GREMLIN Database
RSBRC - RsbT co-antagonist protein RsbRC
UniProt: O31856 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (260)
Sequences: 835 (662)
Seq/√Len: 41.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_R136_D6.0541.00
14_H17_T5.2431.00
220_T252_T4.0011.00
9_E13_Q3.8471.00
243_S272_A3.4371.00
212_L218_I3.4201.00
186_T221_M3.0811.00
186_T217_V2.8831.00
197_L232_A2.8731.00
215_V249_I2.6181.00
98_V139_I2.5361.00
198_H202_K2.4531.00
106_S129_H2.3721.00
20_S24_E2.3671.00
199_Q202_K2.3221.00
161_I169_I2.3181.00
21_T106_S2.2551.00
184_I189_A2.2121.00
220_T256_L2.0920.99
252_T256_L2.0350.99
105_V128_Y2.0180.99
218_I249_I2.0140.99
206_T210_I2.0050.99
207_Q241_T1.9550.99
222_V250_A1.9310.99
176_G205_V1.9100.99
108_V173_H1.9030.99
218_I257_G1.7550.98
176_G200_C1.7530.98
264_S267_S1.7490.98
170_V177_L1.7420.97
186_T190_K1.7410.97
184_I192_I1.7330.97
120_K123_E1.6870.97
213_S233_L1.6700.97
223_A252_T1.6690.97
205_V213_S1.6290.96
14_H107_Y1.6130.96
186_T215_V1.6040.96
221_M252_T1.6020.96
253_A260_F1.5720.95
23_Y50_N1.5550.95
43_I47_K1.5550.95
213_S276_D1.5250.94
234_R239_S1.5240.94
26_I50_N1.5220.94
11_L18_I1.5180.94
220_T223_A1.5040.94
220_T247_P1.4810.94
23_Y26_I1.4510.93
232_A268_T1.4500.93
243_S270_A1.4260.92
157_Q169_I1.4160.92
193_M232_A1.4140.92
76_A138_V1.3950.91
213_S277_L1.3920.91
102_D133_K1.3810.91
7_L15_A1.3790.91
230_I242_L1.3790.91
135_F139_I1.3730.91
196_T208_L1.3670.90
146_M149_N1.3580.90
163_E220_T1.3570.90
93_I142_F1.3570.90
173_H270_A1.3510.90
241_T275_S1.3490.90
215_V222_V1.3470.90
10_Y111_F1.3090.88
109_K126_D1.3010.88
90_I146_M1.3000.88
253_A258_L1.2980.88
177_L229_L1.2980.88
171_L265_L1.2950.88
215_V256_L1.2930.88
219_D252_T1.2830.87
217_V220_T1.2790.87
166_A192_I1.2710.87
175_V276_D1.2680.87
208_L238_V1.2570.86
228_S233_L1.2560.86
173_H204_K1.2390.85
98_V140_H1.2330.85
51_L55_Y1.2310.85
224_H228_S1.2310.85
164_L185_D1.2290.85
52_A78_E1.2190.85
164_L246_R1.1930.83
22_W157_Q1.1890.83
163_E186_T1.1850.83
15_A19_S1.1800.83
245_I250_A1.1720.82
174_S206_T1.1720.82
91_H147_Y1.1670.82
11_L105_V1.1640.82
266_R275_S1.1610.81
21_T107_Y1.1600.81
158_K231_E1.1510.81
200_C205_V1.1500.81
53_F273_I1.1280.80
241_T255_Q1.1270.79
233_L238_V1.1220.79
186_T220_T1.1210.79
172_F243_S1.1200.79
46_L49_Q1.0960.78
17_T20_S1.0940.77
220_T257_G1.0840.77
186_T225_Q1.0790.76
182_G211_D1.0780.76
170_V271_S1.0750.76
210_I233_L1.0720.76
55_Y268_T1.0700.76
110_E126_D1.0680.76
189_A217_V1.0560.75
168_V178_L1.0550.75
89_P146_M1.0540.75
75_W233_L1.0530.75
197_L256_L1.0490.74
213_S229_L1.0460.74
249_I252_T1.0430.74
194_E219_D1.0380.74
196_T229_L1.0370.73
194_E269_L1.0270.73
70_P81_Q1.0250.73
43_I146_M1.0250.73
208_L229_L1.0240.73
213_S238_V1.0190.72
49_Q83_Q1.0090.71
141_I145_E1.0080.71
159_D187_V1.0030.71
213_S272_A1.0020.71
189_A221_M1.0020.71
252_T257_G1.0000.71
186_T222_V0.9950.70
142_F160_M0.9950.70
200_C233_L0.9930.70
189_A192_I0.9890.70
160_M178_L0.9840.69
206_T248_E0.9700.68
189_A220_T0.9660.68
172_F177_L0.9640.68
78_E126_D0.9580.67
219_D249_I0.9530.67
218_I222_V0.9500.67
143_I147_Y0.9490.67
21_T25_T0.9480.67
168_V257_G0.9380.66
14_H110_E0.9310.65
11_L275_S0.9280.65
110_E173_H0.9160.64
197_L254_V0.9150.64
186_T227_F0.9150.64
48_S273_I0.9130.64
215_V252_T0.9110.63
154_L196_T0.9070.63
9_E65_E0.9060.63
272_A276_D0.9050.63
86_L206_T0.9050.63
189_A226_L0.9030.63
219_D250_A0.9000.63
25_T102_D0.8960.62
24_E65_E0.8960.62
94_I139_I0.8960.62
50_N60_I0.8930.62
49_Q161_I0.8910.62
57_I92_Y0.8900.62
72_L143_I0.8890.62
113_H122_E0.8860.61
223_A229_L0.8840.61
259_S262_G0.8820.61
7_L102_D0.8780.61
212_L253_A0.8710.60
185_D266_R0.8680.60
181_I255_Q0.8660.60
61_F131_L0.8640.59
225_Q265_L0.8630.59
178_L213_S0.8600.59
102_D129_H0.8600.59
189_A219_D0.8600.59
163_E227_F0.8570.59
17_T21_T0.8550.59
220_T224_H0.8550.59
97_F139_I0.8550.59
43_I53_F0.8510.58
209_Y243_S0.8490.58
53_F145_E0.8470.58
212_L249_I0.8440.58
13_Q24_E0.8420.57
190_K222_V0.8410.57
11_L48_S0.8410.57
174_S205_V0.8350.57
224_H257_G0.8290.56
199_Q203_K0.8290.56
212_L243_S0.8290.56
155_Q159_D0.8230.56
160_M192_I0.8230.56
209_Y269_L0.8220.56
44_H48_S0.8220.56
21_T274_A0.8220.56
46_L61_F0.8190.55
240_S254_V0.8170.55
249_I256_L0.8030.54
90_I139_I0.8010.54
183_D234_R0.8010.54
62_I70_P0.7950.53
10_Y28_E0.7940.53
15_A55_Y0.7890.52
18_I42_V0.7880.52
160_M181_I0.7870.52
196_T200_C0.7840.52
252_T277_L0.7780.51
191_L240_S0.7760.51
186_T252_T0.7760.51
199_Q213_S0.7750.51
109_K122_E0.7740.51
239_S264_S0.7730.51
219_D222_V0.7710.51
143_I268_T0.7680.51
14_H44_H0.7670.50
132_I136_D0.7650.50
91_H143_I0.7620.50
220_T227_F0.7610.50
48_S52_A0.7590.50
237_G244_G0.7540.49
77_F268_T0.7520.49
90_I144_E0.7480.49
112_V121_S0.7470.49
159_D206_T0.7460.48
180_L277_L0.7420.48
79_V161_I0.7420.48
166_A196_T0.7410.48
217_V252_T0.7400.48
196_T238_V0.7400.48
110_E131_L0.7380.48
26_I96_E0.7370.48
20_S125_E0.7310.47
165_S220_T0.7310.47
228_S254_V0.7300.47
56_K60_I0.7210.46
56_K83_Q0.7180.46
195_N243_S0.7160.46
152_L156_A0.7150.46
188_R222_V0.7140.46
148_K152_L0.7140.46
180_L213_S0.7130.45
80_T84_E0.7120.45
187_V258_L0.7120.45
181_I268_T0.7110.45
9_E12_S0.7100.45
196_T205_V0.7080.45
6_K66_D0.7070.45
221_M246_R0.7060.45
135_F152_L0.7050.45
180_L208_L0.7020.44
204_K268_T0.6980.44
16_E21_T0.6980.44
231_E255_Q0.6980.44
106_S165_S0.6980.44
207_Q276_D0.6970.44
180_L233_L0.6960.44
172_F208_L0.6950.44
29_T61_F0.6910.43
216_A260_F0.6880.43
31_P44_H0.6880.43
208_L221_M0.6850.43
94_I140_H0.6840.43
49_Q82_D0.6790.42
129_H132_I0.6730.42
84_E132_I0.6720.42
11_L72_L0.6690.41
171_L220_T0.6680.41
178_L184_I0.6680.41
135_F267_S0.6670.41
171_L258_L0.6670.41
221_M255_Q0.6650.41
14_H20_S0.6640.41
192_I239_S0.6600.41
23_Y28_E0.6600.41
75_W238_V0.6590.41
53_F56_K0.6570.40
223_A251_Q0.6550.40
211_D237_G0.6530.40
194_E216_A0.6510.40
80_T94_I0.6500.40
58_N61_F0.6490.40
44_H106_S0.6460.39
233_L276_D0.6450.39
172_F190_K0.6430.39
29_T206_T0.6420.39
75_W146_M0.6370.39
211_D244_G0.6360.38
205_V265_L0.6360.38
52_A56_K0.6350.38
188_R250_A0.6330.38
236_I242_L0.6300.38
80_T166_A0.6300.38
213_S273_I0.6280.38
62_I106_S0.6260.38
158_K187_V0.6250.38
19_S54_N0.6230.37
186_T216_A0.6230.37
123_E130_A0.6200.37
179_P237_G0.6170.37
107_Y148_K0.6150.37
58_N106_S0.6140.37
12_S62_I0.6140.37
176_G231_E0.6130.36
92_Y195_N0.6100.36
48_S144_E0.6050.36
103_L171_L0.6010.35
179_P244_G0.6010.35
109_K129_H0.6000.35
21_T24_E0.5990.35
89_P97_F0.5970.35
61_F68_Y0.5970.35
176_G236_I0.5930.35
12_S67_V0.5920.35
24_E55_Y0.5910.35
25_T103_L0.5900.35
55_Y112_V0.5880.34
153_Q161_I0.5880.34
43_I61_F0.5870.34
176_G207_Q0.5840.34
173_H206_T0.5830.34
157_Q276_D0.5820.34
189_A225_Q0.5800.34
222_V252_T0.5780.34
21_T70_P0.5760.33
7_L156_A0.5760.33
22_W250_A0.5750.33
166_A243_S0.5740.33
108_V124_A0.5740.33
13_Q67_V0.5730.33
184_I251_Q0.5720.33
190_K236_I0.5670.33
243_S253_A0.5670.33
15_A58_N0.5670.33
12_S17_T0.5660.33
88_T94_I0.5650.32
24_E110_E0.5650.32
206_T242_L0.5640.32
157_Q166_A0.5640.32
167_P211_D0.5630.32
21_T110_E0.5630.32
186_T236_I0.5600.32
134_A168_V0.5560.32
109_K125_E0.5550.32
188_R211_D0.5530.31
97_F138_V0.5520.31
12_S59_R0.5520.31
208_L213_S0.5510.31
13_Q110_E0.5470.31
142_F200_C0.5450.31
87_K254_V0.5440.31
60_I64_D0.5440.31
61_F125_E0.5430.31
60_I104_Y0.5430.31
80_T93_I0.5410.31
231_E273_I0.5340.30
191_L242_L0.5310.30
200_C209_Y0.5290.30
205_V276_D0.5280.30
185_D188_R0.5280.30
181_I249_I0.5270.29
232_A238_V0.5260.29
16_E59_R0.5250.29
7_L52_A0.5240.29
176_G271_S0.5240.29
10_Y107_Y0.5230.29
147_Y204_K0.5220.29
100_V205_V0.5220.29
17_T27_E0.5220.29
209_Y229_L0.5220.29
196_T272_A0.5200.29
249_I272_A0.5170.29
96_E99_R0.5160.29
44_H236_I0.5140.28
205_V263_I0.5140.28
49_Q61_F0.5120.28
22_W80_T0.5110.28
30_D44_H0.5110.28
59_R63_D0.5100.28
53_F178_L0.5100.28
158_K221_M0.5090.28
160_M186_T0.5090.28
230_I272_A0.5070.28
220_T258_L0.5060.28
182_G237_G0.5050.28
122_E126_D0.5050.28
55_Y125_E0.5020.28
74_E112_V0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.4184 99.6 0.772 Contact Map
3ny7A 1 0.4113 99.2 0.823 Contact Map
4dgfA 1 0.4326 99.2 0.826 Contact Map
1h4xA 1 0.3936 99 0.836 Contact Map
1th8B 1 0.4043 99 0.836 Contact Map
4dghA 4 0.4433 99 0.836 Contact Map
2ka5A 1 0.4433 99 0.837 Contact Map
2klnA 1 0.4255 99 0.838 Contact Map
3t6oA 5 0.3936 99 0.839 Contact Map
3lloA 1 0.4539 99 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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