GREMLIN Database
YMAE - Uncharacterized protein YmaE
UniProt: O31787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (260)
Sequences: 414 (313)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_L252_A4.8151.00
145_V154_F4.7361.00
120_Y243_A4.7231.00
199_I232_V3.9951.00
178_G198_I3.9801.00
63_L194_L3.2861.00
167_D182_H3.0370.99
142_K154_F2.8500.99
103_Q106_E2.8140.99
54_N100_T2.7210.98
8_T32_Y2.6950.98
261_V265_K2.6760.98
109_G131_F2.6450.98
62_H82_Q2.6190.98
129_E149_S2.5890.98
82_Q107_L2.4400.97
173_G220_L2.3840.96
128_A133_A2.2560.95
60_E239_R2.2450.94
87_N109_G2.2400.94
128_A151_H2.2380.94
55_I69_E2.2200.94
251_N254_E2.1740.93
132_Q151_H2.1490.93
94_T122_S2.1230.93
253_D257_Q1.9630.89
13_H24_L1.9510.89
110_I131_F1.8530.86
128_A134_P1.8180.85
87_N131_F1.7810.84
139_E156_S1.7790.84
120_Y123_T1.7600.83
120_Y178_G1.7490.83
36_D39_T1.7180.82
6_C9_C1.6830.80
68_T100_T1.6800.80
8_T31_Q1.6740.80
65_S79_H1.6520.79
12_Q266_A1.6520.79
236_Q253_D1.6440.79
120_Y194_L1.6380.78
169_Y235_L1.6350.78
81_I194_L1.6290.78
24_L146_T1.6220.78
88_V169_Y1.6100.77
50_G95_Y1.6070.77
22_S27_E1.5800.76
206_N255_S1.5760.76
4_Y20_P1.5420.74
161_N164_P1.5390.74
173_G228_I1.5370.74
54_N66_I1.5340.74
54_N68_T1.5280.73
23_C26_C1.5120.72
80_L87_N1.5060.72
125_V149_S1.4920.71
64_Y107_L1.4650.70
229_A257_Q1.4180.67
257_Q261_V1.4090.67
31_Q216_N1.4090.67
121_Y138_H1.4070.67
191_G197_D1.4030.66
233_K257_Q1.3960.66
98_Q102_D1.3630.64
11_V124_Q1.3600.64
90_W155_W1.3410.63
96_L133_A1.3380.63
220_L228_I1.3300.62
228_I253_D1.3000.60
68_T94_T1.2940.60
94_T123_T1.2890.60
88_V181_L1.2770.59
222_A267_L1.2690.59
112_A166_L1.2670.58
202_A207_W1.2620.58
12_Q212_Y1.2590.58
168_L179_A1.2460.57
5_I99_K1.2440.57
5_I41_T1.2440.57
140_D266_A1.2410.57
238_N253_D1.2360.56
213_S216_N1.2310.56
115_L120_Y1.2160.55
11_V137_I1.2080.55
175_F216_N1.2050.54
191_G252_A1.1980.54
103_Q107_L1.1970.54
167_D235_L1.1880.53
210_F215_P1.1770.53
159_T167_D1.1670.52
193_L246_K1.1610.52
114_A168_L1.1580.51
212_Y266_A1.1580.51
228_I231_K1.1580.51
71_E246_K1.1570.51
171_L200_T1.1510.51
240_L256_V1.1500.51
83_H166_L1.1430.51
79_H245_S1.1380.50
59_E79_H1.1290.50
233_K253_D1.1270.50
179_A198_I1.1260.49
91_D97_D1.1020.48
28_D86_F1.0960.48
81_I166_L1.0950.47
239_R250_E1.0940.47
77_T109_G1.0930.47
88_V164_P1.0780.46
204_D218_I1.0780.46
77_T242_N1.0740.46
171_L198_I1.0720.46
145_V148_P1.0710.46
67_K245_S1.0690.46
29_E44_E1.0490.45
92_C128_A1.0450.44
66_I164_P1.0360.44
43_L95_Y1.0300.43
161_N165_G1.0250.43
165_G223_S1.0070.42
20_P221_P1.0010.42
194_L197_D0.9990.41
140_D176_K0.9870.41
6_C10_G0.9770.40
88_V112_A0.9750.40
115_L122_S0.9720.40
121_Y248_V0.9680.40
65_S244_F0.9650.39
64_Y82_Q0.9650.39
255_S258_R0.9580.39
12_Q245_S0.9510.38
85_G156_S0.9460.38
133_A218_I0.9430.38
96_L100_T0.9410.38
197_D201_V0.9370.38
78_A90_W0.9250.37
94_T217_L0.9240.37
175_F213_S0.9210.37
99_K107_L0.9180.37
10_G121_Y0.9140.36
183_W192_C0.9110.36
29_E88_V0.9100.36
86_F176_K0.9100.36
136_Y142_K0.9090.36
62_H185_K0.9050.36
87_N96_L0.9040.36
126_E147_R0.8930.35
77_T87_N0.8930.35
64_Y256_V0.8930.35
29_E176_K0.8900.35
125_V147_R0.8830.34
31_Q38_Q0.8810.34
3_Y12_Q0.8790.34
23_C28_D0.8790.34
40_W155_W0.8770.34
78_A89_L0.8740.34
195_T240_L0.8710.34
94_T266_A0.8710.34
48_E184_S0.8700.34
26_C31_Q0.8660.33
178_G257_Q0.8660.33
114_A138_H0.8650.33
226_E264_I0.8620.33
45_D248_V0.8610.33
90_W198_I0.8590.33
182_H234_P0.8590.33
171_L178_G0.8580.33
131_F136_Y0.8570.33
11_V115_L0.8570.33
155_W191_G0.8510.33
157_G211_M0.8500.33
166_L236_Q0.8500.33
92_C115_L0.8480.32
77_T124_Q0.8480.32
251_N258_R0.8470.32
7_N39_T0.8450.32
67_K244_F0.8430.32
73_A255_S0.8390.32
229_A260_A0.8340.32
38_Q216_N0.8310.32
87_N108_G0.8290.31
9_C30_R0.8270.31
72_F122_S0.8270.31
83_H86_F0.8260.31
9_C23_C0.8170.31
198_I201_V0.8120.30
92_C121_Y0.8100.30
126_E205_R0.8090.30
112_A209_S0.8080.30
91_D127_W0.8070.30
207_W255_S0.8060.30
32_Y78_A0.8040.30
13_H46_M0.8030.30
5_I46_M0.8030.30
13_H32_Y0.8020.30
97_D100_T0.7980.30
229_A240_L0.7960.30
153_H164_P0.7930.29
7_N81_I0.7920.29
155_W214_Y0.7910.29
6_C30_R0.7870.29
91_D215_P0.7870.29
115_L242_N0.7830.29
137_I179_A0.7810.29
76_Q216_N0.7790.29
115_L124_Q0.7770.29
230_A236_Q0.7760.29
115_L169_Y0.7760.29
248_V260_A0.7750.29
23_C30_R0.7740.28
256_V260_A0.7740.28
104_I224_K0.7710.28
210_F260_A0.7650.28
6_C23_C0.7650.28
192_C239_R0.7630.28
34_H86_F0.7580.28
248_V252_A0.7570.28
190_K238_N0.7570.28
101_I209_S0.7560.28
33_I50_G0.7540.27
252_A263_Y0.7500.27
255_S262_R0.7480.27
20_P170_R0.7470.27
129_E151_H0.7380.27
42_T95_Y0.7380.27
11_V25_I0.7290.26
18_D264_I0.7270.26
192_C241_Y0.7260.26
84_K180_V0.7250.26
189_G197_D0.7230.26
84_K99_K0.7220.26
229_A264_I0.7180.26
88_V242_N0.7170.26
20_P60_E0.7140.25
138_H198_I0.7140.25
12_Q120_Y0.7120.25
135_I254_E0.7120.25
25_I31_Q0.7110.25
32_Y214_Y0.7070.25
162_M237_F0.7070.25
139_E162_M0.7060.25
240_L262_R0.7020.25
53_Q192_C0.7010.25
3_Y222_A0.7000.25
85_G163_K0.6990.25
158_E170_R0.6930.24
178_G200_T0.6910.24
129_E132_Q0.6910.24
19_P27_E0.6870.24
113_I128_A0.6860.24
60_E63_L0.6840.24
73_A246_K0.6840.24
105_N131_F0.6840.24
68_T72_F0.6830.24
173_G221_P0.6800.24
171_L231_K0.6790.24
72_F235_L0.6780.24
93_M122_S0.6770.24
4_Y220_L0.6740.24
159_T234_P0.6660.23
81_I165_G0.6650.23
11_V122_S0.6630.23
125_V129_E0.6620.23
10_G72_F0.6590.23
66_I106_E0.6560.23
56_L64_Y0.6540.23
92_C120_Y0.6540.23
124_Q137_I0.6520.23
126_E204_D0.6480.22
185_K190_K0.6480.22
141_D175_F0.6470.22
95_Y207_W0.6460.22
184_S232_V0.6450.22
181_L201_V0.6450.22
233_K236_Q0.6420.22
91_D120_Y0.6420.22
125_V151_H0.6400.22
80_L261_V0.6400.22
33_I252_A0.6390.22
168_L198_I0.6380.22
9_C26_C0.6380.22
48_E164_P0.6380.22
79_H124_Q0.6360.22
31_Q175_F0.6360.22
81_I104_I0.6360.22
224_K229_A0.6330.22
25_I213_S0.6330.22
62_H157_G0.6310.22
143_E176_K0.6310.22
32_Y258_R0.6290.22
50_G94_T0.6290.22
29_E262_R0.6280.22
171_L228_I0.6220.21
227_E231_K0.6220.21
222_A264_I0.6190.21
89_L108_G0.6190.21
208_V240_L0.6180.21
133_A179_A0.6170.21
76_Q210_F0.6170.21
209_S263_Y0.6170.21
254_E258_R0.6170.21
162_M184_S0.6160.21
5_I70_P0.6160.21
224_K227_E0.6160.21
246_K263_Y0.6160.21
129_E184_S0.6140.21
89_L97_D0.6140.21
42_T45_D0.6130.21
128_A212_Y0.6130.21
124_Q242_N0.6130.21
128_A137_I0.6120.21
11_V72_F0.6110.21
126_E139_E0.6100.21
34_H212_Y0.6090.21
232_V235_L0.6060.21
11_V94_T0.6050.21
78_A93_M0.6010.20
246_K249_K0.6000.20
211_M214_Y0.5990.20
31_Q215_P0.5930.20
28_D176_K0.5870.20
204_D262_R0.5860.20
12_Q94_T0.5860.20
220_L231_K0.5840.20
85_G161_N0.5810.20
35_P44_E0.5800.20
12_Q218_I0.5790.19
163_K166_L0.5780.19
24_L32_Y0.5780.19
224_K267_L0.5770.19
83_H165_G0.5760.19
101_I265_K0.5750.19
43_L47_R0.5750.19
89_L96_L0.5750.19
39_T45_D0.5750.19
82_Q131_F0.5740.19
212_Y221_P0.5730.19
142_K182_H0.5730.19
145_V256_V0.5710.19
204_D258_R0.5710.19
6_C26_C0.5700.19
26_C175_F0.5680.19
45_D165_G0.5660.19
47_R235_L0.5650.19
238_N252_A0.5640.19
12_Q125_V0.5640.19
202_A248_V0.5630.19
139_E183_W0.5620.19
188_E197_D0.5570.19
179_A214_Y0.5560.19
34_H255_S0.5540.19
99_K236_Q0.5480.18
138_H155_W0.5450.18
169_Y234_P0.5450.18
8_T34_H0.5450.18
96_L232_V0.5430.18
222_A229_A0.5410.18
225_V263_Y0.5400.18
110_I260_A0.5390.18
77_T245_S0.5390.18
18_D223_S0.5380.18
25_I216_N0.5370.18
140_D159_T0.5340.18
106_E110_I0.5340.18
137_I154_F0.5340.18
63_L143_E0.5310.18
153_H247_V0.5310.18
188_E191_G0.5270.17
173_G231_K0.5260.17
116_S119_H0.5260.17
158_E209_S0.5260.17
162_M182_H0.5240.17
93_M120_Y0.5240.17
36_D165_G0.5240.17
161_N250_E0.5220.17
40_W157_G0.5210.17
86_F242_N0.5200.17
189_G208_V0.5200.17
104_I168_L0.5180.17
102_D106_E0.5160.17
31_Q213_S0.5160.17
221_P264_I0.5140.17
27_E114_A0.5130.17
170_R173_G0.5130.17
252_A262_R0.5120.17
77_T169_Y0.5090.17
130_A193_L0.5080.17
112_A136_Y0.5080.17
222_A225_V0.5030.17
29_E240_L0.5020.17
46_M73_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fekA 1 0.781 99.7 0.854 Contact Map
2p97A 6 0.719 99.7 0.855 Contact Map
4c1hA 1 0.7482 99.7 0.858 Contact Map
4dikA 2 0.7993 99.6 0.863 Contact Map
2q9uA 3 0.7883 99.6 0.865 Contact Map
2zo4A 1 0.7555 99.6 0.865 Contact Map
4c1gA 1 0.7336 99.6 0.865 Contact Map
1k07A 1 0.7847 99.6 0.866 Contact Map
1m2xA 2 0.7299 99.6 0.867 Contact Map
2yntA 2 0.7482 99.6 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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