GREMLIN Database
YOJE - Uncharacterized transporter YojE
UniProt: O31859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (268)
Sequences: 37290 (27531)
Seq/√Len: 1681.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_A157_A3.6661.00
12_Y233_E3.1431.00
233_E237_R2.9901.00
258_G264_E2.9051.00
95_W156_V2.7721.00
47_F187_F2.6491.00
92_V159_L2.4991.00
40_A194_L2.4911.00
135_A280_A2.4351.00
233_E236_K2.4111.00
106_S254_T2.3281.00
92_V156_V2.2371.00
21_G253_I2.2271.00
115_V161_A2.2271.00
126_E172_K2.2231.00
28_K264_E2.1951.00
27_W94_I2.1651.00
13_T234_G2.1461.00
119_L169_L2.1321.00
121_I128_L2.0781.00
120_G126_E1.9571.00
44_I190_M1.9541.00
21_G257_I1.9291.00
100_G104_E1.9001.00
52_I55_F1.8861.00
88_I163_S1.8861.00
116_S244_G1.8831.00
111_I115_V1.8811.00
129_N132_Q1.8751.00
26_Y218_F1.8741.00
51_C183_T1.8451.00
117_V136_V1.8171.00
139_A248_Y1.7741.00
177_P180_I1.7581.00
191_P195_G1.7481.00
195_G198_L1.7321.00
155_Y159_L1.7271.00
47_F190_M1.7151.00
18_I253_I1.7131.00
239_P242_Q1.6881.00
210_S214_W1.6801.00
282_L286_F1.6621.00
115_V165_G1.6491.00
267_S270_K1.6411.00
95_W99_H1.6401.00
92_V163_S1.6141.00
22_L218_F1.6121.00
51_C55_F1.6001.00
105_A157_A1.5771.00
53_V57_L1.5471.00
135_A284_F1.5191.00
16_S234_G1.5151.00
30_L38_I1.5071.00
115_V162_F1.4731.00
171_K232_A1.4631.00
45_W220_A1.4621.00
12_Y230_L1.4551.00
40_A190_M1.4491.00
268_S272_F1.4361.00
120_G124_L1.4201.00
210_S213_T1.4191.00
101_F104_E1.4151.00
145_I276_C1.4041.00
220_A225_A1.4001.00
74_G175_S1.3961.00
102_L258_G1.3861.00
46_S186_T1.3831.00
165_G169_L1.3801.00
119_L123_F1.3761.00
253_I257_I1.3741.00
130_R134_V1.3611.00
95_W98_N1.3581.00
52_I56_F1.3511.00
72_K75_G1.3481.00
135_A283_L1.3451.00
139_A280_A1.3371.00
103_L255_L1.3311.00
34_P37_D1.3271.00
257_I261_V1.3181.00
10_V246_L1.3151.00
131_L283_L1.3141.00
20_W227_P1.3051.00
275_S279_A1.3021.00
74_G77_L1.3001.00
25_L257_I1.2981.00
192_I195_G1.2861.00
142_G273_T1.2801.00
249_I253_I1.2751.00
271_A275_S1.2731.00
99_H156_V1.2721.00
48_V52_I1.2521.00
49_F225_A1.2501.00
133_L137_S1.2451.00
73_N77_L1.2441.00
107_L274_F1.2421.00
145_I269_S1.2381.00
11_I15_V1.2271.00
137_S141_A1.2261.00
55_F59_Q1.2171.00
97_V105_A1.2051.00
22_L257_I1.1921.00
40_A44_I1.1821.00
266_F271_A1.1791.00
211_G215_L1.1721.00
42_R224_T1.1711.00
100_G157_A1.1711.00
146_S273_T1.1711.00
47_F183_T1.1711.00
38_I219_L1.1701.00
19_M222_V1.1531.00
128_L133_L1.1471.00
78_S82_A1.1441.00
85_L166_L1.1421.00
122_L125_K1.1381.00
93_Y97_V1.1351.00
40_A197_L1.1251.00
72_K76_I1.1211.00
126_E132_Q1.1191.00
130_R133_L1.1181.00
108_G161_A1.1161.00
73_N76_I1.0971.00
116_S240_L1.0901.00
131_L286_F1.0901.00
87_S192_I1.0871.00
16_S20_W1.0871.00
119_L165_G1.0871.00
211_G214_W1.0851.00
124_L169_L1.0831.00
36_L196_Y1.0821.00
119_L166_L1.0781.00
172_K239_P1.0761.00
87_S193_A1.0751.00
16_S230_L1.0731.00
39_L94_I1.0711.00
102_L262_Y1.0621.00
121_I127_K1.0611.00
131_L287_S1.0611.00
15_V230_L1.0441.00
55_F58_R1.0401.00
9_G234_G1.0391.00
49_F221_G1.0391.00
142_G277_I1.0391.00
19_M230_L1.0331.00
82_A85_L1.0301.00
44_I194_L1.0221.00
83_S192_I1.0211.00
35_A39_L1.0211.00
116_S168_G1.0201.00
235_A239_P1.0171.00
235_A243_V1.0151.00
33_L212_G1.0151.00
27_W97_V1.0121.00
108_G157_A1.0031.00
9_G237_R1.0021.00
172_K240_L0.9991.00
196_Y200_S0.9961.00
213_T217_L0.9941.00
111_I143_V0.9861.00
32_Q209_E0.9851.00
209_E213_T0.9841.00
77_L81_L0.9761.00
20_W231_F0.9721.00
116_S165_G0.9651.00
268_S271_A0.9601.00
239_P243_V0.9541.00
208_A213_T0.9461.00
212_G215_L0.9461.00
119_L122_L0.9381.00
17_F21_G0.9371.00
195_G199_F0.9371.00
129_N133_L0.9351.00
117_V128_L0.9341.00
214_W218_F0.9331.00
119_L162_F0.9321.00
43_I189_I0.9221.00
102_L264_E0.9211.00
36_L91_F0.9201.00
59_Q177_P0.9191.00
151_G154_P0.9151.00
37_D197_L0.9121.00
51_C187_F0.9111.00
49_F52_I0.9011.00
86_I167_Y0.8981.00
56_F59_Q0.8971.00
138_I280_A0.8921.00
238_L243_V0.8921.00
25_L261_V0.8851.00
13_T246_L0.8841.00
76_I80_F0.8831.00
59_Q62_I0.8831.00
161_A165_G0.8831.00
252_T274_F0.8811.00
107_L144_I0.8781.00
77_L80_F0.8781.00
41_H45_W0.8781.00
217_L221_G0.8711.00
17_F249_I0.8701.00
157_A161_A0.8701.00
55_F60_W0.8611.00
196_Y199_F0.8611.00
141_A145_I0.8541.00
58_R61_K0.8491.00
238_L242_Q0.8451.00
259_L266_F0.8441.00
14_A253_I0.8441.00
17_F253_I0.8371.00
25_L258_G0.8371.00
148_F151_G0.8321.00
234_G243_V0.8311.00
91_F95_W0.8261.00
89_N163_S0.8261.00
209_E212_G0.8221.00
204_Q207_G0.8181.00
255_L266_F0.8141.00
29_L215_L0.8121.00
85_L167_Y0.8091.00
141_A276_C0.8081.00
114_L139_A0.8071.00
187_F191_P0.8031.00
54_L58_R0.7981.00
127_K131_L0.7941.00
145_I272_F0.7901.00
100_G105_A0.7851.00
47_F51_C0.7831.00
272_F276_C0.7801.00
111_I114_L0.7701.00
39_L193_A0.7681.00
50_M225_A0.7671.00
54_L183_T0.7661.00
143_V147_A0.7661.00
180_I184_L0.7641.00
26_Y215_L0.7621.00
10_V242_Q0.7621.00
166_L170_S0.7601.00
218_F222_V0.7601.00
269_S272_F0.7591.00
214_W217_L0.7561.00
188_M192_I0.7541.00
218_F221_G0.7531.00
126_E241_Y0.7511.00
33_L213_T0.7501.00
87_S91_F0.7501.00
49_F220_A0.7461.00
76_I79_L0.7461.00
255_L274_F0.7441.00
249_I252_T0.7401.00
226_L230_L0.7391.00
134_V138_I0.7331.00
164_F168_G0.7331.00
24_P93_Y0.7331.00
127_K130_R0.7291.00
183_T187_F0.7281.00
83_S87_S0.7251.00
118_L122_L0.7221.00
274_F278_W0.7221.00
85_L170_S0.7151.00
57_L61_K0.7151.00
259_L265_P0.7141.00
116_S169_L0.7121.00
37_D41_H0.7101.00
117_V132_Q0.7091.00
88_I92_V0.7091.00
81_L85_L0.7051.00
108_G158_L0.7021.00
128_L132_Q0.7001.00
176_L181_G0.6951.00
258_G262_Y0.6951.00
215_L219_L0.6941.00
33_L37_D0.6941.00
178_S182_L0.6921.00
121_I125_K0.6891.00
79_L188_M0.6891.00
25_L102_L0.6861.00
229_L233_E0.6841.00
32_Q212_G0.6821.00
89_N167_Y0.6801.00
266_F270_K0.6741.00
33_L38_I0.6741.00
222_V226_L0.6731.00
96_A105_A0.6721.00
24_P106_S0.6711.00
74_G176_L0.6711.00
279_A283_L0.6681.00
115_V158_L0.6651.00
53_V56_F0.6651.00
29_L262_Y0.6651.00
138_I283_L0.6641.00
74_G78_S0.6641.00
85_L163_S0.6611.00
56_F60_W0.6551.00
57_L60_W0.6551.00
188_M191_P0.6541.00
198_L201_G0.6521.00
216_L220_A0.6511.00
30_L215_L0.6491.00
86_I228_L0.6491.00
44_I48_V0.6471.00
187_F190_M0.6461.00
75_G83_S0.6431.00
13_T238_L0.6421.00
270_K274_F0.6411.00
217_L220_A0.6401.00
9_G238_L0.6331.00
190_M194_L0.6291.00
164_F231_F0.6251.00
184_L188_M0.6251.00
132_Q239_P0.6241.00
184_L187_F0.6231.00
107_L147_A0.6231.00
142_G280_A0.6231.00
110_Y143_V0.6191.00
28_K31_E0.6171.00
156_V159_L0.6171.00
19_M223_F0.6131.00
256_L260_F0.6131.00
215_L218_F0.6131.00
87_S196_Y0.6121.00
267_S271_A0.6071.00
57_L177_P0.6071.00
83_S188_M0.6061.00
124_L172_K0.6051.00
255_L259_L0.6051.00
221_G225_A0.6051.00
86_I185_E0.6011.00
75_G79_L0.6001.00
93_Y105_A0.5981.00
15_V19_M0.5971.00
280_A284_F0.5931.00
113_P248_Y0.5881.00
111_I161_A0.5861.00
265_P269_S0.5861.00
118_L136_V0.5831.00
23_F223_F0.5831.00
53_V179_A0.5821.00
19_M227_P0.5801.00
245_I284_F0.5801.00
52_I57_L0.5781.00
182_L232_A0.5781.00
167_Y171_K0.5771.00
93_Y160_L0.5771.00
117_V121_I0.5731.00
129_N287_S0.5731.00
34_P201_G0.5691.00
17_F250_A0.5691.00
77_L170_S0.5661.00
92_V160_L0.5651.00
256_L259_L0.5651.00
265_P270_K0.5631.00
75_G82_A0.5631.00
189_I193_A0.5621.00
78_S170_S0.5611.00
281_L284_F0.5601.00
167_Y232_A0.5591.00
57_L179_A0.5591.00
24_P28_K0.5581.00
257_I260_F0.5551.00
191_P194_L0.5541.00
78_S83_S0.5541.00
162_F166_L0.5531.00
194_L198_L0.5521.00
32_Q213_T0.5511.00
82_A188_M0.5501.00
22_L223_F0.5491.00
45_W221_G0.5481.00
23_F94_I0.5451.00
48_V51_C0.5451.00
144_I148_F0.5441.00
45_W48_V0.5431.00
168_G231_F0.5411.00
30_L212_G0.5401.00
81_L170_S0.5381.00
94_I98_N0.5361.00
114_L136_V0.5361.00
212_G216_L0.5351.00
140_A248_Y0.5341.00
110_Y161_A0.5331.00
111_I139_A0.5301.00
110_Y113_P0.5281.00
54_L57_L0.5271.00
248_Y281_L0.5251.00
25_L262_Y0.5251.00
21_G254_T0.5241.00
247_Q250_A0.5231.00
107_L146_S0.5201.00
39_L91_F0.5191.00
120_G241_Y0.5181.00
46_S220_A0.5161.00
36_L200_S0.5151.00
10_V14_A0.5131.00
25_L254_T0.5131.00
14_A17_F0.5121.00
86_I189_I0.5121.00
45_W49_F0.5121.00
13_T231_F0.5101.00
234_G238_L0.5101.00
100_G103_L0.5101.00
182_L185_E0.5071.00
42_R90_W0.5011.00
149_Q154_P0.5001.00
142_G276_C0.5001.00
124_L173_R0.5001.00
36_L193_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2584 99 0.75 Contact Map
3b5dA 2 0.3389 98.1 0.807 Contact Map
2cfqA 1 0.8154 41.2 0.927 Contact Map
4he8J 1 0.5134 34.1 0.93 Contact Map
1u7gA 3 0.7819 32 0.931 Contact Map
3wdoA 1 0.9396 29.2 0.932 Contact Map
2kluA 1 0.1477 21.3 0.937 Contact Map
4qtnA 3 0.6544 20.5 0.937 Contact Map
4pypA 1 0.8322 16.1 0.94 Contact Map
2rddB 1 0.1074 13.4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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