PPSE - BACSU - GREMLIN Contacts

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PPSE - Plipastatin synthase subunit E

UniProt:	O31827	Sequences: MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGWCLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	1279 (1027)
Sequences:	17113 (14225)
Seq/√Len:	443.9

ECOLI - ENTF
BACSU - PPSE SRFAC PPSC PPSB DHBF SRFAA SRFAB PPSD PKSJ PKSN PPSA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
618_L	635_M	4.958	1.00
890_M	927_D	4.434	1.00
813_L	853_A	4.248	1.00
528_T	554_L	4.083	1.00
526_N	617_D	3.687	1.00
526_N	822_K	3.634	1.00
74_V	90_M	3.496	1.00
556_L	565_V	3.447	1.00
637_T	822_K	3.330	1.00
282_D	313_R	3.285	1.00
508_D	608_P	3.166	1.00
320_E	328_R	3.074	1.00
571_E	623_Y	3.070	1.00
1029_P	1032_F	2.845	1.00
508_D	548_K	2.844	1.00
757_A	775_E	2.808	1.00
984_L	1020_L	2.792	1.00
797_I	853_A	2.771	1.00
658_R	683_S	2.691	1.00
854_R	862_E	2.675	1.00
512_N	548_K	2.659	1.00
517_E	521_K	2.651	1.00
987_I	1016_V	2.648	1.00
226_S	421_D	2.618	1.00
47_T	145_E	2.611	1.00
810_P	864_I	2.605	1.00
974_I	1000_D	2.595	1.00
485_Q	489_T	2.586	1.00
980_V	1047_Y	2.564	1.00
772_T	795_A	2.525	1.00
798_L	814_C	2.520	1.00
483_R	508_D	2.512	1.00
273_M	435_A	2.497	1.00
523_F	551_G	2.495	1.00
476_H	484_E	2.495	1.00
1002_D	1005_A	2.491	1.00
797_I	861_L	2.449	1.00
322_F	439_A	2.430	1.00
64_I	172_I	2.415	1.00
700_A	704_E	2.406	1.00
816_G	846_I	2.401	1.00
640_N	768_T	2.373	1.00
413_F	425_I	2.373	1.00
715_A	739_E	2.372	1.00
505_K	509_K	2.366	1.00
514_L	541_I	2.357	1.00
516_R	609_I	2.346	1.00
795_A	815_V	2.337	1.00
277_Y	431_Q	2.322	1.00
977_R	999_I	2.313	1.00
422_A	426_S	2.308	1.00
827_R	830_L	2.298	1.00
657_D	708_T	2.294	1.00
514_L	545_A	2.260	1.00
1000_D	1040_A	2.249	1.00
990_Q	1019_T	2.246	1.00
530_G	574_A	2.236	1.00
911_T	941_W	2.235	1.00
637_T	640_N	2.235	1.00
485_Q	488_K	2.224	1.00
1002_D	1037_P	2.214	1.00
205_A	339_F	2.193	1.00
212_Y	332_E	2.167	1.00
873_I	900_L	2.160	1.00
294_S	298_G	2.156	1.00
527_E	575_K	2.152	1.00
523_F	527_E	2.144	1.00
711_F	770_F	2.135	1.00
525_K	617_D	2.130	1.00
255_A	265_L	2.125	1.00
913_Y	941_W	2.124	1.00
489_T	492_H	2.124	1.00
618_L	822_K	2.123	1.00
527_E	551_G	2.109	1.00
1021_K	1027_D	2.102	1.00
979_L	982_E	2.088	1.00
1038_T	1041_Q	2.071	1.00
978_N	1047_Y	2.070	1.00
49_K	145_E	2.068	1.00
241_F	411_I	2.063	1.00
258_H	323_H	2.059	1.00
914_V	947_M	2.054	1.00
794_T	838_H	2.045	1.00
528_T	621_I	2.042	1.00
794_T	816_G	2.035	1.00
810_P	852_L	2.028	1.00
902_E	907_A	2.021	1.00
621_I	825_L	2.018	1.00
973_I	996_T	2.014	1.00
493_T	501_S	1.999	1.00
643_S	792_N	1.998	1.00
62_Q	66_D	1.993	1.00
912_H	961_P	1.986	1.00
539_F	665_I	1.975	1.00
999_I	1039_I	1.968	1.00
67_R	168_E	1.940	1.00
431_Q	457_E	1.935	1.00
237_E	417_A	1.934	1.00
512_N	516_R	1.933	1.00
413_F	429_K	1.926	1.00
403_V	411_I	1.919	1.00
657_D	732_H	1.919	1.00
251_L	262_L	1.913	1.00
284_V	311_P	1.909	1.00
567_F	630_R	1.903	1.00
323_H	444_H	1.903	1.00
271_G	314_I	1.902	1.00
101_D	140_K	1.901	1.00
669_A	711_F	1.878	1.00
657_D	682_A	1.873	1.00
237_E	422_A	1.871	1.00
985_A	1039_I	1.866	1.00
511_S	548_K	1.861	1.00
496_V	683_S	1.843	1.00
640_N	820_V	1.843	1.00
616_D	639_R	1.833	1.00
871_M	880_P	1.832	1.00
886_R	928_L	1.829	1.00
688_D	691_T	1.829	1.00
64_I	169_F	1.823	1.00
889_E	931_V	1.819	1.00
888_L	895_E	1.817	1.00
20_L	85_P	1.810	1.00
987_I	1020_L	1.806	1.00
998_S	1001_D	1.804	1.00
649_N	791_S	1.803	1.00
884_E	898_V	1.796	1.00
113_Y	116_R	1.793	1.00
531_I	543_V	1.789	1.00
856_L	862_E	1.789	1.00
974_I	999_I	1.782	1.00
133_L	156_L	1.767	1.00
838_H	844_E	1.763	1.00
988_W	1039_I	1.752	1.00
152_H	157_M	1.750	1.00
897_A	955_I	1.747	1.00
252_K	405_P	1.746	1.00
206_A	350_N	1.744	1.00
658_R	707_I	1.744	1.00
978_N	999_I	1.741	1.00
1003_F	1008_G	1.738	1.00
58_Q	62_Q	1.734	1.00
167_Q	301_Q	1.733	1.00
1011_L	1014_L	1.719	1.00
672_F	770_F	1.718	1.00
1032_F	1045_K	1.715	1.00
567_F	623_Y	1.715	1.00
32_F	77_P	1.714	1.00
510_R	538_E	1.705	1.00
795_A	813_L	1.704	1.00
239_L	426_S	1.704	1.00
528_T	552_A	1.699	1.00
663_G	669_A	1.698	1.00
910_Y	942_V	1.697	1.00
774_F	785_P	1.697	1.00
761_I	770_F	1.693	1.00
270_W	365_E	1.691	1.00
687_I	701_Y	1.687	1.00
662_T	713_T	1.685	1.00
446_P	449_D	1.680	1.00
508_D	512_N	1.679	1.00
206_A	342_Q	1.678	1.00
1016_V	1033_L	1.678	1.00
856_L	860_N	1.676	1.00
497_Y	537_P	1.672	1.00
542_S	578_I	1.671	1.00
616_D	637_T	1.669	1.00
74_V	131_D	1.665	1.00
691_T	697_R	1.663	1.00
103_S	143_K	1.659	1.00
491_D	505_K	1.657	1.00
897_A	947_M	1.655	1.00
442_H	445_M	1.655	1.00
270_W	401_L	1.653	1.00
912_H	963_P	1.645	1.00
225_V	424_W	1.645	1.00
685_H	707_I	1.642	1.00
644_L	770_F	1.641	1.00
978_N	982_E	1.640	1.00
531_I	542_S	1.639	1.00
711_F	761_I	1.637	1.00
902_E	905_G	1.636	1.00
483_R	548_K	1.635	1.00
774_F	860_N	1.634	1.00
478_I	641_V	1.634	1.00
508_D	511_S	1.632	1.00
1036_H	1045_K	1.627	1.00
672_F	711_F	1.625	1.00
165_V	303_I	1.622	1.00
216_Y	284_V	1.616	1.00
614_S	617_D	1.614	1.00
269_V	436_L	1.612	1.00
282_D	315_K	1.610	1.00
401_L	413_F	1.604	1.00
644_L	672_F	1.603	1.00
685_H	701_Y	1.600	1.00
913_Y	943_R	1.599	1.00
673_E	711_F	1.598	1.00
496_V	705_N	1.597	1.00
78_H	82_L	1.596	1.00
61_I	136_I	1.591	1.00
451_S	458_K	1.589	1.00
694_T	697_R	1.587	1.00
560_L	568_M	1.585	1.00
524_R	527_E	1.583	1.00
502_I	541_I	1.571	1.00
799_D	803_R	1.571	1.00
841_L	844_E	1.570	1.00
566_S	570_E	1.568	1.00
73_T	87_Q	1.564	1.00
57_F	169_F	1.563	1.00
900_L	907_A	1.559	1.00
991_V	1016_V	1.557	1.00
210_D	350_N	1.557	1.00
321_T	324_E	1.556	1.00
502_I	537_P	1.549	1.00
660_I	687_I	1.547	1.00
711_F	737_G	1.544	1.00
493_T	683_S	1.544	1.00
569_L	574_A	1.534	1.00
944_V	947_M	1.533	1.00
438_T	451_S	1.523	1.00
477_T	480_D	1.519	1.00
869_R	957_R	1.516	1.00
735_Y	761_I	1.512	1.00
247_L	437_S	1.508	1.00
484_E	488_K	1.507	1.00
275_Q	316_T	1.502	1.00
207_A	211_T	1.500	1.00
795_A	853_A	1.499	1.00
701_Y	705_N	1.498	1.00
983_E	986_N	1.496	1.00
483_R	511_S	1.496	1.00
545_A	549_A	1.492	1.00
1031_D	1035_E	1.480	1.00
644_L	737_G	1.475	1.00
1009_H	1012_R	1.473	1.00
233_S	418_F	1.470	1.00
264_T	330_Q	1.466	1.00
465_F	855_W	1.457	1.00
268_A	325_L	1.455	1.00
117_F	139_F	1.450	1.00
516_R	605_N	1.449	1.00
540_M	674_M	1.447	1.00
100_E	137_S	1.446	1.00
560_L	666_S	1.445	1.00
63_A	66_D	1.442	1.00
982_E	986_N	1.430	1.00
984_L	1039_I	1.428	1.00
836_S	846_I	1.423	1.00
634_V	821_A	1.418	1.00
25_E	84_G	1.417	1.00
644_L	711_F	1.414	1.00
311_P	347_I	1.412	1.00
315_K	320_E	1.411	1.00
208_Y	336_A	1.409	1.00
981_E	999_I	1.408	1.00
562_P	566_S	1.407	1.00
876_K	935_Y	1.407	1.00
68_H	168_E	1.400	1.00
1009_H	1030_I	1.398	1.00
52_L	146_H	1.395	1.00
1020_L	1024_Q	1.393	1.00
711_F	714_T	1.391	1.00
271_G	285_F	1.390	1.00
482_F	486_A	1.389	1.00
613_S	617_D	1.388	1.00
663_G	711_F	1.387	1.00
57_F	148_C	1.387	1.00
493_T	496_V	1.381	1.00
669_A	770_F	1.376	1.00
219_P	359_D	1.375	1.00
262_L	409_L	1.374	1.00
1009_H	1013_A	1.373	1.00
886_R	931_V	1.372	1.00
114_I	147_V	1.371	1.00
771_S	815_V	1.371	1.00
521_K	592_T	1.371	1.00
898_V	911_T	1.370	1.00
737_G	770_F	1.368	1.00
977_R	1040_A	1.366	1.00
888_L	896_A	1.365	1.00
481_L	642_V	1.365	1.00
433_T	437_S	1.362	1.00
269_V	439_A	1.361	1.00
205_A	341_C	1.361	1.00
347_I	351_T	1.361	1.00
552_A	618_L	1.360	1.00
554_L	572_T	1.359	1.00
542_S	546_V	1.356	1.00
73_T	89_V	1.354	1.00
49_K	387_D	1.352	1.00
426_S	430_R	1.350	1.00
317_H	320_E	1.345	1.00
985_A	999_I	1.344	1.00
482_F	544_L	1.344	1.00
920_T	923_D	1.343	1.00
75_F	156_L	1.343	1.00
277_Y	428_I	1.342	1.00
103_S	140_K	1.340	1.00
802_G	814_C	1.337	1.00
500_M	510_R	1.329	1.00
242_S	408_E	1.328	1.00
51_S	144_D	1.328	1.00
980_V	983_E	1.327	1.00
812_E	848_R	1.327	1.00
1011_L	1030_I	1.325	1.00
571_E	827_R	1.324	1.00
356_E	359_D	1.324	1.00
479_I	638_N	1.323	1.00
270_W	367_Y	1.320	1.00
1015_Q	1019_T	1.320	1.00
977_R	981_E	1.319	1.00
983_E	1023_Q	1.318	1.00
669_A	737_G	1.316	1.00
342_Q	350_N	1.315	1.00
1009_H	1014_L	1.315	1.00
253_E	257_Q	1.315	1.00
644_L	769_T	1.314	1.00
520_Q	604_E	1.313	1.00
658_R	685_H	1.311	1.00
984_L	1043_A	1.309	1.00
17_I	86_R	1.304	1.00
203_E	207_A	1.303	1.00
476_H	480_D	1.302	1.00
244_N	437_S	1.299	1.00
1020_L	1026_I	1.297	1.00
127_D	130_K	1.294	1.00
709_V	733_T	1.294	1.00
660_I	702_L	1.293	1.00
316_T	320_E	1.291	1.00
459_E	463_T	1.289	1.00
523_F	529_A	1.286	1.00
1013_A	1017_I	1.284	1.00
671_T	769_T	1.282	1.00
880_P	898_V	1.281	1.00
254_T	440_A	1.280	1.00
973_I	998_S	1.278	1.00
172_I	184_L	1.278	1.00
796_Y	840_F	1.272	1.00
493_T	503_S	1.270	1.00
644_L	673_E	1.266	1.00
479_I	613_S	1.266	1.00
54_Y	138_L	1.265	1.00
439_A	450_F	1.264	1.00
838_H	846_I	1.263	1.00
481_L	646_R	1.260	1.00
887_L	911_T	1.256	1.00
672_F	761_I	1.256	1.00
605_N	609_I	1.256	1.00
509_K	606_D	1.255	1.00
69_D	189_P	1.253	1.00
498_G	688_D	1.252	1.00
286_G	363_V	1.250	1.00
580_Q	583_L	1.250	1.00
206_A	210_D	1.249	1.00
458_K	462_V	1.249	1.00
711_F	716_L	1.248	1.00
980_V	1046_L	1.248	1.00
116_R	120_K	1.248	1.00
314_I	329_C	1.247	1.00
497_Y	500_M	1.246	1.00
797_I	813_L	1.245	1.00
648_S	680_N	1.244	1.00
644_L	768_T	1.241	1.00
523_F	549_A	1.241	1.00
526_N	618_L	1.241	1.00
913_Y	924_F	1.238	1.00
657_D	709_V	1.235	1.00
570_E	630_R	1.233	1.00
974_I	1040_A	1.231	1.00
533_A	542_S	1.229	1.00
445_M	449_D	1.227	1.00
669_A	672_F	1.226	1.00
111_N	115_E	1.226	1.00
121_D	124_K	1.221	1.00
1017_I	1033_L	1.220	1.00
1004_F	1034_F	1.219	1.00
121_D	151_S	1.216	1.00
465_F	807_I	1.215	1.00
272_V	435_A	1.214	1.00
435_A	450_F	1.213	1.00
250_K	437_S	1.211	1.00
677_A	682_A	1.211	1.00
233_S	416_N	1.209	1.00
661_M	686_I	1.209	1.00
689_K	692_M	1.209	1.00
496_V	501_S	1.209	1.00
49_K	385_Q	1.205	1.00
985_A	997_I	1.205	1.00
1032_F	1035_E	1.205	1.00
662_T	712_L	1.204	1.00
571_E	630_R	1.202	1.00
1014_L	1030_I	1.201	1.00
58_Q	99_S	1.201	1.00
562_P	586_N	1.199	1.00
636_I	821_A	1.199	1.00
25_E	198_T	1.196	1.00
460_Q	464_Q	1.196	1.00
483_R	608_P	1.192	1.00
830_L	834_V	1.192	1.00
741_L	760_N	1.191	1.00
331_K	335_E	1.187	1.00
272_V	325_L	1.183	1.00
796_Y	838_H	1.182	1.00
63_A	172_I	1.182	1.00
47_T	387_D	1.180	1.00
1009_H	1024_Q	1.178	1.00
572_T	623_Y	1.177	1.00
268_A	329_C	1.170	1.00
486_A	508_D	1.166	1.00
717_F	736_V	1.165	1.00
1013_A	1030_I	1.161	1.00
828_V	832_N	1.161	1.00
273_M	432_F	1.160	1.00
886_R	889_E	1.158	1.00
319_D	448_A	1.157	1.00
53_S	56_W	1.157	1.00
241_F	429_K	1.155	1.00
250_K	441_Q	1.155	1.00
925_R	929_A	1.153	1.00
648_S	676_G	1.151	1.00
925_R	941_W	1.150	1.00
530_G	569_L	1.146	1.00
606_D	609_I	1.146	1.00
852_L	867_I	1.144	1.00
66_D	92_E	1.142	1.00
579_V	583_L	1.142	1.00
722_Q	748_A	1.141	1.00
235_H	418_F	1.139	1.00
239_L	422_A	1.138	1.00
873_I	878_I	1.136	1.00
706_D	730_G	1.136	1.00
767_N	815_V	1.135	1.00
53_S	173_Y	1.135	1.00
266_I	409_L	1.134	1.00
662_T	770_F	1.134	1.00
672_F	737_G	1.134	1.00
873_I	907_A	1.134	1.00
635_M	825_L	1.134	1.00
495_L	537_P	1.134	1.00
737_G	768_T	1.132	1.00
714_T	745_L	1.131	1.00
660_I	701_Y	1.130	1.00
459_E	464_Q	1.130	1.00
742_S	745_L	1.129	1.00
645_V	679_L	1.128	1.00
495_L	540_M	1.127	1.00
479_I	547_L	1.127	1.00
641_V	769_T	1.126	1.00
790_I	793_S	1.125	1.00
767_N	820_V	1.123	1.00
244_N	247_L	1.122	1.00
654_S	657_D	1.119	1.00
430_R	454_D	1.118	1.00
258_H	327_I	1.118	1.00
363_V	366_N	1.117	1.00
76_L	88_V	1.115	1.00
983_E	1024_Q	1.112	1.00
581_K	597_D	1.111	1.00
421_D	424_W	1.111	1.00
662_T	716_L	1.110	1.00
470_T	792_N	1.109	1.00
560_L	951_G	1.107	1.00
75_F	155_I	1.105	1.00
749_V	758_L	1.105	1.00
821_A	835_F	1.102	1.00
794_T	844_E	1.102	1.00
653_A	682_A	1.101	1.00
673_E	761_I	1.101	1.00
212_Y	335_E	1.100	1.00
239_L	429_K	1.099	1.00
538_E	580_Q	1.099	1.00
636_I	768_T	1.097	1.00
1013_A	1033_L	1.096	1.00
1036_H	1041_Q	1.096	1.00
27_M	305_L	1.095	1.00
449_D	803_R	1.094	1.00
58_Q	96_H	1.091	1.00
420_Y	425_I	1.090	1.00
22_H	197_L	1.090	1.00
759_H	775_E	1.089	1.00
644_L	716_L	1.088	1.00
815_V	849_T	1.087	1.00
138_L	148_C	1.085	1.00
713_T	770_F	1.082	1.00
208_Y	212_Y	1.082	1.00
807_I	855_W	1.081	1.00
567_F	571_E	1.080	1.00
415_Y	425_I	1.076	1.00
988_W	1008_G	1.076	1.00
208_Y	335_E	1.075	1.00
733_T	759_H	1.074	1.00
677_A	684_L	1.070	1.00
927_D	931_V	1.068	1.00
718_N	742_S	1.068	1.00
563_E	567_F	1.067	1.00
128_L	155_I	1.067	1.00
483_R	512_N	1.067	1.00
672_F	716_L	1.066	1.00
767_N	771_S	1.065	1.00
663_G	712_L	1.064	1.00
250_K	440_A	1.064	1.00
673_E	770_F	1.063	1.00
193_Y	196_W	1.061	1.00
237_E	415_Y	1.061	1.00
238_D	414_S	1.060	1.00
511_S	545_A	1.059	1.00
788_K	860_N	1.059	1.00
400_N	414_S	1.059	1.00
482_F	508_D	1.055	1.00
1020_L	1046_L	1.055	1.00
999_I	1040_A	1.054	1.00
533_A	578_I	1.053	1.00
45_L	147_V	1.051	1.00
211_T	214_K	1.050	1.00
521_K	576_M	1.050	1.00
989_K	996_T	1.049	1.00
248_T	409_L	1.047	1.00
712_L	717_F	1.046	1.00
1009_H	1020_L	1.046	1.00
401_L	411_I	1.044	1.00
547_L	619_A	1.043	1.00
560_L	935_Y	1.040	1.00
743_P	747_N	1.038	1.00
472_Y	792_N	1.036	1.00
1019_T	1023_Q	1.035	1.00
513_A	606_D	1.035	1.00
710_L	731_L	1.034	1.00
503_S	506_E	1.032	1.00
869_R	884_E	1.032	1.00
1020_L	1028_I	1.031	1.00
668_D	764_P	1.029	1.00
924_F	941_W	1.029	1.00
746_M	758_L	1.028	1.00
644_L	771_S	1.028	1.00
796_Y	816_G	1.025	1.00
645_V	676_G	1.024	1.00
275_Q	278_N	1.024	1.00
890_M	924_F	1.023	1.00
772_T	786_I	1.022	1.00
62_Q	94_E	1.020	1.00
661_M	684_L	1.019	1.00
718_N	745_L	1.019	1.00
534_A	580_Q	1.018	1.00
1016_V	1042_L	1.017	1.00
31_S	36_E	1.017	1.00
58_Q	97_L	1.016	1.00
45_L	149_I	1.015	1.00
1017_I	1021_K	1.015	1.00
480_D	483_R	1.014	1.00
260_V	264_T	1.013	1.00
121_D	137_S	1.013	1.00
427_C	431_Q	1.012	1.00
114_I	139_F	1.008	1.00
737_G	761_I	1.008	1.00
797_I	805_L	1.005	1.00
460_Q	465_F	1.005	1.00
242_S	410_V	0.999	1.00
537_P	541_I	0.998	1.00
519_I	613_S	0.996	1.00
78_H	83_S	0.996	1.00
72_R	89_V	0.996	1.00
526_N	551_G	0.995	1.00
814_C	848_R	0.995	1.00
543_V	674_M	0.994	1.00
736_V	741_L	0.994	1.00
1026_I	1046_L	0.993	1.00
56_W	173_Y	0.992	1.00
764_P	770_F	0.989	1.00
54_Y	99_S	0.986	1.00
530_G	556_L	0.985	1.00
468_T	792_N	0.984	1.00
901_R	962_I	0.984	1.00
47_T	147_V	0.984	1.00
247_L	440_A	0.982	1.00
136_I	150_W	0.982	1.00
517_E	594_I	0.980	1.00
552_A	621_I	0.980	1.00
510_R	513_A	0.979	1.00
201_D	204_K	0.979	1.00
489_T	505_K	0.977	1.00
947_M	955_I	0.977	1.00
215_N	313_R	0.975	1.00
988_W	1042_L	0.975	1.00
688_D	697_R	0.973	1.00
553_Y	671_T	0.972	1.00
434_Q	454_D	0.971	1.00
14_I	18_Y	0.970	1.00
714_T	770_F	0.969	1.00
118_K	149_I	0.967	1.00
21_S	190_Y	0.966	1.00
346_D	349_A	0.966	1.00
519_I	609_I	0.965	1.00
750_R	778_R	0.965	1.00
814_C	836_S	0.964	1.00
669_A	764_P	0.964	1.00
320_E	324_E	0.962	1.00
714_T	717_F	0.962	1.00
984_L	1042_L	0.961	1.00
266_I	403_V	0.958	1.00
647_N	790_I	0.958	1.00
512_N	608_P	0.957	1.00
136_I	148_C	0.955	1.00
74_V	88_V	0.955	1.00
912_H	960_L	0.954	1.00
258_H	326_L	0.954	1.00
973_I	976_P	0.952	1.00
500_M	537_P	0.951	1.00
740_A	863_Y	0.951	1.00
810_P	867_I	0.951	1.00
517_E	520_Q	0.950	1.00
451_S	803_R	0.950	1.00
78_H	84_G	0.949	1.00
994_V	997_I	0.949	1.00
251_L	265_L	0.948	1.00
260_V	326_L	0.948	1.00
673_E	716_L	0.947	1.00
240_I	411_I	0.945	1.00
881_A	884_E	0.943	1.00
790_I	819_G	0.942	1.00
713_T	761_I	0.942	1.00
718_N	744_A	0.942	1.00
853_A	863_Y	0.940	1.00
643_S	818_D	0.940	1.00
203_E	206_A	0.939	1.00
281_D	800_T	0.936	1.00
980_V	1024_Q	0.936	1.00
697_R	700_A	0.936	1.00
466_N	792_N	0.935	1.00
254_T	258_H	0.933	1.00
799_D	805_L	0.933	1.00
117_F	137_S	0.933	1.00
653_A	709_V	0.930	1.00
774_F	777_K	0.930	1.00
682_A	708_T	0.929	1.00
639_R	818_D	0.929	1.00
662_T	692_M	0.928	1.00
663_G	673_E	0.927	1.00
890_M	928_L	0.926	1.00
976_P	999_I	0.925	1.00
267_Q	285_F	0.925	1.00
99_S	140_K	0.925	1.00
496_V	685_H	0.925	1.00
772_T	861_L	0.924	1.00
367_Y	432_F	0.921	1.00
712_L	770_F	0.920	1.00
741_L	746_M	0.919	1.00
484_E	487_E	0.916	1.00
716_L	770_F	0.916	1.00
991_V	1012_R	0.916	1.00
333_M	337_E	0.915	1.00
324_E	327_I	0.909	1.00
662_T	749_V	0.906	1.00
717_F	734_L	0.905	1.00
644_L	662_T	0.903	1.00
1039_I	1042_L	0.901	1.00
717_F	770_F	0.900	1.00
42_E	157_M	0.898	1.00
482_F	679_L	0.898	1.00
890_M	923_D	0.898	1.00
644_L	761_I	0.895	1.00
266_I	369_L	0.895	1.00
267_Q	333_M	0.893	1.00
733_T	757_A	0.892	1.00
361_I	366_N	0.891	1.00
555_P	765_T	0.891	1.00
620_Y	636_I	0.889	1.00
662_T	687_I	0.889	1.00
647_N	650_Y	0.888	1.00
26_G	345_F	0.887	1.00
328_R	332_E	0.887	1.00
986_N	1023_Q	0.887	1.00
140_K	146_H	0.887	1.00
1012_R	1015_Q	0.884	1.00
647_N	713_T	0.882	1.00
555_P	622_M	0.882	1.00
434_Q	438_T	0.879	1.00
264_T	334_L	0.879	1.00
510_R	541_I	0.879	1.00
289_V	337_E	0.878	1.00
365_E	368_P	0.878	1.00
670_V	674_M	0.874	1.00
884_E	911_T	0.873	1.00
898_V	909_L	0.873	1.00
902_E	906_E	0.872	1.00
367_Y	403_V	0.872	1.00
347_I	350_N	0.872	1.00
644_L	669_A	0.870	1.00
989_K	995_N	0.867	1.00
22_H	198_T	0.867	1.00
622_M	765_T	0.866	1.00
746_M	776_M	0.865	1.00
663_G	770_F	0.863	1.00
516_R	519_I	0.863	1.00
321_T	446_P	0.862	1.00
344_L	348_Q	0.862	1.00
260_V	265_L	0.859	1.00
903_K	908_Q	0.859	1.00
52_L	138_L	0.858	1.00
647_N	791_S	0.858	1.00
528_T	551_G	0.857	1.00
247_L	250_K	0.856	1.00
974_I	977_R	0.856	1.00
702_L	706_D	0.854	1.00
70_I	75_F	0.854	1.00
487_E	608_P	0.854	1.00
248_T	252_K	0.853	1.00
477_T	638_N	0.852	1.00
563_E	630_R	0.851	1.00
798_L	846_I	0.850	1.00
560_L	565_V	0.850	1.00
1014_L	1018_H	0.849	1.00
702_L	730_G	0.847	1.00
509_K	513_A	0.847	1.00
711_F	769_T	0.846	1.00
687_I	698_F	0.846	1.00
190_Y	193_Y	0.846	1.00
725_A	728_F	0.845	1.00
175_S	179_G	0.843	1.00
554_L	574_A	0.842	1.00
734_L	749_V	0.842	1.00
139_F	149_I	0.841	1.00
785_P	860_N	0.840	1.00
927_D	930_R	0.839	1.00
838_H	841_L	0.839	1.00
669_A	761_I	0.839	1.00
20_L	75_F	0.838	1.00
711_F	717_F	0.837	1.00
981_E	1043_A	0.837	1.00
713_T	737_G	0.836	1.00
541_I	545_A	0.835	1.00
17_I	78_H	0.833	1.00
449_D	801_K	0.833	1.00
273_M	277_Y	0.832	1.00
52_L	57_F	0.831	1.00
364_F	368_P	0.831	1.00
661_M	711_F	0.830	1.00
892_G	927_D	0.830	1.00
478_I	547_L	0.830	1.00
771_S	795_A	0.830	1.00
921_D	941_W	0.830	1.00
239_L	425_I	0.829	1.00
741_L	758_L	0.829	1.00
563_E	566_S	0.828	1.00
661_M	672_F	0.827	1.00
985_A	989_K	0.827	1.00
786_I	863_Y	0.826	1.00
43_Q	151_S	0.826	1.00
463_T	466_N	0.825	1.00
640_N	643_S	0.822	1.00
663_G	672_F	0.821	1.00
263_A	287_A	0.819	1.00
767_N	770_F	0.818	1.00
997_I	1006_I	0.817	1.00
641_V	671_T	0.817	1.00
663_G	761_I	0.817	1.00
576_M	594_I	0.816	1.00
187_V	302_M	0.816	1.00
661_M	673_E	0.815	1.00
899_T	912_H	0.813	1.00
26_G	305_L	0.813	1.00
48_I	386_I	0.812	1.00
661_M	669_A	0.812	1.00
172_I	182_L	0.811	1.00
761_I	773_F	0.811	1.00
512_N	519_I	0.811	1.00
698_F	716_L	0.810	1.00
923_D	926_A	0.809	1.00
125_G	135_R	0.809	1.00
598_A	602_M	0.808	1.00
598_A	601_L	0.807	1.00
660_I	707_I	0.806	1.00
500_M	538_E	0.805	1.00
659_F	677_A	0.804	1.00
853_A	864_I	0.804	1.00
1033_L	1042_L	0.802	1.00
713_T	716_L	0.802	1.00
676_G	770_F	0.802	1.00
470_T	649_N	0.802	1.00
273_M	428_I	0.801	1.00
672_F	771_S	0.800	1.00
167_Q	171_Q	0.799	1.00
432_F	436_L	0.799	1.00
23_M	305_L	0.799	1.00
711_F	736_V	0.799	1.00
702_L	710_L	0.798	1.00
669_A	673_E	0.797	1.00
20_L	155_I	0.797	1.00
687_I	691_T	0.797	1.00
662_T	672_F	0.796	1.00
55_D	58_Q	0.796	1.00
806_P	809_V	0.795	1.00
250_K	253_E	0.795	1.00
207_A	210_D	0.795	1.00
533_A	580_Q	0.794	1.00
479_I	483_R	0.794	1.00
711_F	771_S	0.792	1.00
240_I	412_K	0.792	1.00
255_A	260_V	0.791	1.00
670_V	711_F	0.790	1.00
264_T	326_L	0.789	1.00
247_L	433_T	0.788	1.00
461_I	804_L	0.787	1.00
669_A	769_T	0.786	1.00
853_A	861_L	0.786	1.00
461_I	855_W	0.786	1.00
114_I	118_K	0.785	1.00
717_F	749_V	0.785	1.00
926_A	930_R	0.785	1.00
346_D	350_N	0.785	1.00
532_L	565_V	0.784	1.00
454_D	457_E	0.784	1.00
507_L	541_I	0.784	1.00
309_T	366_N	0.783	1.00
645_V	675_F	0.783	1.00
462_V	804_L	0.782	1.00
661_M	770_F	0.782	1.00
363_V	368_P	0.782	1.00
272_V	447_I	0.781	1.00
1020_L	1029_P	0.781	1.00
1009_H	1026_I	0.781	1.00
768_T	771_S	0.780	1.00
653_A	657_D	0.780	1.00
640_N	821_A	0.780	1.00
519_I	612_S	0.780	1.00
240_I	410_V	0.780	1.00
636_I	640_N	0.779	1.00
798_L	804_L	0.779	1.00
647_N	761_I	0.779	1.00
670_V	673_E	0.778	1.00
241_F	433_T	0.777	1.00
737_G	771_S	0.777	1.00
142_A	145_E	0.777	1.00
109_D	112_E	0.776	1.00
712_L	716_L	0.776	1.00
29_F	33_L	0.775	1.00
672_F	769_T	0.775	1.00
976_P	981_E	0.773	1.00
528_T	574_A	0.773	1.00
189_P	192_T	0.773	1.00
152_H	156_L	0.773	1.00
121_D	135_R	0.772	1.00
986_N	990_Q	0.772	1.00
1020_L	1030_I	0.772	1.00
568_M	666_S	0.772	1.00
651_T	672_F	0.772	1.00
64_I	165_V	0.771	1.00
540_M	678_L	0.770	1.00
855_W	861_L	0.769	1.00
711_F	767_N	0.769	1.00
532_L	556_L	0.767	1.00
854_R	864_I	0.767	1.00
908_Q	940_H	0.766	1.00
672_F	713_T	0.766	1.00
485_Q	490_P	0.765	1.00
462_V	796_Y	0.765	1.00
761_I	769_T	0.765	1.00
672_F	717_F	0.764	1.00
771_S	819_G	0.764	1.00
533_A	579_V	0.764	1.00
270_W	432_F	0.764	1.00
796_Y	846_I	0.763	1.00
988_W	1016_V	0.763	1.00
696_D	723_V	0.763	1.00
41_V	151_S	0.762	1.00
669_A	712_L	0.761	1.00
14_I	69_D	0.760	1.00
512_N	609_I	0.760	1.00
795_A	861_L	0.760	1.00
884_E	957_R	0.759	1.00
267_Q	271_G	0.759	1.00
69_D	72_R	0.758	1.00
228_K	419_V	0.757	1.00
248_T	262_L	0.756	1.00
315_K	328_R	0.756	1.00
358_I	363_V	0.754	1.00
264_T	337_E	0.754	1.00
789_P	795_A	0.753	1.00
771_S	793_S	0.752	1.00
537_P	686_I	0.751	1.00
57_F	173_Y	0.751	1.00
1014_L	1031_D	0.749	1.00
266_I	432_F	0.749	1.00
434_Q	437_S	0.749	1.00
267_Q	367_Y	0.748	1.00
135_R	151_S	0.748	1.00
793_S	819_G	0.747	1.00
737_G	764_P	0.747	1.00
1018_H	1021_K	0.747	1.00
976_P	985_A	0.746	1.00
479_I	486_A	0.746	1.00
669_A	716_L	0.745	1.00
475_N	639_R	0.744	1.00
647_N	770_F	0.743	1.00
999_I	1043_A	0.743	1.00
663_G	716_L	0.742	1.00
115_E	119_E	0.742	1.00
576_M	592_T	0.742	1.00
361_I	365_E	0.741	1.00
273_M	431_Q	0.741	1.00
251_L	440_A	0.740	1.00
299_V	302_M	0.739	1.00
74_V	132_M	0.738	1.00
814_C	846_I	0.738	1.00
594_I	598_A	0.738	1.00
567_F	827_R	0.738	1.00
659_F	712_L	0.737	1.00
653_A	676_G	0.736	1.00
658_R	706_D	0.736	1.00
514_L	578_I	0.736	1.00
1032_F	1036_H	0.735	1.00
896_A	928_L	0.734	1.00
245_K	249_D	0.733	1.00
712_L	720_L	0.733	1.00
672_F	676_G	0.732	1.00
774_F	784_I	0.732	1.00
759_H	773_F	0.732	1.00
249_D	253_E	0.731	1.00
349_A	1009_H	0.730	1.00
973_I	1001_D	0.730	1.00
481_L	679_L	0.730	1.00
929_A	934_D	0.729	1.00
554_L	568_M	0.729	1.00
262_L	440_A	0.728	1.00
507_L	544_L	0.728	1.00
671_T	675_F	0.727	1.00
253_E	256_K	0.727	1.00
517_E	604_E	0.727	1.00
205_A	342_Q	0.727	1.00
978_N	981_E	0.727	1.00
1037_P	1041_Q	0.725	1.00
411_I	429_K	0.725	1.00
814_C	834_V	0.725	1.00
984_L	1016_V	0.723	1.00
190_Y	306_F	0.721	1.00
281_D	315_K	0.721	1.00
270_W	403_V	0.721	1.00
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168_E	303_I	0.719	1.00
543_V	665_I	0.718	1.00
206_A	346_D	0.718	1.00
530_G	572_T	0.717	1.00
839_P	846_I	0.717	1.00
97_L	138_L	0.717	1.00
97_L	136_I	0.717	1.00
513_A	517_E	0.717	1.00
979_L	983_E	0.716	1.00
887_L	896_A	0.715	1.00
252_K	256_K	0.715	1.00
883_I	909_L	0.714	1.00
816_G	844_E	0.714	1.00
669_A	713_T	0.714	1.00
238_D	412_K	0.713	1.00
343_P	346_D	0.713	1.00
368_P	400_N	0.711	1.00
160_W	290_S	0.710	1.00
534_A	689_K	0.707	1.00
493_T	497_Y	0.706	1.00
102_I	110_Q	0.705	1.00
827_R	833_A	0.705	1.00
532_L	558_A	0.705	1.00
896_A	911_T	0.705	1.00
516_R	608_P	0.703	1.00
984_L	987_I	0.702	1.00
244_N	433_T	0.701	1.00
241_F	430_R	0.700	1.00
1037_P	1042_L	0.700	1.00
150_W	165_V	0.699	1.00
49_K	144_D	0.697	1.00
571_E	826_N	0.697	1.00
660_I	698_F	0.697	1.00
15_K	195_S	0.697	1.00
18_Y	89_V	0.696	1.00
715_A	949_L	0.696	1.00
906_E	1009_H	0.696	1.00
647_N	662_T	0.695	1.00
889_E	927_D	0.695	1.00
676_G	711_F	0.695	1.00
714_T	718_N	0.695	1.00
534_A	582_G	0.695	1.00
901_R	963_P	0.695	1.00
316_T	447_I	0.694	1.00
894_Q	914_V	0.694	1.00
1011_L	1024_Q	0.693	1.00
477_T	613_S	0.692	1.00
168_E	172_I	0.691	1.00
337_E	340_T	0.690	1.00
499_N	704_E	0.690	1.00
564_R	882_E	0.690	1.00
134_M	150_W	0.689	1.00
269_V	432_F	0.689	1.00
269_V	435_A	0.687	1.00
669_A	736_V	0.686	1.00
119_E	123_Q	0.686	1.00
481_L	485_Q	0.686	1.00
243_L	433_T	0.686	1.00
663_G	764_P	0.685	1.00
659_F	709_V	0.685	1.00
157_M	162_L	0.685	1.00
659_F	770_F	0.684	1.00
1001_D	1006_I	0.684	1.00
430_R	433_T	0.683	1.00
492_H	656_D	0.683	1.00
734_L	756_L	0.683	1.00
672_F	714_T	0.682	1.00
522_G	551_G	0.682	1.00
161_C	303_I	0.682	1.00
45_L	118_K	0.682	1.00
662_T	711_F	0.682	1.00
573_Q	826_N	0.681	1.00
395_S	414_S	0.681	1.00
816_G	820_V	0.681	1.00
711_F	741_L	0.681	1.00
618_L	637_T	0.680	1.00
747_N	751_H	0.679	1.00
192_T	196_W	0.678	1.00
110_Q	113_Y	0.678	1.00
710_L	734_L	0.677	1.00
100_E	117_F	0.677	1.00
659_F	711_F	0.677	1.00
513_A	516_R	0.676	1.00
666_S	952_N	0.676	1.00
721_A	749_V	0.675	1.00
67_R	172_I	0.675	1.00
651_T	761_I	0.675	1.00
270_W	285_F	0.675	1.00
211_T	335_E	0.675	1.00
661_M	749_V	0.674	1.00
736_V	761_I	0.673	1.00
664_S	711_F	0.673	1.00
685_H	705_N	0.673	1.00
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50_G	146_H	0.672	1.00
109_D	113_Y	0.672	1.00
528_T	618_L	0.671	1.00
1021_K	1026_I	0.671	1.00
816_G	838_H	0.671	1.00
289_V	310_I	0.671	1.00
711_F	735_Y	0.670	1.00
23_M	26_G	0.669	1.00
677_A	680_N	0.669	1.00
217_S	284_V	0.669	1.00
802_G	846_I	0.669	1.00
956_D	959_A	0.668	1.00
647_N	672_F	0.667	1.00
514_L	517_E	0.667	1.00
644_L	670_V	0.666	1.00
1024_Q	1027_D	0.666	1.00
465_F	468_T	0.666	1.00
175_S	182_L	0.665	1.00
517_E	601_L	0.665	1.00
70_I	73_T	0.665	1.00
316_T	325_L	0.663	1.00
437_S	441_Q	0.663	1.00
925_R	1005_A	0.662	1.00
568_M	633_G	0.661	1.00
605_N	608_P	0.661	1.00
460_Q	463_T	0.661	1.00
870_Q	879_E	0.661	1.00
281_D	317_H	0.660	1.00
659_F	764_P	0.659	1.00
60_S	172_I	0.659	1.00
712_L	749_V	0.658	1.00
15_K	91_T	0.657	1.00
100_E	139_F	0.656	1.00
67_R	184_L	0.656	1.00
1035_E	1045_K	0.654	1.00
644_L	647_N	0.653	1.00
499_N	705_N	0.653	1.00
461_I	465_F	0.652	1.00
523_F	576_M	0.652	1.00
476_H	481_L	0.652	1.00
802_G	836_S	0.651	1.00
937_I	941_W	0.651	1.00
692_M	713_T	0.651	1.00
254_T	265_L	0.651	1.00
141_T	147_V	0.650	1.00
362_I	368_P	0.650	1.00
266_I	367_Y	0.649	0.99
1016_V	1020_L	0.648	0.99
533_A	539_F	0.648	0.99
212_Y	336_A	0.647	0.99
745_L	748_A	0.646	0.99
272_V	322_F	0.646	0.99
621_I	635_M	0.646	0.99
244_N	248_T	0.645	0.99
615_P	639_R	0.645	0.99
764_P	771_S	0.645	0.99
403_V	409_L	0.645	0.99
529_A	551_G	0.644	0.99
431_Q	454_D	0.644	0.99
1017_I	1030_I	0.644	0.99
56_W	60_S	0.643	0.99
641_V	768_T	0.643	0.99
660_I	672_F	0.643	0.99
671_T	770_F	0.642	0.99
802_G	839_P	0.642	0.99
175_S	180_K	0.640	0.99
15_K	69_D	0.640	0.99
761_I	764_P	0.640	0.99
18_Y	191_S	0.639	0.99
805_L	809_V	0.639	0.99
1017_I	1031_D	0.638	0.99
472_Y	818_D	0.637	0.99
93_R	131_D	0.637	0.99
381_D	386_I	0.636	0.99
662_T	673_E	0.636	0.99
613_S	638_N	0.636	0.99
232_E	416_N	0.635	0.99
658_R	708_T	0.635	0.99
659_F	682_A	0.634	0.99
1008_G	1013_A	0.634	0.99
661_M	670_V	0.634	0.99
62_Q	95_F	0.633	0.99
762_Y	786_I	0.633	0.99
942_V	963_P	0.632	0.99
659_F	669_A	0.631	0.99
916_D	919_K	0.631	0.99
1024_Q	1046_L	0.630	0.99
673_E	736_V	0.630	0.99
361_I	364_F	0.629	0.99
880_P	909_L	0.629	0.99
643_S	770_F	0.629	0.99
200_R	203_E	0.628	0.99
342_Q	347_I	0.628	0.99
495_L	502_I	0.627	0.99
659_F	672_F	0.627	0.99
671_T	749_V	0.627	0.99
635_M	822_K	0.627	0.99
1032_F	1049_K	0.626	0.99
901_R	910_Y	0.626	0.99
712_L	736_V	0.626	0.99
837_P	843_G	0.626	0.99
764_P	768_T	0.625	0.99
712_L	764_P	0.625	0.99
1011_L	1037_P	0.624	0.99
672_F	712_L	0.624	0.99
516_R	607_I	0.623	0.99
1017_I	1028_I	0.623	0.99
797_I	855_W	0.623	0.99
662_T	735_Y	0.622	0.99
674_M	678_L	0.621	0.99
713_T	721_A	0.621	0.99
455_A	459_E	0.621	0.99
311_P	314_I	0.620	0.99
112_E	116_R	0.620	0.99
891_E	927_D	0.619	0.99
736_V	770_F	0.619	0.99
659_F	673_E	0.619	0.99
687_I	692_M	0.619	0.99
737_G	767_N	0.619	0.99
647_N	651_T	0.618	0.99
714_T	761_I	0.618	0.99
976_P	998_S	0.618	0.99
530_G	577_L	0.618	0.99
662_T	737_G	0.618	0.99
834_V	867_I	0.617	0.99
427_C	457_E	0.617	0.99
63_A	182_L	0.617	0.99
141_T	145_E	0.617	0.99
559_E	689_K	0.616	0.99
987_I	991_V	0.616	0.99
714_T	736_V	0.615	0.99
973_I	985_A	0.615	0.99
531_I	546_V	0.614	0.99
302_M	306_F	0.614	0.99
1011_L	1015_Q	0.614	0.99
673_E	769_T	0.612	0.99
662_T	669_A	0.612	0.99
216_Y	311_P	0.612	0.99
692_M	716_L	0.612	0.99
989_K	994_V	0.611	0.99
746_M	750_R	0.611	0.99
644_L	767_N	0.611	0.99
75_F	133_L	0.610	0.99
567_F	570_E	0.610	0.99
518_L	522_G	0.609	0.99
464_Q	467_N	0.609	0.99
425_I	429_K	0.609	0.99
702_L	707_I	0.609	0.99
715_A	740_A	0.609	0.99
989_K	997_I	0.608	0.99
1030_I	1037_P	0.608	0.99
132_M	156_L	0.608	0.99
990_Q	1023_Q	0.608	0.99
656_D	708_T	0.607	0.99
77_P	83_S	0.607	0.99
220_S	365_E	0.607	0.99
470_T	791_S	0.606	0.99
31_S	34_R	0.606	0.99
899_T	961_P	0.605	0.99
659_F	761_I	0.604	0.99
718_N	748_A	0.604	0.99
880_P	936_M	0.604	0.99
739_E	863_Y	0.604	0.99
651_T	735_Y	0.603	0.99
667_F	670_V	0.602	0.99
677_A	711_F	0.602	0.99
713_T	719_Q	0.602	0.99
912_H	964_E	0.602	0.99
750_R	777_K	0.601	0.99
912_H	944_V	0.601	0.99
330_Q	334_L	0.601	0.99
662_T	721_A	0.601	0.99
98_N	124_K	0.600	0.99
651_T	711_F	0.600	0.99
895_E	947_M	0.600	0.99
204_K	207_A	0.599	0.99
262_L	369_L	0.599	0.99
581_K	595_I	0.598	0.99
31_S	37_E	0.598	0.99
676_G	761_I	0.598	0.99
674_M	684_L	0.597	0.99
587_A	590_S	0.597	0.99
662_T	698_F	0.596	0.99
670_V	761_I	0.596	0.99
569_L	577_L	0.596	0.99
528_T	825_L	0.595	0.99
60_S	169_F	0.595	0.99
783_P	862_E	0.595	0.99
157_M	303_I	0.594	0.99
521_K	594_I	0.594	0.99
67_R	187_V	0.593	0.99
257_Q	323_H	0.593	0.99
174_Q	382_S	0.593	0.99
359_D	364_F	0.593	0.99
270_W	413_F	0.593	0.99
662_T	769_T	0.592	0.99
695_P	716_L	0.592	0.99
496_V	658_R	0.592	0.99
640_N	818_D	0.591	0.99
736_V	758_L	0.591	0.99
455_A	458_K	0.590	0.99
712_L	734_L	0.590	0.99
840_F	846_I	0.589	0.99
812_E	852_L	0.588	0.99
910_Y	940_H	0.588	0.99
676_G	712_L	0.587	0.99
492_H	683_S	0.586	0.99
915_G	919_K	0.586	0.99
157_M	165_V	0.586	0.99
1028_I	1042_L	0.586	0.99
17_I	88_V	0.586	0.99
1024_Q	1029_P	0.586	0.99
1030_I	1033_L	0.585	0.99
883_I	898_V	0.585	0.99
423_A	426_S	0.585	0.99
669_A	771_S	0.585	0.99
453_L	461_I	0.585	0.99
895_E	946_R	0.585	0.99
903_K	906_E	0.584	0.99
553_Y	670_V	0.584	0.99
201_D	205_A	0.584	0.99
281_D	318_Q	0.584	0.99
466_N	855_W	0.584	0.99
716_L	749_V	0.583	0.99
16_N	191_S	0.583	0.99
52_L	384_L	0.583	0.99
78_H	86_R	0.581	0.99
940_H	943_R	0.581	0.99
164_I	303_I	0.581	0.99
627_S	881_A	0.581	0.99
65_I	95_F	0.580	0.99
1013_A	1031_D	0.580	0.99
689_K	693_L	0.579	0.99
735_Y	770_F	0.579	0.99
275_Q	283_V	0.579	0.99
311_P	362_I	0.579	0.99
152_H	165_V	0.578	0.99
362_I	366_N	0.578	0.99
984_L	1046_L	0.578	0.99
1026_I	1029_P	0.578	0.99
647_N	659_F	0.578	0.99
988_W	1003_F	0.577	0.99
767_N	793_S	0.577	0.99
584_E	595_I	0.577	0.99
675_F	713_T	0.576	0.99
712_L	761_I	0.576	0.99
65_I	134_M	0.576	0.99
661_M	677_A	0.576	0.99
575_K	592_T	0.575	0.99
322_F	443_P	0.574	0.99
506_E	509_K	0.574	0.99
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1020_L	1032_F	0.574	0.99
565_V	569_L	0.574	0.99
669_A	717_F	0.573	0.99
659_F	676_G	0.572	0.99
366_N	370_Q	0.572	0.99
70_I	303_I	0.572	0.99
536_S	686_I	0.572	0.99
1009_H	1037_P	0.572	0.99
711_F	746_M	0.572	0.99
650_Y	775_E	0.572	0.99
761_I	767_N	0.571	0.99
711_F	715_A	0.571	0.99
746_M	749_V	0.571	0.99
263_A	267_Q	0.571	0.99
659_F	716_L	0.570	0.99
415_Y	420_Y	0.570	0.99
714_T	740_A	0.570	0.99
617_D	822_K	0.570	0.99
519_I	549_A	0.570	0.99
1011_L	1020_L	0.569	0.99
41_V	126_F	0.569	0.99
829_D	833_A	0.569	0.99
19_P	195_S	0.569	0.99
661_M	674_M	0.569	0.99
682_A	711_F	0.568	0.99
661_M	712_L	0.568	0.99
1015_Q	1018_H	0.568	0.99
220_S	274_L	0.568	0.99
202_K	346_D	0.568	0.99
749_V	756_L	0.567	0.99
764_P	767_N	0.567	0.99
560_L	664_S	0.567	0.99
523_F	575_K	0.566	0.99
506_E	510_R	0.566	0.99
542_S	545_A	0.566	0.99
61_I	97_L	0.565	0.99
322_F	435_A	0.565	0.99
672_F	709_V	0.565	0.99
35_K	38_G	0.565	0.99
669_A	735_Y	0.564	0.99
557_D	560_L	0.564	0.99
554_L	623_Y	0.564	0.99
368_P	371_Q	0.564	0.99
486_A	505_K	0.564	0.99
477_T	642_V	0.563	0.99
830_L	833_A	0.563	0.99
505_K	508_D	0.563	0.99
651_T	770_F	0.563	0.99
126_F	135_R	0.563	0.99
248_T	405_P	0.563	0.99
929_A	937_I	0.563	0.99
619_A	641_V	0.563	0.99
975_L	999_I	0.562	0.99
54_Y	146_H	0.561	0.99
121_D	149_I	0.561	0.99
380_T	385_Q	0.561	0.99
358_I	365_E	0.561	0.99
453_L	458_K	0.559	0.99
644_L	676_G	0.559	0.99
413_F	432_F	0.559	0.99
560_L	567_F	0.559	0.99
713_T	717_F	0.558	0.98
661_M	713_T	0.558	0.98
268_A	326_L	0.557	0.98
715_A	955_I	0.557	0.98
640_N	819_G	0.557	0.98
430_R	434_Q	0.556	0.98
168_E	171_Q	0.556	0.98
260_V	330_Q	0.555	0.98
663_G	749_V	0.555	0.98
892_G	923_D	0.555	0.98
76_L	86_R	0.554	0.98
814_C	867_I	0.554	0.98
486_A	490_P	0.554	0.98
1017_I	1020_L	0.554	0.98
878_I	936_M	0.554	0.98
507_L	511_S	0.553	0.98
396_G	414_S	0.553	0.98
540_M	686_I	0.552	0.98
287_A	312_I	0.552	0.98
320_E	325_L	0.552	0.98
260_V	268_A	0.551	0.98
994_V	1006_I	0.550	0.98
267_Q	312_I	0.550	0.98
138_L	146_H	0.550	0.98
923_D	927_D	0.549	0.98
659_F	663_G	0.549	0.98
363_V	369_L	0.549	0.98
512_N	611_I	0.549	0.98
264_T	333_M	0.549	0.98
235_H	417_A	0.546	0.98
26_G	30_H	0.546	0.98
54_Y	140_K	0.546	0.98
89_V	191_S	0.546	0.98
473_P	646_R	0.545	0.98
480_D	612_S	0.545	0.98
1026_I	1049_K	0.545	0.98
703_L	727_M	0.545	0.98
893_V	896_A	0.544	0.98
103_S	146_H	0.544	0.98
760_N	863_Y	0.544	0.98
366_N	400_N	0.543	0.98
403_V	432_F	0.543	0.98
670_V	770_F	0.543	0.98
61_I	165_V	0.542	0.98
1003_F	1016_V	0.542	0.98
991_V	1019_T	0.541	0.98
663_G	736_V	0.541	0.98
184_L	187_V	0.541	0.98
335_E	338_P	0.541	0.98
588_A	591_G	0.541	0.98
322_F	326_L	0.541	0.98
358_I	364_F	0.540	0.98
28_L	85_P	0.540	0.98
315_K	318_Q	0.540	0.98
19_P	87_Q	0.539	0.98
732_H	757_A	0.539	0.98
98_N	121_D	0.539	0.98
1042_L	1045_K	0.539	0.98
248_T	408_E	0.539	0.98
293_P	340_T	0.538	0.98
640_N	644_L	0.537	0.98
113_Y	117_F	0.537	0.98
708_T	732_H	0.537	0.98
873_I	876_K	0.537	0.98
430_R	456_T	0.537	0.98
986_N	989_K	0.536	0.98
711_F	734_L	0.536	0.98
651_T	759_H	0.535	0.98
650_Y	788_K	0.535	0.98
978_N	985_A	0.535	0.98
216_Y	219_P	0.535	0.98
21_S	194_I	0.535	0.98
497_Y	688_D	0.535	0.98
674_M	677_A	0.533	0.98
673_E	771_S	0.533	0.98
583_L	586_N	0.533	0.98
1011_L	1026_I	0.533	0.98
502_I	510_R	0.532	0.98
676_G	714_T	0.531	0.98
431_Q	452_F	0.531	0.98
764_P	786_I	0.531	0.98
749_V	770_F	0.531	0.98
480_D	484_E	0.531	0.98
883_I	936_M	0.531	0.98
648_S	672_F	0.531	0.98
702_L	720_L	0.530	0.98
69_D	89_V	0.530	0.98
59_R	62_Q	0.529	0.98
110_Q	114_I	0.529	0.98
699_G	728_F	0.529	0.98
252_K	262_L	0.529	0.98
245_K	408_E	0.528	0.98
363_V	397_Y	0.528	0.98
661_M	761_I	0.528	0.98
643_S	793_S	0.528	0.98
283_V	314_I	0.527	0.98
672_F	735_Y	0.527	0.98
708_T	731_L	0.527	0.98
52_L	173_Y	0.527	0.98
48_I	384_L	0.526	0.98
424_W	427_C	0.526	0.98
644_L	675_F	0.526	0.98
928_L	937_I	0.526	0.98
54_Y	58_Q	0.526	0.98
460_Q	807_I	0.526	0.98
46_F	386_I	0.526	0.98
567_F	572_T	0.524	0.98
154_H	159_G	0.524	0.98
961_P	964_E	0.524	0.98
634_V	765_T	0.524	0.98
246_P	250_K	0.523	0.98
734_L	758_L	0.523	0.98
483_R	487_E	0.523	0.98
245_K	407_E	0.521	0.98
623_Y	633_G	0.521	0.98
1021_K	1028_I	0.521	0.98
731_L	756_L	0.521	0.98
770_F	773_F	0.521	0.98
864_I	867_I	0.521	0.98
716_L	719_Q	0.521	0.98
366_N	369_L	0.521	0.98
321_T	444_H	0.521	0.98
159_G	370_Q	0.520	0.98
869_R	880_P	0.520	0.98
748_A	751_H	0.520	0.98
839_P	843_G	0.519	0.98
267_Q	287_A	0.519	0.98
914_V	944_V	0.519	0.98
265_L	326_L	0.519	0.98
516_R	606_D	0.519	0.98
886_R	927_D	0.518	0.98
710_L	713_T	0.518	0.98
660_I	691_T	0.518	0.98
438_T	445_M	0.517	0.98
717_F	745_L	0.517	0.98
662_T	761_I	0.517	0.98
43_Q	122_K	0.517	0.98
673_E	712_L	0.517	0.98
973_I	1000_D	0.517	0.98
672_F	768_T	0.516	0.98
659_F	662_T	0.515	0.97
1002_D	1038_T	0.515	0.97
710_L	770_F	0.515	0.97
643_S	790_I	0.515	0.97
31_S	35_K	0.514	0.97
772_T	815_V	0.514	0.97
171_Q	182_L	0.514	0.97
676_G	769_T	0.514	0.97
852_L	864_I	0.514	0.97
675_F	711_F	0.514	0.97
519_I	610_N	0.513	0.97
711_F	764_P	0.513	0.97
675_F	770_F	0.513	0.97
427_C	857_P	0.511	0.97
676_G	679_L	0.511	0.97
709_V	735_Y	0.510	0.97
272_V	275_Q	0.510	0.97
788_K	855_W	0.508	0.97
146_H	384_L	0.508	0.97
215_N	282_D	0.508	0.97
1003_F	1012_R	0.508	0.97
453_L	457_E	0.508	0.97
75_F	87_Q	0.507	0.97
271_G	283_V	0.507	0.97
272_V	316_T	0.507	0.97
987_I	1024_Q	0.507	0.97
645_V	672_F	0.507	0.97
620_Y	765_T	0.507	0.97
363_V	367_Y	0.506	0.97
1036_H	1042_L	0.506	0.97
645_V	711_F	0.506	0.97
671_T	761_I	0.506	0.97
538_E	541_I	0.506	0.97
532_L	587_A	0.505	0.97
975_L	982_E	0.505	0.97
170_M	174_Q	0.505	0.97
644_L	663_G	0.505	0.97
272_V	276_Q	0.504	0.97
672_F	677_A	0.504	0.97
761_I	790_I	0.504	0.97
643_S	717_F	0.503	0.97
291_G	340_T	0.503	0.97
22_H	346_D	0.502	0.97
371_Q	405_P	0.502	0.97
668_D	769_T	0.501	0.97
56_W	175_S	0.501	0.97
741_L	776_M	0.501	0.97
323_H	443_P	0.501	0.97
682_A	746_M	0.501	0.97
993_G	1015_Q	0.501	0.97
527_E	576_M	0.500	0.97
837_P	845_R	0.500	0.97
711_F	745_L	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dg8A	1	0.3831	100	0.568	Contact Map
4iz6A	2	0.4558	100	0.597	Contact Map
4r0mB	1	0.4472	100	0.609	Contact Map
1amuA	1	0.3941	100	0.629	Contact Map
4d4iA	1	0.3628	100	0.643	Contact Map
3tsyA	2	0.509	100	0.651	Contact Map
4gr5A	1	0.3573	100	0.661	Contact Map
3g7sA	2	0.3612	100	0.666	Contact Map
3wvnA	1	0.294	100	0.668	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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