GREMLIN Database
CZRA - HTH-type transcriptional repressor CzrA
UniProt: O31844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 107 (88)
Sequences: 5311 (3488)
Seq/√Len: 371.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_E78_R3.3041.00
77_S84_I3.0161.00
76_K87_S2.9581.00
79_R84_I2.3341.00
76_K89_E2.2611.00
28_A72_L2.1531.00
20_F32_P1.8881.00
70_K77_S1.8701.00
57_L62_V1.8431.00
45_E87_S1.8201.00
95_D99_Q1.7831.00
40_L54_K1.7031.00
24_Q71_N1.6011.00
67_R71_N1.5911.00
38_L74_L1.5781.00
45_E85_Y1.5521.00
23_A32_P1.5341.00
47_A83_S1.5251.00
40_L46_H1.4541.00
66_L75_V1.3691.00
57_L61_T1.3561.00
28_A68_F1.3491.00
37_I51_I1.3461.00
15_D18_T1.3461.00
31_D64_H1.3151.00
42_S94_L1.2911.00
52_A59_Q1.2711.00
46_H50_G1.2661.00
16_E36_R1.2651.00
41_L75_V1.2541.00
47_A50_G1.2511.00
61_T64_H1.2461.00
48_V66_L1.2451.00
26_F96_V1.2351.00
26_F100_M1.2231.00
33_T62_V1.2121.00
94_L98_Q1.1991.00
68_F72_L1.1951.00
58_L61_T1.1831.00
22_V100_M1.1631.00
98_Q102_H1.1311.00
46_H54_K1.1171.00
45_E80_E1.0931.00
55_L62_V1.0691.00
64_H82_T1.0691.00
51_I62_V1.0661.00
42_S98_Q1.0651.00
95_D102_H1.0571.00
73_R89_E1.0401.00
49_N83_S1.0381.00
66_L70_K1.0151.00
38_L88_P1.0031.00
68_F71_N1.0021.00
50_G53_E0.9951.00
33_T57_L0.9781.00
19_L36_R0.9721.00
25_T74_L0.9521.00
18_T21_L0.9441.00
41_L46_H0.9431.00
52_A62_V0.9381.00
91_E94_L0.9051.00
20_F24_Q0.8951.00
95_D98_Q0.8911.00
80_E83_S0.8871.00
17_E20_F0.8811.00
70_K84_I0.8671.00
26_F29_L0.8601.00
16_E20_F0.8511.00
23_A30_S0.8371.00
19_L39_H0.8171.00
37_I41_L0.8151.00
90_D93_V0.8021.00
92_H96_V0.7851.00
26_F30_S0.7821.00
69_L75_V0.7821.00
91_E95_D0.7741.00
64_H68_F0.7531.00
36_R40_L0.7441.00
48_V70_K0.7311.00
23_A35_I0.7311.00
58_L64_H0.7251.00
38_L97_L0.7171.00
15_D19_L0.7111.00
93_V97_L0.7010.99
46_H51_I0.6820.99
25_T96_V0.6750.99
33_T36_R0.6720.99
47_A85_Y0.6720.99
79_R82_T0.6720.99
61_T65_Q0.6710.99
76_K90_D0.6640.99
21_L24_Q0.6610.99
40_L55_L0.6470.99
40_L51_I0.6420.99
49_N53_E0.6340.99
29_L32_P0.6340.99
43_Q46_H0.6180.99
28_A74_L0.6130.99
70_K79_R0.6120.99
31_D61_T0.6080.98
21_L73_R0.6080.98
52_A56_N0.6070.98
64_H67_R0.5980.98
80_E85_Y0.5830.98
39_H97_L0.5820.98
96_V100_M0.5790.98
33_T65_Q0.5790.98
32_P36_R0.5790.98
27_K30_S0.5760.98
67_R70_K0.5700.98
31_D65_Q0.5680.98
58_L82_T0.5570.97
52_A55_L0.5530.97
60_S64_H0.5500.97
99_Q102_H0.5480.97
25_T92_H0.5480.97
39_H43_Q0.5480.97
17_E91_E0.5440.97
21_L95_D0.5440.97
50_G54_K0.5410.97
26_F35_I0.5340.97
89_E92_H0.5310.96
92_H100_M0.5260.96
16_E19_L0.5220.96
48_V63_S0.5210.96
36_R39_H0.5170.96
44_G50_G0.5100.95
22_V101_I0.5100.95
22_V92_H0.5090.95
39_H42_S0.5080.95
58_L65_Q0.5010.95
21_L92_H0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r1tA 2 0.9159 99.7 0.49 Contact Map
1u2wA 2 1 99.7 0.491 Contact Map
1r1uA 2 0.8972 99.7 0.505 Contact Map
2kkoA 2 0.9346 99.7 0.507 Contact Map
2jscA 2 0.8131 99.6 0.528 Contact Map
4k2eA 2 0.8879 99.6 0.532 Contact Map
3pqkA 2 0.9065 99.6 0.534 Contact Map
1q1hA 1 0.7477 99.6 0.541 Contact Map
3f6vA 2 0.8037 99.6 0.541 Contact Map
2vxzA 1 0.7664 99.6 0.545 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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