GREMLIN Database
YOJG - Uncharacterized deacetylase YojG
UniProt: O31857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (187)
Sequences: 4633 (3271)
Seq/√Len: 239.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_A128_C2.9671.00
4_H32_P2.9451.00
83_L99_I2.9231.00
21_G169_I2.8531.00
34_T107_V2.8481.00
68_N71_K2.8111.00
28_K175_I2.7201.00
28_K172_V2.6001.00
26_N31_I2.4271.00
34_T79_R2.3921.00
25_L29_K2.3861.00
127_A130_E2.3081.00
7_V23_I2.3081.00
5_V26_N2.2921.00
72_E182_A2.2631.00
8_I132_V2.2301.00
25_L172_V2.2241.00
40_L63_K2.1411.00
34_T77_D1.9971.00
36_A103_I1.9681.00
79_R106_D1.9341.00
178_N181_R1.8191.00
24_A175_I1.8051.00
64_Q68_N1.7971.00
114_T132_V1.7651.00
112_I136_L1.7631.00
6_L104_I1.7211.00
6_L36_A1.6961.00
79_R103_I1.6911.00
68_N182_A1.6811.00
96_L131_A1.6491.00
37_C66_L1.6231.00
32_P77_D1.5751.00
72_E178_N1.5701.00
27_R33_V1.5591.00
4_H110_S1.5551.00
16_S69_A1.5351.00
26_N113_V1.5281.00
8_I36_A1.5031.00
97_A134_R1.4881.00
99_I102_E1.4591.00
7_V15_E1.4481.00
23_I27_R1.4411.00
40_L82_G1.4121.00
23_I33_V1.4101.00
72_E175_I1.4021.00
177_M181_R1.3881.00
101_E138_R1.3761.00
63_K67_I1.3661.00
126_D130_E1.3571.00
10_P115_F1.3501.00
21_G176_K1.3381.00
7_V113_V1.3221.00
79_R107_V1.3141.00
4_H34_T1.3081.00
148_I151_A1.2801.00
68_N184_R1.2731.00
112_I132_V1.2701.00
155_N158_E1.2651.00
54_N57_T1.2361.00
63_K82_G1.2331.00
19_V113_V1.2291.00
24_A73_M1.2101.00
24_A28_K1.2091.00
175_I178_N1.2031.00
28_K171_E1.1971.00
103_I106_D1.1951.00
104_I112_I1.1891.00
103_I107_V1.1821.00
101_E105_D1.1711.00
22_L26_N1.1661.00
25_L167_L1.1651.00
64_Q67_I1.1571.00
25_L171_E1.1541.00
144_R147_T1.1521.00
95_Y99_I1.1151.00
36_A100_M1.1151.00
23_I73_M1.1021.00
105_D139_K1.1011.00
73_M179_A1.0951.00
174_D178_N1.0901.00
67_I71_K1.0751.00
173_A177_M1.0751.00
24_A179_A1.0641.00
63_K80_M1.0631.00
38_A81_L1.0571.00
93_D97_A1.0431.00
20_A73_M1.0431.00
65_E186_Q1.0431.00
81_L99_I1.0351.00
128_C132_V1.0261.00
154_R157_E1.0221.00
37_C78_L1.0151.00
9_L115_F1.0141.00
21_G168_D1.0061.00
57_T60_L1.0011.00
20_A179_A0.9961.00
69_A179_A0.9961.00
24_A172_V0.9931.00
32_P76_N0.9861.00
8_I100_M0.9811.00
9_L15_E0.9781.00
146_R150_M0.9761.00
93_D130_E0.9701.00
27_R76_N0.9701.00
129_G133_I0.9661.00
168_D172_V0.9661.00
94_E98_D0.9661.00
172_V175_I0.9661.00
43_M84_R0.9651.00
66_L80_M0.9621.00
143_D146_R0.9591.00
68_N72_E0.9581.00
194_L197_K0.9571.00
144_R149_C0.9551.00
70_C78_L0.9521.00
184_R188_E0.9071.00
67_I78_L0.9061.00
77_D107_V0.9011.00
23_I35_Y0.8921.00
15_E35_Y0.8901.00
8_I38_A0.8870.99
66_L183_H0.8860.99
146_R149_C0.8850.99
12_P41_G0.8840.99
6_L107_V0.8790.99
97_A138_R0.8780.99
39_T88_L0.8780.99
83_L96_L0.8760.99
127_A131_A0.8710.99
148_I152_I0.8700.99
147_T151_A0.8650.99
27_R74_D0.8600.99
41_G85_D0.8510.99
100_M131_A0.8500.99
53_A57_T0.8470.99
191_L194_L0.8450.99
6_L109_P0.8420.99
145_P151_A0.8400.99
144_R148_I0.8390.99
152_I158_E0.8370.99
84_R87_T0.8220.99
98_D138_R0.8210.99
45_R58_L0.8160.99
5_V31_I0.8090.99
101_E135_A0.8000.99
61_L185_T0.7980.99
153_T156_R0.7980.99
31_I110_S0.7980.99
97_A135_A0.7970.99
65_E185_T0.7950.99
134_R137_Y0.7880.99
35_Y70_C0.7850.99
67_I80_M0.7840.99
102_E106_D0.7840.99
99_I103_I0.7830.99
93_D96_L0.7790.99
154_R158_E0.7780.99
24_A27_R0.7750.99
42_E84_R0.7690.99
85_D124_D0.7640.98
70_C75_I0.7640.98
16_S183_H0.7530.98
38_A88_L0.7500.98
6_L103_I0.7500.98
91_E95_Y0.7500.98
40_L59_P0.7360.98
93_D134_R0.7360.98
152_I156_R0.7360.98
169_I172_V0.7330.98
13_D122_H0.7280.98
147_T150_M0.7280.98
37_C80_M0.7280.98
42_E59_P0.7270.98
93_D127_A0.7250.98
43_M86_K0.7240.98
51_F54_N0.7170.98
16_S66_L0.7120.98
97_A101_E0.7100.98
152_I157_E0.7060.97
5_V113_V0.6970.97
98_D102_E0.6930.97
169_I173_A0.6880.97
91_E96_L0.6850.97
104_I136_L0.6810.97
100_M132_V0.6770.97
144_R150_M0.6740.97
193_E197_K0.6740.97
145_P149_C0.6730.97
35_Y75_I0.6690.96
38_A100_M0.6680.96
44_G186_Q0.6650.96
69_A182_A0.6630.96
149_C152_I0.6600.96
22_L167_L0.6550.96
36_A81_L0.6540.96
31_I113_V0.6520.96
62_R85_D0.6520.96
190_M193_E0.6480.96
104_I135_A0.6470.96
52_F55_R0.6450.96
192_R195_E0.6450.96
40_L80_M0.6450.96
4_H31_I0.6430.96
5_V111_L0.6430.96
114_T129_G0.6420.96
60_L64_Q0.6410.96
152_I155_N0.6340.95
130_E134_R0.6320.95
41_G86_K0.6310.95
135_A139_K0.6310.95
101_E139_K0.6230.95
17_Y20_A0.6220.95
36_A107_V0.6180.95
44_G86_K0.6160.94
88_L128_C0.6160.94
43_M87_T0.6100.94
88_L96_L0.6070.94
160_L163_A0.6060.94
13_D125_H0.6050.94
44_G85_D0.6040.94
105_D141_K0.6020.94
20_A27_R0.6000.94
191_L195_E0.5970.94
12_P183_H0.5950.93
94_E138_R0.5940.93
41_G62_R0.5930.93
8_I128_C0.5890.93
94_E134_R0.5890.93
9_L19_V0.5890.93
16_S20_A0.5890.93
15_E66_L0.5880.93
84_R88_L0.5880.93
66_L70_C0.5870.93
14_D125_H0.5820.93
83_L88_L0.5820.93
117_P129_G0.5810.93
146_R153_T0.5800.93
56_E60_L0.5780.92
88_L127_A0.5770.92
20_A176_K0.5760.92
119_H126_D0.5740.92
150_M154_R0.5740.92
139_K142_E0.5720.92
115_F120_G0.5630.91
22_L113_V0.5620.91
193_E196_E0.5600.91
149_C155_N0.5590.91
145_P148_I0.5540.91
189_G192_R0.5540.91
143_D149_C0.5540.91
159_V162_E0.5520.91
81_L103_I0.5520.91
93_D131_A0.5520.91
136_L140_K0.5490.90
94_E97_A0.5440.90
21_G172_V0.5420.90
13_D62_R0.5400.90
148_I155_N0.5360.89
174_D177_M0.5340.89
62_R186_Q0.5320.89
169_I176_K0.5310.89
149_C157_E0.5270.88
143_D148_I0.5270.88
5_V33_V0.5260.88
151_A156_R0.5260.88
105_D142_E0.5250.88
11_H14_D0.5240.88
30_D33_V0.5240.88
146_R151_A0.5240.88
4_H107_V0.5200.88
188_E192_R0.5160.87
159_V163_A0.5130.87
151_A155_N0.5110.87
20_A24_A0.5110.87
9_L114_T0.5090.87
149_C153_T0.5030.86
128_C131_A0.5010.86
22_L25_L0.5010.86
153_T157_E0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xlzA 5 0.9774 100 0.259 Contact Map
5bmoA 3 0.9502 100 0.265 Contact Map
2ixdA 5 0.914 100 0.267 Contact Map
1uanA 5 0.8914 100 0.276 Contact Map
1q74A 1 0.9683 100 0.283 Contact Map
3dffA 1 0.9548 100 0.299 Contact Map
3dfiA 1 0.9276 100 0.312 Contact Map
3ot5A 2 0.8371 93.3 0.896 Contact Map
4nesA 2 0.8371 87.7 0.909 Contact Map
4fkzA 2 0.8371 85.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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