GREMLIN Database
YNDF - Spore germination protein YndF
UniProt: O31810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (363)
Sequences: 2203 (1910)
Seq/√Len: 100.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_H388_T5.3351.00
304_D390_S4.4841.00
134_E138_H4.2281.00
44_K139_T4.1901.00
252_E347_K4.1831.00
272_D316_N3.6181.00
68_T169_R3.6091.00
338_K342_G3.5531.00
134_E165_K3.5151.00
131_V164_A3.2171.00
281_Y333_I2.9851.00
167_E170_D2.9641.00
306_E392_N2.9451.00
334_E393_V2.8561.00
141_P242_K2.8011.00
221_N247_T2.7241.00
301_F359_F2.6211.00
66_N103_T2.5711.00
338_K391_V2.5631.00
301_F385_A2.5351.00
169_R173_Q2.5211.00
300_S386_D2.4701.00
349_Q382_F2.4321.00
305_I341_V2.4201.00
348_I382_F2.3881.00
71_Y114_V2.3641.00
244_M247_T2.3611.00
69_L110_I2.3581.00
308_E396_T2.3441.00
235_A244_M2.2931.00
353_K383_S2.2681.00
163_S235_A2.1961.00
300_S388_T2.1921.00
70_T168_A2.1781.00
255_G344_V2.1601.00
207_L217_F2.1481.00
234_A253_T2.1051.00
246_G352_Y2.0881.00
345_L387_I2.0801.00
137_L163_S2.0671.00
348_I356_V2.0261.00
68_T103_T1.9861.00
377_N380_D1.9461.00
132_M145_M1.9421.00
302_H390_S1.9411.00
161_V207_L1.9401.00
147_D151_R1.9251.00
66_N105_D1.9211.00
348_I357_A1.9131.00
43_D168_A1.8801.00
102_E113_E1.8511.00
42_I136_V1.8331.00
234_A256_I1.8241.00
303_V359_F1.8221.00
218_L256_I1.7891.00
37_T122_V1.7741.00
39_A182_A1.7711.00
45_G103_T1.7671.00
293_I302_H1.7651.00
327_D330_E1.7611.00
207_L219_L1.7201.00
370_L374_V1.7121.00
41_A168_A1.7101.00
162_L222_V1.7061.00
43_D133_S1.6461.00
133_S168_A1.6371.00
281_Y309_G1.6341.00
360_D378_W1.6191.00
40_I127_L1.6031.00
304_D392_N1.5931.00
112_S282_D1.5861.00
298_D386_D1.5821.00
111_G124_S1.5821.00
249_N252_E1.5811.00
68_T101_S1.5721.00
307_S393_V1.5561.00
308_E394_T1.5521.00
39_A172_L1.5081.00
101_S169_R1.4991.00
255_G337_V1.4911.00
328_R332_T1.4771.00
292_P299_I1.4741.00
133_S136_V1.4731.00
236_V356_V1.4691.00
290_I301_F1.4621.00
345_L389_Y1.4611.00
45_G68_T1.4471.00
68_T167_E1.4361.00
185_L222_V1.4341.00
329_L395_I1.4261.00
132_M142_I1.4251.00
294_V299_I1.4211.00
330_E334_E1.4201.00
214_G360_D1.4161.00
221_N244_M1.4151.00
334_E338_K1.4111.00
336_E340_I1.3971.00
165_K223_V1.3911.00
301_F363_F1.3840.99
170_D173_Q1.3730.99
163_S237_I1.3730.99
137_L237_I1.3690.99
105_D109_Q1.3670.99
15_V19_M1.3550.99
40_I149_F1.3520.99
216_S354_A1.3480.99
344_V348_I1.3480.99
336_E339_K1.3280.99
132_M137_L1.3070.99
162_L189_G1.3030.99
246_G354_A1.3020.99
157_L205_A1.2950.99
331_T334_E1.2920.99
341_V389_Y1.2860.99
104_G110_I1.2720.99
322_D325_F1.2610.99
261_G288_S1.2590.99
223_V232_S1.2570.99
346_K349_Q1.2530.99
259_I357_A1.2400.99
216_S379_D1.2400.99
288_S305_I1.2130.99
37_T124_S1.2080.99
34_L123_F1.2000.99
309_G333_I1.1990.99
295_K300_S1.1880.98
128_K186_I1.1790.98
259_I303_V1.1690.98
67_I136_V1.1600.98
319_E322_D1.1450.98
35_G73_F1.1420.98
363_F370_L1.1420.98
255_G348_I1.1420.98
236_V352_Y1.1410.98
333_I393_V1.1390.98
38_F74_V1.1360.98
42_I107_L1.1320.98
292_P366_T1.1270.98
378_W382_F1.1240.98
108_Q112_S1.1210.98
292_P367_Y1.1130.98
291_Q302_H1.1100.98
104_G109_Q1.1060.98
164_A171_A1.1020.97
307_S337_V1.0990.97
332_T335_N1.0970.97
289_R304_D1.0950.97
104_G113_E1.0910.97
127_L155_I1.0850.97
108_Q312_V1.0830.97
70_T101_S1.0820.97
70_T99_N1.0810.97
108_Q282_D1.0790.97
135_D168_A1.0710.97
97_Y181_P1.0670.97
359_F387_I1.0630.97
279_L329_L1.0620.97
18_L21_C1.0620.97
108_Q148_Q1.0600.97
310_D397_H1.0550.97
22_V25_C1.0540.97
256_I356_V1.0530.97
150_F208_I1.0480.97
363_F367_Y1.0400.96
349_Q378_W1.0380.96
130_V159_C1.0310.96
223_V230_K1.0310.96
291_Q304_D1.0240.96
326_I330_E1.0210.96
97_Y180_I1.0150.96
117_R228_A1.0100.96
252_E343_Q1.0070.96
249_N253_T0.9960.95
72_Q181_P0.9930.95
102_E114_V0.9930.95
131_V162_L0.9910.95
165_K247_T0.9900.95
361_E364_R0.9880.95
126_H156_R0.9880.95
372_K375_K0.9860.95
335_N339_K0.9840.95
121_E154_E0.9720.95
45_G65_D0.9710.95
267_V282_D0.9660.95
259_I341_V0.9580.94
135_D138_H0.9550.94
137_L235_A0.9550.94
248_L252_E0.9520.94
346_K350_H0.9510.94
256_I260_R0.9470.94
162_L220_Q0.9430.94
342_G346_K0.9410.94
342_G389_Y0.9380.94
219_L237_I0.9380.94
130_V149_F0.9380.94
349_Q383_S0.9330.93
41_A167_E0.9310.93
292_P301_F0.9300.93
215_S358_G0.9270.93
137_L141_P0.9250.93
133_S163_S0.9250.93
361_E365_L0.9230.93
76_E178_G0.9180.93
143_D242_K0.9170.93
225_A230_K0.9170.93
32_E157_L0.9170.93
106_S278_T0.9100.93
335_N338_K0.9100.93
362_S365_L0.9040.92
133_S164_A0.9030.92
152_D312_V0.8970.92
268_V340_I0.8870.92
207_L211_L0.8790.91
117_R230_K0.8790.91
367_Y370_L0.8780.91
292_P362_S0.8750.91
379_D382_F0.8750.91
105_D278_T0.8680.91
305_I391_V0.8620.90
279_L314_N0.8610.90
214_G358_G0.8590.90
41_A70_T0.8580.90
102_E110_I0.8530.90
363_F371_W0.8480.90
290_I303_V0.8440.90
134_E247_T0.8410.89
42_I69_L0.8400.89
314_N318_K0.8390.89
294_V367_Y0.8340.89
381_T384_K0.8340.89
142_I207_L0.8310.89
339_K343_Q0.8290.89
138_H237_I0.8280.89
299_I385_A0.8280.89
325_F328_R0.8270.89
72_Q97_Y0.8260.88
331_T335_N0.8240.88
362_S366_T0.8230.88
130_V161_V0.8190.88
11_A22_V0.8150.88
40_I130_V0.8140.88
218_L356_V0.8130.88
245_I354_A0.8100.88
29_R34_L0.8100.88
45_G66_N0.8080.87
129_V162_L0.8070.87
258_W263_G0.8060.87
171_A222_V0.8040.87
293_I300_S0.8000.87
40_I71_Y0.7990.87
11_A15_V0.7980.87
294_V370_L0.7980.87
368_P371_W0.7970.87
137_L244_M0.7960.87
271_H278_T0.7940.86
11_A19_M0.7940.86
327_D331_T0.7910.86
370_L373_R0.7860.86
19_M23_T0.7850.86
174_L224_A0.7840.86
338_K389_Y0.7800.85
255_G341_V0.7790.85
216_S382_F0.7790.85
368_P372_K0.7780.85
337_V341_V0.7770.85
224_A227_G0.7760.85
236_V248_L0.7740.85
47_E66_N0.7730.85
281_Y395_I0.7660.84
141_P237_I0.7630.84
108_Q313_E0.7590.84
255_G258_W0.7580.84
109_Q269_K0.7560.84
347_K352_Y0.7530.83
8_Q21_C0.7520.83
210_K215_S0.7520.83
151_R399_G0.7520.83
79_A96_A0.7490.83
100_I114_V0.7480.83
41_A133_S0.7420.83
39_A129_V0.7410.82
73_F118_R0.7380.82
207_L237_I0.7360.82
345_L349_Q0.7360.82
164_A168_A0.7310.82
28_S36_L0.7310.82
163_S244_M0.7280.81
14_I17_L0.7230.81
213_S361_E0.7220.81
115_A153_N0.7210.81
106_S280_A0.7190.80
240_K379_D0.7190.80
102_E117_R0.7170.80
106_S313_E0.7160.80
23_T26_W0.7150.80
257_T262_E0.7150.80
282_D312_V0.7100.80
165_K221_N0.7090.80
237_I244_M0.7060.79
292_P359_F0.7030.79
71_Y111_G0.7030.79
44_K135_D0.6990.79
39_A72_Q0.6990.79
374_V381_T0.6980.79
41_A169_R0.6970.78
206_K210_K0.6940.78
108_Q152_D0.6920.78
160_L186_I0.6900.78
203_T206_K0.6840.77
103_T107_L0.6840.77
308_E397_H0.6840.77
197_R254_E0.6820.77
255_G340_I0.6800.77
132_M163_S0.6800.77
168_A172_L0.6800.77
40_I69_L0.6800.77
259_I288_S0.6800.77
149_F204_L0.6790.77
71_Y124_S0.6770.76
33_D187_G0.6730.76
142_I237_I0.6720.76
30_E126_H0.6710.76
142_I242_K0.6700.76
221_N235_A0.6690.76
113_E116_L0.6680.75
75_N78_A0.6670.75
30_E120_R0.6660.75
341_V344_V0.6660.75
311_L320_A0.6640.75
8_Q19_M0.6640.75
184_R188_L0.6630.75
124_S130_V0.6620.75
353_K380_D0.6590.74
345_L357_A0.6570.74
42_I67_I0.6560.74
36_L123_F0.6550.74
258_W337_V0.6550.74
205_A209_G0.6530.74
119_D176_E0.6520.74
307_S332_T0.6510.74
100_I118_R0.6500.73
273_K332_T0.6480.73
165_K244_M0.6470.73
187_G191_N0.6470.73
240_K245_I0.6450.73
258_W307_S0.6450.73
289_R296_G0.6420.73
188_L231_Y0.6410.72
161_V219_L0.6400.72
134_E221_N0.6400.72
19_M22_V0.6400.72
42_I130_V0.6400.72
318_K325_F0.6390.72
295_K298_D0.6360.72
183_F186_I0.6310.71
38_F205_A0.6300.71
83_T373_R0.6290.71
319_E323_T0.6270.71
127_L159_C0.6270.71
11_A18_L0.6260.71
236_V354_A0.6260.71
133_S244_M0.6260.71
132_M146_L0.6250.71
348_I352_Y0.6240.70
283_I307_S0.6240.70
19_M343_Q0.6240.70
337_V393_V0.6230.70
116_L250_E0.6210.70
35_G118_R0.6160.69
306_E394_T0.6160.69
309_G330_E0.6150.69
284_N310_D0.6140.69
12_M16_C0.6140.69
257_T261_G0.6130.69
12_M332_T0.6120.69
67_I303_V0.6110.69
290_I385_A0.6090.69
21_C331_T0.6080.68
183_F187_G0.6070.68
118_R122_V0.6060.68
248_L256_I0.6050.68
70_T169_R0.6050.68
217_F358_G0.6050.68
359_F382_F0.6040.68
142_I270_S0.6000.67
72_Q156_R0.6000.67
202_M210_K0.5990.67
299_I374_V0.5990.67
295_K324_Q0.5970.67
10_P22_V0.5950.67
114_V212_H0.5940.67
163_S219_L0.5920.66
10_P324_Q0.5920.66
129_V185_L0.5910.66
344_V347_K0.5910.66
44_K67_I0.5910.66
117_R225_A0.5910.66
108_Q153_N0.5900.66
16_C331_T0.5900.66
39_A183_F0.5890.66
71_Y155_I0.5880.66
164_A233_G0.5880.66
254_E340_I0.5880.66
283_I286_I0.5870.66
31_I189_G0.5870.66
70_T164_A0.5860.66
14_I21_C0.5860.66
138_H324_Q0.5860.66
318_K321_L0.5850.65
136_V145_M0.5850.65
263_G266_G0.5850.65
298_D384_K0.5840.65
73_F100_I0.5840.65
276_Q289_R0.5810.65
95_K175_K0.5810.65
290_I362_S0.5800.65
256_I344_V0.5790.65
72_Q99_N0.5790.65
257_T400_T0.5790.65
31_I96_A0.5780.65
197_R263_G0.5780.65
134_E166_G0.5780.65
19_M69_L0.5780.65
36_L97_Y0.5780.65
218_L234_A0.5770.64
376_N380_D0.5770.64
309_G393_V0.5760.64
19_M342_G0.5750.64
129_V182_A0.5740.64
282_D310_D0.5720.64
216_S356_V0.5720.64
270_S332_T0.5700.63
269_K280_A0.5690.63
20_I138_H0.5680.63
248_L344_V0.5670.63
299_I363_F0.5660.63
245_I352_Y0.5650.63
166_G233_G0.5640.63
232_S250_E0.5630.63
349_Q385_A0.5630.63
27_S33_D0.5620.62
23_T27_S0.5620.62
9_L21_C0.5610.62
11_A139_T0.5610.62
8_Q22_V0.5610.62
32_E184_R0.5590.62
72_Q182_A0.5580.62
147_D313_E0.5570.62
13_V21_C0.5560.62
8_Q335_N0.5560.62
193_H201_P0.5550.61
67_I145_M0.5550.61
251_Y340_I0.5540.61
120_R178_G0.5540.61
279_L309_G0.5530.61
19_M271_H0.5530.61
125_P217_F0.5520.61
9_L12_M0.5510.61
131_V168_A0.5510.61
138_H247_T0.5510.61
210_K270_S0.5500.61
137_L142_I0.5480.60
123_F128_K0.5470.60
13_V297_K0.5470.60
206_K251_Y0.5470.60
42_I132_M0.5470.60
363_F368_P0.5470.60
226_N331_T0.5460.60
8_Q20_I0.5450.60
274_K347_K0.5450.60
263_G286_I0.5430.60
254_E357_A0.5420.60
45_G135_D0.5420.60
37_T71_Y0.5390.59
37_T114_V0.5390.59
204_L207_L0.5390.59
74_V179_E0.5390.59
309_G395_I0.5380.59
178_G187_G0.5380.59
25_C151_R0.5380.59
138_H244_M0.5370.59
112_S115_A0.5370.59
299_I370_L0.5360.59
144_E333_I0.5360.59
41_A131_V0.5360.59
390_S393_V0.5360.59
267_V280_A0.5350.59
304_D307_S0.5340.58
296_G306_E0.5330.58
28_S178_G0.5320.58
334_E392_N0.5310.58
70_T172_L0.5310.58
246_G382_F0.5310.58
83_T322_D0.5310.58
237_I242_K0.5300.58
243_K335_N0.5300.58
215_S361_E0.5300.58
236_V348_I0.5280.58
105_D269_K0.5280.58
41_A173_Q0.5280.58
134_E244_M0.5280.58
31_I120_R0.5270.58
120_R365_L0.5270.58
152_D282_D0.5270.58
220_Q231_Y0.5270.58
165_K353_K0.5260.57
133_S167_E0.5250.57
211_L242_K0.5230.57
159_C205_A0.5230.57
96_A181_P0.5220.57
214_G217_F0.5210.57
115_A122_V0.5210.57
27_S220_Q0.5190.56
356_V382_F0.5190.56
10_P21_C0.5180.56
10_P23_T0.5180.56
272_D279_L0.5170.56
143_D181_P0.5170.56
42_I110_I0.5160.56
283_I309_G0.5140.56
292_P368_P0.5130.56
216_S358_G0.5130.56
270_S333_I0.5130.56
106_S269_K0.5120.55
309_G334_E0.5120.55
273_K277_Q0.5120.55
46_K65_D0.5110.55
38_F128_K0.5100.55
125_P257_T0.5100.55
378_W383_S0.5100.55
8_Q11_A0.5100.55
146_L251_Y0.5100.55
76_E120_R0.5090.55
39_A107_L0.5090.55
39_A168_A0.5090.55
200_P204_L0.5080.55
34_L125_P0.5070.55
190_E279_L0.5050.54
215_S364_R0.5020.54
367_Y376_N0.5020.54
293_I390_S0.5010.54
377_N381_T0.5010.54
174_L183_F0.5000.54
11_A394_T0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n54B 5 0.7624 100 0.238 Contact Map
3wfdC 1 0.3267 38.6 0.963 Contact Map
3utkA 1 0.2203 16.7 0.969 Contact Map
1xt8A 1 0.5644 11.5 0.971 Contact Map
4fybB 1 0.354 9.3 0.972 Contact Map
4n6kA 1 0.6535 9.1 0.972 Contact Map
3zbiC 1 0.0668 7.9 0.973 Contact Map
4uslA 2 0.3985 7 0.974 Contact Map
4inwA 1 0.1559 6.4 0.974 Contact Map
3hd7A 1 0.0767 5.8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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