GREMLIN Database
YOAS - Uncharacterized membrane protein YoaS
UniProt: O31833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 160 (158)
Sequences: 376 (285)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_L56_T3.4131.00
144_K148_E3.1761.00
113_A118_A3.0831.00
110_Y122_I2.9470.99
5_S148_E2.8210.99
114_E122_I2.6580.99
144_K147_K2.4850.98
107_P118_A2.3860.98
73_Y84_S2.2880.97
31_V39_F2.1570.96
48_L52_Y2.1360.95
147_K151_D2.1100.95
107_P113_A2.1050.95
16_I60_F2.0790.95
109_F128_I2.0550.94
112_M121_I2.0100.93
119_P123_V1.9840.93
53_L102_Y1.9700.93
6_T141_V1.9660.93
56_T102_Y1.9500.92
52_Y105_G1.9290.92
27_L46_K1.9160.92
57_A139_A1.9140.92
4_M148_E1.9030.91
39_F42_I1.7490.87
110_Y118_A1.7450.87
46_K105_G1.7250.87
78_K147_K1.7150.86
29_P32_A1.6990.86
155_E160_V1.6600.85
116_D120_G1.6190.83
58_I106_M1.5730.81
100_I104_A1.5690.81
12_A16_I1.5250.79
48_L109_F1.5250.79
58_I72_S1.5070.78
114_E118_A1.5040.78
124_I133_M1.4720.76
60_F102_Y1.4710.76
54_Y157_D1.4340.75
88_L95_A1.4320.74
106_M113_A1.3970.73
82_G93_Y1.3720.71
96_V100_I1.3710.71
40_P48_L1.3420.69
10_K92_K1.3360.69
34_Y105_G1.3000.67
86_R90_N1.2920.66
15_L77_N1.2910.66
6_T75_D1.2840.66
14_V62_F1.2690.65
116_D141_V1.2240.62
92_K143_Q1.2230.62
6_T152_I1.2210.62
56_T128_I1.1890.60
5_S144_K1.1770.59
31_V105_G1.1740.59
14_V127_V1.1560.58
19_P107_P1.1520.57
107_P119_P1.1420.57
97_T147_K1.1390.56
27_L56_T1.1330.56
107_P110_Y1.1110.55
126_L150_I1.1030.54
146_L150_I1.0710.52
23_L110_Y1.0570.51
99_S154_S1.0530.51
57_A61_Y1.0520.50
134_V138_F1.0430.50
115_I122_I1.0320.49
58_I157_D1.0280.49
117_D120_G1.0200.48
73_Y83_L1.0170.48
15_L151_D1.0150.48
68_F101_F1.0100.48
22_A89_K1.0040.47
14_V18_I1.0040.47
57_A137_V1.0020.47
18_I51_I0.9840.46
29_P35_S0.9760.45
48_L108_V0.9730.45
72_S126_L0.9710.45
27_L44_Y0.9670.45
19_P22_A0.9650.45
49_V69_K0.9600.44
53_L128_I0.9560.44
109_F123_V0.9490.43
35_S105_G0.9480.43
34_Y112_M0.9480.43
38_L121_I0.9450.43
28_V66_Q0.9420.43
28_V48_L0.9300.42
12_A19_P0.9270.42
114_E117_D0.9270.42
19_P60_F0.9200.41
95_A142_L0.9110.41
124_I129_I0.9070.41
68_F157_D0.9070.41
151_D157_D0.8950.40
102_Y129_I0.8820.39
4_M152_I0.8750.38
123_V126_L0.8740.38
23_L108_V0.8740.38
9_L74_I0.8660.38
42_I127_V0.8620.38
73_Y96_V0.8580.37
31_V112_M0.8340.36
61_Y68_F0.8290.36
66_Q98_I0.8290.36
72_S78_K0.8280.35
83_L147_K0.8210.35
100_I123_V0.8160.35
122_I129_I0.8160.35
123_V128_I0.8150.35
112_M133_M0.8130.35
17_G64_L0.8120.34
5_S45_I0.8100.34
82_G141_V0.8100.34
17_G60_F0.8080.34
75_D138_F0.8010.34
53_L121_I0.7970.34
31_V46_K0.7950.33
128_I135_I0.7950.33
102_Y128_I0.7940.33
110_Y124_I0.7920.33
118_A122_I0.7880.33
49_V101_F0.7810.33
124_I128_I0.7780.32
86_R126_L0.7750.32
14_V104_A0.7650.32
50_F105_G0.7630.31
102_Y119_P0.7620.31
123_V129_I0.7600.31
35_S52_Y0.7600.31
32_A86_R0.7580.31
39_F48_L0.7570.31
35_S49_V0.7550.31
46_K160_V0.7520.31
13_L64_L0.7520.31
12_A20_I0.7480.31
8_F92_K0.7430.30
35_S39_F0.7410.30
28_V50_F0.7410.30
146_L159_T0.7380.30
42_I49_V0.7340.30
7_I152_I0.7280.29
59_P62_F0.7270.29
75_D107_P0.7210.29
14_V77_N0.7190.29
107_P114_E0.7140.29
36_A110_Y0.7070.28
108_V129_I0.7020.28
85_V92_K0.7020.28
21_L29_P0.6990.28
36_A49_V0.6990.28
126_L160_V0.6960.28
51_I90_N0.6950.28
53_L136_A0.6790.27
95_A129_I0.6790.27
91_I95_A0.6780.27
85_V150_I0.6770.27
114_E125_G0.6770.27
27_L62_F0.6700.26
39_F105_G0.6670.26
8_F146_L0.6660.26
80_F159_T0.6630.26
65_Y90_N0.6620.26
130_F134_V0.6610.26
109_F121_I0.6600.26
88_L142_L0.6520.25
17_G94_C0.6470.25
24_C142_L0.6420.25
11_I82_G0.6420.25
34_Y39_F0.6390.25
65_Y96_V0.6380.25
10_K68_F0.6370.24
155_E159_T0.6360.24
91_I135_I0.6350.24
40_P105_G0.6340.24
48_L55_V0.6310.24
110_Y114_E0.6290.24
69_K116_D0.6230.24
31_V35_S0.6220.24
27_L35_S0.6210.24
92_K146_L0.6200.24
65_Y73_Y0.6150.23
30_K52_Y0.6110.23
111_L133_M0.6090.23
44_Y105_G0.6050.23
10_K89_K0.6010.23
72_S76_K0.5990.23
42_I135_I0.5930.22
70_L135_I0.5920.22
11_I62_F0.5880.22
99_S132_S0.5880.22
82_G86_R0.5830.22
149_A159_T0.5810.22
69_K148_E0.5790.22
36_A40_P0.5750.21
3_R16_I0.5720.21
60_F67_A0.5700.21
48_L61_Y0.5650.21
34_Y48_L0.5640.21
28_V57_A0.5630.21
42_I48_L0.5580.21
38_L159_T0.5580.21
24_C57_A0.5570.21
45_I139_A0.5570.21
87_A132_S0.5560.21
34_Y38_L0.5550.21
52_Y111_L0.5510.20
63_A132_S0.5510.20
72_S127_V0.5490.20
85_V116_D0.5470.20
70_L84_S0.5430.20
86_R147_K0.5420.20
7_I93_Y0.5420.20
91_I139_A0.5360.20
113_A119_P0.5340.20
3_R148_E0.5330.20
52_Y109_F0.5300.19
76_K133_M0.5280.19
129_I155_E0.5280.19
30_K34_Y0.5240.19
100_I133_M0.5230.19
70_L81_S0.5230.19
92_K156_N0.5190.19
21_L25_I0.5180.19
6_T65_Y0.5170.19
75_D81_S0.5080.19
89_K134_V0.5080.19
35_S53_L0.5070.18
80_F155_E0.5060.18
7_I134_V0.5020.18
10_K136_A0.5010.18
64_L94_C0.5010.18
43_A78_K0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksdA 1 0.4313 8.1 0.951 Contact Map
2mc7A 1 0.1875 6.8 0.953 Contact Map
1fftB 1 0.7 6.6 0.953 Contact Map
4a2nB 1 0.675 5.9 0.954 Contact Map
4il3A 1 0.9688 5.8 0.954 Contact Map
4aw6A 2 0.9375 5.1 0.955 Contact Map
4zwjA 1 0.95 5 0.956 Contact Map
3hb3B 1 0.6562 4.1 0.957 Contact Map
4yayA 1 0.8562 4.1 0.957 Contact Map
2k1eA 3 0.4562 3.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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