GREMLIN Database
YOJA - Uncharacterized permease YojA
UniProt: O31862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (420)
Sequences: 5308 (3563)
Seq/√Len: 173.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_F200_R3.6251.00
300_E303_S3.3421.00
290_S293_E3.1541.00
9_G318_F3.1341.00
268_P272_M3.1241.00
180_I184_P3.0981.00
12_I34_L3.0491.00
320_Q324_D3.0361.00
9_G35_V2.9041.00
87_T228_F2.8631.00
77_D297_S2.8511.00
329_D333_D2.8021.00
237_F278_L2.7841.00
414_S417_E2.7521.00
228_F232_A2.7511.00
171_I175_L2.7451.00
49_S324_D2.6841.00
87_T91_K2.5741.00
344_F434_L2.5231.00
234_T238_P2.4901.00
347_W430_S2.4891.00
193_F197_A2.4491.00
11_L15_F2.4111.00
42_D45_K2.3881.00
52_T56_G2.3871.00
170_H175_L2.3191.00
268_P271_A2.3181.00
200_R204_A2.2871.00
87_T90_D2.2811.00
435_G439_L2.2731.00
333_D336_R2.2651.00
227_G230_I2.2371.00
172_G175_L2.2191.00
229_A233_V2.1941.00
427_T431_V2.1941.00
48_L52_T2.1871.00
431_V435_G2.1541.00
182_A185_T2.1441.00
15_F19_K2.0761.00
170_H173_Q2.0701.00
192_L196_F2.0461.00
82_Y86_I2.0441.00
177_F180_I2.0251.00
199_K202_P2.0061.00
167_Y389_T2.0001.00
231_S234_T1.9291.00
204_A207_K1.9221.00
350_A367_T1.9121.00
197_A200_R1.9111.00
198_M202_P1.8391.00
338_T341_S1.8321.00
77_D293_E1.8181.00
198_M201_F1.8171.00
176_L179_I1.8121.00
181_I185_T1.8031.00
171_I176_L1.7551.00
173_Q176_L1.7421.00
12_I31_V1.7321.00
175_L178_G1.7311.00
330_Y334_F1.7261.00
197_A201_F1.7251.00
420_Q424_L1.7251.00
238_P242_M1.7091.00
45_K48_L1.7081.00
234_T242_M1.7041.00
193_F196_F1.7041.00
179_I182_A1.6961.00
188_I192_L1.6751.00
177_F181_I1.6641.00
346_A389_T1.6641.00
351_A395_I1.6631.00
42_D46_I1.6581.00
379_S382_P1.6551.00
375_M385_M1.6491.00
163_I364_A1.6371.00
172_G176_L1.6311.00
170_H174_V1.6271.00
178_G182_A1.6271.00
355_L396_A1.6201.00
201_F205_Y1.6201.00
192_L195_K1.6181.00
169_A174_V1.6151.00
198_M204_A1.6051.00
176_L180_I1.5941.00
140_G411_F1.5931.00
178_G184_P1.5891.00
235_S242_M1.5871.00
73_R77_D1.5751.00
199_K203_G1.5601.00
152_G394_V1.5451.00
99_A191_P1.5431.00
94_R131_E1.5281.00
179_I183_V1.5131.00
178_G181_I1.4981.00
192_L200_R1.4851.00
202_P206_Q1.4811.00
193_F200_R1.4731.00
101_V105_S1.4711.00
5_I38_G1.4671.00
424_L428_V1.4621.00
277_L281_Y1.4581.00
196_F199_K1.4581.00
70_M298_I1.4531.00
49_S320_Q1.4441.00
272_M276_L1.4391.00
241_F274_I1.4391.00
133_K204_A1.4261.00
261_I265_I1.4231.00
193_F201_F1.4111.00
105_S108_I1.3991.00
436_C440_A1.3941.00
195_K199_K1.3931.00
200_R203_G1.3841.00
115_E402_A1.3821.00
238_P246_T1.3811.00
39_L42_D1.3791.00
83_R87_T1.3741.00
170_H176_L1.3731.00
263_E266_G1.3631.00
175_L180_I1.3571.00
22_L27_S1.3561.00
190_G193_F1.3471.00
272_M275_S1.3441.00
226_P231_S1.3391.00
438_L441_G1.3371.00
203_G206_Q1.3371.00
69_A298_I1.3331.00
293_E296_R1.3291.00
175_L179_I1.3271.00
12_I16_L1.3221.00
180_I185_T1.3161.00
10_V13_L1.3151.00
228_F231_S1.3141.00
262_I266_G1.3081.00
395_I430_S1.2911.00
235_S238_P1.2811.00
101_V104_A1.2781.00
13_L31_V1.2771.00
230_I233_V1.2741.00
115_E312_I1.2641.00
166_A368_A1.2611.00
319_K323_I1.2561.00
81_G85_A1.2441.00
230_I234_T1.2441.00
261_I266_G1.2311.00
200_R206_Q1.2281.00
54_I62_A1.2251.00
73_R297_S1.2251.00
82_Y223_D1.2241.00
296_R300_E1.2141.00
200_R207_K1.2101.00
174_V386_V1.2071.00
202_P205_Y1.2031.00
269_G273_L1.2001.00
78_A283_M1.1981.00
229_A234_T1.1971.00
194_N200_R1.1951.00
261_I267_T1.1941.00
53_G320_Q1.1861.00
114_F403_G1.1841.00
391_A437_V1.1831.00
50_I317_A1.1671.00
181_I440_A1.1611.00
391_A433_G1.1521.00
395_I427_T1.1431.00
179_I184_P1.1361.00
378_G382_P1.1341.00
197_A204_A1.1331.00
195_K198_M1.1331.00
80_G231_S1.1331.00
178_G185_T1.1291.00
241_F245_A1.1271.00
355_L395_I1.1271.00
246_T249_S1.1251.00
102_V186_T1.1211.00
245_A249_S1.1171.00
114_F117_G1.1171.00
425_L429_L1.1161.00
270_T274_I1.1111.00
237_F275_S1.1111.00
242_M246_T1.1071.00
6_V10_V1.1051.00
86_I131_E1.1021.00
359_S362_V1.1021.00
86_I90_D1.1021.00
416_K420_Q1.1011.00
275_S279_A1.1011.00
312_I402_A1.1001.00
229_A232_A1.0971.00
118_L410_F1.0971.00
199_K204_A1.0931.00
292_Q296_R1.0921.00
199_K207_K1.0861.00
397_C401_D1.0861.00
196_F204_A1.0861.00
271_A276_L1.0851.00
278_L282_T1.0841.00
191_P194_N1.0831.00
408_K418_T1.0781.00
173_Q177_F1.0751.00
195_K200_R1.0741.00
9_G34_L1.0731.00
194_N198_M1.0731.00
164_S168_G1.0661.00
190_G196_F1.0651.00
231_S238_P1.0471.00
177_F182_A1.0471.00
25_F310_L1.0471.00
261_I264_F1.0440.99
190_G194_N1.0310.99
188_I196_F1.0230.99
93_G100_A1.0220.99
130_K136_F1.0210.99
116_V119_V1.0120.99
177_F383_A1.0010.99
234_T250_L1.0000.99
173_Q179_I0.9980.99
227_G231_S0.9980.99
74_L279_A0.9970.99
198_M206_Q0.9950.99
34_L38_G0.9930.99
397_C422_W0.9840.99
376_E382_P0.9840.99
190_G195_K0.9770.99
145_A190_G0.9720.99
150_T154_L0.9700.99
233_V237_F0.9690.99
268_P273_L0.9680.99
326_G329_D0.9680.99
150_T157_H0.9650.99
182_A186_T0.9650.99
396_A423_T0.9570.99
360_A397_C0.9540.99
44_N48_L0.9520.99
27_S31_V0.9500.99
193_F428_V0.9500.99
101_V107_I0.9450.99
433_G437_V0.9440.99
195_K203_G0.9400.99
387_L437_V0.9380.99
247_I251_L0.9380.99
268_P279_A0.9370.99
320_Q323_I0.9350.99
240_I244_M0.9320.99
171_I174_V0.9320.99
201_F204_A0.9310.99
233_V282_T0.9270.99
181_I184_P0.9270.99
116_V159_A0.9230.99
417_E420_Q0.9210.99
77_D300_E0.9210.99
248_F252_L0.9190.99
174_V178_G0.9150.99
220_F224_E0.9150.99
196_F201_F0.9130.99
180_I183_V0.9100.99
364_A393_S0.9100.99
175_L184_P0.9100.99
194_N201_F0.9090.99
169_A173_Q0.9090.99
184_P188_I0.9080.99
191_P195_K0.9080.99
305_I309_L0.9080.99
289_I294_I0.9040.99
227_G233_V0.9030.99
438_L442_L0.8990.98
434_L438_L0.8970.98
247_I250_L0.8970.98
264_F267_T0.8920.98
266_G279_A0.8900.98
171_I178_G0.8890.98
228_F235_S0.8870.98
354_R401_D0.8820.98
341_S344_F0.8790.98
141_I145_A0.8770.98
193_F198_M0.8760.98
347_W434_L0.8740.98
148_N426_T0.8710.98
84_I231_S0.8690.98
222_L225_T0.8680.98
49_S53_G0.8630.98
169_A172_G0.8610.98
41_M49_S0.8610.98
35_V318_F0.8570.98
149_V182_A0.8560.98
134_M138_Y0.8560.98
213_G216_P0.8550.98
196_F202_P0.8540.98
16_L22_L0.8540.98
246_T250_L0.8530.98
387_L391_A0.8520.98
363_A401_D0.8520.98
237_F241_F0.8520.98
415_M419_F0.8480.98
113_F116_V0.8460.98
426_T429_L0.8450.98
33_F270_T0.8450.98
197_A207_K0.8450.98
279_A283_M0.8420.98
86_I225_T0.8260.97
177_F387_L0.8250.97
7_A11_L0.8220.97
83_R228_F0.8200.97
57_Q316_G0.8200.97
189_A194_N0.8180.97
31_V34_L0.8160.97
234_T282_T0.8120.97
280_L283_M0.8120.97
101_V108_I0.8120.97
108_I121_L0.8100.97
32_S36_A0.8090.97
35_V321_V0.8080.97
117_G147_L0.8080.97
177_F184_P0.8070.97
160_P164_S0.8070.97
179_I185_T0.8030.97
223_D231_S0.8030.97
384_L440_A0.8010.97
403_G407_V0.8010.97
383_A387_L0.7990.97
270_T275_S0.7990.97
144_A404_F0.7980.97
162_A365_L0.7930.97
39_L325_G0.7920.97
220_F223_D0.7920.97
104_A108_I0.7900.97
262_I265_I0.7890.97
372_A376_E0.7880.96
271_A279_A0.7810.96
91_K95_K0.7780.96
193_F424_L0.7780.96
276_L280_L0.7780.96
63_L67_L0.7780.96
172_G177_F0.7770.96
432_T436_C0.7730.96
354_R360_A0.7730.96
373_P378_G0.7710.96
161_T164_S0.7670.96
178_G186_T0.7630.96
222_L226_P0.7630.96
52_T55_G0.7630.96
181_I436_C0.7610.96
175_L182_A0.7610.96
418_T422_W0.7600.96
103_V107_I0.7580.96
198_M205_Y0.7550.96
245_A250_L0.7550.96
176_L181_I0.7530.95
110_I113_F0.7500.95
109_G150_T0.7470.95
109_G113_F0.7460.95
174_V177_F0.7440.95
94_R132_L0.7440.95
106_F110_I0.7430.95
190_G197_A0.7410.95
226_P234_T0.7390.95
10_V17_I0.7350.95
189_A193_F0.7340.95
192_L199_K0.7340.95
117_G157_H0.7320.95
360_A402_A0.7320.95
166_A369_G0.7270.95
153_F433_G0.7240.94
270_T273_L0.7230.94
16_L27_S0.7220.94
360_A393_S0.7220.94
423_T427_T0.7210.94
384_L437_V0.7200.94
439_L442_L0.7160.94
104_A107_I0.7140.94
429_L433_G0.7140.94
5_I39_L0.7130.94
243_A246_T0.7130.94
421_T424_L0.7110.94
432_T435_G0.7110.94
193_F202_P0.7110.94
194_N197_A0.7100.94
194_N199_K0.7070.94
276_L282_T0.7070.94
266_G271_A0.7050.94
231_S242_M0.7050.94
248_F251_L0.7030.93
354_R397_C0.7020.93
201_F206_Q0.7000.93
239_V242_M0.6990.93
227_G235_S0.6990.93
12_I15_F0.6970.93
280_L298_I0.6960.93
280_L294_I0.6960.93
173_Q178_G0.6960.93
5_I9_G0.6940.93
231_S250_L0.6920.93
172_G179_I0.6920.93
5_I31_V0.6920.93
109_G112_L0.6880.93
226_P230_I0.6880.93
96_R106_F0.6870.93
23_N26_V0.6860.93
229_A238_P0.6850.93
222_L227_G0.6840.93
290_S294_I0.6830.92
196_F207_K0.6810.92
344_F438_L0.6790.92
180_I202_P0.6780.92
10_V14_L0.6770.92
202_P207_K0.6750.92
270_T276_L0.6750.92
191_P198_M0.6750.92
354_R363_A0.6670.92
237_F240_I0.6660.92
279_A282_T0.6640.91
244_M247_I0.6620.91
170_H179_I0.6610.91
171_I179_I0.6580.91
125_V143_M0.6580.91
41_M45_K0.6570.91
73_R300_E0.6570.91
373_P377_A0.6570.91
146_A150_T0.6560.91
148_N394_V0.6540.91
196_F203_G0.6520.91
48_L51_E0.6520.91
189_A192_L0.6510.91
179_I186_T0.6510.91
115_E118_L0.6470.90
267_T272_M0.6470.90
191_P196_F0.6460.90
221_Q337_Q0.6450.90
9_G13_L0.6450.90
230_I238_P0.6440.90
350_A393_S0.6440.90
228_F242_M0.6430.90
270_T283_M0.6430.90
16_L30_V0.6430.90
185_T432_T0.6430.90
102_V106_F0.6430.90
243_A247_I0.6420.90
200_R205_Y0.6420.90
171_I182_A0.6410.90
26_V276_L0.6400.90
176_L184_P0.6390.90
177_F183_V0.6390.90
102_V105_S0.6380.90
8_V12_I0.6380.90
363_A367_T0.6370.90
397_C426_T0.6370.90
364_A367_T0.6360.90
67_L403_G0.6360.90
73_R76_S0.6340.89
357_L362_V0.6320.89
267_T276_L0.6310.89
267_T270_T0.6300.89
114_F118_L0.6290.89
129_A134_M0.6290.89
340_M344_F0.6290.89
184_P436_C0.6280.89
238_P241_F0.6270.89
54_I57_Q0.6260.89
115_E119_V0.6260.89
47_V51_E0.6260.89
174_V383_A0.6250.89
190_G200_R0.6250.89
233_V240_I0.6240.89
50_I53_G0.6240.89
96_R102_V0.6240.89
178_G183_V0.6210.88
399_V419_F0.6190.88
362_V366_T0.6190.88
181_I387_L0.6150.88
249_S263_E0.6140.88
75_V80_G0.6130.88
189_A432_T0.6120.88
5_I8_V0.6110.88
140_G413_L0.6110.88
228_F234_T0.6110.88
135_P201_F0.6090.87
192_L197_A0.6090.87
422_W426_T0.6090.87
169_A175_L0.6060.87
103_V106_F0.6060.87
271_A282_T0.6060.87
343_L380_V0.6050.87
109_G157_H0.6050.87
203_G207_K0.6050.87
269_G272_M0.6050.87
58_L313_G0.6040.87
265_I269_G0.6040.87
88_L92_F0.6030.87
335_F349_I0.6000.87
96_R100_A0.6000.87
40_G44_N0.6000.87
40_G45_K0.5980.87
346_A371_A0.5970.86
151_H155_P0.5960.86
351_A355_L0.5960.86
70_M294_I0.5950.86
189_A196_F0.5940.86
214_L218_K0.5940.86
330_Y333_D0.5940.86
229_A251_L0.5920.86
109_G114_F0.5910.86
70_M275_S0.5910.86
244_M249_S0.5910.86
277_L282_T0.5900.86
331_V349_I0.5900.86
357_L366_T0.5880.86
231_S235_S0.5880.86
153_F391_A0.5880.86
191_P200_R0.5870.86
262_I267_T0.5840.85
264_F268_P0.5830.85
217_R221_Q0.5790.85
236_L243_A0.5780.85
189_A200_R0.5780.85
351_A430_S0.5780.85
157_H364_A0.5770.85
109_G119_V0.5770.85
52_T324_D0.5760.84
268_P276_L0.5740.84
112_L119_V0.5740.84
33_F217_R0.5730.84
96_R99_A0.5720.84
345_V375_M0.5710.84
214_L217_R0.5700.84
173_Q383_A0.5700.84
423_T430_S0.5700.84
197_A202_P0.5700.84
145_A425_L0.5690.84
188_I191_P0.5680.84
188_I432_T0.5670.84
355_L423_T0.5660.83
378_G381_N0.5660.83
248_F262_I0.5660.83
284_G288_K0.5640.83
44_N47_V0.5630.83
238_P243_A0.5620.83
138_Y142_P0.5610.83
194_N203_G0.5590.83
346_A350_A0.5580.83
41_M46_I0.5580.83
273_L277_L0.5580.83
421_T425_L0.5570.82
195_K207_K0.5560.82
52_T320_Q0.5550.82
83_R227_G0.5550.82
51_E75_V0.5510.82
239_V243_A0.5500.82
154_L157_H0.5500.82
83_R225_T0.5490.82
189_A198_M0.5480.81
63_L66_G0.5480.81
278_L281_Y0.5480.81
80_G83_R0.5460.81
112_L272_M0.5460.81
234_T241_F0.5450.81
404_F408_K0.5440.81
350_A363_A0.5430.81
224_E230_I0.5430.81
91_K94_R0.5420.81
7_A435_G0.5420.81
41_M325_G0.5420.81
67_L158_P0.5420.81
141_I425_L0.5400.80
375_M382_P0.5380.80
174_V179_I0.5360.80
184_P196_F0.5350.80
145_A149_V0.5340.80
396_A419_F0.5330.80
227_G234_T0.5320.80
40_G43_I0.5300.79
53_G56_G0.5300.79
63_L269_G0.5290.79
228_F233_V0.5290.79
174_V180_I0.5290.79
396_A427_T0.5290.79
384_L441_G0.5280.79
38_G45_K0.5270.79
116_V312_I0.5270.79
269_G279_A0.5270.79
245_A251_L0.5270.79
83_R231_S0.5260.79
233_V238_P0.5260.79
398_H426_T0.5250.79
157_H312_I0.5240.78
232_A236_L0.5230.78
236_L244_M0.5220.78
8_V11_L0.5210.78
222_L229_A0.5190.78
190_G201_F0.5170.78
436_C439_L0.5170.78
122_I411_F0.5170.78
224_E228_F0.5170.78
226_P238_P0.5160.77
227_G244_M0.5160.77
117_G121_L0.5160.77
106_F149_V0.5150.77
353_L357_L0.5150.77
214_L222_L0.5140.77
185_T436_C0.5140.77
284_G294_I0.5140.77
398_H421_T0.5140.77
367_T389_T0.5140.77
226_P240_I0.5140.77
197_A203_G0.5130.77
125_V129_A0.5130.77
311_I365_L0.5130.77
219_E222_L0.5120.77
45_K49_S0.5120.77
96_R108_I0.5110.77
112_L319_K0.5110.77
368_A389_T0.5110.77
177_F185_T0.5100.77
272_M280_L0.5100.77
90_D192_L0.5090.76
105_S121_L0.5090.76
296_R303_S0.5080.76
237_F274_I0.5070.76
136_F140_G0.5070.76
169_A176_L0.5060.76
113_F159_A0.5060.76
244_M248_F0.5050.76
272_M279_A0.5050.76
13_L356_C0.5050.76
331_V356_C0.5040.76
150_T160_P0.5040.76
129_A139_L0.5040.76
232_A235_S0.5030.76
351_A396_A0.5020.76
195_K201_F0.5010.75
90_D293_E0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9797 100 0.573 Contact Map
4r0cA 3 0.9662 100 0.601 Contact Map
4f35D 2 0.8896 100 0.634 Contact Map
2cfqA 1 0.8266 78.4 0.945 Contact Map
4pd6A 3 0.7568 67.2 0.949 Contact Map
2nwlA 3 0.7477 51.5 0.954 Contact Map
3aqpA 1 0.3266 44.3 0.956 Contact Map
4dx5A 3 0.3559 40.9 0.957 Contact Map
3qnqA 2 0.4617 37.6 0.958 Contact Map
4m64A 1 0.8739 37.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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