GREMLIN Database
YNGB - Probable UTP--glucose-1-phosphate uridylyltransferase YngB
UniProt: O31822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (237)
Sequences: 21570 (13157)
Seq/√Len: 854.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_E219_K3.5971.00
36_K44_E2.8711.00
175_N187_N2.7791.00
175_N188_D2.6831.00
53_D99_N2.6661.00
109_L113_H2.6161.00
177_S185_E2.5401.00
40_Q68_H2.5401.00
217_V241_K2.3861.00
7_K53_D2.3731.00
62_K66_E2.2791.00
8_A51_I2.2781.00
162_S201_E2.2501.00
126_P211_N2.1771.00
185_E245_H2.1371.00
8_A46_A2.1121.00
177_S187_N2.0601.00
153_Y245_H2.0591.00
162_S248_L2.0561.00
194_S197_E2.0401.00
150_Y157_V2.0371.00
217_V237_E2.0171.00
160_V246_A1.9831.00
103_I117_C1.9651.00
58_T62_K1.9561.00
155_T245_H1.9241.00
43_V54_I1.9241.00
236_R240_R1.8891.00
237_E241_K1.8791.00
126_P151_D1.8381.00
116_L119_E1.8311.00
12_A56_I1.8091.00
115_V129_V1.7731.00
46_A130_L1.7631.00
142_A145_Q1.7341.00
9_V118_A1.7291.00
144_R148_D1.7091.00
176_T202_I1.6861.00
149_V153_Y1.6791.00
63_R67_D1.6721.00
62_K104_R1.6611.00
53_D101_H1.6581.00
26_Q32_P1.6431.00
237_E240_R1.6331.00
149_V247_R1.6331.00
254_Y264_K1.6251.00
202_I248_L1.6221.00
188_D236_R1.6161.00
167_D170_K1.5721.00
30_M64_S1.5141.00
55_L121_F1.5051.00
40_Q44_E1.5001.00
26_Q64_S1.4851.00
186_V246_A1.4831.00
54_I98_A1.4791.00
148_D152_V1.4721.00
122_I127_F1.4701.00
213_S216_S1.4611.00
126_P209_V1.4591.00
64_S67_D1.4491.00
174_I186_V1.4361.00
145_Q148_D1.4241.00
192_K198_A1.4121.00
20_L24_K1.3961.00
37_P40_Q1.3861.00
233_D236_R1.3821.00
197_E200_S1.3611.00
113_H117_C1.3561.00
157_V160_V1.3371.00
186_V244_I1.3371.00
66_E104_R1.3311.00
160_V174_I1.3111.00
190_V199_P1.3091.00
156_E211_N1.2971.00
262_C266_S1.2821.00
252_N268_E1.2801.00
127_F212_S1.2791.00
47_A98_A1.2631.00
220_T241_K1.2621.00
179_S185_E1.2581.00
217_V234_A1.2551.00
157_V161_Q1.2441.00
185_E243_P1.2361.00
146_L159_G1.2341.00
172_G191_E1.2291.00
258_D261_G1.2201.00
158_V161_Q1.2161.00
116_L219_K1.2121.00
210_L235_L1.2111.00
216_S220_T1.2081.00
220_T237_E1.2081.00
101_H121_F1.2041.00
55_L103_I1.2001.00
19_F31_L1.1941.00
129_V210_L1.1941.00
217_V220_T1.1861.00
216_S219_K1.1771.00
126_P212_S1.1591.00
70_D102_Y1.1591.00
113_H116_L1.1571.00
15_L108_P1.1511.00
125_E212_S1.1441.00
196_E200_S1.1391.00
145_Q149_V1.1341.00
263_F267_T1.1091.00
149_V152_V1.0951.00
256_I265_A1.0911.00
35_D41_Y1.0851.00
30_M68_H1.0841.00
146_L209_V1.0831.00
128_A209_V1.0731.00
110_G232_T1.0691.00
51_I128_A1.0661.00
196_E199_P1.0651.00
40_Q72_S1.0641.00
160_V163_V1.0551.00
13_A57_I1.0521.00
7_K125_E1.0501.00
176_T246_A1.0461.00
131_L206_G1.0461.00
261_G264_K1.0351.00
55_L118_A1.0331.00
156_E243_P1.0301.00
150_Y209_V1.0291.00
6_R125_E1.0151.00
58_T102_Y1.0141.00
175_N200_S1.0111.00
36_K41_Y1.0061.00
175_N190_V1.0041.00
9_V127_F1.0021.00
170_K261_G0.9881.00
58_T104_R0.9831.00
141_P144_R0.9781.00
155_T243_P0.9781.00
254_Y268_E0.9711.00
173_I203_A0.9691.00
124_D213_S0.9681.00
160_V202_I0.9651.00
58_T66_E0.9591.00
149_V245_H0.9571.00
260_L264_K0.9571.00
148_D151_D0.9521.00
38_A256_I0.9441.00
44_E47_A0.9411.00
267_T270_G0.9331.00
19_F23_T0.9291.00
39_I56_I0.9291.00
159_G162_S0.9271.00
169_S192_K0.9251.00
6_R151_D0.9221.00
39_I69_F0.9201.00
55_L101_H0.9121.00
61_N64_S0.9091.00
188_D197_E0.8991.00
235_L244_I0.8991.00
58_T65_I0.8941.00
150_Y211_N0.8931.00
157_V162_S0.8921.00
134_D253_R0.8911.00
119_E215_F0.8831.00
111_L131_L0.8821.00
116_L218_L0.8791.00
62_K65_I0.8791.00
63_R66_E0.8731.00
39_I65_I0.8681.00
234_A237_E0.8591.00
7_K55_L0.8521.00
137_V272_M0.8511.00
43_V69_F0.8501.00
32_P37_P0.8481.00
254_Y265_A0.8481.00
138_S252_N0.8391.00
38_A42_I0.8391.00
137_V252_N0.8381.00
264_K268_E0.8351.00
263_F266_S0.8311.00
23_T31_L0.8281.00
49_S144_R0.8251.00
36_K40_Q0.8201.00
11_P131_L0.8201.00
10_I132_G0.8191.00
264_K267_T0.8171.00
103_I118_A0.8131.00
204_V208_Y0.8111.00
66_E102_Y0.8091.00
37_P68_H0.8081.00
7_K122_I0.8001.00
128_A147_M0.7991.00
147_M151_D0.7971.00
187_N190_V0.7941.00
115_V214_I0.7931.00
29_E132_G0.7921.00
150_Y154_G0.7861.00
124_D212_S0.7841.00
7_K123_G0.7801.00
122_I215_F0.7741.00
51_I147_M0.7681.00
66_E70_D0.7681.00
52_E99_N0.7661.00
141_P145_Q0.7661.00
146_L247_R0.7641.00
158_V162_S0.7591.00
213_S241_K0.7581.00
9_V57_I0.7571.00
222_G233_D0.7521.00
103_I121_F0.7521.00
22_A26_Q0.7511.00
213_S217_V0.7481.00
11_P111_L0.7461.00
138_S141_P0.7441.00
232_T236_R0.7431.00
48_E144_R0.7391.00
189_L204_V0.7371.00
34_V41_Y0.7361.00
154_G211_N0.7331.00
244_I249_L0.7321.00
216_S241_K0.7301.00
37_P41_Y0.7281.00
138_S142_A0.7271.00
45_E49_S0.7271.00
34_V266_S0.7251.00
213_S243_P0.7201.00
67_D70_D0.7141.00
245_H248_L0.7121.00
47_A52_E0.7061.00
181_G248_L0.7051.00
22_A259_K0.6981.00
196_E201_E0.6961.00
266_S270_G0.6941.00
44_E72_S0.6931.00
147_M209_V0.6931.00
158_V174_I0.6921.00
130_L143_L0.6901.00
69_F100_I0.6901.00
8_A54_I0.6891.00
268_E271_L0.6861.00
153_Y156_E0.6841.00
47_A54_I0.6801.00
70_D73_A0.6781.00
43_V56_I0.6781.00
56_I69_F0.6781.00
123_G212_S0.6761.00
70_D74_E0.6751.00
170_K192_K0.6741.00
226_G230_Q0.6741.00
27_P64_S0.6731.00
202_I246_A0.6721.00
41_Y44_E0.6681.00
108_P113_H0.6611.00
119_E127_F0.6561.00
174_I246_A0.6561.00
198_A201_E0.6561.00
135_I265_A0.6551.00
57_I114_A0.6531.00
263_F270_G0.6521.00
43_V100_I0.6451.00
16_G28_K0.6441.00
103_I106_K0.6411.00
57_I118_A0.6411.00
221_I237_E0.6371.00
18_R28_K0.6331.00
162_S202_I0.6311.00
41_Y269_I0.6291.00
31_L262_C0.6281.00
9_V55_L0.6281.00
47_A72_S0.6261.00
149_V157_V0.6261.00
170_K258_D0.6261.00
267_T271_L0.6251.00
150_Y247_R0.6241.00
46_A128_A0.6241.00
212_S215_F0.6241.00
178_G181_G0.6221.00
98_A101_H0.6181.00
126_P154_G0.6181.00
264_K274_P0.6161.00
11_P114_A0.6141.00
161_Q205_M0.6131.00
45_E207_R0.6091.00
186_V189_L0.6071.00
40_Q69_F0.6061.00
221_I234_A0.6051.00
33_I266_S0.6031.00
190_V193_P0.6021.00
58_T63_R0.6011.00
260_L274_P0.5981.00
110_G233_D0.5971.00
190_V197_E0.5941.00
111_L204_V0.5921.00
107_E113_H0.5901.00
197_E201_E0.5901.00
153_Y157_V0.5901.00
9_V115_V0.5891.00
118_A121_F0.5891.00
142_A252_N0.5871.00
269_I273_R0.5871.00
259_K263_F0.5841.00
168_V173_I0.5811.00
217_V238_V0.5801.00
22_A31_L0.5791.00
98_A102_Y0.5771.00
233_D237_E0.5741.00
131_L134_D0.5701.00
160_V248_L0.5671.00
145_Q247_R0.5641.00
7_K127_F0.5641.00
120_H123_G0.5631.00
171_Y255_D0.5611.00
10_I42_I0.5611.00
105_Q113_H0.5581.00
270_G274_P0.5571.00
125_E211_N0.5571.00
56_I100_I0.5551.00
238_V242_E0.5521.00
72_S102_Y0.5511.00
219_K223_R0.5491.00
22_A25_A0.5481.00
59_G108_P0.5471.00
57_I103_I0.5471.00
28_K133_D0.5461.00
176_T179_S0.5451.00
44_E48_E0.5451.00
41_Y45_E0.5441.00
56_I102_Y0.5431.00
74_E100_I0.5421.00
119_E123_G0.5411.00
6_R52_E0.5411.00
190_V201_E0.5381.00
142_A146_L0.5351.00
213_S242_E0.5331.00
43_V98_A0.5321.00
144_R147_M0.5321.00
136_M205_M0.5311.00
13_A29_E0.5281.00
42_I45_E0.5251.00
113_H229_I0.5251.00
221_I229_I0.5241.00
130_L207_R0.5241.00
226_G229_I0.5231.00
210_L234_A0.5221.00
188_D240_R0.5201.00
46_A51_I0.5191.00
178_G185_E0.5151.00
106_K113_H0.5151.00
271_L274_P0.5101.00
156_E213_S0.5081.00
235_L239_C0.5071.00
9_V122_I0.5061.00
151_D154_G0.5061.00
119_E216_S0.5031.00
254_Y261_G0.5021.00
134_D205_M0.5021.00
34_V269_I0.5011.00
171_Y191_E0.5011.00
205_M249_L0.5001.00
59_G132_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e3dA 3 0.9428 100 0.309 Contact Map
3jukA 3 0.8721 100 0.31 Contact Map
2ux8A 4 0.9596 100 0.319 Contact Map
2pa4A 3 0.9832 100 0.321 Contact Map
1iimA 3 0.8889 100 0.362 Contact Map
1lvwA 3 0.8889 100 0.366 Contact Map
4ho4A 3 0.8788 100 0.37 Contact Map
1mc3A 3 0.8822 100 0.374 Contact Map
3brkX 2 0.8721 100 0.377 Contact Map
4ecmA 3 0.8148 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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