GREMLIN Database
YOJK - Uncharacterized UDP-glucosyltransferase YojK
UniProt: O31853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (387)
Sequences: 12778 (10123)
Seq/√Len: 514.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_V362_V4.3661.00
371_K374_E4.3091.00
336_V342_G3.9001.00
305_G322_V3.7771.00
258_D356_K3.6751.00
322_V333_A3.3921.00
6_M22_M3.3411.00
254_E352_E3.1451.00
376_G380_K3.0481.00
361_E365_N2.9581.00
356_K360_Q2.9031.00
41_K45_T2.8991.00
303_T320_L2.7031.00
343_K361_E2.6051.00
369_A373_K2.5341.00
28_R393_L2.5121.00
195_G378_S2.3871.00
301_F309_S2.3721.00
360_Q364_N2.3171.00
24_E27_S2.3061.00
106_Y124_R2.2881.00
193_S379_L2.2251.00
251_Q352_E2.2201.00
224_P227_Q2.1561.00
313_G320_L2.1341.00
283_F286_R2.1301.00
321_V358_T2.1251.00
373_K376_G2.1201.00
310_T336_V2.0921.00
317_E372_A2.0901.00
337_E344_V2.0521.00
377_Q381_A2.0451.00
341_A375_I2.0191.00
296_K316_F1.9601.00
31_N50_E1.9231.00
158_S161_Q1.8771.00
258_D352_E1.8731.00
24_E28_R1.8681.00
223_F227_Q1.8681.00
224_P228_I1.8661.00
259_F360_Q1.8111.00
343_K362_V1.7881.00
256_C263_V1.7711.00
125_F187_L1.7511.00
370_E374_E1.7451.00
250_N254_E1.7451.00
300_L359_I1.7261.00
314_L341_A1.7231.00
117_A124_R1.7201.00
383_G386_K1.7121.00
236_I256_C1.7121.00
22_M49_I1.7041.00
157_E161_Q1.6981.00
286_R289_V1.6831.00
374_E378_S1.6751.00
85_C112_A1.6721.00
362_V368_Y1.6631.00
314_L372_A1.6511.00
264_V294_I1.6381.00
85_C88_I1.6331.00
340_G371_K1.6311.00
336_V341_A1.6301.00
334_D338_K1.6181.00
343_K358_T1.5921.00
301_F313_G1.5881.00
28_R389_A1.5831.00
192_T197_Q1.5831.00
275_E278_D1.5731.00
340_G367_S1.5591.00
235_F291_Q1.5461.00
85_C89_A1.5311.00
5_L35_Y1.5261.00
6_M105_I1.5211.00
255_V355_L1.5181.00
90_T94_E1.5161.00
343_K368_Y1.5081.00
118_N184_D1.4911.00
13_G17_P1.4881.00
335_Q338_K1.4841.00
234_L302_V1.4821.00
33_T52_R1.4711.00
365_N368_Y1.4651.00
4_V103_Y1.4591.00
30_E393_L1.4511.00
279_I285_V1.4471.00
361_E368_Y1.4291.00
82_L86_K1.4151.00
221_N227_Q1.4101.00
246_K250_N1.4081.00
91_H95_E1.4061.00
28_R390_D1.4051.00
228_I262_K1.4041.00
255_V356_K1.3991.00
377_Q380_K1.3981.00
161_Q167_N1.3851.00
257_K278_D1.3691.00
390_D394_E1.3691.00
91_H94_E1.3681.00
230_N298_A1.3661.00
208_V391_S1.3631.00
14_H107_D1.3601.00
106_Y113_G1.3591.00
357_E361_E1.3581.00
373_K377_Q1.3561.00
315_Y380_K1.3551.00
257_K282_N1.3441.00
370_E373_K1.3431.00
84_A87_D1.3381.00
93_Y119_M1.3301.00
79_C83_K1.3271.00
221_N224_P1.3261.00
351_S354_L1.3171.00
352_E356_K1.3071.00
83_K86_K1.3041.00
73_D76_E1.2991.00
225_F228_I1.2921.00
104_V122_L1.2911.00
322_V336_V1.2911.00
229_D262_K1.2881.00
279_I282_N1.2881.00
38_K53_E1.2851.00
231_E262_K1.2801.00
40_Y43_K1.2751.00
6_M18_S1.2741.00
26_K49_I1.2691.00
4_V30_E1.2661.00
163_A167_N1.2651.00
155_H159_Y1.2551.00
148_G151_E1.2531.00
346_K349_E1.2501.00
255_V352_E1.2451.00
279_I283_F1.2351.00
233_V300_L1.2301.00
320_L336_V1.2301.00
291_Q312_E1.2251.00
41_K51_F1.2251.00
155_H158_S1.2151.00
387_K391_S1.2031.00
254_E257_K1.2011.00
84_A88_I1.1951.00
261_G360_Q1.1901.00
251_Q254_E1.1901.00
156_Y160_Q1.1891.00
385_S389_A1.1771.00
155_H160_Q1.1681.00
329_Q332_V1.1671.00
104_V117_A1.1641.00
138_A141_M1.1631.00
345_I358_T1.1621.00
12_E16_N1.1601.00
83_K87_D1.1581.00
320_L342_G1.1521.00
317_E376_G1.1511.00
70_E73_D1.1511.00
282_N286_R1.1501.00
235_F266_S1.1491.00
374_E377_Q1.1481.00
5_L101_Y1.1461.00
255_V359_I1.1461.00
158_S162_L1.1451.00
301_F318_T1.1451.00
310_T320_L1.1431.00
24_E389_A1.1421.00
161_Q165_T1.1411.00
187_L208_V1.1411.00
84_A89_A1.1371.00
157_E160_Q1.1331.00
87_D90_T1.1311.00
18_S34_Y1.1231.00
354_L358_T1.1151.00
302_V355_L1.1121.00
366_R370_E1.1111.00
8_G18_S1.1091.00
76_E79_C1.1061.00
232_N299_S1.1001.00
140_E143_G1.0991.00
94_E97_K1.0961.00
11_G241_I1.0931.00
367_S370_E1.0921.00
143_G147_K1.0891.00
42_E45_T1.0801.00
321_V343_K1.0741.00
387_K390_D1.0701.00
253_L265_L1.0691.00
253_L283_F1.0671.00
235_F289_V1.0661.00
82_L85_C1.0661.00
24_E385_S1.0601.00
43_K46_A1.0601.00
382_A387_K1.0571.00
160_Q167_N1.0521.00
82_L88_I1.0461.00
103_Y125_F1.0431.00
223_F226_D1.0411.00
391_S394_E1.0381.00
233_V262_K1.0371.00
90_T93_Y1.0351.00
367_S371_K1.0351.00
221_N293_E1.0321.00
292_L316_F1.0291.00
21_V213_S1.0291.00
274_S278_D1.0291.00
144_A147_K1.0261.00
40_Y44_I1.0231.00
168_A171_Q1.0181.00
159_Y163_A1.0111.00
160_Q164_E1.0091.00
341_A372_A1.0091.00
160_Q166_L1.0031.00
242_F325_M1.0001.00
221_N228_I0.9941.00
378_S381_A0.9941.00
249_F267_I0.9921.00
38_K41_K0.9901.00
295_L301_F0.9881.00
258_D353_S0.9871.00
235_F298_A0.9831.00
4_V25_L0.9811.00
291_Q295_L0.9751.00
143_G146_M0.9691.00
42_E46_A0.9671.00
386_K390_D0.9651.00
172_A176_K0.9641.00
337_E343_K0.9571.00
305_G333_A0.9571.00
23_K27_S0.9561.00
118_N186_D0.9531.00
162_L167_N0.9531.00
22_M32_I0.9521.00
261_G363_M0.9481.00
88_I91_H0.9481.00
156_Y163_A0.9441.00
33_T99_E0.9441.00
334_D337_E0.9431.00
93_Y96_V0.9421.00
314_L375_I0.9421.00
310_T332_V0.9351.00
24_E386_K0.9321.00
78_L81_F0.9311.00
274_S277_N0.9301.00
80_A84_A0.9271.00
114_K124_R0.9241.00
125_F395_A0.9241.00
389_A393_L0.9241.00
161_Q164_E0.9201.00
261_G364_N0.9201.00
156_Y161_Q0.9181.00
302_V323_I0.9161.00
281_E286_R0.9151.00
280_P283_F0.9121.00
32_I49_I0.9111.00
384_G389_A0.9081.00
231_E260_D0.9021.00
41_K44_I0.9021.00
88_I93_Y0.9021.00
354_L357_E0.9001.00
333_A344_V0.9001.00
116_I120_L0.8991.00
181_F184_D0.8991.00
26_K32_I0.8971.00
335_Q339_V0.8971.00
235_F294_I0.8961.00
86_K89_A0.8901.00
6_M25_L0.8881.00
75_T79_C0.8861.00
160_Q163_A0.8861.00
140_E145_Y0.8831.00
162_L165_T0.8801.00
276_L279_I0.8781.00
159_Y166_L0.8751.00
139_K144_A0.8731.00
173_E176_K0.8711.00
155_H161_Q0.8661.00
259_F356_K0.8641.00
163_A166_L0.8631.00
164_E167_N0.8631.00
290_P293_E0.8591.00
142_M146_M0.8581.00
236_I302_V0.8551.00
33_T50_E0.8541.00
231_E261_G0.8501.00
255_V259_F0.8481.00
76_E80_A0.8441.00
252_C256_C0.8411.00
36_A51_F0.8371.00
368_Y372_A0.8341.00
168_A172_A0.8331.00
245_Q248_F0.8331.00
169_D172_A0.8331.00
234_L261_G0.8321.00
350_L355_L0.8301.00
157_E163_A0.8301.00
162_L166_L0.8281.00
281_E284_I0.8281.00
159_Y167_N0.8281.00
215_T218_A0.8201.00
142_M145_Y0.8161.00
156_Y159_Y0.8141.00
139_K145_Y0.8131.00
80_A83_K0.8111.00
87_D91_H0.8081.00
236_I263_V0.8061.00
138_A142_M0.8051.00
225_F290_P0.8031.00
303_T310_T0.7941.00
97_K120_L0.7941.00
81_F85_C0.7921.00
150_L154_P0.7911.00
139_K142_M0.7891.00
19_I23_K0.7861.00
189_I210_V0.7861.00
187_L391_S0.7851.00
237_S309_S0.7851.00
229_D232_N0.7841.00
304_H308_N0.7841.00
159_Y162_L0.7831.00
156_Y167_N0.7811.00
156_Y164_E0.7811.00
375_I378_S0.7791.00
141_M145_Y0.7771.00
193_S382_A0.7751.00
251_Q350_L0.7751.00
86_K90_T0.7731.00
318_T369_A0.7691.00
177_P180_V0.7681.00
140_E146_M0.7641.00
158_S165_T0.7631.00
264_V284_I0.7601.00
75_T78_L0.7591.00
222_D226_D0.7561.00
226_D297_R0.7541.00
10_P14_H0.7521.00
197_Q200_A0.7511.00
291_Q308_N0.7431.00
368_Y371_K0.7431.00
303_T322_V0.7431.00
341_A371_K0.7421.00
92_I96_V0.7391.00
106_Y114_K0.7371.00
251_Q255_V0.7361.00
266_S291_Q0.7361.00
21_V388_A0.7341.00
161_Q166_L0.7341.00
141_M144_A0.7311.00
302_V321_V0.7301.00
262_K284_I0.7261.00
138_A144_A0.7211.00
211_G214_I0.7191.00
74_F81_F0.7171.00
303_T309_S0.7131.00
89_A95_E0.7121.00
292_L312_E0.7121.00
156_Y166_L0.7111.00
7_I113_G0.7111.00
109_H327_G0.7111.00
44_I51_F0.7081.00
30_E102_D0.7071.00
198_P335_Q0.7071.00
157_E165_T0.7071.00
159_Y165_T0.7051.00
20_G24_E0.7041.00
308_N312_E0.7031.00
384_G388_A0.7011.00
228_I284_I0.7001.00
238_M323_I0.6971.00
148_G154_P0.6971.00
196_F339_V0.6971.00
48_D52_R0.6941.00
379_L382_A0.6931.00
90_T95_E0.6921.00
253_L279_I0.6911.00
240_T288_Y0.6911.00
224_P284_I0.6891.00
88_I96_V0.6871.00
13_G308_N0.6871.00
157_E166_L0.6871.00
353_S357_E0.6861.00
314_L379_L0.6861.00
240_T329_Q0.6841.00
235_F239_G0.6831.00
103_Y396_V0.6811.00
323_I350_L0.6781.00
293_E296_K0.6771.00
159_Y164_E0.6771.00
73_D81_F0.6761.00
158_S163_A0.6761.00
372_A376_G0.6751.00
72_R75_T0.6751.00
210_V213_S0.6751.00
392_I396_V0.6741.00
52_R95_E0.6731.00
74_F77_M0.6731.00
237_S301_F0.6731.00
232_N261_G0.6701.00
69_D73_D0.6691.00
291_Q301_F0.6631.00
303_T313_G0.6621.00
48_D51_F0.6601.00
89_A93_Y0.6581.00
105_I189_I0.6581.00
288_Y291_Q0.6571.00
383_G387_K0.6551.00
336_V340_G0.6521.00
13_G16_N0.6521.00
72_R76_E0.6501.00
333_A342_G0.6491.00
7_I110_L0.6481.00
257_K260_D0.6481.00
13_G19_I0.6481.00
114_K118_N0.6461.00
71_E77_M0.6461.00
151_E154_P0.6451.00
304_H309_S0.6441.00
35_Y92_I0.6441.00
132_A197_Q0.6411.00
208_V387_K0.6381.00
142_M147_K0.6351.00
73_D77_M0.6351.00
138_A145_Y0.6341.00
145_Y148_G0.6341.00
260_D282_N0.6331.00
264_V289_V0.6331.00
71_E74_F0.6311.00
160_Q165_T0.6301.00
289_V294_I0.6301.00
393_L396_V0.6301.00
92_I95_E0.6291.00
171_Q176_K0.6291.00
195_G381_A0.6291.00
170_F173_E0.6291.00
54_Y58_R0.6261.00
4_V32_I0.6241.00
127_L213_S0.6231.00
234_L359_I0.6211.00
168_A173_E0.6201.00
334_D344_V0.6181.00
237_S291_Q0.6181.00
33_T101_Y0.6151.00
188_T207_Y0.6151.00
156_Y162_L0.6151.00
79_C82_L0.6151.00
242_F326_G0.6141.00
275_E279_I0.6141.00
260_D281_E0.6131.00
49_I52_R0.6101.00
69_D72_R0.6091.00
157_E162_L0.6081.00
90_T119_M0.6081.00
321_V345_I0.6071.00
157_E164_E0.6051.00
87_D93_Y0.6051.00
187_L191_F0.6041.00
310_T329_Q0.6031.00
346_K354_L0.6031.00
18_S127_L0.6021.00
50_E53_E0.6021.00
137_F141_M0.6010.99
70_E74_F0.6010.99
11_G14_H0.6010.99
350_L354_L0.6000.99
129_T329_Q0.5990.99
38_K55_H0.5980.99
47_L50_E0.5980.99
328_D332_V0.5940.99
94_E98_H0.5940.99
20_G23_K0.5940.99
67_T70_E0.5940.99
251_Q355_L0.5920.99
179_D182_L0.5910.99
275_E280_P0.5900.99
357_E360_Q0.5890.99
390_D393_L0.5870.99
191_F311_S0.5850.99
366_R369_A0.5810.99
148_G152_D0.5780.99
115_V181_F0.5770.99
385_S390_D0.5750.99
140_E144_A0.5750.99
157_E167_N0.5750.99
90_T96_V0.5740.99
71_E80_A0.5740.99
69_D74_F0.5740.99
244_N268_G0.5740.99
67_T71_E0.5730.99
71_E75_T0.5730.99
307_M311_S0.5730.99
221_N226_D0.5710.99
78_L82_L0.5700.99
239_G306_G0.5690.99
72_R77_M0.5680.99
339_V375_I0.5680.99
131_F134_N0.5670.99
210_V388_A0.5630.99
158_S167_N0.5620.99
31_N99_E0.5610.99
15_I34_Y0.5590.99
26_K47_L0.5580.99
242_F327_G0.5550.99
149_S154_P0.5550.99
319_P369_A0.5550.99
48_D53_E0.5540.99
132_A135_E0.5530.99
139_K147_K0.5510.99
385_S388_A0.5500.99
304_H329_Q0.5490.99
240_T332_V0.5490.99
371_K375_I0.5490.99
155_H165_T0.5480.99
84_A93_Y0.5470.99
144_A148_G0.5460.99
224_P290_P0.5450.99
88_I92_I0.5440.99
36_A40_Y0.5440.99
155_H167_N0.5410.99
17_P308_N0.5400.99
4_V392_I0.5390.99
234_L363_M0.5380.99
190_V207_Y0.5380.99
97_K100_S0.5360.99
25_L32_I0.5360.99
158_S166_L0.5340.99
375_I379_L0.5340.99
124_R186_D0.5330.99
306_G328_D0.5320.99
330_F333_A0.5320.99
126_S185_G0.5320.99
47_L52_R0.5290.99
149_S153_S0.5290.99
150_L153_S0.5280.99
361_E367_S0.5280.99
156_Y165_T0.5270.99
141_M146_M0.5270.99
236_I252_C0.5260.99
324_P344_V0.5260.99
138_A143_G0.5250.99
128_C135_E0.5240.99
79_C86_K0.5230.99
67_T72_R0.5230.99
90_T169_D0.5230.99
193_S196_F0.5230.99
324_P329_Q0.5220.99
169_D176_K0.5220.99
126_S188_T0.5210.99
264_V298_A0.5210.99
217_R220_N0.5210.99
233_V299_S0.5190.99
68_G72_R0.5180.99
74_F78_L0.5170.98
95_E98_H0.5160.98
358_T361_E0.5150.98
128_C132_A0.5140.98
214_I315_Y0.5130.98
51_F54_Y0.5120.98
77_M81_F0.5120.98
113_G117_A0.5120.98
235_F301_F0.5110.98
29_G48_D0.5110.98
196_F212_P0.5110.98
252_C355_L0.5110.98
80_A85_C0.5110.98
99_E102_D0.5090.98
167_N172_A0.5090.98
244_N252_C0.5080.98
254_E356_K0.5070.98
250_N352_E0.5060.98
224_P286_R0.5060.98
85_C93_Y0.5060.98
73_D79_C0.5060.98
30_E389_A0.5060.98
83_K88_I0.5060.98
73_D80_A0.5050.98
288_Y297_R0.5050.98
140_E147_K0.5040.98
52_R58_R0.5040.98
41_K53_E0.5040.98
72_R80_A0.5040.98
291_Q304_H0.5030.98
19_I22_M0.5030.98
248_F251_Q0.5020.98
93_Y97_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9556 100 0.337 Contact Map
2pq6A 1 0.9333 100 0.355 Contact Map
3rscA 1 0.9679 100 0.359 Contact Map
1rrvA 1 0.9506 100 0.362 Contact Map
2iyfA 1 0.963 100 0.368 Contact Map
3ia7A 2 0.9654 100 0.377 Contact Map
2p6pA 2 0.9136 100 0.391 Contact Map
2vchA 1 0.963 100 0.395 Contact Map
3otiA 2 0.8889 100 0.406 Contact Map
3hbfA 1 0.9704 100 0.406 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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