GREMLIN Database
YNGA - Uncharacterized membrane protein YngA
UniProt: O31821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (123)
Sequences: 2759 (2107)
Seq/√Len: 190.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_N68_W2.9351.00
39_V60_A2.5911.00
132_N136_V2.5151.00
32_N65_S2.4471.00
21_T133_R2.3581.00
63_V85_I2.3531.00
20_K24_R2.2871.00
106_F116_S2.0601.00
54_Q117_K2.0401.00
35_I64_N1.9991.00
40_F57_S1.9201.00
66_Y81_D1.8901.00
91_I131_G1.8681.00
70_R84_E1.8401.00
31_G64_N1.8221.00
36_D57_S1.7851.00
102_L120_A1.7071.00
40_F113_L1.6951.00
36_D54_Q1.6951.00
54_Q103_L1.6191.00
41_F114_L1.6161.00
36_D99_T1.5781.00
120_A124_G1.5271.00
28_V68_W1.5131.00
58_Y62_I1.5121.00
24_R72_W1.5021.00
21_T129_F1.4891.00
69_N73_T1.4551.00
43_L56_C1.4531.00
55_I96_S1.4381.00
44_T113_L1.4061.00
87_R135_W1.3531.00
55_I100_F1.3261.00
130_I134_I1.3251.00
58_Y96_S1.3241.00
83_K87_R1.3161.00
40_F117_K1.3131.00
54_Q100_F1.3001.00
70_R137_F1.2891.00
66_Y84_E1.2671.00
98_I127_M1.2471.00
36_D117_K1.2441.00
51_L100_F1.2271.00
26_C30_V1.1991.00
86_V90_M1.1621.00
32_N64_N1.1581.00
122_I126_M1.1581.00
42_L46_C1.1561.00
65_S92_N1.1481.00
43_L53_A1.1481.00
85_I89_L1.1401.00
105_L108_N1.1301.00
22_L26_C1.1191.00
39_V43_L1.1161.00
18_K129_F1.1151.00
51_L104_Y1.0991.00
18_K21_T1.0861.00
37_F117_K1.0811.00
25_F128_N1.0791.00
76_V84_E1.0781.00
93_I97_G1.0691.00
98_I124_G1.0531.00
59_T89_L1.0461.00
62_I92_N1.0451.00
90_M94_A1.0221.00
88_F96_S1.0211.00
106_F111_C1.0071.00
102_L106_F1.0071.00
95_A127_M1.0041.00
126_M130_I1.0011.00
111_C116_S1.0000.99
92_N132_N0.9970.99
65_S69_N0.9890.99
59_T63_V0.9690.99
50_Y103_L0.9660.99
30_V33_T0.9660.99
40_F44_T0.9610.99
48_V53_A0.9570.99
31_G68_W0.9430.99
38_G42_L0.9400.99
67_V71_N0.9390.99
37_F41_F0.9370.99
82_G86_V0.9130.99
27_T31_G0.8980.99
50_Y107_Q0.8980.99
37_F121_T0.8940.99
30_V34_L0.8930.99
105_L109_C0.8910.99
19_I26_C0.8840.99
65_S88_F0.8800.99
96_S100_F0.8700.99
35_I61_G0.8690.99
127_M131_G0.8610.98
33_T36_D0.8540.98
99_T103_L0.8470.98
104_Y107_Q0.8390.98
45_A113_L0.8290.98
33_T125_M0.8270.98
33_T65_S0.8150.98
99_T117_K0.8060.98
95_A124_G0.8030.98
49_S52_P0.7970.98
41_F45_A0.7930.97
40_F103_L0.7880.97
91_I136_V0.7850.97
98_I102_L0.7800.97
103_L117_K0.7760.97
118_L122_I0.7750.97
131_G135_W0.7740.97
26_C125_M0.7450.96
32_N69_N0.7430.96
43_L48_V0.7310.96
32_N36_D0.7300.96
24_R28_V0.7300.96
99_T121_T0.7220.96
54_Q65_S0.7190.95
80_A83_K0.7120.95
99_T124_G0.7060.95
97_G101_L0.7040.95
79_K83_K0.7040.95
20_K75_C0.7030.95
25_F132_N0.7020.95
81_D84_E0.6980.95
100_F103_L0.6910.94
70_R76_V0.6900.94
36_D61_G0.6870.94
55_I59_T0.6840.94
32_N68_W0.6810.94
131_G136_V0.6750.94
66_Y70_R0.6730.94
57_S61_G0.6730.94
99_T120_A0.6690.93
39_V61_G0.6680.93
23_G27_T0.6630.93
25_F28_V0.6600.93
129_F133_R0.6580.93
33_T66_Y0.6560.93
51_L54_Q0.6540.93
28_V73_T0.6510.92
19_I23_G0.6500.92
22_L130_I0.6500.92
104_Y108_N0.6480.92
58_Y128_N0.6450.92
117_K121_T0.6430.92
25_F92_N0.6410.92
37_F125_M0.6390.92
63_V89_L0.6380.92
100_F104_Y0.6370.92
103_L120_A0.6360.92
63_V67_V0.6360.92
36_D40_F0.6340.91
92_N95_A0.6260.91
61_G92_N0.6200.90
74_F88_F0.6200.90
96_S103_L0.6180.90
102_L124_G0.6180.90
25_F125_M0.6140.90
32_N121_T0.6100.90
106_F109_C0.6060.89
23_G26_C0.6050.89
61_G64_N0.5930.88
81_D85_I0.5830.88
20_K23_G0.5760.87
44_T55_I0.5650.86
43_L46_C0.5630.86
19_I22_L0.5530.85
40_F95_A0.5500.84
127_M137_F0.5470.84
96_S121_T0.5470.84
73_T129_F0.5460.84
25_F124_G0.5440.84
32_N62_I0.5430.84
96_S124_G0.5390.83
61_G65_S0.5330.83
52_P86_V0.5220.81
62_I85_I0.5220.81
88_F92_N0.5190.81
25_F117_K0.5160.81
74_F133_R0.5090.80
40_F45_A0.5070.79
40_F96_S0.5040.79
37_F114_L0.5030.79
107_Q110_G0.5010.79
25_F32_N0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.9122 30.3 0.914 Contact Map
1mhsA 2 0.973 29.1 0.915 Contact Map
4n7wA 2 0.8986 25.7 0.917 Contact Map
3zuxA 1 0.8716 20.3 0.921 Contact Map
3mktA 1 0.9527 14.8 0.926 Contact Map
4humA 1 0.9392 13.3 0.927 Contact Map
2kncA 1 0.3243 13 0.928 Contact Map
4av3A 2 0.6419 8.9 0.932 Contact Map
2l8sA 1 0.3041 8.9 0.933 Contact Map
4lz6A 1 0.9392 8.8 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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