_A132_S0.7090.52
151_F223_E0.7060.51
194_S201_Q0.7060.51
162_T205_I0.7040.51
181_D213_N0.6990.51
84_K91_K0.6960.50
162_T188_Y0.6960.50
193_V202_A0.6940.50
18_N22_L0.6890.50
201_Q212_K0.6890.50
55_Y58_K0.6880.49
160_T166_V0.6880.49
176_R196_E0.6870.49
143_V187_L0.6820.49
145_A218_I0.6800.49
143_V232_K0.6740.48
208_G217_D0.6730.48
184_V187_L0.6710.48
101_T106_K0.6700.48
115_K119_T0.6700.48
63_Q67_H0.6630.47
15_H42_T0.6600.47
181_D204_A0.6590.46
202_A207_T0.6580.46
189_S205_I0.6570.46
31_V35_Y0.6550.46
193_V216_I0.6550.46
169_T237_S0.6530.46
14_Y17_I0.6470.45
21_A26_I0.6460.45
189_S203_Y0.6460.45
69_I88_S0.6440.45
165_D205_I0.6440.45
66_I74_I0.6410.45
224_Q227_N0.6410.45
150_A176_R0.6390.44
147_A226_A0.6300.44
32_G36_S0.6280.43
88_S104_N0.6270.43
100_L108_A0.6250.43
10_K40_L0.6250.43
51_K103_E0.6240.43
180_V196_E0.6210.43
143_V194_S0.6190.42
151_F154_T0.6170.42
23_F29_L0.6160.42
13_V17_I0.6130.42
196_E204_A0.6110.42
73_R79_K0.6070.41
116_V119_T0.6010.41
35_Y177_I0.5990.40
72_P83_E0.5980.40
102_E107_A0.5970.40
184_V210_D0.5960.40
221_D225_E0.5930.40
149_T154_T0.5880.39
132_S136_K0.5880.39
112_K116_V0.5860.39
159_K215_R0.5860.39
197_G218_I0.5830.39
72_P75_L0.5830.39
36_S48_V0.5800.39
182_P207_T0.5800.39
32_G38_K0.5770.38
151_F156_C0.5770.38
17_I21_A0.5770.38
68_E79_K0.5750.38
165_D168_N0.5740.38
147_A232_K0.5720.38
187_L191_V0.5710.38
116_V233_N0.5700.38
194_S197_G0.5690.38
187_L193_V0.5680.38
94_N120_N0.5670.37
176_R205_I0.5630.37
143_V189_S0.5600.37
226_A232_K0.5600.37
12_Y15_H0.5580.37
192_Q197_G0.5580.37
176_R237_S0.5540.36
29_L54_F0.5530.36
120_N124_N0.5520.36
152_C176_R0.5490.36
219_L223_E0.5470.36
158_G177_I0.5470.36
69_I84_K0.5460.35
169_T193_V0.5430.35
21_A24_A0.5400.35
44_Q64_K0.5390.35
135_A237_S0.5380.35
15_H27_G0.5380.35
151_F155_G0.5370.35
113_T116_V0.5360.35
16_R19_K0.5300.34
165_D176_R0.5290.34
133_T136_K0.5290.34
193_V235_R0.5260.34
108_A218_I0.5260.34
181_D216_I0.5260.34
15_H23_F0.5250.34
30_G40_L0.5250.34
187_L211_I0.5240.33
142_E232_K0.5230.33
16_R26_I0.5230.33
154_T158_G0.5220.33
67_H104_N0.5210.33
88_S93_L0.5200.33
168_N221_D0.5190.33
70_D94_N0.5180.33
196_E229_F0.5170.33
155_G166_V0.5150.33
21_A38_K0.5140.33
63_Q74_I0.5130.32
184_V236_V0.5120.32
121_T124_N0.5100.32
116_V125_L0.5100.32
13_V23_F0.5080.32
115_K122_K0.5070.32
191_V202_A0.5070.32
217_D230_G0.5070.32
149_T157_T0.5060.32
49_S57_N0.5050.32
101_T109_K0.5040.32
184_V207_T0.5020.31
48_V84_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wjtA 2 0.437 100 0.484 Contact Map
2ae0X 1 0.7437 99.9 0.646 Contact Map
2g5dA 1 0.7269 99.9 0.662 Contact Map
2pnwA 1 0.7521 99.9 0.669 Contact Map
3czbA 2 0.7227 99.8 0.684 Contact Map
4fuoA 2 0.542 97.2 0.883 Contact Map
4avrA 2 0.3739 96.8 0.89 Contact Map
3eo5A 1 0.6891 96.6 0.892 Contact Map
4fzqA 4 0.3319 95.6 0.901 Contact Map
2ltjA 1 0.4664 95.5 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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