GREMLIN Database
YOZE - UPF0346 protein YozE
UniProt: O31864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 74 (69)
Sequences: 250 (170)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_L27_A3.4931.00
37_S42_E3.4441.00
40_Y49_L2.1290.94
13_H21_S2.1000.93
23_F53_Y2.0770.93
2_K10_K2.0520.92
8_L23_F1.8300.87
23_F27_A1.8060.86
54_L59_T1.8010.86
9_L27_A1.7560.85
2_K36_T1.6580.81
20_I63_A1.6230.80
41_H45_S1.6130.79
37_S64_W1.5660.77
25_N53_Y1.5550.77
16_P21_S1.4810.73
23_F54_L1.4620.72
12_R28_Y1.4440.71
37_S43_I1.4300.70
30_D46_Y1.4030.69
11_Y31_H1.3770.67
8_L14_P1.2880.62
22_E26_Q1.2710.61
40_Y64_W1.2540.60
58_A69_S1.2250.58
7_Y11_Y1.2200.58
38_T70_E1.1740.55
20_I66_Q1.1680.54
40_Y45_S1.1670.54
6_H31_H1.1310.52
43_I64_W1.1160.51
7_Y15_K1.1160.51
53_Y57_M1.1140.51
9_L28_Y1.1080.50
13_H16_P1.0200.45
26_Q55_H1.0040.44
2_K7_Y1.0030.43
28_Y32_S0.9940.43
40_Y70_E0.9730.42
38_T68_E0.9680.41
17_K21_S0.9650.41
7_Y52_D0.9530.40
14_P25_N0.9460.40
13_H36_T0.9460.40
50_N54_L0.9250.39
10_K36_T0.9040.37
26_Q56_T0.9020.37
38_T66_Q0.8950.37
15_K38_T0.8670.35
6_H42_E0.8650.35
18_D30_D0.8620.35
52_D66_Q0.8520.34
51_A56_T0.8430.34
9_L67_Y0.8220.32
3_S6_H0.8140.32
54_L57_M0.8070.32
4_F48_E0.7950.31
14_P18_D0.7590.29
2_K52_D0.7550.29
23_F49_L0.7460.28
18_D21_S0.7380.28
39_D42_E0.7250.27
26_Q53_Y0.7250.27
62_E65_D0.7240.27
12_R38_T0.7190.27
35_K43_I0.6880.25
29_E39_D0.6840.25
31_H70_E0.6690.24
11_Y40_Y0.6590.24
3_S22_E0.6450.23
53_Y63_A0.6430.23
8_L25_N0.6430.23
16_P41_H0.6350.23
19_S22_E0.6240.22
12_R47_L0.6220.22
11_Y70_E0.6150.22
59_T62_E0.6140.22
25_N36_T0.6130.22
38_T69_S0.6030.21
27_A58_A0.6020.21
10_K20_I0.5880.21
14_P23_F0.5860.20
58_A65_D0.5780.20
19_S57_M0.5770.20
44_S48_E0.5770.20
12_R15_K0.5730.20
11_Y66_Q0.5680.20
50_N59_T0.5640.20
43_I55_H0.5620.19
32_S70_E0.5580.19
28_Y31_H0.5530.19
16_P36_T0.5520.19
40_Y69_S0.5500.19
65_D69_S0.5500.19
17_K41_H0.5480.19
4_F47_L0.5460.19
55_H68_E0.5440.19
39_D45_S0.5370.18
10_K28_Y0.5230.18
28_Y70_E0.5160.18
19_S41_H0.5140.18
40_Y55_H0.5060.17
3_S14_P0.5040.17
13_H26_Q0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fj6A 1 1 100 0.235 Contact Map
2o6kA 1 0.9459 99.9 0.322 Contact Map
2kvsA 1 0.973 99.7 0.53 Contact Map
3i1aA 1 0.8108 10.3 0.93 Contact Map
3ax1A 1 0.7027 7.6 0.934 Contact Map
2dtgE 2 0.8649 6.1 0.937 Contact Map
3vtxA 2 0.5676 5.5 0.938 Contact Map
3hncA 2 0.8784 5.5 0.938 Contact Map
2wghA 2 0.8784 5.4 0.938 Contact Map
3k8tA 2 0.8784 4.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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