GREMLIN Database
YNDL - UPF0714 protein YndL
UniProt: O31815 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (198)
Sequences: 167 (139)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_I240_F5.6101.00
65_E115_K4.0470.99
115_K121_V3.8270.98
216_F240_F3.7610.98
157_I216_F3.3460.96
152_E213_S3.0430.93
86_I158_E2.9290.91
212_M248_L2.4060.81
109_Y129_F2.3980.80
229_R234_N2.3640.79
115_K124_I2.2750.77
85_A95_T2.2480.76
113_G119_N2.2480.76
109_Y131_E2.2470.76
150_Y213_S2.2210.75
231_V234_N2.1980.74
84_L138_T2.1550.72
58_F124_I2.0760.69
163_D204_T1.9930.66
128_H195_P1.9540.65
82_L144_V1.9520.64
174_L179_F1.9510.64
86_I99_A1.9280.63
144_V202_S1.9190.63
59_E124_I1.8950.62
86_I187_D1.8830.62
85_A99_A1.8800.61
60_E64_N1.8480.60
162_T207_S1.8290.59
186_M244_M1.8280.59
109_Y132_P1.8050.58
207_S247_F1.7080.54
149_G217_R1.7010.53
145_I166_R1.6870.53
225_S229_R1.6390.51
96_S192_G1.6310.50
96_S112_E1.6120.49
224_F234_N1.5260.46
84_L134_A1.5130.45
103_S108_M1.5090.45
107_S131_E1.5010.44
58_F129_F1.4890.44
72_V131_E1.4740.43
109_Y174_L1.4610.43
90_G117_A1.4200.41
74_T210_I1.3960.40
101_E241_T1.3930.40
94_G97_E1.3750.39
199_A207_S1.3690.39
134_A198_I1.3690.39
71_G126_S1.3670.38
86_I146_S1.3590.38
70_Y181_A1.3550.38
225_S228_S1.3490.38
83_V196_N1.3280.37
116_S215_G1.3200.36
168_A210_I1.3190.36
101_E201_K1.2990.36
227_K234_N1.2870.35
158_E190_H1.2330.33
107_S141_H1.2290.33
82_L199_A1.2190.32
171_V181_A1.2160.32
127_T194_S1.2070.32
55_Y179_F1.2040.32
108_M124_I1.2040.32
60_E86_I1.1890.31
181_A212_M1.1880.31
65_E70_Y1.1560.30
55_Y94_G1.1530.30
94_G157_I1.1500.30
70_Y110_L1.1430.29
158_E187_D1.1410.29
95_T99_A1.1360.29
57_N124_I1.1030.28
155_Q236_R1.1010.28
90_G118_G1.0990.28
67_P96_S1.0900.27
150_Y216_F1.0840.27
228_S232_T1.0820.27
170_L208_I1.0770.27
174_L220_L1.0730.27
104_K245_F1.0710.27
146_S163_D1.0630.26
102_L244_M1.0600.26
124_I131_E1.0540.26
117_A129_F1.0450.26
215_G219_S1.0440.26
139_G151_A1.0390.26
226_L229_R1.0280.25
129_F132_P1.0280.25
170_L174_L1.0150.25
141_H234_N1.0090.25
129_F237_F1.0080.25
179_F220_L1.0080.25
159_V181_A1.0040.24
134_A138_T1.0040.24
147_L240_F1.0040.24
90_G195_P0.9680.23
124_I129_F0.9650.23
216_F219_S0.9630.23
107_S110_L0.9620.23
144_V170_L0.9600.23
224_F227_K0.9570.23
171_V190_H0.9530.23
112_E145_I0.9360.22
82_L137_M0.9280.22
130_D178_G0.9280.22
244_M250_N0.9270.22
128_H180_P0.9190.22
111_F197_N0.9080.21
176_H246_R0.9070.21
76_E159_V0.9020.21
159_V235_E0.8970.21
166_R207_S0.8940.21
96_S212_M0.8940.21
123_H211_E0.8840.21
123_H148_H0.8840.21
148_H211_E0.8840.21
230_A234_N0.8780.20
58_F109_Y0.8740.20
212_M227_K0.8720.20
88_G94_G0.8680.20
128_H182_V0.8670.20
167_A247_F0.8630.20
114_L188_H0.8600.20
62_K115_K0.8580.20
135_L213_S0.8570.20
95_T137_M0.8540.20
71_G113_G0.8470.20
85_A103_S0.8470.20
98_V147_L0.8440.19
170_L240_F0.8440.19
156_Q213_S0.8410.19
84_L144_V0.8390.19
62_K131_E0.8370.19
223_I227_K0.8360.19
238_Y241_T0.8280.19
113_G141_H0.8260.19
124_I145_I0.8240.19
88_G192_G0.8220.19
124_I179_F0.8220.19
185_N223_I0.8150.19
147_L170_L0.8150.19
156_Q180_P0.8100.18
136_K163_D0.8100.18
237_F245_F0.7980.18
189_P201_K0.7950.18
95_T102_L0.7940.18
86_I198_I0.7920.18
116_S249_K0.7910.18
210_I246_R0.7900.18
73_V112_E0.7870.18
83_V96_S0.7860.18
58_F131_E0.7840.18
157_I170_L0.7840.18
117_A195_P0.7770.18
145_I242_E0.7760.18
57_N239_E0.7750.18
145_I232_T0.7750.18
115_K213_S0.7710.17
98_V239_E0.7660.17
113_G208_I0.7630.17
93_G141_H0.7630.17
196_N223_I0.7550.17
93_G198_I0.7550.17
82_L141_H0.7540.17
199_A247_F0.7530.17
58_F62_K0.7520.17
234_N237_F0.7510.17
81_V205_G0.7510.17
58_F237_F0.7490.17
78_G169_D0.7470.17
208_I243_V0.7440.17
102_L147_L0.7390.17
112_E186_M0.7280.16
90_G226_L0.7250.16
99_A110_L0.7190.16
157_I210_I0.7170.16
139_G153_E0.7130.16
71_G112_E0.7080.16
125_T211_E0.7060.16
125_T148_H0.7060.16
143_Y206_L0.7050.16
74_T145_I0.7050.16
70_Y190_H0.7010.16
65_E69_D0.6980.16
96_S201_K0.6950.16
137_M202_S0.6920.15
166_R208_I0.6900.15
163_D226_L0.6890.15
56_Q60_E0.6890.15
230_A233_Q0.6870.15
83_V240_F0.6800.15
179_F239_E0.6790.15
158_E181_A0.6780.15
70_Y208_I0.6720.15
119_N220_L0.6700.15
85_A102_L0.6680.15
243_V247_F0.6670.15
121_V124_I0.6670.15
100_R104_K0.6670.15
54_V121_V0.6600.15
98_V220_L0.6600.15
59_E229_R0.6520.15
59_E131_E0.6500.15
219_S225_S0.6490.14
129_F242_E0.6470.14
68_S220_L0.6460.14
55_Y115_K0.6430.14
190_H243_V0.6430.14
126_S139_G0.6420.14
187_D213_S0.6400.14
108_M207_S0.6350.14
124_I247_F0.6310.14
155_Q213_S0.6290.14
192_G209_Q0.6230.14
151_A172_E0.6190.14
135_L201_K0.6180.14
229_R232_T0.6180.14
138_T220_L0.6160.14
84_L234_N0.6160.14
236_R242_E0.6160.14
98_V205_G0.6160.14
164_R167_A0.6130.14
60_E151_A0.6080.14
112_E244_M0.6080.14
220_L236_R0.6060.14
54_V60_E0.6030.13
120_S163_D0.5980.13
156_Q216_F0.5900.13
52_E205_G0.5880.13
220_L228_S0.5880.13
137_M214_T0.5880.13
99_A240_F0.5870.13
109_Y124_I0.5870.13
94_G240_F0.5860.13
55_Y112_E0.5860.13
75_K174_L0.5850.13
95_T111_F0.5820.13
58_F208_I0.5810.13
177_A246_R0.5800.13
63_N144_V0.5800.13
103_S228_S0.5790.13
75_K241_T0.5760.13
235_E239_E0.5750.13
53_D61_L0.5750.13
181_A187_D0.5730.13
167_A171_V0.5700.13
93_G162_T0.5680.13
162_T247_F0.5650.13
114_L248_L0.5650.13
117_A121_V0.5650.13
60_E242_E0.5640.13
186_M218_K0.5630.13
166_R181_A0.5550.12
57_N242_E0.5540.12
99_A131_E0.5520.12
83_V219_S0.5500.12
162_T230_A0.5490.12
202_S245_F0.5490.12
127_T244_M0.5430.12
74_T191_A0.5420.12
80_P176_H0.5420.12
97_E125_T0.5410.12
53_D82_L0.5400.12
57_N98_V0.5370.12
158_E237_F0.5350.12
103_S201_K0.5310.12
189_P218_K0.5310.12
102_L146_S0.5300.12
116_S178_G0.5290.12
136_K246_R0.5280.12
100_R247_F0.5230.12
97_E229_R0.5210.12
138_T192_G0.5200.12
219_S248_L0.5170.12
159_V199_A0.5160.12
174_L208_I0.5150.12
62_K109_Y0.5150.12
80_P118_G0.5130.12
152_E187_D0.5120.12
219_S238_Y0.5090.12
54_V236_R0.5080.12
101_E237_F0.5070.12
65_E107_S0.5060.12
127_T178_G0.5060.12
90_G202_S0.5040.12
59_E192_G0.5030.11
108_M197_N0.5020.11
138_T144_V0.5020.11
100_R202_S0.5010.11
119_N221_F0.5010.11
162_T180_P0.5010.11
75_K201_K0.5010.11
152_E215_G0.5000.11
56_Q151_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a9lA 2 0.7857 100 0.294 Contact Map
2odfA 2 0.7222 93.5 0.943 Contact Map
2q7sA 1 0.6825 78.2 0.956 Contact Map
3czxA 2 0.623 64.7 0.96 Contact Map
3qayA 1 0.6071 55.8 0.962 Contact Map
1xovA 1 0.6111 33 0.967 Contact Map
4lq6A 1 0.631 29.5 0.968 Contact Map
1jwqA 1 0.5992 26.3 0.968 Contact Map
4rn7A 1 0.6071 23.6 0.969 Contact Map
1riiA 4 0.4563 20.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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