GREMLIN Database
NRNB - Oligoribonuclease NrnB
UniProt: O31824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (310)
Sequences: 174 (133)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G115_T4.4460.98
38_N41_V3.3670.92
90_T264_T3.2560.90
14_G137_F3.2020.89
143_Q152_Y3.0970.88
137_F141_V3.0780.87
218_F223_C3.0490.87
40_Q162_D2.6410.77
14_G141_V2.6260.77
222_H269_I2.6080.76
186_F237_G2.5000.73
18_V118_L2.4840.73
134_L287_S2.4360.71
182_T253_L2.4070.70
203_I232_Y2.3800.69
45_L54_Q2.2250.64
23_F229_A2.1050.59
98_E178_Q2.0220.56
260_V284_A1.9310.52
6_S287_S1.9020.51
66_E294_E1.8730.50
7_H35_N1.8170.48
260_V279_G1.8150.48
45_L253_L1.8040.47
228_H314_F1.7750.46
182_T217_T1.7610.46
81_K187_F1.7210.44
158_K162_D1.6990.43
6_S13_V1.6710.42
62_L69_E1.6640.42
165_F195_L1.6540.41
163_L225_G1.6450.41
57_L171_E1.6360.41
113_S222_H1.6320.41
132_N182_T1.6190.40
72_L94_L1.5930.39
85_I214_M1.5790.39
18_V128_M1.5730.38
160_L236_L1.5660.38
60_T118_L1.5370.37
216_Q247_L1.5370.37
44_F172_F1.5340.37
3_H76_V1.5260.37
41_V72_L1.5160.36
63_A224_V1.5100.36
262_L291_I1.5100.36
229_A236_L1.4760.35
51_S139_E1.4450.34
277_R297_E1.4420.34
3_H55_D1.4370.33
18_V156_Q1.4320.33
228_H258_K1.4310.33
262_L279_G1.4030.32
90_T160_L1.3850.32
217_T315_R1.3850.32
156_Q287_S1.3810.31
278_Y298_L1.3770.31
233_H252_I1.3740.31
150_E221_E1.3710.31
90_T113_S1.3670.31
302_E315_R1.3580.31
6_S118_L1.3540.30
137_F266_H1.3470.30
277_R309_V1.3450.30
77_H156_Q1.3370.30
73_N128_M1.3320.30
157_A275_A1.3300.30
114_A271_V1.3300.30
108_D118_L1.3160.29
113_S273_E1.3130.29
5_Y162_D1.3110.29
72_L291_I1.3000.29
6_S162_D1.2980.29
40_Q158_K1.2700.28
72_L261_S1.2690.28
58_F318_Y1.2650.28
179_R279_G1.2650.28
141_V237_G1.2600.27
283_H286_A1.2450.27
89_K272_S1.2400.27
8_N168_S1.2400.27
225_G285_K1.2380.27
96_E253_L1.2340.27
103_Q228_H1.2280.26
137_F237_G1.2270.26
143_Q154_Q1.2130.26
81_K198_L1.2120.26
52_N77_H1.2120.26
82_V277_R1.2090.26
46_E171_E1.2050.26
61_D282_G1.2040.26
11_D280_G1.2040.26
11_D263_R1.2040.26
263_R280_G1.2040.26
61_D288_G1.2040.26
11_D145_D1.2040.26
11_D281_G1.2040.26
145_D288_G1.2040.26
87_H263_R1.2040.26
87_H280_G1.2040.26
11_D282_G1.2040.26
87_H281_G1.2040.26
61_D145_D1.2040.26
87_H282_G1.2040.26
87_H145_D1.2040.26
61_D281_G1.2040.26
61_D280_G1.2040.26
263_R282_G1.2040.26
61_D86_D1.2040.26
263_R288_G1.2040.26
88_H288_G1.2040.26
88_H145_D1.2040.26
88_H282_G1.2040.26
88_H281_G1.2040.26
280_G288_G1.2040.26
88_H280_G1.2040.26
263_R281_G1.2040.26
11_D88_H1.2040.26
11_D87_H1.2040.26
61_D263_R1.2040.26
11_D86_D1.2040.26
11_D61_D1.2040.26
87_H288_G1.2040.26
61_D88_H1.2040.26
61_D87_H1.2040.26
88_H263_R1.2040.26
11_D288_G1.2040.26
86_D282_G1.2040.26
86_D281_G1.2040.26
12_G87_H1.2040.26
12_G288_G1.2040.26
12_G145_D1.2040.26
282_G288_G1.2040.26
12_G88_H1.2040.26
86_D280_G1.2040.26
12_G282_G1.2040.26
12_G263_R1.2040.26
86_D145_D1.2040.26
86_D263_R1.2040.26
86_D288_G1.2040.26
12_G281_G1.2040.26
145_D281_G1.2040.26
145_D280_G1.2040.26
12_G86_D1.2040.26
145_D263_R1.2040.26
145_D282_G1.2040.26
281_G288_G1.2040.26
12_G280_G1.2040.26
12_G61_D1.2040.26
90_T132_N1.2030.26
214_M303_A1.1980.25
73_N77_H1.1920.25
58_F296_Y1.1870.25
120_G284_A1.1800.25
62_L114_A1.1740.25
139_E153_D1.1740.25
62_L150_E1.1590.24
35_N108_D1.1540.24
84_L99_W1.1480.24
124_E193_E1.1410.24
92_L141_V1.1200.23
142_R235_E1.1130.23
135_D218_F1.1120.23
203_I237_G1.1100.23
96_E133_A1.1070.23
178_Q182_T1.0950.22
228_H237_G1.0930.22
72_L82_V1.0860.22
7_H231_S1.0850.22
57_L209_R1.0780.22
92_L95_N1.0690.22
7_H113_S1.0670.22
21_L237_G1.0580.21
2_Y143_Q1.0580.21
14_G177_I1.0550.21
34_V249_Y1.0540.21
269_I306_I1.0480.21
25_K190_D1.0480.21
96_E125_N1.0470.21
213_E261_S1.0450.21
94_L261_S1.0420.21
135_D189_D1.0380.21
195_L232_Y1.0310.21
37_L205_R1.0310.21
99_W238_N1.0190.20
90_T164_F1.0160.20
149_W225_G1.0040.20
3_H261_S0.9970.20
135_D170_D0.9970.20
26_D134_L0.9960.20
26_D78_A0.9950.20
97_H257_S0.9870.20
45_L69_E0.9810.19
93_H304_F0.9810.19
250_I264_T0.9780.19
46_E167_L0.9780.19
104_V272_S0.9780.19
218_F221_E0.9770.19
205_R266_H0.9730.19
110_R223_C0.9720.19
136_Q179_R0.9710.19
18_V180_L0.9690.19
58_F305_R0.9690.19
10_L114_A0.9680.19
244_N287_S0.9670.19
258_K290_S0.9660.19
68_N258_K0.9590.19
52_N132_N0.9580.19
6_S262_L0.9580.19
95_N179_R0.9540.19
113_S276_G0.9530.19
124_E130_P0.9480.19
123_I262_L0.9460.19
182_T302_E0.9410.18
36_G83_K0.9410.18
292_T315_R0.9380.18
262_L289_C0.9370.18
85_I117_L0.9330.18
311_P314_F0.9290.18
237_G274_I0.9270.18
86_D283_H0.9260.18
12_G283_H0.9260.18
145_D283_H0.9260.18
87_H283_H0.9260.18
263_R283_H0.9260.18
88_H283_H0.9260.18
61_D283_H0.9260.18
280_G283_H0.9260.18
283_H288_G0.9260.18
11_D283_H0.9260.18
41_V64_V0.9230.18
73_N78_A0.9230.18
98_E201_E0.9200.18
114_A262_L0.9180.18
32_N68_N0.9180.18
6_S238_N0.9070.18
96_E156_Q0.9070.18
75_Y213_E0.8990.18
71_R287_S0.8980.17
3_H40_Q0.8920.17
14_G70_E0.8900.17
210_K236_L0.8890.17
26_D315_R0.8860.17
36_G108_D0.8860.17
114_A287_S0.8820.17
137_F203_I0.8810.17
44_F207_L0.8780.17
120_G134_L0.8750.17
163_L227_V0.8740.17
41_V68_N0.8720.17
30_R176_M0.8690.17
214_M244_N0.8630.17
241_G295_V0.8620.17
8_N148_E0.8620.17
63_A194_K0.8590.17
219_V224_V0.8580.17
14_G23_F0.8550.17
112_T261_S0.8540.17
13_V63_A0.8510.16
113_S221_E0.8470.16
303_A317_I0.8450.16
89_K310_R0.8300.16
15_C62_L0.8290.16
38_N243_D0.8280.16
90_T311_P0.8270.16
60_T238_N0.8270.16
5_Y120_G0.8240.16
59_I294_E0.8200.16
216_Q277_R0.8200.16
211_K284_A0.8200.16
28_E53_R0.8170.16
197_D202_K0.8140.16
78_A181_S0.8130.16
120_G310_R0.8110.16
220_H278_Y0.8100.16
7_H84_L0.8050.15
34_V231_S0.7960.15
117_L146_T0.7910.15
130_P260_V0.7880.15
244_N276_G0.7870.15
140_L163_L0.7870.15
160_L192_E0.7850.15
71_R226_I0.7830.15
158_K195_L0.7820.15
14_G218_F0.7810.15
4_L99_W0.7800.15
144_Y176_M0.7760.15
110_R287_S0.7700.15
45_L130_P0.7640.15
98_E129_K0.7630.15
181_S277_R0.7620.15
99_W186_F0.7570.14
136_Q170_D0.7570.14
223_C298_L0.7560.14
140_L227_V0.7560.14
71_R294_E0.7550.14
37_L242_K0.7480.14
124_E310_R0.7470.14
187_F193_E0.7450.14
60_T99_W0.7380.14
97_H138_T0.7350.14
26_D132_N0.7340.14
124_E220_H0.7280.14
98_E214_M0.7230.14
312_D315_R0.7200.14
15_C210_K0.7190.14
23_F140_L0.7180.14
121_Y236_L0.7170.14
103_Q108_D0.7170.14
58_F85_I0.7140.14
130_P178_Q0.7120.14
68_N237_G0.7080.14
32_N36_G0.7080.14
8_N34_V0.7070.14
146_T227_V0.7040.13
98_E133_A0.7030.13
95_N254_S0.7030.13
42_Q123_I0.6990.13
192_E312_D0.6980.13
141_V264_T0.6970.13
18_V201_E0.6940.13
138_T166_L0.6900.13
169_I194_K0.6890.13
223_C226_I0.6840.13
54_Q132_N0.6800.13
46_E128_M0.6790.13
139_E163_L0.6790.13
149_W271_V0.6790.13
28_E132_N0.6770.13
222_H232_Y0.6740.13
53_R135_D0.6740.13
186_F238_N0.6710.13
118_L252_I0.6710.13
66_E70_E0.6680.13
92_L262_L0.6660.13
186_F203_I0.6600.13
148_E212_R0.6590.13
15_C162_D0.6590.13
199_E300_V0.6580.13
32_N104_V0.6580.13
214_M254_S0.6580.13
85_I114_A0.6570.13
166_L188_F0.6550.13
193_E311_P0.6510.13
139_E251_A0.6500.12
207_L289_C0.6500.12
204_E221_E0.6490.12
175_K284_A0.6490.12
148_E173_E0.6470.12
188_F274_I0.6460.12
59_I120_G0.6460.12
212_R216_Q0.6320.12
160_L210_K0.6310.12
84_L165_F0.6280.12
170_D201_E0.6270.12
43_Y65_N0.6200.12
143_Q304_F0.6180.12
131_T156_Q0.6180.12
192_E236_L0.6170.12
111_L231_S0.6160.12
164_F172_F0.6160.12
224_V301_A0.6140.12
76_V261_S0.6120.12
52_N193_E0.6120.12
97_H222_H0.6120.12
90_T158_K0.6110.12
70_E132_N0.6100.12
221_E313_A0.6080.12
95_N216_Q0.6060.12
234_S271_V0.6060.12
270_D275_A0.6040.12
267_D285_K0.6030.12
23_F74_E0.6010.12
18_V101_F0.6000.12
200_D243_D0.6000.12
17_I115_T0.5980.12
119_Y238_N0.5980.12
18_V120_G0.5960.12
90_T100_G0.5960.12
72_L173_E0.5940.12
202_K232_Y0.5940.12
124_E277_R0.5930.12
7_H261_S0.5890.11
52_N218_F0.5860.11
77_H130_P0.5850.11
7_H284_A0.5830.11
176_M241_G0.5830.11
15_C119_Y0.5820.11
157_A262_L0.5800.11
38_N302_E0.5790.11
314_F317_I0.5770.11
253_L290_S0.5740.11
137_F177_I0.5730.11
299_F307_D0.5710.11
13_V169_I0.5680.11
57_L92_L0.5670.11
2_Y222_H0.5660.11
176_M198_L0.5650.11
83_K180_L0.5640.11
68_N196_L0.5640.11
250_I266_H0.5640.11
187_F201_E0.5590.11
41_V236_L0.5580.11
74_E125_N0.5580.11
29_I69_E0.5580.11
139_E278_Y0.5570.11
159_R197_D0.5540.11
253_L291_I0.5540.11
83_K132_N0.5530.11
3_H150_E0.5520.11
228_H291_I0.5510.11
34_V113_S0.5500.11
28_E314_F0.5500.11
34_V111_L0.5480.11
162_D166_L0.5470.11
64_V112_T0.5470.11
76_V185_E0.5450.11
214_M278_Y0.5450.11
222_H284_A0.5410.11
119_Y135_D0.5410.11
132_N156_Q0.5410.11
211_K214_M0.5400.11
140_L143_Q0.5400.11
103_Q305_R0.5390.11
133_A317_I0.5380.11
74_E120_G0.5350.11
46_E168_S0.5350.11
14_G181_S0.5320.11
204_E253_L0.5300.11
261_S281_G0.5290.11
61_D261_S0.5290.11
88_H261_S0.5290.11
86_D261_S0.5290.11
261_S288_G0.5290.11
12_G261_S0.5290.11
145_D261_S0.5290.11
261_S280_G0.5290.11
87_H261_S0.5290.11
11_D261_S0.5290.11
261_S282_G0.5290.11
103_Q107_D0.5280.11
6_S276_G0.5270.11
8_N206_Y0.5240.10
31_Y212_R0.5220.10
221_E309_V0.5220.10
78_A132_N0.5190.10
45_L291_I0.5190.10
131_T135_D0.5180.10
14_G62_L0.5170.10
141_V279_G0.5160.10
204_E301_A0.5140.10
98_E130_P0.5120.10
160_L264_T0.5110.10
103_Q134_L0.5110.10
98_E132_N0.5100.10
155_K178_Q0.5070.10
182_T290_S0.5070.10
62_L271_V0.5070.10
113_S306_I0.5060.10
211_K274_I0.5050.10
141_V203_I0.5050.10
215_V269_I0.5030.10
231_S249_Y0.5030.10
190_D206_Y0.5000.10
109_G264_T0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ls9A 2 0.6892 100 0.802 Contact Map
3devA 2 0.6917 99.9 0.817 Contact Map
4py9A 2 0.7093 99.9 0.821 Contact Map
2zxrA 1 0.812 99.7 0.868 Contact Map
2hawA 2 0.6842 99.7 0.876 Contact Map
4rpaA 3 0.6792 99.4 0.893 Contact Map
2eb0A 2 0.6692 98.4 0.928 Contact Map
1k20A 2 0.6742 98.2 0.932 Contact Map
1wpnA 2 0.4261 98.1 0.934 Contact Map
2qb7A 1 0.782 97.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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