GREMLIN Database
YNGC - Uncharacterized membrane protein YngC
UniProt: O31823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (184)
Sequences: 6856 (4886)
Seq/√Len: 360.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_I132_F3.3831.00
48_G51_G3.1951.00
57_V144_I2.8111.00
185_L189_I2.6901.00
187_F191_K2.6621.00
61_T140_V2.5301.00
103_Y106_G2.4621.00
42_V155_I2.4401.00
65_I136_V2.4211.00
109_F141_L2.3871.00
105_A134_K2.3731.00
25_M66_F2.3591.00
53_I148_I2.3261.00
188_V192_R2.1441.00
89_K92_H2.1291.00
131_P134_K2.1201.00
55_A59_G2.0291.00
97_E101_Q2.0161.00
56_G147_S2.0091.00
105_A138_L1.9411.00
173_T177_I1.9311.00
49_F152_Y1.8311.00
12_L16_G1.8241.00
182_V186_Y1.7991.00
53_I151_V1.7971.00
24_L59_G1.7551.00
72_R129_R1.7481.00
25_M62_I1.7111.00
152_Y156_Q1.6881.00
21_A59_G1.6601.00
170_T174_P1.6461.00
17_Y48_G1.6331.00
49_F53_I1.6261.00
21_A55_A1.6031.00
76_R97_E1.5751.00
90_K94_D1.5661.00
35_L151_V1.5281.00
27_E31_S1.5271.00
132_F136_V1.5231.00
38_G52_A1.5111.00
69_W73_Y1.4981.00
17_Y51_G1.4901.00
49_F151_V1.4861.00
64_Q112_R1.4301.00
20_I56_G1.4131.00
52_A151_V1.3951.00
94_D98_N1.3941.00
69_W132_F1.3831.00
21_A58_I1.3791.00
17_Y55_A1.3771.00
71_G127_I1.3531.00
113_F145_P1.3471.00
186_Y190_K1.3441.00
15_M19_G1.3191.00
174_P178_L1.2911.00
106_G110_S1.2901.00
80_D90_K1.2781.00
168_A171_Y1.2781.00
133_L137_V1.2761.00
42_V49_F1.2551.00
51_G55_A1.2471.00
91_H95_M1.2451.00
61_T143_I1.2401.00
111_A121_I1.2151.00
10_T13_T1.2061.00
167_I170_T1.2021.00
165_E169_G1.1861.00
184_A188_V1.1851.00
50_I152_Y1.1771.00
39_G154_G1.1511.00
35_L56_G1.1461.00
83_G88_I1.1451.00
54_I58_I1.1401.00
97_E128_A1.1381.00
76_R80_D1.1321.00
83_G86_L1.1251.00
67_I123_I1.1251.00
98_N102_K1.1141.00
183_I186_Y1.1141.00
50_I54_I1.1131.00
61_T136_V1.1081.00
188_V191_K1.0921.00
10_T14_N1.0881.00
73_Y77_P1.0661.00
57_V61_T1.0641.00
43_S155_I1.0551.00
15_M18_A1.0491.00
100_F125_A1.0461.00
169_G173_T1.0411.00
109_F145_P1.0411.00
53_I57_V1.0371.00
171_Y174_P1.0361.00
35_L39_G1.0331.00
47_I52_A1.0311.00
176_M180_V1.0311.00
108_V130_M1.0221.00
57_V147_S1.0061.00
190_K193_T0.9981.00
65_I69_W0.9961.00
179_A182_V0.9931.00
94_D97_E0.9881.00
39_G151_V0.9721.00
162_D166_N0.9721.00
139_T143_I0.9671.00
56_G151_V0.9611.00
77_P81_K0.9601.00
69_W72_R0.9591.00
145_P148_I0.9581.00
53_I152_Y0.9571.00
118_R146_W0.9441.00
137_V141_L0.9431.00
21_A62_I0.9431.00
20_I52_A0.9421.00
79_L88_I0.9411.00
32_E118_R0.9411.00
17_Y47_I0.9411.00
133_L136_V0.9321.00
122_S139_T0.9271.00
54_I57_V0.9251.00
183_I187_F0.9191.00
50_I53_I0.9191.00
186_Y189_I0.9181.00
40_Y43_S0.9081.00
79_L93_I0.9051.00
70_I74_G0.8951.00
92_H95_M0.8861.00
43_S159_S0.8861.00
60_G143_I0.8801.00
99_W107_V0.8701.00
74_G77_P0.8591.00
24_L147_S0.8541.00
178_L182_V0.8491.00
96_S128_A0.8481.00
51_G54_I0.8461.00
189_I193_T0.8451.00
58_I62_I0.8451.00
68_Y132_F0.8401.00
176_M179_A0.8401.00
64_Q139_T0.8381.00
16_G19_G0.8361.00
172_T176_M0.8361.00
160_Q163_D0.8361.00
177_I180_V0.8351.00
148_I152_Y0.8321.00
82_Y86_L0.8321.00
189_I192_R0.8271.00
77_P80_D0.8131.00
162_D165_E0.8031.00
104_G130_M0.7991.00
175_I179_A0.7981.00
61_T139_T0.7931.00
37_Y41_M0.7911.00
114_I117_V0.7841.00
8_I12_L0.7811.00
76_R79_L0.7741.00
181_V185_L0.7731.00
164_V167_I0.7691.00
136_V140_V0.7681.00
180_V184_A0.7641.00
40_Y161_W0.7631.00
60_G112_R0.7611.00
75_G79_L0.7601.00
149_L152_Y0.7581.00
14_N18_A0.7541.00
106_G138_L0.7451.00
137_V140_V0.7421.00
185_L188_V0.7411.00
12_L15_M0.7361.00
107_V110_S0.7271.00
157_L160_Q0.7261.00
65_I139_T0.7160.99
20_I38_G0.7110.99
186_Y191_K0.7100.99
144_I148_I0.7100.99
112_R118_R0.7060.99
39_G52_A0.7040.99
28_I112_R0.7030.99
98_N101_Q0.7020.99
67_I119_H0.6890.99
153_L156_Q0.6870.99
163_D167_I0.6860.99
42_V52_A0.6850.99
74_G78_F0.6820.99
166_N170_T0.6820.99
107_V121_I0.6780.99
182_V185_L0.6760.99
185_L191_K0.6730.99
17_Y42_V0.6660.99
11_W16_G0.6660.99
13_T16_G0.6620.99
31_S139_T0.6600.99
160_Q164_V0.6600.99
83_G90_K0.6580.99
29_I119_H0.6550.99
68_Y126_G0.6530.99
97_E129_R0.6440.99
147_S151_V0.6380.99
173_T176_M0.6380.99
42_V151_V0.6380.99
12_L19_G0.6370.99
37_Y40_Y0.6340.99
88_I92_H0.6310.99
125_A130_M0.6300.99
31_S115_P0.6280.99
38_G47_I0.6280.99
163_D166_N0.6250.99
169_G172_T0.6190.98
21_A25_M0.6160.98
9_L41_M0.6120.98
145_P149_L0.6120.98
100_F107_V0.6110.98
157_L161_W0.6090.98
64_Q132_F0.6090.98
181_V188_V0.6080.98
91_H94_D0.6070.98
92_H96_S0.6070.98
68_Y129_R0.6040.98
11_W14_N0.6030.98
140_V144_I0.6010.98
135_F139_T0.5970.98
115_P119_H0.5880.98
9_L13_T0.5840.98
38_G42_V0.5810.98
32_E142_A0.5800.98
11_W15_M0.5780.98
165_E168_A0.5760.98
80_D91_H0.5740.98
62_I66_F0.5740.98
24_L56_G0.5730.97
28_I119_H0.5720.97
108_V125_A0.5700.97
167_I171_Y0.5680.97
155_I159_S0.5660.97
82_Y88_I0.5660.97
109_F113_F0.5600.97
111_A115_P0.5590.97
32_E150_F0.5570.97
174_P177_I0.5570.97
13_T46_T0.5540.97
28_I64_Q0.5540.97
185_L190_K0.5520.97
179_A183_I0.5520.97
29_I33_I0.5500.97
134_K138_L0.5490.97
67_I115_P0.5480.97
95_M98_N0.5460.97
27_E119_H0.5440.97
37_Y168_A0.5420.96
99_W103_Y0.5410.96
24_L119_H0.5370.96
118_R143_I0.5360.96
112_R139_T0.5360.96
28_I122_S0.5330.96
28_I139_T0.5320.96
27_E112_R0.5310.96
75_G78_F0.5310.96
49_F148_I0.5280.96
66_F69_W0.5260.96
35_L147_S0.5240.96
43_S46_T0.5220.96
167_I174_P0.5210.96
20_I55_A0.5150.95
60_G119_H0.5140.95
134_K137_V0.5130.95
38_G151_V0.5120.95
65_I140_V0.5110.95
166_N169_G0.5100.95
99_W102_K0.5100.95
82_Y90_K0.5090.95
31_S135_F0.5070.95
81_K88_I0.5070.95
88_I120_A0.5060.95
16_G47_I0.5050.95
156_Q160_Q0.5040.95
67_I116_V0.5010.95
106_G124_P0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1818 55.7 0.914 Contact Map
2l2tA 2 0.197 48.8 0.918 Contact Map
2ks1B 1 0.2222 47.9 0.918 Contact Map
2jwaA 2 0.2222 34.6 0.924 Contact Map
4dx5A 3 0.8081 29.5 0.927 Contact Map
2kluA 1 0.202 25.2 0.929 Contact Map
2kv5A 1 0.1667 24.9 0.93 Contact Map
3w9iA 3 0.7727 17.7 0.934 Contact Map
2rddB 1 0.1515 13.3 0.938 Contact Map
4mt1A 3 0.8131 11.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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