GREMLIN Database
APRX - Serine protease AprX
UniProt: O31788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (356)
Sequences: 7435 (5520)
Seq/√Len: 292.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_G348_L4.1071.00
221_L227_G3.7841.00
393_I435_A3.6471.00
118_N230_A3.5451.00
151_V195_V3.4101.00
315_A330_A3.3861.00
358_R378_F3.1961.00
145_T212_E3.1121.00
393_I433_V3.0871.00
418_D434_N2.8311.00
332_F352_V2.7871.00
315_A332_F2.7451.00
190_H385_M2.7371.00
290_A387_T2.6791.00
147_K212_E2.6661.00
358_R380_M2.6541.00
255_S387_T2.5981.00
286_V311_I2.5431.00
305_G312_T2.5091.00
183_D186_G2.4591.00
330_A352_V2.4541.00
218_V235_G2.3801.00
405_T408_E2.3521.00
193_G356_S2.3351.00
154_V220_V2.2281.00
286_V394_A2.2001.00
191_C255_S2.1081.00
152_A251_I2.0971.00
174_M238_W2.0711.00
194_D389_I2.0691.00
54_S118_N2.0591.00
153_V195_V2.0241.00
193_G357_L2.0031.00
416_G438_S1.9761.00
124_L290_A1.9661.00
347_I433_V1.9361.00
121_V229_L1.9251.00
387_T391_A1.9131.00
190_H356_S1.9121.00
133_H434_N1.9081.00
315_A352_V1.9061.00
278_E309_K1.9031.00
150_T214_N1.8711.00
410_K414_K1.8421.00
216_I251_I1.8311.00
255_S391_A1.7901.00
236_V280_A1.7831.00
218_V238_W1.7471.00
317_D352_V1.7431.00
401_N404_L1.7361.00
404_L412_L1.7291.00
152_A239_C1.7151.00
398_L409_V1.6991.00
192_A217_G1.6961.00
390_C433_V1.6911.00
240_I285_I1.6871.00
347_I413_L1.6821.00
197_S357_L1.6821.00
289_V310_V1.6691.00
240_I280_A1.6561.00
316_L348_L1.6411.00
232_I258_L1.6311.00
196_A215_L1.6141.00
184_D223_K1.5991.00
288_C387_T1.5701.00
411_E415_N1.5641.00
98_T101_A1.5621.00
150_T216_I1.5591.00
329_V348_L1.5531.00
228_T231_D1.5521.00
274_V278_E1.5481.00
191_C388_P1.5451.00
436_E440_P1.5381.00
252_D398_L1.5381.00
290_A386_A1.5301.00
144_L399_Q1.5291.00
278_E308_E1.5181.00
194_D385_M1.5161.00
278_E282_S1.5051.00
85_S234_E1.5051.00
397_I438_S1.4931.00
173_D178_K1.4911.00
394_A409_V1.4811.00
58_E113_R1.4791.00
220_V258_L1.4761.00
158_I215_L1.4711.00
128_A389_I1.4561.00
196_A213_A1.4531.00
315_A351_G1.4511.00
151_V395_A1.4461.00
149_V398_L1.4271.00
158_I217_G1.3891.00
288_C390_C1.3851.00
153_V191_C1.3841.00
127_T131_A1.3731.00
60_E113_R1.3681.00
190_H194_D1.3631.00
380_M385_M1.3531.00
288_C394_A1.3491.00
434_N437_N1.3451.00
401_N412_L1.3431.00
58_E114_K1.3411.00
316_L432_A1.3311.00
209_P392_G1.3201.00
271_D275_R1.3181.00
279_E282_S1.3161.00
350_P354_I1.3151.00
190_H380_M1.3131.00
154_V235_G1.3071.00
145_T399_Q1.3031.00
329_V333_S1.2981.00
311_I410_K1.2951.00
291_A312_T1.2771.00
327_D432_A1.2751.00
220_V235_G1.2741.00
130_E135_K1.2701.00
286_V409_V1.2661.00
355_I379_T1.2611.00
352_V381_S1.2601.00
169_I216_I1.2481.00
277_V310_V1.2481.00
397_I409_V1.2461.00
165_E168_I1.2451.00
233_I276_A1.2451.00
169_I214_N1.2381.00
210_A395_A1.2321.00
400_Q439_V1.2281.00
236_V254_M1.2221.00
237_E241_Q1.2211.00
116_Y272_P1.2021.00
151_V213_A1.1951.00
313_V347_I1.1901.00
286_V406_P1.1871.00
393_I413_L1.1841.00
233_I272_P1.1731.00
76_Q81_S1.1721.00
156_T183_D1.1691.00
146_G210_A1.1661.00
149_V395_A1.1651.00
236_V256_M1.1581.00
158_I192_A1.1571.00
153_V192_A1.1411.00
158_I164_L1.1381.00
295_G329_V1.1311.00
167_R198_S1.1261.00
253_I391_A1.1181.00
133_H136_E1.1011.00
131_A327_D1.0971.00
317_D328_T1.0951.00
209_P389_I1.0931.00
394_A413_L1.0871.00
356_S385_M1.0851.00
119_R229_L1.0841.00
126_D129_T1.0751.00
335_R427_I1.0731.00
156_T185_N1.0731.00
394_A397_I1.0721.00
332_F381_S1.0681.00
414_K430_A1.0661.00
112_I115_V1.0591.00
137_V140_N1.0581.00
143_T146_G1.0521.00
136_E436_E1.0421.00
163_D357_L1.0411.00
296_P300_T1.0351.00
278_E307_S1.0331.00
236_V277_V1.0291.00
418_D432_A1.0281.00
102_L107_S1.0201.00
329_V427_I1.0151.00
349_A390_C1.0121.00
218_V239_C1.0091.00
129_T209_P1.0001.00
307_S310_V0.9991.00
398_L402_P0.9971.00
218_V249_E0.9951.00
199_G207_R0.9941.00
288_C391_A0.9931.00
397_I404_L0.9911.00
257_S388_P0.9901.00
159_Y374_G0.9891.00
133_H436_E0.9761.00
275_R279_E0.9751.00
232_I256_M0.9691.00
137_V439_V0.9671.00
294_S334_S0.9661.00
227_G231_D0.9641.00
329_V335_R0.9611.00
164_L357_L0.9581.00
104_S108_E0.9571.00
417_T431_G0.9571.00
237_E279_E0.9551.00
168_I217_G0.9531.00
192_A215_L0.9531.00
132_S389_I0.9521.00
281_W410_K0.9451.00
254_M280_A0.9441.00
425_P428_Y0.9431.00
274_V307_S0.9371.00
210_A213_A0.9371.00
239_C251_I0.9281.00
161_H377_Y0.9231.00
171_F174_M0.9211.00
280_A287_V0.9211.00
177_Q180_E0.9191.00
420_W432_A0.9141.00
390_C413_L0.9131.00
396_L435_A0.9131.00
253_I286_V0.9101.00
91_N95_A0.9081.00
255_S288_C0.9081.00
165_E169_I0.9071.00
168_I171_F0.9061.00
419_K425_P0.9031.00
258_L289_V0.9031.00
314_G333_S0.9031.00
281_W407_D0.9031.00
148_G214_N0.9011.00
186_G358_R0.9001.00
97_V101_A0.8931.00
60_E111_N0.8931.00
170_G216_I0.8871.00
129_T134_A0.8861.00
238_W241_Q0.8851.00
162_P375_S0.8851.00
53_M117_L0.8841.00
239_C254_M0.8841.00
425_P430_A0.8841.00
140_N436_E0.8761.00
385_M388_P0.8761.00
65_E69_Q0.8751.00
313_V390_C0.8741.00
197_S206_Y0.8721.00
160_P182_Y0.8701.00
315_A381_S0.8661.00
103_H107_S0.8631.00
346_D414_K0.8631.00
240_I283_A0.8611.00
64_H67_G0.8611.00
330_A381_S0.8571.00
195_V392_G0.8561.00
54_S96_E0.8551.00
254_M285_I0.8551.00
253_I394_A0.8541.00
136_E139_R0.8471.00
55_V59_F0.8441.00
189_T357_L0.8441.00
238_W249_E0.8421.00
159_Y359_S0.8411.00
360_P376_Q0.8401.00
155_D187_H0.8371.00
131_A316_L0.8371.00
311_I394_A0.8351.00
154_V256_M0.8311.00
148_G210_A0.8291.00
120_E228_T0.8291.00
163_D199_G0.8281.00
294_S302_A0.8271.00
85_S94_S0.8261.00
240_I279_E0.8251.00
102_L115_V0.8231.00
107_S115_V0.8201.00
373_V376_Q0.8191.00
59_F93_C0.8171.00
132_S209_P0.8151.00
286_V398_L0.8121.00
424_D430_A0.8101.00
64_H68_F0.8081.00
165_E171_F0.8081.00
154_V218_V0.8071.00
121_V232_I0.8051.00
173_D219_K0.8041.00
256_M287_V0.8031.00
159_Y375_S0.8020.99
159_Y182_Y0.8000.99
101_A104_S0.7960.99
302_A305_G0.7930.99
183_D219_K0.7910.99
295_G334_S0.7900.99
124_L259_G0.7850.99
105_L112_I0.7840.99
116_Y270_E0.7820.99
134_A138_V0.7820.99
347_I390_C0.7820.99
184_D219_K0.7790.99
144_L400_Q0.7780.99
407_D411_E0.7770.99
89_K237_E0.7750.99
254_M287_V0.7740.99
163_D377_Y0.7710.99
281_W286_V0.7690.99
353_N381_S0.7670.99
123_A221_L0.7670.99
398_L404_L0.7650.99
296_P335_R0.7640.99
156_T186_G0.7630.99
404_L408_E0.7620.99
221_L258_L0.7560.99
397_I439_V0.7540.99
256_M289_V0.7540.99
186_G380_M0.7520.99
75_L78_E0.7510.99
152_A216_I0.7460.99
173_D181_P0.7440.99
152_A218_V0.7410.99
418_D437_N0.7400.99
284_G406_P0.7400.99
134_A435_A0.7390.99
135_K138_V0.7390.99
94_S230_A0.7370.99
185_N380_M0.7360.99
152_A254_M0.7360.99
116_Y271_D0.7360.99
150_T251_I0.7300.99
175_V178_K0.7300.99
118_N121_V0.7290.99
220_V232_I0.7290.99
76_Q80_R0.7280.99
121_V260_G0.7260.99
174_M218_V0.7260.99
146_G213_A0.7260.99
51_K54_S0.7220.99
72_G76_Q0.7190.99
281_W406_P0.7170.99
162_P376_Q0.7160.99
358_R376_Q0.7150.99
412_L416_G0.7070.99
158_I168_I0.7060.99
347_I414_K0.7030.99
221_L231_D0.7020.99
234_E237_E0.7010.99
338_T342_K0.7010.99
279_E283_A0.7010.99
128_A131_A0.7010.99
436_E439_V0.6970.99
70_M74_V0.6950.99
309_K407_D0.6950.99
91_N94_S0.6930.99
125_L128_A0.6930.99
347_I417_T0.6930.99
204_G377_Y0.6930.99
213_A395_A0.6900.98
83_L87_F0.6880.98
178_K181_P0.6870.98
172_A238_W0.6850.98
278_E281_W0.6840.98
163_D197_S0.6830.98
350_P389_I0.6800.98
209_P393_I0.6780.98
312_T346_D0.6760.98
424_D427_I0.6760.98
67_G70_M0.6720.98
239_C280_A0.6690.98
173_D176_N0.6680.98
127_T319_N0.6650.98
171_F175_V0.6610.98
140_N440_P0.6600.98
262_A306_V0.6590.98
149_V399_Q0.6590.98
291_A314_G0.6570.98
229_L260_G0.6560.98
58_E61_E0.6550.98
276_A280_A0.6540.98
118_N228_T0.6520.98
316_L327_D0.6520.98
127_T130_E0.6490.98
55_V115_V0.6480.98
281_W309_K0.6480.98
354_I389_I0.6470.98
271_D274_V0.6460.98
235_G239_C0.6440.98
167_R171_F0.6410.98
419_K423_E0.6410.98
219_K222_N0.6390.98
311_I347_I0.6380.97
169_I172_A0.6380.97
398_L401_N0.6380.97
385_M389_I0.6360.97
102_L105_L0.6330.97
168_I173_D0.6330.97
222_N225_G0.6330.97
138_V396_L0.6320.97
353_N379_T0.6290.97
236_V273_L0.6290.97
126_D131_A0.6240.97
402_P405_T0.6210.97
79_K82_K0.6180.97
89_K241_Q0.6160.97
114_K275_R0.6150.97
84_K96_E0.6140.97
303_S306_V0.6110.97
311_I414_K0.6090.97
388_P391_A0.6080.97
253_I409_V0.6060.97
274_V306_V0.6060.97
229_L273_L0.6050.97
339_V345_P0.6040.97
397_I412_L0.6030.96
251_I285_I0.6030.96
398_L406_P0.6020.96
126_D206_Y0.6020.96
171_F181_P0.6020.96
164_L167_R0.6010.96
95_A98_T0.6010.96
132_S393_I0.5990.96
191_C385_M0.5990.96
281_W287_V0.5990.96
301_I312_T0.5990.96
277_V287_V0.5980.96
253_I288_C0.5980.96
66_T69_Q0.5980.96
97_V105_L0.5970.96
233_I273_L0.5960.96
314_G339_V0.5960.96
65_E68_F0.5960.96
87_F237_E0.5950.96
72_G75_L0.5950.96
406_P410_K0.5950.96
272_P275_R0.5940.96
174_M235_G0.5940.96
63_C67_G0.5940.96
194_D356_S0.5930.96
329_V428_Y0.5930.96
69_Q72_G0.5870.96
229_L232_I0.5860.96
249_E252_D0.5850.96
150_T249_E0.5850.96
159_Y373_V0.5830.96
138_V207_R0.5830.96
302_A334_S0.5820.96
437_N440_P0.5820.96
417_T430_A0.5810.96
420_W428_Y0.5810.96
386_A389_I0.5790.96
220_V256_M0.5790.96
81_S95_A0.5780.96
423_E428_Y0.5780.96
359_S373_V0.5740.95
150_T250_P0.5740.95
236_V276_A0.5740.95
153_V255_S0.5740.95
290_A388_P0.5730.95
54_S228_T0.5730.95
216_I249_E0.5680.95
319_N328_T0.5680.95
149_V252_D0.5680.95
150_T169_I0.5670.95
176_N180_E0.5650.95
397_I401_N0.5650.95
87_F94_S0.5650.95
191_C387_T0.5630.95
295_G300_T0.5630.95
360_P374_G0.5620.95
176_N179_T0.5610.95
83_L86_R0.5600.95
311_I390_C0.5580.95
421_K428_Y0.5580.95
349_A433_V0.5580.95
289_V303_S0.5580.95
290_A302_A0.5570.95
149_V253_I0.5570.95
132_S350_P0.5560.95
177_Q181_P0.5560.95
383_T388_P0.5560.95
295_G335_R0.5560.95
159_Y360_P0.5550.94
153_V217_G0.5520.94
275_R278_E0.5520.94
99_P103_H0.5520.94
222_N231_D0.5490.94
119_R270_E0.5450.94
167_R174_M0.5450.94
164_L193_G0.5450.94
161_H357_L0.5450.94
57_I61_E0.5440.94
284_G398_L0.5440.94
282_S309_K0.5440.94
74_V78_E0.5430.94
166_G198_S0.5430.94
261_D294_S0.5430.94
170_G217_G0.5430.94
123_A156_T0.5420.94
68_F72_G0.5390.94
148_G213_A0.5380.94
129_T132_S0.5370.93
84_K88_N0.5370.93
154_V236_V0.5370.93
131_A432_A0.5370.93
208_G392_G0.5370.93
346_D410_K0.5350.93
113_R117_L0.5340.93
74_V77_K0.5320.93
231_D234_E0.5320.93
116_Y229_L0.5310.93
406_P409_V0.5310.93
51_K55_V0.5310.93
297_D300_T0.5310.93
166_G171_F0.5300.93
122_K261_D0.5290.93
86_R89_K0.5270.93
419_K422_D0.5270.93
81_S86_R0.5260.93
397_I400_Q0.5260.93
289_V312_T0.5250.93
419_K428_Y0.5250.93
77_K80_R0.5240.93
259_G290_A0.5230.93
128_A134_A0.5220.92
149_V213_A0.5210.92
163_D206_Y0.5210.92
227_G232_I0.5200.92
331_S381_S0.5190.92
237_E240_I0.5170.92
256_M277_V0.5160.92
401_N405_T0.5160.92
146_G399_Q0.5150.92
219_K223_K0.5140.92
151_V253_I0.5120.92
314_G329_V0.5120.92
140_N144_L0.5120.92
417_T429_G0.5120.92
274_V277_V0.5110.92
132_S432_A0.5100.92
291_A301_I0.5090.92
65_E72_G0.5080.91
393_I397_I0.5070.91
161_H193_G0.5070.91
204_G207_R0.5070.91
435_A439_V0.5070.91
393_I396_L0.5060.91
254_M258_L0.5050.91
104_S109_C0.5050.91
259_G294_S0.5010.91
328_T331_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3afgA 1 0.8982 100 0.245 Contact Map
3whiA 2 0.7692 100 0.276 Contact Map
3wiuA 2 0.7783 100 0.306 Contact Map
4tr2A 2 0.7873 100 0.311 Contact Map
1r6vA 1 0.8665 100 0.311 Contact Map
3t41A 1 0.81 100 0.327 Contact Map
1xf1A 2 0.6516 100 0.329 Contact Map
3vtaA 1 0.6787 100 0.342 Contact Map
2p4eP 2 0.7964 100 0.344 Contact Map
4i0wB 1 0.6584 100 0.345 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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