GREMLIN Database
YNDH - Uncharacterized protein YndH
UniProt: O31812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (195)
Sequences: 249 (189)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_I132_A4.9541.00
166_V181_V3.6910.99
5_Y88_W3.6610.99
61_F99_R3.2960.98
11_N14_L2.8600.96
63_E99_R2.8370.96
16_H22_R2.4230.90
105_M168_E2.3970.90
144_K155_P2.3190.88
117_F146_W2.2530.87
133_S167_C2.1990.85
127_V146_W2.1640.84
140_I161_T2.1390.84
70_F116_D2.0620.81
176_C197_T2.0210.80
79_L83_H1.9980.79
5_Y61_F1.9260.76
8_S191_L1.8750.74
55_V61_F1.8370.73
15_L35_G1.8340.73
39_E195_K1.8240.72
86_I149_I1.7860.71
96_G172_E1.7840.71
74_N168_E1.7360.68
11_N131_E1.7280.68
74_N142_S1.7250.68
174_K178_T1.7210.68
37_M40_I1.6760.66
32_S115_L1.6700.65
18_K21_K1.6490.64
73_Q91_T1.6470.64
137_S169_T1.5870.61
19_L31_F1.5440.59
52_K55_V1.5260.58
20_Q182_H1.5180.58
59_C118_F1.5140.57
145_Q185_N1.5050.57
22_R200_E1.4940.56
180_E195_K1.4940.56
36_T141_T1.4900.56
170_F197_T1.4820.56
43_G185_N1.4610.55
169_T178_T1.4570.54
160_L186_T1.4400.54
30_T75_R1.4030.52
105_M128_L1.4000.51
27_G84_T1.3990.51
74_N194_Y1.3980.51
79_L85_G1.3970.51
38_S67_D1.3800.50
18_K177_F1.3790.50
55_V62_S1.3760.50
37_M88_W1.3430.48
16_H170_F1.3010.46
101_F177_F1.2890.45
40_I140_I1.2810.45
11_N180_E1.2750.45
8_S107_Y1.2620.44
13_H78_L1.2550.44
182_H191_L1.2500.43
177_F185_N1.2460.43
53_L156_L1.2310.42
140_I166_V1.2180.42
69_P92_F1.2160.42
187_I199_Q1.2100.41
131_E152_K1.2060.41
186_T191_L1.2060.41
6_E13_H1.2000.41
121_P193_F1.1910.40
74_N181_V1.1910.40
140_I181_V1.1830.40
177_F198_F1.1550.39
4_I9_I1.1490.38
23_Y44_S1.1490.38
95_K98_K1.1460.38
12_Y74_N1.1410.38
7_K173_K1.1380.38
5_Y94_F1.1320.37
128_L140_I1.1010.36
86_I154_I1.1000.36
86_I103_A1.0930.35
80_K91_T1.0930.35
22_R37_M1.0930.35
148_L153_R1.0910.35
25_L29_H1.0880.35
126_S145_Q1.0870.35
103_A140_I1.0770.35
105_M192_F1.0730.34
28_S67_D1.0710.34
31_F88_W1.0700.34
70_F99_R1.0670.34
22_R198_F1.0620.34
68_I159_W1.0580.34
22_R31_F1.0560.34
10_I13_H1.0480.33
98_K114_I1.0450.33
18_K184_Q1.0390.33
5_Y99_R1.0340.33
118_F164_S1.0270.32
22_R145_Q1.0250.32
20_Q148_L1.0230.32
101_F162_G1.0200.32
105_M181_V1.0110.32
148_L156_L1.0060.31
67_D190_T1.0040.31
100_F188_L0.9980.31
37_M103_A0.9890.31
39_E175_N0.9870.30
11_N176_C0.9850.30
114_I192_F0.9820.30
49_M150_C0.9710.30
39_E64_R0.9670.30
68_I138_L0.9630.29
10_I184_Q0.9630.29
49_M118_F0.9600.29
40_I128_L0.9560.29
40_I101_F0.9520.29
37_M65_G0.9520.29
5_Y31_F0.9370.28
88_W105_M0.9330.28
42_G54_G0.9310.28
116_D183_V0.9290.28
133_S137_S0.9230.28
10_I191_L0.9220.28
84_T131_E0.9080.27
5_Y181_V0.8920.26
58_R120_K0.8850.26
162_G168_E0.8810.26
19_L74_N0.8780.26
168_E181_V0.8780.26
25_L177_F0.8760.26
46_L188_L0.8740.26
80_K95_K0.8720.26
47_V50_L0.8710.25
141_T166_V0.8680.25
54_G192_F0.8680.25
103_A181_V0.8680.25
126_S140_I0.8660.25
51_L73_Q0.8660.25
138_L199_Q0.8660.25
44_S93_F0.8620.25
49_M132_A0.8610.25
35_G90_R0.8580.25
5_Y98_K0.8530.25
156_L160_L0.8520.25
21_K61_F0.8510.25
13_H98_K0.8470.25
64_R88_W0.8400.24
65_G95_K0.8370.24
131_E172_E0.8350.24
16_H118_F0.8220.24
57_F60_F0.8180.23
4_I130_F0.8150.23
10_I68_I0.8030.23
15_L90_R0.7930.22
90_R196_G0.7910.22
23_Y126_S0.7840.22
22_R103_A0.7830.22
102_D120_K0.7820.22
4_I86_I0.7820.22
70_F74_N0.7800.22
34_T100_F0.7770.22
25_L139_T0.7770.22
11_N78_L0.7750.22
147_L154_I0.7750.22
34_T112_N0.7740.22
41_S200_E0.7690.22
169_T175_N0.7690.22
92_F166_V0.7670.22
14_L177_F0.7620.21
37_M145_Q0.7610.21
145_Q177_F0.7490.21
67_D131_E0.7480.21
19_L88_W0.7440.21
105_M114_I0.7420.21
157_P198_F0.7420.21
41_S190_T0.7400.21
20_Q150_C0.7380.20
86_I114_I0.7380.20
125_L177_F0.7370.20
88_W103_A0.7370.20
174_K197_T0.7300.20
26_D106_I0.7290.20
34_T177_F0.7270.20
28_S159_W0.7250.20
12_Y116_D0.7250.20
33_G194_Y0.7220.20
129_T191_L0.7180.20
76_T169_T0.7080.19
20_Q81_S0.7000.19
55_V99_R0.6980.19
44_S200_E0.6940.19
80_K175_N0.6940.19
54_G149_I0.6900.19
68_I95_K0.6880.19
99_R181_V0.6880.19
168_E194_Y0.6870.19
43_G121_P0.6830.19
3_S147_L0.6820.19
130_F138_L0.6750.18
171_D178_T0.6750.18
16_H70_F0.6730.18
31_F200_E0.6670.18
32_S139_T0.6610.18
47_V154_I0.6590.18
128_L164_S0.6570.18
63_E70_F0.6560.18
111_E115_L0.6560.18
13_H97_K0.6540.18
92_F181_V0.6470.18
40_I103_A0.6440.17
58_R62_S0.6440.17
13_H158_K0.6410.17
38_S178_T0.6410.17
78_L160_L0.6390.17
11_N149_I0.6380.17
22_R185_N0.6330.17
142_S179_I0.6320.17
170_F177_F0.6310.17
53_L80_K0.6290.17
5_Y42_G0.6290.17
88_W98_K0.6230.17
122_H164_S0.6230.17
113_R159_W0.6230.17
113_R143_G0.6230.17
6_E112_N0.6220.17
55_V175_N0.6210.17
103_A116_D0.6180.17
93_F197_T0.6160.17
119_G142_S0.6120.16
62_S99_R0.6090.16
157_P187_I0.6050.16
86_I147_L0.5990.16
155_P159_W0.5970.16
28_S66_K0.5950.16
90_R189_G0.5920.16
38_S190_T0.5920.16
100_F120_K0.5910.16
19_L63_E0.5900.16
156_L173_K0.5890.16
163_T194_Y0.5880.16
157_P192_F0.5870.16
20_Q197_T0.5870.16
70_F119_G0.5870.16
169_T192_F0.5850.16
62_S118_F0.5850.16
13_H20_Q0.5830.16
5_Y142_S0.5800.16
27_G30_T0.5780.15
92_F118_F0.5760.15
22_R43_G0.5750.15
97_K114_I0.5750.15
54_G128_L0.5730.15
147_L156_L0.5730.15
39_E188_L0.5720.15
95_K175_N0.5710.15
13_H199_Q0.5670.15
78_L197_T0.5660.15
108_D111_E0.5640.15
65_G162_G0.5600.15
72_I179_I0.5590.15
81_S148_L0.5590.15
20_Q179_I0.5580.15
10_I66_K0.5560.15
131_E141_T0.5550.15
80_K187_I0.5550.15
106_I183_V0.5530.15
149_I156_L0.5470.15
131_E174_K0.5440.15
12_Y146_W0.5410.14
43_G162_G0.5350.14
43_G181_V0.5340.14
36_T129_T0.5290.14
6_E24_Q0.5290.14
83_H178_T0.5270.14
124_L163_T0.5260.14
104_L122_H0.5250.14
28_S36_T0.5240.14
22_R146_W0.5240.14
65_G101_F0.5230.14
47_V191_L0.5180.14
13_H180_E0.5180.14
116_D170_F0.5160.14
21_K97_K0.5160.14
141_T191_L0.5150.14
29_H76_T0.5150.14
47_V194_Y0.5100.14
77_C87_E0.5090.14
16_H119_G0.5020.13
99_R116_D0.5010.13
118_F125_L0.5000.13
119_G183_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eudA 1 0.4341 23.7 0.957 Contact Map
4pbdA 1 0.4585 22 0.957 Contact Map
2mnwA 1 0.4049 14.1 0.961 Contact Map
4khbD 1 0.3902 8.6 0.964 Contact Map
1sfuA 1 0.322 7.1 0.966 Contact Map
2xzeA 1 0.2488 4.7 0.968 Contact Map
1n0eA 5 0.3073 4.7 0.968 Contact Map
2k8qA 1 0.4878 4.5 0.969 Contact Map
3qd7X 1 0.1951 3.1 0.971 Contact Map
3n98A 1 0.8244 2.6 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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