GREMLIN Database
YOZB - Uncharacterized membrane protein YozB
UniProt: O31845 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (161)
Sequences: 632 (377)
Seq/√Len: 29.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_Y112_M5.0911.00
137_T153_A4.7181.00
141_G146_V4.0891.00
67_M79_F3.6941.00
137_T156_T3.1541.00
64_A80_I2.9851.00
67_M75_A2.9521.00
68_I73_I2.9211.00
74_K78_R2.8131.00
60_F79_F2.5240.99
81_L142_F2.5000.99
113_R117_F2.1950.98
21_L25_L2.1410.98
60_F86_T2.1050.98
25_L28_V2.0880.98
18_L22_I2.0860.98
131_V134_A1.9710.97
72_N75_A1.9350.96
62_L161_L1.7300.93
121_I125_C1.6680.92
50_N164_S1.6490.91
77_K81_L1.6100.90
111_I115_I1.5760.89
158_P162_Y1.5660.89
114_P118_F1.5620.89
133_L155_W1.5510.88
65_L71_K1.5290.88
17_T21_L1.5280.88
130_I159_L1.4990.87
58_F165_L1.4850.86
19_T24_G1.4320.84
148_R151_K1.4150.83
53_F86_T1.4130.83
55_S168_V1.4050.83
22_I26_I1.4010.83
43_I96_T1.3970.83
140_R153_A1.3940.82
153_A156_T1.3940.82
49_L77_K1.3910.82
49_L93_C1.3840.82
118_F122_T1.3740.81
21_L148_R1.3550.81
111_I114_P1.3510.80
137_T140_R1.3440.80
125_C128_A1.3150.78
65_L69_K1.2840.77
13_G17_T1.2660.76
140_R152_I1.2660.76
16_L20_V1.2450.75
47_P170_V1.2450.75
84_F138_L1.2400.74
50_N93_C1.2200.73
172_L177_Y1.2180.73
88_L92_I1.1910.71
33_P127_S1.1670.70
62_L66_I1.1600.69
158_P163_V1.1460.68
135_L139_I1.1350.67
73_I146_V1.1330.67
40_H106_Y1.1270.67
88_L155_W1.1220.66
54_N87_T1.1120.66
58_F161_L1.1100.66
109_E112_M1.1080.65
33_P36_D1.0930.64
136_F152_I1.0650.62
95_V134_A1.0640.62
84_F134_A1.0620.62
141_G144_M1.0580.62
104_T174_I1.0500.61
81_L85_T1.0460.61
87_T157_M1.0310.60
75_A79_F1.0310.60
133_L159_L1.0300.60
58_F164_S1.0160.59
56_F60_F1.0150.59
111_I122_T1.0120.58
14_I18_L1.0090.58
112_M115_I1.0030.58
19_T132_P1.0020.58
142_F152_I1.0010.57
15_V19_T0.9980.57
142_F145_Q0.9830.56
87_T164_S0.9820.56
64_A84_F0.9810.56
117_F121_I0.9640.55
54_N61_L0.9600.54
112_M117_F0.9590.54
145_Q148_R0.9550.54
105_L114_P0.9370.52
152_I156_T0.9310.52
122_T162_Y0.9240.51
73_I156_T0.9220.51
80_I141_G0.9030.50
140_R145_Q0.8980.49
27_A30_F0.8940.49
106_Y136_F0.8890.49
136_F141_G0.8850.48
82_A86_T0.8810.48
130_I134_A0.8800.48
60_F83_A0.8780.48
65_L157_M0.8730.47
111_I129_I0.8700.47
36_D53_F0.8580.46
23_N27_A0.8500.46
78_R81_L0.8420.45
20_V23_N0.8420.45
68_I85_T0.8330.44
48_M52_I0.8300.44
130_I153_A0.8240.44
25_L95_V0.8230.44
24_G28_V0.8160.43
21_L28_V0.8140.43
142_F147_E0.8070.42
71_K138_L0.8060.42
103_N124_I0.8040.42
40_H43_I0.8000.42
52_I56_F0.7920.41
157_M161_L0.7810.40
59_I114_P0.7680.39
63_A85_T0.7670.39
105_L113_R0.7570.38
60_F82_A0.7540.38
41_A127_S0.7510.38
27_A32_M0.7500.38
69_K77_K0.7490.38
52_I72_N0.7480.38
89_L169_I0.7470.38
81_L138_L0.7430.37
140_R148_R0.7420.37
52_I83_A0.7370.37
53_F93_C0.7300.36
20_V32_M0.7290.36
162_Y168_V0.7280.36
48_M171_Y0.7260.36
104_T175_S0.7220.36
85_T165_L0.7200.36
50_N127_S0.7200.36
108_G112_M0.7180.36
61_L168_V0.7170.36
97_Y174_I0.7120.35
13_G32_M0.7090.35
41_A45_I0.7070.35
110_G115_I0.7050.35
98_H173_M0.7040.35
13_G16_L0.6980.34
22_I27_A0.6970.34
22_I131_V0.6970.34
56_F157_M0.6960.34
136_F139_I0.6960.34
97_Y100_I0.6940.34
95_V173_M0.6940.34
104_T113_R0.6940.34
109_E117_F0.6910.34
82_A110_G0.6860.33
18_L21_L0.6860.33
73_I84_F0.6830.33
21_L95_V0.6830.33
128_A148_R0.6830.33
118_F150_K0.6790.33
153_A157_M0.6770.33
132_P159_L0.6770.33
69_K73_I0.6710.32
64_A82_A0.6710.32
108_G111_I0.6700.32
49_L62_L0.6670.32
23_N87_T0.6670.32
86_T164_S0.6580.31
93_C96_T0.6570.31
13_G41_A0.6550.31
80_I144_M0.6540.31
46_L124_I0.6530.31
70_Q150_K0.6510.31
54_N164_S0.6490.31
49_L56_F0.6480.31
23_N57_T0.6390.30
79_F82_A0.6370.30
69_K138_L0.6350.30
133_L143_S0.6340.30
51_A54_N0.6340.30
17_T59_I0.6340.30
45_I81_L0.6230.29
131_V135_L0.6180.29
49_L104_T0.6170.29
78_R82_A0.6140.28
83_A161_L0.6120.28
128_A143_S0.6050.28
152_I171_Y0.6020.28
70_Q75_A0.6010.28
119_I133_L0.6000.28
18_L142_F0.5980.27
96_T100_I0.5980.27
56_F63_A0.5970.27
153_A163_V0.5970.27
30_F139_I0.5960.27
88_L150_K0.5910.27
57_T131_V0.5910.27
46_L61_L0.5880.27
130_I133_L0.5860.27
29_L47_P0.5850.27
19_T25_L0.5750.26
57_T102_E0.5710.26
81_L139_I0.5650.25
65_L122_T0.5620.25
154_R157_M0.5610.25
23_N134_A0.5580.25
103_N117_F0.5570.25
114_P122_T0.5510.25
46_L97_Y0.5480.24
73_I138_L0.5470.24
53_F87_T0.5470.24
36_D42_N0.5410.24
20_V113_R0.5400.24
122_T163_V0.5380.24
27_A99_S0.5380.24
77_K100_I0.5360.24
128_A136_F0.5320.24
16_L136_F0.5290.23
107_G178_Y0.5290.23
48_M55_S0.5250.23
106_Y114_P0.5240.23
72_N147_E0.5220.23
64_A67_M0.5200.23
14_I25_L0.5180.23
133_L137_T0.5180.23
136_F140_R0.5170.23
28_V121_I0.5170.23
160_W167_G0.5160.23
89_L93_C0.5130.22
13_G33_P0.5120.22
28_V36_D0.5120.22
28_V31_F0.5120.22
150_K159_L0.5110.22
64_A79_F0.5100.22
122_T153_A0.5070.22
21_L70_Q0.5060.22
65_L73_I0.5050.22
23_N30_F0.5020.22
31_F53_F0.5010.22
15_V23_N0.5010.22
20_V143_S0.5010.22
19_T23_N0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.9663 97.1 0.883 Contact Map
2yevA 1 0.9775 95.7 0.899 Contact Map
1v54C 1 0.9831 95.3 0.901 Contact Map
1qleC 1 0.9831 92.9 0.912 Contact Map
1m56C 2 0.9831 92.3 0.913 Contact Map
4o6yA 2 0.8764 52.3 0.941 Contact Map
3j1zP 8 0.927 30.4 0.949 Contact Map
4n6hA 1 0.8539 22.5 0.952 Contact Map
3dh4A 3 0.8708 20.9 0.952 Contact Map
2lnlA 1 0.8427 20.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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