GREMLIN Database
NORM - Probable multidrug resistance protein NorM
UniProt: O31855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (422)
Sequences: 18149 (13550)
Seq/√Len: 659.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_K86_K4.6561.00
143_P205_W3.9481.00
132_H194_V3.4211.00
51_A278_Q3.1911.00
344_A357_T3.1181.00
114_D131_K3.0751.00
339_F342_Q3.0541.00
76_A303_G3.0541.00
239_K243_K2.9151.00
159_K162_V2.7911.00
114_D118_G2.7841.00
112_A115_L2.7701.00
310_R313_D2.7481.00
136_F194_V2.5591.00
180_V189_P2.5181.00
71_V94_A2.4971.00
184_G189_P2.4651.00
173_I206_C2.4631.00
235_W239_K2.4341.00
131_K135_G2.4301.00
78_L86_K2.3791.00
38_M182_I2.3521.00
38_M179_Y2.3211.00
49_G129_I2.2771.00
386_D438_R2.2221.00
170_S207_I2.2011.00
129_I132_H2.1921.00
45_A125_H2.1771.00
166_I210_I2.1111.00
359_H418_F2.0851.00
146_V208_C2.0841.00
123_D271_T2.0721.00
298_L321_G2.0651.00
319_L323_M2.0641.00
351_P355_R2.0571.00
89_F234_S2.0341.00
12_K16_H2.0031.00
194_V198_L2.0011.00
128_Q132_H1.9741.00
276_S356_L1.9511.00
136_F197_G1.9391.00
352_D355_R1.9361.00
340_R362_I1.9191.00
191_L198_L1.9131.00
341_E358_Q1.9101.00
416_G419_G1.9041.00
305_E313_D1.8971.00
140_G201_A1.8931.00
39_S196_A1.8921.00
182_I196_A1.8831.00
35_D200_S1.8831.00
98_A149_V1.8721.00
22_F293_S1.8671.00
272_V352_D1.8441.00
78_L83_K1.8331.00
38_M178_N1.8091.00
118_G127_H1.7991.00
19_I23_I1.7661.00
43_S46_D1.7541.00
78_L81_A1.7491.00
161_R165_M1.7431.00
44_P350_D1.7181.00
136_F198_L1.7141.00
113_V131_K1.7031.00
209_I213_F1.6981.00
139_L142_F1.6951.00
340_R358_Q1.6901.00
166_I211_S1.6771.00
301_V317_Y1.6731.00
181_F189_P1.6611.00
115_L118_G1.6591.00
316_S319_L1.6581.00
370_S429_A1.6531.00
234_S237_A1.6461.00
110_Y135_G1.6441.00
306_A384_Y1.6341.00
18_L297_A1.6311.00
337_L362_I1.6251.00
316_S320_I1.6101.00
318_S377_I1.6081.00
172_P176_V1.5991.00
325_A372_A1.5831.00
74_I90_T1.5771.00
179_Y183_F1.5641.00
315_R319_L1.5601.00
143_P208_C1.5501.00
127_H131_K1.5371.00
34_L175_F1.5361.00
341_E345_G1.5351.00
178_N196_A1.5161.00
125_H271_T1.5161.00
306_A314_A1.5101.00
333_A337_L1.5071.00
408_M413_T1.4991.00
136_F201_A1.4901.00
113_V135_G1.4901.00
177_L199_A1.4891.00
342_Q345_G1.4831.00
305_E310_R1.4831.00
386_D389_Y1.4711.00
150_L211_S1.4591.00
114_D128_Q1.4471.00
345_G354_L1.4431.00
106_L142_F1.4341.00
318_S380_A1.4311.00
117_L127_H1.4291.00
312_K316_S1.4271.00
173_I177_L1.4241.00
176_V180_V1.4211.00
39_S50_V1.4211.00
53_G134_L1.4171.00
125_H128_Q1.3981.00
433_V437_F1.3981.00
109_G138_S1.3951.00
118_G124_I1.3921.00
124_I128_Q1.3901.00
78_L90_T1.3891.00
213_F217_K1.3791.00
437_F440_A1.3771.00
176_V179_Y1.3701.00
363_Y422_I1.3691.00
415_L419_G1.3681.00
84_K88_P1.3581.00
358_Q362_I1.3551.00
86_K89_F1.3541.00
85_Q89_F1.3531.00
436_F440_A1.3521.00
342_Q346_M1.3511.00
115_L119_R1.3341.00
194_V197_G1.3301.00
35_D174_N1.3301.00
355_R359_H1.3301.00
48_A275_A1.3281.00
106_L110_Y1.3251.00
337_L365_L1.3221.00
323_M327_G1.3171.00
165_M169_S1.3161.00
46_D129_I1.3091.00
23_I164_M1.3081.00
77_Q81_A1.3011.00
77_Q303_G1.2951.00
79_L304_F1.2951.00
181_F191_L1.2891.00
114_D127_H1.2871.00
27_G168_L1.2831.00
325_A376_P1.2811.00
311_F315_R1.2621.00
166_I214_I1.2551.00
177_L202_L1.2481.00
283_F343_I1.2451.00
86_K237_A1.2371.00
389_Y438_R1.2371.00
344_A354_L1.2371.00
11_I324_M1.2341.00
388_N392_A1.2241.00
79_L87_I1.2171.00
11_I320_I1.2171.00
334_A338_L1.2101.00
80_G307_G1.2071.00
437_F441_K1.2061.00
44_P272_V1.2001.00
36_T282_N1.1991.00
396_V400_V1.1951.00
415_L422_I1.1881.00
174_N200_S1.1851.00
169_S210_I1.1711.00
41_K349_S1.1601.00
181_F202_L1.1581.00
401_I430_A1.1581.00
77_Q385_K1.1581.00
356_L359_H1.1541.00
178_N199_A1.1511.00
45_A271_T1.1491.00
236_K239_K1.1471.00
93_Q233_F1.1401.00
49_G126_V1.1391.00
45_A129_I1.1381.00
179_Y182_I1.1371.00
91_V153_F1.1321.00
180_V184_G1.1321.00
233_F238_C1.1241.00
93_Q238_C1.1231.00
50_V193_G1.1201.00
117_L130_A1.1201.00
246_L250_F1.1051.00
404_P408_M1.1041.00
42_V46_D1.1041.00
438_R441_K1.1001.00
36_T47_L1.0951.00
75_V156_S1.0921.00
302_V314_A1.0871.00
419_G423_G1.0861.00
41_K183_F1.0841.00
295_S379_G1.0821.00
159_K163_T1.0781.00
173_I203_T1.0761.00
98_A145_F1.0711.00
273_T417_A1.0701.00
264_L268_H1.0701.00
354_L357_T1.0691.00
392_A396_V1.0641.00
393_A435_L1.0611.00
14_L321_G1.0591.00
265_L269_F1.0581.00
97_V238_C1.0561.00
35_D178_N1.0471.00
280_A360_F1.0411.00
162_V214_I1.0401.00
374_A428_L1.0321.00
318_S439_L1.0241.00
158_G304_F1.0131.00
377_I439_L1.0121.00
320_I324_M1.0081.00
272_V356_L1.0071.00
135_G139_L1.0071.00
400_V404_P1.0031.00
240_N243_K0.9941.00
89_F237_A0.9891.00
79_L157_L0.9881.00
90_T237_A0.9801.00
305_E317_Y0.9771.00
348_T353_V0.9761.00
327_G331_F0.9761.00
94_A241_L0.9751.00
15_L19_I0.9721.00
99_A146_V0.9701.00
381_L438_R0.9671.00
96_Y233_F0.9651.00
198_L201_A0.9631.00
406_G410_G0.9611.00
341_E355_R0.9601.00
80_G308_A0.9591.00
106_L139_L0.9591.00
52_I122_L0.9521.00
427_G431_G0.9521.00
184_G190_A0.9471.00
168_L172_P0.9471.00
179_Y184_G0.9391.00
178_N200_S0.9391.00
363_Y418_F0.9371.00
79_L84_K0.9361.00
283_F336_I0.9361.00
227_F230_M0.9361.00
331_F335_C0.9301.00
32_T54_S0.9271.00
409_V415_L0.9261.00
132_H135_G0.9261.00
355_R358_Q0.9231.00
201_A205_W0.9231.00
77_Q306_A0.9201.00
293_S297_A0.9201.00
107_V111_A0.9151.00
279_A347_Y0.9151.00
405_V426_A0.9141.00
150_L208_C0.9131.00
21_I296_M0.9121.00
37_V40_G0.9091.00
265_L268_H0.9091.00
370_S432_A0.9071.00
113_V134_L0.9071.00
360_F417_A0.9061.00
276_S353_V0.9051.00
314_A318_S0.9041.00
352_D356_L0.8991.00
64_L145_F0.8981.00
34_L174_N0.8961.00
13_Q16_H0.8951.00
337_L341_E0.8911.00
302_V380_A0.8911.00
322_I373_V0.8901.00
331_F334_A0.8901.00
330_L334_A0.8861.00
177_L181_F0.8851.00
206_C210_I0.8721.00
77_Q240_N0.8711.00
338_L342_Q0.8711.00
423_G427_G0.8691.00
154_I215_I0.8681.00
92_L230_M0.8661.00
205_W209_I0.8641.00
254_F395_F0.8621.00
344_A358_Q0.8551.00
129_I193_G0.8551.00
100_L104_A0.8541.00
159_K214_I0.8511.00
276_S357_T0.8501.00
418_F422_I0.8441.00
401_I404_P0.8411.00
314_A384_Y0.8391.00
265_L407_Y0.8381.00
210_I213_F0.8371.00
302_V383_G0.8351.00
354_L358_Q0.8341.00
291_P329_S0.8321.00
96_Y231_Y0.8321.00
92_L231_Y0.8321.00
111_A115_L0.8311.00
48_A126_V0.8301.00
17_I160_T0.8301.00
38_M183_F0.8291.00
305_E308_A0.8291.00
217_K220_P0.8281.00
169_S173_I0.8271.00
108_I112_A0.8251.00
243_K388_N0.8251.00
34_L171_L0.8221.00
45_A126_V0.8221.00
147_Y207_I0.8211.00
27_G171_L0.8211.00
124_I127_H0.8201.00
405_V409_V0.8201.00
397_S431_G0.8191.00
294_V321_G0.8181.00
174_N178_N0.8171.00
57_W137_L0.8151.00
273_T356_L0.8111.00
250_F391_L0.8111.00
164_M168_L0.8071.00
150_L215_I0.8031.00
373_V432_A0.8021.00
71_V75_V0.8021.00
320_I323_M0.8011.00
165_M168_L0.7981.00
316_S323_M0.7971.00
13_Q301_V0.7971.00
104_A108_I0.7961.00
94_A149_V0.7961.00
282_N347_Y0.7921.00
159_K218_N0.7921.00
128_Q131_K0.7911.00
139_L201_A0.7901.00
277_H421_W0.7881.00
42_V190_A0.7871.00
351_P354_L0.7871.00
312_K319_L0.7871.00
313_D316_S0.7861.00
113_V138_S0.7861.00
178_N182_I0.7811.00
327_G330_L0.7771.00
39_S182_I0.7771.00
107_V110_Y0.7741.00
75_V153_F0.7631.00
269_F410_G0.7631.00
74_I244_I0.7621.00
136_F139_L0.7621.00
266_M417_A0.7611.00
73_P77_Q0.7601.00
154_I211_S0.7581.00
340_R361_L0.7571.00
267_S274_I0.7561.00
126_V274_I0.7551.00
174_N203_T0.7551.00
63_G249_G0.7551.00
429_A433_V0.7551.00
96_Y100_L0.7551.00
198_L202_L0.7541.00
305_E314_A0.7531.00
279_A357_T0.7521.00
13_Q304_F0.7521.00
155_D163_T0.7521.00
181_F184_G0.7501.00
132_H193_G0.7491.00
31_I200_S0.7461.00
88_P230_M0.7461.00
276_S360_F0.7451.00
76_A156_S0.7421.00
49_G193_G0.7421.00
74_I78_L0.7411.00
269_F273_T0.7401.00
409_V419_G0.7391.00
326_I330_L0.7381.00
213_F216_H0.7371.00
110_Y114_D0.7361.00
110_Y138_S0.7341.00
14_L320_I0.7341.00
190_A194_V0.7341.00
266_M420_Y0.7331.00
422_I425_I0.7311.00
240_N385_K0.7311.00
81_A307_G0.7301.00
44_P353_V0.7261.00
419_G422_I0.7251.00
330_L369_L0.7241.00
212_F216_H0.7231.00
321_G376_P0.7231.00
18_L293_S0.7231.00
33_F286_L0.7221.00
265_L406_G0.7211.00
30_L34_L0.7171.00
37_V346_M0.7161.00
366_F369_L0.7161.00
323_M326_I0.7151.00
363_Y425_I0.7151.00
253_F257_S0.7141.00
237_A240_N0.7131.00
24_T167_T0.7121.00
245_G249_G0.7121.00
154_I162_V0.7121.00
312_K315_R0.7081.00
27_G30_L0.7071.00
326_I372_A0.7071.00
350_D354_L0.7031.00
117_L134_L0.7021.00
294_V325_A0.7011.00
40_G47_L0.6991.00
379_G383_G0.6981.00
302_V318_S0.6971.00
169_S206_C0.6911.00
389_Y393_A0.6861.00
140_G143_P0.6841.00
272_V275_A0.6841.00
102_S142_F0.6841.00
134_L138_S0.6831.00
49_G130_A0.6821.00
294_V328_F0.6811.00
191_L194_V0.6811.00
339_F343_I0.6801.00
138_S141_I0.6781.00
139_L143_P0.6761.00
110_Y139_L0.6731.00
133_F178_N0.6721.00
242_L246_L0.6711.00
377_I435_L0.6711.00
401_I405_V0.6711.00
39_S193_G0.6701.00
86_K90_T0.6701.00
162_V210_I0.6701.00
337_L340_R0.6691.00
37_V41_K0.6691.00
244_I387_V0.6671.00
329_S372_A0.6661.00
434_G437_F0.6661.00
14_L297_A0.6631.00
75_V87_I0.6631.00
104_A107_V0.6621.00
11_I15_L0.6621.00
11_I323_M0.6611.00
362_I366_F0.6611.00
138_S142_F0.6601.00
181_F196_A0.6591.00
266_M277_H0.6581.00
203_T206_C0.6561.00
341_E354_L0.6541.00
328_F332_T0.6501.00
340_R344_A0.6481.00
197_G201_A0.6471.00
108_I111_A0.6461.00
311_F314_A0.6461.00
140_G204_Y0.6451.00
417_A421_W0.6441.00
168_L171_L0.6411.00
135_G194_V0.6401.00
202_L205_W0.6391.00
284_A368_Q0.6381.00
112_A116_I0.6381.00
34_L38_M0.6341.00
380_A384_Y0.6341.00
403_L407_Y0.6331.00
287_L332_T0.6331.00
228_L231_Y0.6321.00
127_H130_A0.6311.00
26_A30_L0.6311.00
247_P391_L0.6301.00
85_Q230_M0.6301.00
39_S42_V0.6291.00
125_H129_I0.6281.00
306_A311_F0.6281.00
150_L212_F0.6271.00
298_L302_V0.6271.00
114_D135_G0.6231.00
335_C339_F0.6231.00
81_A309_A0.6191.00
89_F92_L0.6181.00
99_A103_I0.6181.00
126_V129_I0.6161.00
73_P244_I0.6161.00
31_I170_S0.6141.00
173_I176_V0.6141.00
348_T351_P0.6131.00
262_V420_Y0.6121.00
88_P227_F0.6111.00
66_G249_G0.6091.00
246_L249_G0.6081.00
103_I107_V0.6081.00
381_L386_D0.6071.00
353_V357_T0.6051.00
89_F93_Q0.6041.00
48_A51_A0.6041.00
85_Q88_P0.6041.00
173_I202_L0.6031.00
338_L341_E0.6031.00
210_I214_I0.6021.00
290_L328_F0.6001.00
377_I436_F0.5991.00
147_Y208_C0.5971.00
31_I204_Y0.5961.00
47_L279_A0.5941.00
83_K89_F0.5931.00
288_Y371_D0.5931.00
47_L348_T0.5921.00
299_T382_R0.5901.00
218_N222_S0.5891.00
404_P407_Y0.5881.00
219_A222_S0.5881.00
75_V90_T0.5861.00
326_I373_V0.5861.00
214_I218_N0.5851.00
273_T276_S0.5831.00
326_I369_L0.5831.00
409_V413_T0.5821.00
402_G427_G0.5821.00
174_N199_A0.5821.00
276_S421_W0.5811.00
304_F308_A0.5811.00
324_M327_G0.5791.00
122_L267_S0.5791.00
72_T152_S0.5771.00
30_L171_L0.5751.00
405_V408_M0.5751.00
102_S106_L0.5751.00
45_A48_A0.5751.00
132_H136_F0.5741.00
270_H273_T0.5741.00
181_F198_L0.5731.00
263_T267_S0.5731.00
133_F196_A0.5721.00
117_L122_L0.5681.00
73_P303_G0.5681.00
151_R155_D0.5681.00
102_S138_S0.5671.00
373_V436_F0.5671.00
422_I426_A0.5641.00
67_I249_G0.5641.00
183_F191_L0.5631.00
13_Q313_D0.5611.00
410_G413_T0.5611.00
117_L131_K0.5601.00
228_L232_K0.5581.00
169_S172_P0.5571.00
82_E308_A0.5571.00
236_K240_N0.5561.00
42_V193_G0.5551.00
93_Q237_A0.5551.00
147_Y151_R0.5541.00
92_L96_Y0.5541.00
110_Y113_V0.5531.00
322_I326_I0.5531.00
284_A364_A0.5531.00
103_I106_L0.5521.00
54_S58_T0.5501.00
216_H219_A0.5481.00
99_A102_S0.5471.00
21_I293_S0.5471.00
67_I101_L0.5461.00
69_M296_M0.5451.00
272_V353_V0.5431.00
52_I130_A0.5421.00
393_A434_G0.5411.00
365_L369_L0.5411.00
280_A361_L0.5401.00
87_I91_V0.5401.00
191_L195_G0.5401.00
106_L138_S0.5401.00
291_P372_A0.5401.00
377_I432_A0.5401.00
39_S46_D0.5401.00
121_N124_I0.5381.00
199_A203_T0.5371.00
175_F179_Y0.5361.00
407_Y410_G0.5351.00
208_C212_F0.5351.00
184_G191_L0.5351.00
402_G423_G0.5341.00
359_H362_I0.5341.00
269_F416_G0.5331.00
195_G199_A0.5331.00
285_S288_Y0.5331.00
261_A403_L0.5300.99
142_F205_W0.5300.99
126_V130_A0.5290.99
155_D160_T0.5290.99
265_L410_G0.5290.99
348_T354_L0.5280.99
60_V109_G0.5280.99
259_F263_T0.5270.99
258_I398_Y0.5270.99
271_T275_A0.5260.99
319_L439_L0.5260.99
238_C242_L0.5260.99
166_I207_I0.5250.99
34_L37_V0.5250.99
394_A397_S0.5240.99
152_S155_D0.5240.99
42_V182_I0.5240.99
143_P201_A0.5230.99
322_I377_I0.5220.99
299_T379_G0.5210.99
279_A353_V0.5210.99
32_T137_L0.5210.99
254_F391_L0.5210.99
350_D353_V0.5190.99
397_S434_G0.5180.99
15_L324_M0.5180.99
70_A245_G0.5170.99
402_G406_G0.5160.99
345_G349_S0.5160.99
46_D49_G0.5160.99
262_V406_G0.5150.99
333_A369_L0.5150.99
46_D192_G0.5130.99
60_V141_I0.5130.99
162_V218_N0.5120.99
318_S322_I0.5100.99
192_G195_G0.5100.99
103_I142_F0.5090.99
216_H220_P0.5080.99
374_A431_G0.5080.99
387_V391_L0.5070.99
430_A434_G0.5070.99
430_A433_V0.5060.99
416_G423_G0.5060.99
84_K223_E0.5060.99
116_I119_R0.5060.99
98_A102_S0.5050.99
319_L322_I0.5040.99
154_I157_L0.5040.99
433_V436_F0.5040.99
41_K348_T0.5040.99
410_G414_S0.5030.99
272_V350_D0.5020.99
38_M199_A0.5010.99
220_P223_E0.5000.99
252_V256_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9956 100 0.261 Contact Map
4humA 1 1 100 0.268 Contact Map
4lz6A 1 0.9757 100 0.296 Contact Map
3w4tA 1 0.9646 100 0.354 Contact Map
2cfqA 1 0.8805 71.4 0.944 Contact Map
4xnjA 1 0.8717 58.9 0.948 Contact Map
3wdoA 1 0.8562 58.3 0.949 Contact Map
4tphA 2 0.8363 54.5 0.95 Contact Map
1pw4A 1 0.896 45.2 0.952 Contact Map
4w6vA 1 0.8761 31.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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