GREMLIN Database
YOZO - Uncharacterized protein YozO
UniProt: O31847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 114 (104)
Sequences: 576 (378)
Seq/√Len: 37.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E110_K2.9741.00
59_F112_L2.6741.00
33_V49_K2.5521.00
66_E87_R2.5191.00
60_L91_F2.4551.00
83_L92_E2.3981.00
35_Q46_F2.3501.00
70_I82_L2.2910.99
38_F62_Y2.2660.99
33_V50_M2.2380.99
96_A99_T2.1960.99
54_K84_L2.0950.99
15_L18_L2.0560.99
21_E106_A2.0130.99
105_Q109_T1.9830.98
70_I105_Q1.9050.98
45_F93_L1.8880.98
57_R69_A1.8070.97
67_S89_K1.7800.97
36_I45_F1.7520.97
36_I93_L1.7230.96
49_K53_K1.6540.95
14_K48_N1.5920.94
43_I93_L1.5730.94
15_L37_C1.4770.91
50_M53_K1.4250.90
24_R40_N1.4190.90
17_A100_D1.3990.89
55_K71_Q1.3240.86
16_E100_D1.2430.82
47_D57_R1.2350.82
21_E40_N1.2100.81
33_V52_S1.2090.81
98_D103_E1.1970.80
16_E25_I1.1440.77
26_E40_N1.1390.77
57_R83_L1.1310.76
33_V53_K1.1290.76
55_K77_D1.1150.75
14_K43_I1.1050.74
11_D104_V1.0940.74
43_I65_I1.0920.73
20_V109_T1.0890.73
48_N56_V1.0630.71
26_E111_H1.0500.70
15_L107_V1.0350.69
52_S75_M1.0340.69
31_L108_L1.0300.69
79_D94_E1.0290.69
105_Q108_L0.9980.66
73_A97_K0.9960.66
59_F71_Q0.9940.66
75_M78_P0.9890.66
38_F59_F0.9880.66
80_T83_L0.9800.65
54_K72_E0.9760.65
61_P77_D0.9700.64
31_L36_I0.9660.64
30_K37_C0.9470.62
51_F76_F0.9410.62
21_E80_T0.9330.61
82_L101_L0.9150.60
95_F103_E0.9140.60
36_I41_K0.9100.59
86_T105_Q0.9070.59
60_L86_T0.9060.59
11_D16_E0.8890.57
36_I67_S0.8800.57
35_Q48_N0.8750.56
57_R91_F0.8730.56
68_F109_T0.8680.56
28_I61_P0.8630.55
45_F60_L0.8530.54
9_S54_K0.8420.53
25_I28_I0.8150.51
11_D24_R0.8110.51
73_A102_S0.8090.50
29_Y103_E0.8050.50
107_V111_H0.8050.50
22_G110_K0.8050.50
17_A102_S0.7980.49
29_Y95_F0.7960.49
85_M109_T0.7870.48
35_Q75_M0.7850.48
68_F77_D0.7770.48
10_T29_Y0.7760.47
94_E99_T0.7690.47
64_T109_T0.7680.47
54_K75_M0.7510.45
13_K97_K0.7410.44
28_I37_C0.7400.44
102_S105_Q0.7400.44
95_F104_V0.7390.44
31_L112_L0.7310.44
100_D103_E0.7280.43
50_M81_G0.7270.43
104_V111_H0.7260.43
42_R59_F0.7180.42
29_Y48_N0.7130.42
83_L90_T0.7060.41
89_K111_H0.6840.40
30_K63_K0.6830.39
48_N79_D0.6810.39
58_V75_M0.6790.39
60_L73_A0.6780.39
43_I109_T0.6770.39
81_G104_V0.6750.39
82_L95_F0.6720.39
37_C41_K0.6600.38
37_C94_E0.6520.37
33_V81_G0.6510.37
62_Y68_F0.6510.37
70_I102_S0.6480.37
38_F82_L0.6450.36
47_D93_L0.6440.36
82_L93_L0.6350.35
27_S103_E0.6310.35
17_A106_A0.6270.35
53_K72_E0.6240.35
69_A85_M0.6240.35
68_F85_M0.6230.35
76_F87_R0.6150.34
37_C103_E0.6140.34
35_Q99_T0.6110.34
86_T95_F0.5910.32
96_A107_V0.5820.31
60_L67_S0.5800.31
93_L97_K0.5730.31
31_L94_E0.5700.30
72_E95_F0.5690.30
12_A98_D0.5650.30
27_S70_I0.5630.30
40_N89_K0.5580.30
76_F95_F0.5560.29
99_T111_H0.5540.29
72_E105_Q0.5540.29
18_L95_F0.5430.28
64_T86_T0.5430.28
15_L81_G0.5390.28
40_N101_L0.5370.28
62_Y77_D0.5340.28
12_A107_V0.5330.28
49_K55_K0.5320.28
20_V69_A0.5320.28
28_I36_I0.5280.27
95_F101_L0.5150.26
20_V56_V0.5130.26
71_Q81_G0.5120.26
27_S107_V0.5100.26
13_K24_R0.5100.26
64_T67_S0.5090.26
19_L25_I0.5060.26
65_I105_Q0.5060.26
27_S73_A0.5050.26
95_F102_S0.5020.26
68_F72_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hsaA 3 0.9123 100 0.179 Contact Map
3b77A 4 0.9737 100 0.343 Contact Map
2cayA 4 0.9474 96.5 0.863 Contact Map
2hthB 1 0.8684 94.7 0.88 Contact Map
1zsqA 1 0.8509 89.4 0.898 Contact Map
1lw3A 1 0.8421 87.2 0.902 Contact Map
1w7pD 1 0 71.5 0.916 Contact Map
1zyiA 1 0.7105 66.6 0.919 Contact Map
4f7uQ 1 0.8684 62.7 0.921 Contact Map
4k17A 1 0.8684 55.6 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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