GREMLIN Database
YNDE - Spore germination protein YndE
UniProt: O31809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (346)
Sequences: 22615 (13989)
Seq/√Len: 752.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_L317_Y4.6941.00
50_G227_T3.8401.00
213_K217_K3.2661.00
209_M214_N2.9591.00
9_T210_K2.8601.00
165_S236_M2.7351.00
14_T221_I2.7121.00
89_S300_V2.6421.00
10_T221_I2.6371.00
73_Y303_K2.6261.00
208_F295_L2.5781.00
269_R273_F2.4291.00
298_S302_K2.4181.00
13_A209_M2.3671.00
207_A302_K2.3591.00
314_P318_I2.3141.00
10_T14_T2.3011.00
134_Y138_Q2.3001.00
255_D258_R2.2831.00
10_T214_N2.2541.00
217_K221_I2.2211.00
9_T12_Q2.2191.00
245_G259_S2.2131.00
77_R85_G2.2101.00
117_E120_P2.1951.00
137_T310_F2.1901.00
141_D145_R2.1691.00
77_R82_K2.0991.00
76_S88_I2.0611.00
133_L313_L2.0501.00
152_P156_I2.0331.00
93_I316_I2.0251.00
242_S245_G1.9811.00
51_V55_I1.9501.00
33_V42_G1.9461.00
255_D259_S1.9411.00
220_V224_G1.9251.00
14_T225_V1.9191.00
12_Q148_E1.9091.00
17_I222_G1.8711.00
126_M321_C1.8601.00
130_W317_Y1.8471.00
306_L310_F1.8381.00
211_K214_N1.8181.00
45_S188_G1.7991.00
104_V286_F1.7881.00
170_E173_N1.7751.00
169_F239_G1.7721.00
129_L320_S1.7681.00
137_T314_P1.7501.00
8_I12_Q1.7481.00
263_P269_R1.7431.00
353_V357_W1.7391.00
258_R271_E1.7131.00
205_L291_Y1.6991.00
249_R255_D1.6921.00
49_G192_T1.6781.00
136_I287_I1.6561.00
107_M128_V1.6561.00
138_Q306_L1.6531.00
111_V124_I1.6341.00
100_G320_S1.6301.00
12_Q144_A1.6181.00
119_T123_A1.6011.00
156_I160_T1.5921.00
57_G223_T1.5891.00
120_P123_A1.5811.00
104_V129_L1.5811.00
81_G84_L1.5781.00
224_G228_S1.5771.00
212_P216_V1.5711.00
258_R263_P1.5691.00
157_I277_I1.5581.00
70_E207_A1.5571.00
5_T307_S1.5541.00
321_C325_N1.5491.00
311_G315_V1.5341.00
344_F347_L1.5341.00
293_A316_I1.5331.00
297_V312_L1.5301.00
62_K65_Q1.5281.00
57_G219_V1.5261.00
10_T217_K1.5191.00
67_Y78_H1.5151.00
126_M130_W1.5061.00
321_C324_K1.5021.00
162_A232_I1.4641.00
272_S276_V1.4591.00
211_K217_K1.4551.00
214_N217_K1.4511.00
324_K328_D1.4361.00
132_G286_F1.4271.00
181_G184_P1.4221.00
58_M220_V1.4181.00
166_L236_M1.4111.00
129_L317_Y1.4021.00
107_M279_I1.3821.00
161_I165_S1.3781.00
74_E78_H1.3781.00
41_D178_L1.3781.00
80_V84_L1.3651.00
165_S240_A1.3631.00
21_M226_V1.3601.00
43_W235_I1.3511.00
228_S232_I1.3411.00
325_N328_D1.3391.00
59_I351_L1.3381.00
261_E270_F1.3271.00
133_L314_P1.3251.00
294_S313_L1.3231.00
86_H90_I1.3201.00
155_V159_L1.3191.00
173_N176_P1.3181.00
41_D185_V1.2991.00
116_L119_T1.2901.00
172_N175_R1.2811.00
13_A218_A1.2761.00
170_E174_L1.2621.00
18_I225_V1.2581.00
347_L355_S1.2551.00
64_S75_Y1.2511.00
60_I72_F1.2491.00
7_K210_K1.2461.00
69_K74_E1.2421.00
251_W255_D1.2391.00
146_L150_I1.2331.00
28_T106_V1.2331.00
167_G172_N1.2311.00
8_I13_A1.2301.00
352_L356_K1.2271.00
122_W126_M1.2071.00
93_I297_V1.2061.00
351_L355_S1.2041.00
103_E285_T1.2031.00
11_A15_I1.2031.00
16_I205_L1.2031.00
133_L137_T1.2021.00
8_I144_A1.1991.00
210_K214_N1.1881.00
177_V180_D1.1691.00
17_I202_M1.1671.00
171_I174_L1.1601.00
34_T42_G1.1561.00
311_G314_P1.1551.00
150_I284_A1.1491.00
169_F173_N1.1481.00
108_S124_I1.1471.00
167_G171_I1.1291.00
80_V356_K1.1251.00
160_T164_M1.1181.00
73_Y299_Q1.1151.00
169_F174_L1.1141.00
235_I239_G1.1121.00
249_R252_P1.1071.00
47_L231_M1.0971.00
145_R149_M1.0971.00
83_W87_L1.0901.00
18_I226_V1.0901.00
132_G287_I1.0841.00
69_K78_H1.0831.00
347_L353_V1.0791.00
131_I283_F1.0771.00
102_F194_L1.0731.00
80_V352_L1.0651.00
167_G170_E1.0651.00
147_F287_I1.0621.00
170_E176_P1.0581.00
242_S259_S1.0551.00
135_S146_L1.0501.00
127_T131_I1.0501.00
171_I175_R1.0431.00
137_T308_C1.0431.00
43_W238_I1.0391.00
10_T218_A1.0381.00
76_S84_L1.0381.00
130_W134_Y1.0331.00
168_I171_I1.0311.00
333_G336_V1.0241.00
140_L291_Y1.0211.00
206_V215_A1.0191.00
124_I127_T1.0081.00
200_E204_I1.0071.00
15_I148_E1.0011.00
111_V279_I0.9891.00
162_A166_L0.9851.00
350_L353_V0.9811.00
108_S125_I0.9741.00
107_M283_F0.9711.00
324_K327_N0.9701.00
240_A256_L0.9691.00
134_Y137_T0.9661.00
7_K141_D0.9661.00
118_G121_S0.9621.00
159_L163_L0.9601.00
55_I59_I0.9601.00
145_R148_E0.9541.00
340_A347_L0.9541.00
77_R303_K0.9511.00
348_P351_L0.9491.00
155_V229_F0.9471.00
88_I349_I0.9461.00
22_L25_G0.9321.00
161_I257_M0.9271.00
54_V220_V0.9251.00
111_V115_L0.9251.00
347_L350_L0.9211.00
326_E329_V0.9151.00
117_E121_S0.9141.00
295_L298_S0.9101.00
227_T231_M0.9071.00
50_G196_F0.9031.00
12_Q145_R0.9031.00
322_M326_E0.9021.00
305_P310_F0.8981.00
123_A127_T0.8981.00
54_V58_M0.8951.00
92_F96_F0.8951.00
221_I225_V0.8921.00
323_P328_D0.8921.00
172_N176_P0.8891.00
40_P238_I0.8851.00
107_M282_L0.8841.00
257_M262_I0.8801.00
138_Q142_P0.8791.00
154_T281_Q0.8791.00
322_M325_N0.8781.00
14_T218_A0.8771.00
80_V353_V0.8751.00
310_F314_P0.8731.00
62_K66_Q0.8691.00
62_K355_S0.8681.00
132_G283_F0.8641.00
290_F317_Y0.8621.00
168_I172_N0.8621.00
162_A236_M0.8611.00
21_M222_G0.8601.00
125_I324_K0.8561.00
187_R191_T0.8551.00
11_A145_R0.8511.00
169_F172_N0.8491.00
178_L185_V0.8451.00
44_I185_V0.8441.00
211_K216_V0.8381.00
116_L120_P0.8361.00
132_G290_F0.8351.00
350_L355_S0.8341.00
63_L75_Y0.8331.00
347_L357_W0.8321.00
201_I292_A0.8301.00
97_L319_L0.8251.00
33_V192_T0.8251.00
26_V233_T0.8191.00
105_R332_L0.8131.00
44_I47_L0.8111.00
44_I48_L0.8111.00
11_A148_E0.8091.00
295_L309_M0.8051.00
137_T306_L0.8031.00
116_L121_S0.7971.00
108_S121_S0.7941.00
269_R272_S0.7921.00
136_I291_Y0.7901.00
118_G122_W0.7831.00
42_G234_M0.7821.00
19_N151_F0.7791.00
130_W321_C0.7781.00
354_I357_W0.7771.00
182_I186_L0.7771.00
309_M312_L0.7771.00
59_I348_P0.7751.00
323_P326_E0.7751.00
332_L336_V0.7721.00
7_K140_L0.7711.00
346_A350_L0.7711.00
207_A298_S0.7701.00
168_I173_N0.7701.00
232_I236_M0.7701.00
83_W86_H0.7691.00
169_F176_P0.7681.00
209_M215_A0.7681.00
262_I270_F0.7661.00
171_I239_G0.7631.00
182_I185_V0.7601.00
332_L355_S0.7561.00
174_L238_I0.7521.00
349_I353_V0.7501.00
340_A343_I0.7501.00
197_T343_I0.7481.00
225_V229_F0.7461.00
323_P327_N0.7431.00
73_Y77_R0.7431.00
233_T237_V0.7421.00
30_P234_M0.7411.00
61_A65_Q0.7411.00
290_F294_S0.7361.00
203_F219_V0.7351.00
170_E175_R0.7321.00
112_D121_S0.7321.00
171_I176_P0.7271.00
142_P145_R0.7271.00
166_L232_I0.7261.00
162_A233_T0.7251.00
144_A148_E0.7251.00
110_I278_W0.7241.00
113_F275_L0.7221.00
281_Q284_A0.7191.00
53_A199_S0.7191.00
32_T35_E0.7171.00
46_V195_S0.7171.00
139_G142_P0.7161.00
178_L181_G0.7141.00
197_T200_E0.7131.00
215_A219_V0.7111.00
33_V38_Q0.7101.00
330_F334_D0.7101.00
22_L154_T0.7091.00
169_F175_R0.7081.00
43_W47_L0.7071.00
7_K11_A0.7071.00
23_A27_L0.7051.00
257_M261_E0.7041.00
47_L51_V0.7041.00
20_Y289_T0.7031.00
213_K216_V0.7031.00
57_G199_S0.7021.00
216_V219_V0.6951.00
341_L344_F0.6941.00
11_A14_T0.6901.00
130_W133_L0.6891.00
335_T339_I0.6891.00
73_Y89_S0.6891.00
128_V286_F0.6891.00
144_A287_I0.6881.00
126_M325_N0.6821.00
22_L27_L0.6791.00
46_V234_M0.6791.00
208_F309_M0.6781.00
20_Y288_I0.6781.00
64_S215_A0.6761.00
136_I313_L0.6761.00
14_T17_I0.6761.00
49_G196_F0.6741.00
57_G61_A0.6731.00
88_I346_A0.6731.00
81_G85_G0.6731.00
114_F279_I0.6721.00
293_A297_V0.6691.00
111_V128_V0.6681.00
351_L354_I0.6661.00
63_L79_I0.6631.00
344_F355_S0.6631.00
301_F304_K0.6621.00
64_S203_F0.6611.00
54_V224_G0.6611.00
48_L189_V0.6591.00
330_F333_G0.6591.00
170_E239_G0.6581.00
70_E298_S0.6571.00
168_I174_L0.6551.00
103_E286_F0.6541.00
79_I350_L0.6521.00
252_P256_L0.6511.00
204_I292_A0.6491.00
54_V223_T0.6491.00
347_L351_L0.6491.00
18_I151_F0.6481.00
176_P179_G0.6461.00
178_L182_I0.6451.00
40_P43_W0.6441.00
334_D337_S0.6441.00
24_A194_L0.6411.00
338_H342_Y0.6401.00
41_D177_V0.6391.00
257_M270_F0.6381.00
117_E122_W0.6371.00
315_V319_L0.6361.00
340_A350_L0.6361.00
96_F289_T0.6341.00
148_E152_P0.6331.00
286_F289_T0.6321.00
43_W231_M0.6301.00
257_M260_F0.6281.00
297_V315_V0.6261.00
71_T203_F0.6241.00
73_Y85_G0.6221.00
142_P146_L0.6211.00
350_L354_I0.6191.00
251_W254_L0.6191.00
321_C328_D0.6171.00
126_M323_P0.6161.00
294_S312_L0.6161.00
340_A344_F0.6161.00
339_I343_I0.6141.00
49_G193_N0.6111.00
72_F200_E0.6101.00
151_F154_T0.6091.00
273_F277_I0.6071.00
174_L239_G0.6071.00
310_F313_L0.6061.00
104_V108_S0.6031.00
149_M153_I0.6031.00
106_V110_I0.6021.00
236_M239_G0.6011.00
133_L290_F0.5991.00
20_Y201_I0.5991.00
114_F276_V0.5981.00
23_A230_Y0.5981.00
119_T122_W0.5981.00
164_M262_I0.5971.00
342_Y347_L0.5941.00
331_I334_D0.5931.00
140_L205_L0.5931.00
314_P317_Y0.5931.00
137_T313_L0.5921.00
72_F204_I0.5921.00
338_H341_L0.5921.00
99_L103_E0.5911.00
6_S210_K0.5911.00
76_S85_G0.5881.00
164_M261_E0.5881.00
184_P187_R0.5861.00
342_Y357_W0.5841.00
325_N329_V0.5821.00
103_E282_L0.5821.00
17_I21_M0.5801.00
41_D44_I0.5801.00
30_P237_V0.5801.00
348_P355_S0.5771.00
107_M111_V0.5771.00
224_G227_T0.5771.00
22_L229_F0.5751.00
237_V253_G0.5751.00
143_I291_Y0.5751.00
221_I224_G0.5731.00
343_I347_L0.5721.00
60_I350_L0.5711.00
91_V346_A0.5711.00
128_V283_F0.5691.00
28_T31_R0.5691.00
240_A260_F0.5681.00
276_V280_M0.5671.00
108_S111_V0.5671.00
230_Y234_M0.5661.00
324_K329_V0.5661.00
131_I135_S0.5641.00
99_L102_F0.5641.00
76_S353_V0.5631.00
344_F348_P0.5631.00
225_V228_S0.5611.00
110_I254_L0.5601.00
114_F275_L0.5591.00
87_L91_V0.5591.00
233_T253_G0.5571.00
118_G123_A0.5571.00
27_L158_F0.5541.00
101_A104_V0.5531.00
56_A200_E0.5531.00
204_I296_G0.5521.00
63_L66_Q0.5511.00
46_V230_Y0.5511.00
290_F316_I0.5501.00
328_D331_I0.5491.00
297_V301_F0.5481.00
241_L245_G0.5471.00
103_E106_V0.5451.00
128_V132_G0.5451.00
337_S344_F0.5441.00
352_L355_S0.5431.00
45_S185_V0.5421.00
50_G54_V0.5411.00
156_I159_L0.5411.00
15_I151_F0.5411.00
130_W314_P0.5401.00
97_L316_I0.5391.00
263_P272_S0.5391.00
348_P352_L0.5391.00
329_V333_G0.5381.00
147_F288_I0.5361.00
339_I347_L0.5351.00
9_T214_N0.5321.00
125_I322_M0.5311.00
58_M62_K0.5311.00
344_F351_L0.5301.00
8_I140_L0.5261.00
252_P257_M0.5261.00
159_L229_F0.5231.00
272_S275_L0.5221.00
173_N239_G0.5191.00
103_E194_L0.5191.00
7_K307_S0.5181.00
56_A348_P0.5171.00
353_V356_K0.5161.00
344_F357_W0.5151.00
153_I157_I0.5151.00
202_M219_V0.5151.00
241_L255_D0.5141.00
209_M218_A0.5121.00
13_A205_L0.5121.00
153_I277_I0.5121.00
91_V95_Y0.5101.00
202_M215_A0.5101.00
84_L87_L0.5091.00
336_V340_A0.5091.00
84_L349_I0.5081.00
28_T282_L0.5081.00
40_P243_V0.5081.00
69_K207_A0.5071.00
259_S263_P0.5061.00
85_G89_S0.5061.00
186_L190_K0.5051.00
335_T338_H0.5051.00
30_P33_V0.5041.00
168_I175_R0.5031.00
63_L67_Y0.5021.00
26_V158_F0.5021.00
263_P271_E0.5021.00
61_A219_V0.5011.00
61_A216_V0.5011.00
13_A202_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9504 100 0.259 Contact Map
3giaA 1 0.9697 100 0.297 Contact Map
4djkA 2 0.9394 100 0.358 Contact Map
3dh4A 3 0.9477 98.8 0.826 Contact Map
2xq2A 2 0.9477 98.8 0.827 Contact Map
2jlnA 1 0.9614 98.6 0.841 Contact Map
4wgvA 2 0.9174 98 0.863 Contact Map
4us3A 1 0.9669 97.7 0.873 Contact Map
2a65A 2 0.9669 97.5 0.879 Contact Map
4xp4A 1 0.9532 97.2 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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