GREMLIN Database
YOZG - Uncharacterized HTH-type transcriptional regulator YozG
UniProt: O31834 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (69)
Sequences: 1130 (509)
Seq/√Len: 61.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_N64_E2.7081.00
34_I40_A2.5721.00
19_T29_M2.4571.00
24_R54_A2.4011.00
9_V12_A2.3341.00
10_M13_K2.2361.00
42_A46_S2.2081.00
9_V13_K2.1041.00
10_M14_R1.8691.00
58_Q64_E1.8591.00
11_L16_M1.7460.99
18_V32_L1.7210.99
20_E24_R1.7160.99
2_A49_E1.7040.99
3_I65_Y1.6060.99
35_L40_A1.5910.99
16_M54_A1.5420.99
50_A53_K1.4620.98
4_I15_K1.4270.98
18_V29_M1.4100.97
5_I45_L1.4010.97
53_K67_S1.3240.96
6_N13_K1.2870.95
18_V22_S1.2810.95
4_I66_R1.2340.94
11_L17_S1.2220.94
17_S29_M1.1340.91
34_I42_A1.1340.91
22_S29_M1.1080.90
19_T42_A1.0770.89
18_V36_K1.0400.87
25_V32_L1.0340.87
5_I63_L1.0320.87
18_V37_N1.0240.86
8_D15_K1.0130.86
12_A15_K0.9920.85
49_E65_Y0.9890.84
46_S50_A0.9860.84
5_I38_G0.9730.83
50_A54_A0.9610.83
28_T40_A0.9440.82
17_S30_A0.9260.80
16_M24_R0.9220.80
17_S20_E0.9110.79
9_V15_K0.9080.79
56_E67_S0.8960.78
27_I31_N0.8700.76
35_L43_I0.8410.73
18_V25_V0.8410.73
17_S37_N0.8360.73
11_L18_V0.8330.73
31_N35_L0.8300.73
11_L37_N0.8180.71
7_I33_S0.8150.71
21_L33_S0.8030.70
7_I45_L0.7990.70
11_L38_G0.7780.68
34_I39_K0.7660.66
2_A68_D0.7640.66
4_I64_E0.7470.64
49_E53_K0.7230.62
6_N9_V0.7190.61
53_K65_Y0.7140.61
8_D64_E0.7020.60
18_V26_G0.7010.59
51_I62_I0.6980.59
58_Q65_Y0.6940.59
21_L32_L0.6770.57
32_L44_R0.6720.56
18_V42_A0.6710.56
5_I35_L0.6680.56
38_G58_Q0.6480.54
28_T41_K0.6340.52
34_I41_K0.6200.50
37_N40_A0.6080.49
48_L63_L0.6040.49
11_L29_M0.6030.48
37_N45_L0.6020.48
6_N62_I0.5990.48
4_I12_A0.5920.47
42_A50_A0.5850.46
7_I37_N0.5830.46
55_L60_G0.5830.46
6_N63_L0.5800.46
43_I60_G0.5800.46
27_I48_L0.5770.46
3_I9_V0.5750.45
1_M49_E0.5710.45
25_V51_I0.5550.43
5_I60_G0.5540.43
4_I53_K0.5530.43
30_A34_I0.5490.42
22_S59_P0.5470.42
29_M39_K0.5360.41
7_I18_V0.5350.41
29_M34_I0.5240.40
25_V47_T0.5220.39
19_T37_N0.5200.39
22_S60_G0.5170.39
33_S43_I0.5170.39
14_R56_E0.5120.38
4_I67_S0.5090.38
23_E26_G0.5010.37
65_Y69_E0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tysA 2 0.7857 98.7 0.714 Contact Map
3b7hA 2 0.8452 98.7 0.717 Contact Map
2k9qA 2 0.9167 98.6 0.727 Contact Map
4mctA 2 0.9881 98.5 0.73 Contact Map
3trbA 3 0.9881 98.5 0.733 Contact Map
2o38A 2 0.9405 98.5 0.734 Contact Map
3g5gA 2 0.869 98.5 0.735 Contact Map
3cecA 1 0.9881 98.5 0.735 Contact Map
4mcxA 2 0.9881 98.5 0.736 Contact Map
2b5aA 2 0.8214 98.5 0.736 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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