GREMLIN Database
FOSB - Metallothiol transferase FosB
UniProt: O31817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (130)
Sequences: 409 (298)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_I31_L4.4681.00
72_I80_M3.9141.00
129_Y136_M3.4881.00
84_L89_V3.3641.00
80_M117_F3.2191.00
81_S105_I2.9291.00
10_L38_T2.8681.00
21_D25_K2.7100.99
10_L48_L2.3920.99
33_V136_M2.3110.98
12_S53_E2.2930.98
29_A43_M2.2560.98
72_I105_I2.2440.98
37_T52_E2.1750.97
72_I119_T2.0780.96
19_S23_Y2.0510.96
77_F81_S2.0000.96
82_A86_R1.7740.92
68_I129_Y1.7480.91
85_K94_G1.7140.90
73_E76_E1.6740.89
26_V87_L1.5890.86
78_E103_K1.5740.86
5_G46_I1.5500.85
81_S85_K1.5220.84
17_D34_K1.4480.81
6_I46_I1.4230.79
74_D119_T1.4070.79
43_M48_L1.3840.77
66_T113_H1.3670.77
22_F110_P1.3560.76
35_G38_T1.3470.75
4_K73_E1.3440.75
74_D103_K1.3420.75
65_Y106_Y1.3380.75
33_V129_Y1.3080.73
64_S114_K1.2770.71
27_F44_N1.2740.71
42_D45_G1.2460.70
7_N71_T1.2380.69
78_E105_I1.2120.67
9_L123_Q1.2120.67
3_I43_M1.2110.67
22_F26_V1.1780.65
50_L66_T1.1700.65
55_D60_D1.1690.64
19_S22_F1.1640.64
3_I34_K1.1560.64
51_N95_R1.1470.63
65_Y113_H1.1360.62
15_H86_R1.1340.62
15_H18_T1.1220.61
31_L39_A1.0810.58
20_I39_A1.0620.57
14_S54_P1.0580.57
15_H88_H1.0560.56
22_F89_V1.0530.56
80_M83_K1.0440.56
32_L42_D1.0430.56
27_F76_E1.0430.56
19_S110_P1.0220.54
32_L44_N1.0000.52
24_Q31_L0.9730.50
23_Y40_Y0.9640.50
51_N65_Y0.9610.49
100_R131_Q0.9560.49
11_F49_A0.9510.49
134_T137_H0.9490.49
36_R134_T0.9260.47
77_F119_T0.9190.46
21_D79_E0.9170.46
38_T100_R0.9090.46
34_K137_H0.9040.45
40_Y110_P0.9020.45
107_F129_Y0.8930.44
77_F85_K0.8910.44
68_I136_M0.8840.44
106_Y113_H0.8690.43
29_A48_L0.8690.43
23_Y110_P0.8690.43
27_F80_M0.8640.42
3_I46_I0.8560.42
39_A110_P0.8420.41
93_P96_E0.8360.40
50_L110_P0.8330.40
82_A137_H0.8310.40
108_T114_K0.8290.40
95_R129_Y0.8220.39
35_G98_D0.8120.39
73_E82_A0.8100.39
9_L46_I0.8040.38
72_I77_F0.7930.37
74_D88_H0.7670.36
123_Q127_R0.7660.35
18_T131_Q0.7480.34
89_V107_F0.7450.34
5_G8_H0.7440.34
9_L68_I0.7420.34
7_N40_Y0.7360.33
33_V66_T0.7290.33
10_L137_H0.7270.33
86_R103_K0.7240.33
106_Y118_H0.7230.33
105_I119_T0.7230.33
7_N12_S0.7220.33
23_Y39_A0.7210.32
46_I113_H0.7210.32
11_F113_H0.7200.32
31_L136_M0.7200.32
71_T123_Q0.7160.32
31_L121_T0.7150.32
93_P103_K0.7150.32
38_T98_D0.7130.32
119_T132_E0.7110.32
36_R135_H0.7100.32
18_T30_K0.7100.32
37_T137_H0.7070.32
19_S50_L0.7020.31
74_D86_R0.6990.31
85_K88_H0.6970.31
19_S40_Y0.6960.31
30_K48_L0.6940.31
12_S66_T0.6910.31
44_N76_E0.6870.30
64_S95_R0.6820.30
73_E86_R0.6800.30
37_T131_Q0.6750.30
18_T127_R0.6650.29
53_E101_D0.6600.29
113_H120_G0.6570.28
5_G44_N0.6560.28
63_L93_P0.6550.28
56_I63_L0.6550.28
101_D135_H0.6530.28
54_P131_Q0.6380.27
30_K82_A0.6350.27
22_F40_Y0.6330.27
60_D123_Q0.6330.27
4_K71_T0.6320.27
89_V122_L0.6280.27
75_H82_A0.6230.26
49_A95_R0.6170.26
7_N23_Y0.6160.26
82_A131_Q0.6150.26
12_S64_S0.6110.26
25_K80_M0.6100.26
6_I72_I0.6060.25
18_T88_H0.5990.25
28_G73_E0.5960.25
59_N63_L0.5910.25
59_N123_Q0.5820.24
123_Q132_E0.5820.24
77_F124_D0.5810.24
10_L101_D0.5790.24
81_S127_R0.5770.24
73_E93_P0.5770.24
35_G101_D0.5750.24
18_T54_P0.5750.24
35_G95_R0.5720.24
44_N96_E0.5720.24
18_T25_K0.5690.23
17_D31_L0.5650.23
6_I42_D0.5620.23
61_I64_S0.5620.23
22_F39_A0.5560.23
33_V51_N0.5550.23
18_T86_R0.5540.23
12_S23_Y0.5530.23
94_G119_T0.5520.23
26_V130_K0.5510.23
101_D133_K0.5510.23
72_I131_Q0.5510.23
21_D86_R0.5480.22
34_K39_A0.5430.22
85_K89_V0.5430.22
71_T121_T0.5390.22
106_Y114_K0.5380.22
127_R131_Q0.5370.22
106_Y126_L0.5360.22
74_D121_T0.5320.22
43_M84_L0.5310.21
12_S51_N0.5300.21
54_P82_A0.5280.21
23_Y50_L0.5270.21
70_F107_F0.5240.21
55_D78_E0.5210.21
38_T101_D0.5210.21
116_E125_R0.5200.21
17_D20_I0.5190.21
101_D106_Y0.5170.21
11_F65_Y0.5100.20
93_P127_R0.5050.20
10_L102_R0.5040.20
35_G40_Y0.5010.20
53_E96_E0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jh2A 2 0.9583 100 0.586 Contact Map
4ir0A 2 1 99.9 0.589 Contact Map
2p7oA 2 0.8333 99.9 0.603 Contact Map
4nazA 2 0.9028 99.9 0.605 Contact Map
1nkiA 2 0.9236 99.9 0.606 Contact Map
1npbA 3 0.9583 99.9 0.621 Contact Map
1r9cA 2 0.8333 99.9 0.647 Contact Map
3kolA 2 0.8333 99.8 0.671 Contact Map
2p25A 2 0.8125 99.8 0.677 Contact Map
2rk0A 4 0.875 99.8 0.678 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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