GREMLIN Database
YNEN - Thioredoxin-like protein YneN
UniProt: O31820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (141)
Sequences: 10065 (7809)
Seq/√Len: 657.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K146_E3.7341.00
46_T50_E3.0091.00
106_E110_R2.8351.00
60_K93_A2.6901.00
82_E119_T2.6831.00
145_D149_V2.6681.00
145_D151_Q2.4141.00
45_K51_K2.2941.00
82_E86_K2.2711.00
43_S51_K2.2611.00
53_S56_D2.1051.00
43_S53_S2.0031.00
52_S57_A1.9611.00
62_V93_A1.9601.00
38_Q149_V1.9591.00
65_N77_E1.9191.00
144_L150_I1.8681.00
96_A120_F1.8481.00
75_R116_Y1.7921.00
63_L143_I1.7911.00
87_E164_E1.7891.00
105_S108_Q1.6821.00
83_K160_K1.6741.00
46_T52_S1.6611.00
85_Q89_A1.6351.00
39_A133_Y1.5881.00
41_D55_Q1.5161.00
61_K143_I1.5121.00
65_N141_T1.5061.00
98_N109_V1.4331.00
110_R114_D1.4301.00
75_R115_T1.4141.00
80_A83_K1.3961.00
162_E165_Q1.3691.00
71_C74_C1.3561.00
160_K164_E1.2811.00
41_D53_S1.2771.00
34_Q37_Q1.2731.00
80_A160_K1.2631.00
107_K111_A1.2521.00
63_L81_M1.2511.00
47_L113_A1.2321.00
113_A122_I1.2111.00
68_A138_Y1.2061.00
63_L92_L1.1981.00
106_E124_I1.1971.00
63_L141_T1.1901.00
78_M118_L1.1841.00
83_K86_K1.1691.00
77_E141_T1.1661.00
88_Y91_K1.1581.00
75_R112_F1.1501.00
83_K87_E1.1471.00
112_F116_Y1.1421.00
76_Q157_T1.1411.00
61_K151_Q1.1381.00
100_T104_K1.1371.00
16_G20_W1.1341.00
69_T109_V1.1341.00
44_L123_L1.1321.00
36_G149_V1.1261.00
62_V144_L1.1251.00
111_A115_T1.1171.00
99_F138_Y1.1061.00
55_Q58_K1.1041.00
109_V124_I1.1031.00
66_F133_Y1.0931.00
140_T153_I1.0901.00
52_S56_D1.0791.00
125_D128_G1.0711.00
81_M94_V1.0671.00
111_A114_D1.0661.00
64_L144_L1.0651.00
142_Y150_I1.0591.00
87_E160_K1.0501.00
72_K76_Q1.0491.00
19_G22_L1.0471.00
152_D166_K1.0381.00
65_N73_P1.0341.00
57_A95_V1.0261.00
159_T162_E1.0151.00
86_K89_A0.9951.00
33_I36_G0.9881.00
93_A121_P0.9821.00
41_D54_L0.9741.00
99_F130_N0.9731.00
42_F129_I0.9461.00
16_G19_G0.9361.00
44_L129_I0.9271.00
45_K106_E0.9261.00
82_E117_D0.9151.00
69_T112_F0.9141.00
66_F97_V0.9121.00
57_A62_V0.8951.00
100_T128_G0.8861.00
84_L163_M0.8831.00
89_A93_A0.8831.00
143_I166_K0.8821.00
84_L88_Y0.8771.00
161_K164_E0.8661.00
54_L58_K0.8481.00
82_E120_F0.8331.00
62_V95_V0.8291.00
143_I152_D0.8271.00
144_L148_G0.8191.00
85_Q93_A0.8121.00
46_T121_P0.8111.00
150_I153_I0.8011.00
73_P138_Y0.8001.00
35_E152_D0.7981.00
78_M116_Y0.7951.00
135_V140_T0.7951.00
52_S123_L0.7911.00
162_E166_K0.7881.00
78_M120_F0.7841.00
85_Q119_T0.7831.00
107_K110_R0.7831.00
18_T21_N0.7821.00
54_L62_V0.7681.00
58_K62_V0.7681.00
70_W138_Y0.7671.00
33_I37_Q0.7611.00
86_K119_T0.7571.00
42_F54_L0.7551.00
108_Q111_A0.7521.00
113_A118_L0.7501.00
71_C79_P0.7491.00
80_A157_T0.7421.00
69_T73_P0.7411.00
96_A118_L0.7411.00
154_H158_M0.7241.00
54_L57_A0.7221.00
46_T123_L0.7221.00
59_G146_E0.7211.00
154_H166_K0.7201.00
88_Y164_E0.7151.00
129_I132_D0.7151.00
47_L110_R0.7081.00
130_N135_V0.7001.00
73_P157_T0.6991.00
143_I154_H0.6871.00
18_T22_L0.6841.00
72_K75_R0.6741.00
81_M141_T0.6701.00
79_P83_K0.6691.00
38_Q58_K0.6691.00
96_A122_I0.6621.00
160_K163_M0.6601.00
80_A84_L0.6601.00
62_V148_G0.6591.00
78_M82_E0.6581.00
59_G148_G0.6551.00
66_F135_V0.6531.00
66_F129_I0.6511.00
109_V112_F0.6491.00
48_S110_R0.6491.00
67_W122_I0.6401.00
154_H157_T0.6391.00
104_K108_Q0.6341.00
58_K148_G0.6321.00
85_Q88_Y0.6281.00
35_E153_I0.6281.00
81_M96_A0.6251.00
84_L87_E0.6211.00
109_V122_I0.6191.00
65_N81_M0.6141.00
113_A117_D0.6111.00
31_V34_Q0.6061.00
61_K92_L0.6001.00
140_T155_V0.5991.00
73_P79_P0.5981.00
71_C139_P0.5971.00
77_E157_T0.5941.00
45_K126_K0.5911.00
59_G62_V0.5901.00
63_L94_V0.5891.00
161_K165_Q0.5891.00
82_E116_Y0.5881.00
129_I133_Y0.5881.00
82_E85_Q0.5801.00
67_W78_M0.5801.00
78_M112_F0.5801.00
97_V125_D0.5791.00
76_Q80_A0.5701.00
46_T49_G0.5621.00
79_P139_P0.5611.00
45_K49_G0.5611.00
85_Q120_F0.5601.00
69_T78_M0.5581.00
75_R78_M0.5541.00
74_C79_P0.5511.00
76_Q79_P0.5501.00
114_D117_D0.5481.00
137_S140_T0.5461.00
158_M163_M0.5451.00
135_V142_Y0.5401.00
68_A98_N0.5341.00
39_A64_L0.5331.00
118_L122_I0.5331.00
84_L94_V0.5300.99
68_A73_P0.5290.99
52_S121_P0.5280.99
71_C116_Y0.5280.99
65_N78_M0.5280.99
88_Y92_L0.5160.99
125_D130_N0.5100.99
32_G36_G0.5080.99
59_G145_D0.5070.99
67_W98_N0.5030.99
131_A136_M0.5020.99
64_L133_Y0.5020.99
97_V129_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hyxA 2 0.9647 100 0.322 Contact Map
3eytA 4 0.8059 100 0.347 Contact Map
3lorA 3 0.8059 100 0.357 Contact Map
3eurA 1 0.7824 100 0.357 Contact Map
2p5qA 3 0.7882 100 0.366 Contact Map
4yodA 1 0.9647 100 0.368 Contact Map
3fw2A 2 0.7882 100 0.371 Contact Map
2ggtA 1 0.7882 100 0.372 Contact Map
3hczA 2 0.8118 100 0.373 Contact Map
2f9sA 1 0.7882 100 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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