RSBRC - BACSU - GREMLIN Contacts

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RSBRC - RsbT co-antagonist protein RsbRC

UniProt:	O31856	Sequences: MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIHNLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRDLYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDMITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVIDTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASDLKLKKV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (260)
Sequences:	835 (662)
Seq/√Len:	41.0

BACSU - RSBRC RSBRD RSBRB RSBRA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_R	136_D	6.054	1.00
14_H	17_T	5.243	1.00
220_T	252_T	4.001	1.00
9_E	13_Q	3.847	1.00
243_S	272_A	3.437	1.00
212_L	218_I	3.420	1.00
186_T	221_M	3.081	1.00
186_T	217_V	2.883	1.00
197_L	232_A	2.873	1.00
215_V	249_I	2.618	1.00
98_V	139_I	2.536	1.00
198_H	202_K	2.453	1.00
106_S	129_H	2.372	1.00
20_S	24_E	2.367	1.00
199_Q	202_K	2.322	1.00
161_I	169_I	2.318	1.00
21_T	106_S	2.255	1.00
184_I	189_A	2.212	1.00
220_T	256_L	2.092	0.99
252_T	256_L	2.035	0.99
105_V	128_Y	2.018	0.99
218_I	249_I	2.014	0.99
206_T	210_I	2.005	0.99
207_Q	241_T	1.955	0.99
222_V	250_A	1.931	0.99
176_G	205_V	1.910	0.99
108_V	173_H	1.903	0.99
218_I	257_G	1.755	0.98
176_G	200_C	1.753	0.98
264_S	267_S	1.749	0.98
170_V	177_L	1.742	0.97
186_T	190_K	1.741	0.97
184_I	192_I	1.733	0.97
120_K	123_E	1.687	0.97
213_S	233_L	1.670	0.97
223_A	252_T	1.669	0.97
205_V	213_S	1.629	0.96
14_H	107_Y	1.613	0.96
186_T	215_V	1.604	0.96
221_M	252_T	1.602	0.96
253_A	260_F	1.572	0.95
23_Y	50_N	1.555	0.95
43_I	47_K	1.555	0.95
213_S	276_D	1.525	0.94
234_R	239_S	1.524	0.94
26_I	50_N	1.522	0.94
11_L	18_I	1.518	0.94
220_T	223_A	1.504	0.94
220_T	247_P	1.481	0.94
23_Y	26_I	1.451	0.93
232_A	268_T	1.450	0.93
243_S	270_A	1.426	0.92
157_Q	169_I	1.416	0.92
193_M	232_A	1.414	0.92
76_A	138_V	1.395	0.91
213_S	277_L	1.392	0.91
102_D	133_K	1.381	0.91
7_L	15_A	1.379	0.91
230_I	242_L	1.379	0.91
135_F	139_I	1.373	0.91
196_T	208_L	1.367	0.90
146_M	149_N	1.358	0.90
163_E	220_T	1.357	0.90
93_I	142_F	1.357	0.90
173_H	270_A	1.351	0.90
241_T	275_S	1.349	0.90
215_V	222_V	1.347	0.90
10_Y	111_F	1.309	0.88
109_K	126_D	1.301	0.88
90_I	146_M	1.300	0.88
253_A	258_L	1.298	0.88
177_L	229_L	1.298	0.88
171_L	265_L	1.295	0.88
215_V	256_L	1.293	0.88
219_D	252_T	1.283	0.87
217_V	220_T	1.279	0.87
166_A	192_I	1.271	0.87
175_V	276_D	1.268	0.87
208_L	238_V	1.257	0.86
228_S	233_L	1.256	0.86
173_H	204_K	1.239	0.85
98_V	140_H	1.233	0.85
51_L	55_Y	1.231	0.85
224_H	228_S	1.231	0.85
164_L	185_D	1.229	0.85
52_A	78_E	1.219	0.85
164_L	246_R	1.193	0.83
22_W	157_Q	1.189	0.83
163_E	186_T	1.185	0.83
15_A	19_S	1.180	0.83
245_I	250_A	1.172	0.82
174_S	206_T	1.172	0.82
91_H	147_Y	1.167	0.82
11_L	105_V	1.164	0.82
266_R	275_S	1.161	0.81
21_T	107_Y	1.160	0.81
158_K	231_E	1.151	0.81
200_C	205_V	1.150	0.81
53_F	273_I	1.128	0.80
241_T	255_Q	1.127	0.79
233_L	238_V	1.122	0.79
186_T	220_T	1.121	0.79
172_F	243_S	1.120	0.79
46_L	49_Q	1.096	0.78
17_T	20_S	1.094	0.77
220_T	257_G	1.084	0.77
186_T	225_Q	1.079	0.76
182_G	211_D	1.078	0.76
170_V	271_S	1.075	0.76
210_I	233_L	1.072	0.76
55_Y	268_T	1.070	0.76
110_E	126_D	1.068	0.76
189_A	217_V	1.056	0.75
168_V	178_L	1.055	0.75
89_P	146_M	1.054	0.75
75_W	233_L	1.053	0.75
197_L	256_L	1.049	0.74
213_S	229_L	1.046	0.74
249_I	252_T	1.043	0.74
194_E	219_D	1.038	0.74
196_T	229_L	1.037	0.73
194_E	269_L	1.027	0.73
70_P	81_Q	1.025	0.73
43_I	146_M	1.025	0.73
208_L	229_L	1.024	0.73
213_S	238_V	1.019	0.72
49_Q	83_Q	1.009	0.71
141_I	145_E	1.008	0.71
159_D	187_V	1.003	0.71
213_S	272_A	1.002	0.71
189_A	221_M	1.002	0.71
252_T	257_G	1.000	0.71
186_T	222_V	0.995	0.70
142_F	160_M	0.995	0.70
200_C	233_L	0.993	0.70
189_A	192_I	0.989	0.70
160_M	178_L	0.984	0.69
206_T	248_E	0.970	0.68
189_A	220_T	0.966	0.68
172_F	177_L	0.964	0.68
78_E	126_D	0.958	0.67
219_D	249_I	0.953	0.67
218_I	222_V	0.950	0.67
143_I	147_Y	0.949	0.67
21_T	25_T	0.948	0.67
168_V	257_G	0.938	0.66
14_H	110_E	0.931	0.65
11_L	275_S	0.928	0.65
110_E	173_H	0.916	0.64
197_L	254_V	0.915	0.64
186_T	227_F	0.915	0.64
48_S	273_I	0.913	0.64
215_V	252_T	0.911	0.63
154_L	196_T	0.907	0.63
9_E	65_E	0.906	0.63
272_A	276_D	0.905	0.63
86_L	206_T	0.905	0.63
189_A	226_L	0.903	0.63
219_D	250_A	0.900	0.63
25_T	102_D	0.896	0.62
24_E	65_E	0.896	0.62
94_I	139_I	0.896	0.62
50_N	60_I	0.893	0.62
49_Q	161_I	0.891	0.62
57_I	92_Y	0.890	0.62
72_L	143_I	0.889	0.62
113_H	122_E	0.886	0.61
223_A	229_L	0.884	0.61
259_S	262_G	0.882	0.61
7_L	102_D	0.878	0.61
212_L	253_A	0.871	0.60
185_D	266_R	0.868	0.60
181_I	255_Q	0.866	0.60
61_F	131_L	0.864	0.59
225_Q	265_L	0.863	0.59
178_L	213_S	0.860	0.59
102_D	129_H	0.860	0.59
189_A	219_D	0.860	0.59
163_E	227_F	0.857	0.59
17_T	21_T	0.855	0.59
220_T	224_H	0.855	0.59
97_F	139_I	0.855	0.59
43_I	53_F	0.851	0.58
209_Y	243_S	0.849	0.58
53_F	145_E	0.847	0.58
212_L	249_I	0.844	0.58
13_Q	24_E	0.842	0.57
190_K	222_V	0.841	0.57
11_L	48_S	0.841	0.57
174_S	205_V	0.835	0.57
224_H	257_G	0.829	0.56
199_Q	203_K	0.829	0.56
212_L	243_S	0.829	0.56
155_Q	159_D	0.823	0.56
160_M	192_I	0.823	0.56
209_Y	269_L	0.822	0.56
44_H	48_S	0.822	0.56
21_T	274_A	0.822	0.56
46_L	61_F	0.819	0.55
240_S	254_V	0.817	0.55
249_I	256_L	0.803	0.54
90_I	139_I	0.801	0.54
183_D	234_R	0.801	0.54
62_I	70_P	0.795	0.53
10_Y	28_E	0.794	0.53
15_A	55_Y	0.789	0.52
18_I	42_V	0.788	0.52
160_M	181_I	0.787	0.52
196_T	200_C	0.784	0.52
252_T	277_L	0.778	0.51
191_L	240_S	0.776	0.51
186_T	252_T	0.776	0.51
199_Q	213_S	0.775	0.51
109_K	122_E	0.774	0.51
239_S	264_S	0.773	0.51
219_D	222_V	0.771	0.51
143_I	268_T	0.768	0.51
14_H	44_H	0.767	0.50
132_I	136_D	0.765	0.50
91_H	143_I	0.762	0.50
220_T	227_F	0.761	0.50
48_S	52_A	0.759	0.50
237_G	244_G	0.754	0.49
77_F	268_T	0.752	0.49
90_I	144_E	0.748	0.49
112_V	121_S	0.747	0.49
159_D	206_T	0.746	0.48
180_L	277_L	0.742	0.48
79_V	161_I	0.742	0.48
166_A	196_T	0.741	0.48
217_V	252_T	0.740	0.48
196_T	238_V	0.740	0.48
110_E	131_L	0.738	0.48
26_I	96_E	0.737	0.48
20_S	125_E	0.731	0.47
165_S	220_T	0.731	0.47
228_S	254_V	0.730	0.47
56_K	60_I	0.721	0.46
56_K	83_Q	0.718	0.46
195_N	243_S	0.716	0.46
152_L	156_A	0.715	0.46
188_R	222_V	0.714	0.46
148_K	152_L	0.714	0.46
180_L	213_S	0.713	0.45
80_T	84_E	0.712	0.45
187_V	258_L	0.712	0.45
181_I	268_T	0.711	0.45
9_E	12_S	0.710	0.45
196_T	205_V	0.708	0.45
6_K	66_D	0.707	0.45
221_M	246_R	0.706	0.45
135_F	152_L	0.705	0.45
180_L	208_L	0.702	0.44
204_K	268_T	0.698	0.44
16_E	21_T	0.698	0.44
231_E	255_Q	0.698	0.44
106_S	165_S	0.698	0.44
207_Q	276_D	0.697	0.44
180_L	233_L	0.696	0.44
172_F	208_L	0.695	0.44
29_T	61_F	0.691	0.43
216_A	260_F	0.688	0.43
31_P	44_H	0.688	0.43
208_L	221_M	0.685	0.43
94_I	140_H	0.684	0.43
49_Q	82_D	0.679	0.42
129_H	132_I	0.673	0.42
84_E	132_I	0.672	0.42
11_L	72_L	0.669	0.41
171_L	220_T	0.668	0.41
178_L	184_I	0.668	0.41
135_F	267_S	0.667	0.41
171_L	258_L	0.667	0.41
221_M	255_Q	0.665	0.41
14_H	20_S	0.664	0.41
192_I	239_S	0.660	0.41
23_Y	28_E	0.660	0.41
75_W	238_V	0.659	0.41
53_F	56_K	0.657	0.40
223_A	251_Q	0.655	0.40
211_D	237_G	0.653	0.40
194_E	216_A	0.651	0.40
80_T	94_I	0.650	0.40
58_N	61_F	0.649	0.40
44_H	106_S	0.646	0.39
233_L	276_D	0.645	0.39
172_F	190_K	0.643	0.39
29_T	206_T	0.642	0.39
75_W	146_M	0.637	0.39
211_D	244_G	0.636	0.38
205_V	265_L	0.636	0.38
52_A	56_K	0.635	0.38
188_R	250_A	0.633	0.38
236_I	242_L	0.630	0.38
80_T	166_A	0.630	0.38
213_S	273_I	0.628	0.38
62_I	106_S	0.626	0.38
158_K	187_V	0.625	0.38
19_S	54_N	0.623	0.37
186_T	216_A	0.623	0.37
123_E	130_A	0.620	0.37
179_P	237_G	0.617	0.37
107_Y	148_K	0.615	0.37
58_N	106_S	0.614	0.37
12_S	62_I	0.614	0.37
176_G	231_E	0.613	0.36
92_Y	195_N	0.610	0.36
48_S	144_E	0.605	0.36
103_L	171_L	0.601	0.35
179_P	244_G	0.601	0.35
109_K	129_H	0.600	0.35
21_T	24_E	0.599	0.35
89_P	97_F	0.597	0.35
61_F	68_Y	0.597	0.35
176_G	236_I	0.593	0.35
12_S	67_V	0.592	0.35
24_E	55_Y	0.591	0.35
25_T	103_L	0.590	0.35
55_Y	112_V	0.588	0.34
153_Q	161_I	0.588	0.34
43_I	61_F	0.587	0.34
176_G	207_Q	0.584	0.34
173_H	206_T	0.583	0.34
157_Q	276_D	0.582	0.34
189_A	225_Q	0.580	0.34
222_V	252_T	0.578	0.34
21_T	70_P	0.576	0.33
7_L	156_A	0.576	0.33
22_W	250_A	0.575	0.33
166_A	243_S	0.574	0.33
108_V	124_A	0.574	0.33
13_Q	67_V	0.573	0.33
184_I	251_Q	0.572	0.33
190_K	236_I	0.567	0.33
243_S	253_A	0.567	0.33
15_A	58_N	0.567	0.33
12_S	17_T	0.566	0.33
88_T	94_I	0.565	0.32
24_E	110_E	0.565	0.32
206_T	242_L	0.564	0.32
157_Q	166_A	0.564	0.32
167_P	211_D	0.563	0.32
21_T	110_E	0.563	0.32
186_T	236_I	0.560	0.32
134_A	168_V	0.556	0.32
109_K	125_E	0.555	0.32
188_R	211_D	0.553	0.31
97_F	138_V	0.552	0.31
12_S	59_R	0.552	0.31
208_L	213_S	0.551	0.31
13_Q	110_E	0.547	0.31
142_F	200_C	0.545	0.31
87_K	254_V	0.544	0.31
60_I	64_D	0.544	0.31
61_F	125_E	0.543	0.31
60_I	104_Y	0.543	0.31
80_T	93_I	0.541	0.31
231_E	273_I	0.534	0.30
191_L	242_L	0.531	0.30
200_C	209_Y	0.529	0.30
205_V	276_D	0.528	0.30
185_D	188_R	0.528	0.30
181_I	249_I	0.527	0.29
232_A	238_V	0.526	0.29
16_E	59_R	0.525	0.29
7_L	52_A	0.524	0.29
176_G	271_S	0.524	0.29
10_Y	107_Y	0.523	0.29
147_Y	204_K	0.522	0.29
100_V	205_V	0.522	0.29
17_T	27_E	0.522	0.29
209_Y	229_L	0.522	0.29
196_T	272_A	0.520	0.29
249_I	272_A	0.517	0.29
96_E	99_R	0.516	0.29
44_H	236_I	0.514	0.28
205_V	263_I	0.514	0.28
49_Q	61_F	0.512	0.28
22_W	80_T	0.511	0.28
30_D	44_H	0.511	0.28
59_R	63_D	0.510	0.28
53_F	178_L	0.510	0.28
158_K	221_M	0.509	0.28
160_M	186_T	0.509	0.28
230_I	272_A	0.507	0.28
220_T	258_L	0.506	0.28
182_G	237_G	0.505	0.28
122_E	126_D	0.505	0.28
55_Y	125_E	0.502	0.28
74_E	112_V	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zxnA	1	0.4184	99.6	0.772	Contact Map
3ny7A	1	0.4113	99.2	0.823	Contact Map
4dgfA	1	0.4326	99.2	0.826	Contact Map
1h4xA	1	0.3936	99	0.836	Contact Map
1th8B	1	0.4043	99	0.836	Contact Map
4dghA	4	0.4433	99	0.836	Contact Map
2ka5A	1	0.4433	99	0.837	Contact Map
2klnA	1	0.4255	99	0.838	Contact Map
3t6oA	5	0.3936	99	0.839	Contact Map
3lloA	1	0.4539	99	0.84	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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