GREMLIN Database
YMCC - Uncharacterized membrane protein YmcC
UniProt: O31780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (174)
Sequences: 412 (310)
Seq/√Len: 23.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V38_F4.4801.00
116_A171_F3.6301.00
29_F38_F3.0051.00
25_V29_F2.9301.00
24_A28_V2.8550.99
122_H163_D2.8300.99
79_A128_I2.5060.98
40_A77_S2.3910.98
31_R34_L2.3670.98
161_G165_L2.3490.98
28_V92_F2.2310.97
80_Y122_H2.2090.97
134_A138_Y2.1680.96
11_C49_L2.1640.96
83_Q121_R2.1080.95
122_H156_W2.0930.95
132_L136_M2.0500.95
142_D145_R2.0000.94
126_Y157_T1.9410.93
75_G79_A1.9290.93
156_W163_D1.9190.93
152_I155_L1.9100.92
37_L40_A1.8010.90
41_L44_V1.7800.89
122_H167_T1.7410.88
32_H35_G1.7310.88
68_G133_L1.7090.87
116_A167_T1.7030.87
163_D167_T1.6950.87
130_A153_L1.6710.86
18_V45_I1.6690.86
164_F168_A1.6570.86
7_M52_A1.5530.82
92_F96_V1.5480.81
166_I169_S1.4960.79
76_I88_A1.4830.78
72_V152_I1.4790.78
68_G152_I1.4780.78
25_V34_L1.4640.78
130_A157_T1.4390.76
72_V156_W1.4390.76
83_Q117_K1.4250.76
163_D169_S1.4210.75
94_Y102_K1.4190.75
118_G163_D1.3930.74
21_L35_G1.3750.73
117_K121_R1.3710.73
80_Y163_D1.3530.72
111_H115_G1.3440.71
111_H116_A1.3340.71
167_T170_Y1.3250.70
116_A164_F1.2910.68
42_T46_D1.2850.68
88_A92_F1.2450.65
163_D168_A1.2220.64
21_L38_F1.2210.63
31_R78_I1.2200.63
119_W164_F1.2110.63
47_L132_L1.1820.61
122_H126_Y1.1770.61
140_I146_T1.1740.60
134_A153_L1.1630.60
95_Y99_K1.1590.59
115_G118_G1.1560.59
116_A168_A1.1540.59
120_L124_L1.1480.59
156_W167_T1.1460.58
169_S174_P1.1410.58
87_W91_K1.1300.57
100_G104_L1.1120.56
166_I170_Y1.1080.56
171_F174_P1.1010.55
111_H168_A1.0930.55
76_I84_M1.0930.55
25_V51_A1.0900.55
113_K117_K1.0820.54
5_A9_V1.0770.54
93_Q96_V1.0720.53
51_A159_I1.0690.53
116_A156_W1.0680.53
115_G119_W1.0570.52
49_L73_Y1.0520.52
111_H175_K1.0430.51
84_M88_A1.0370.51
20_V51_A1.0300.50
80_Y106_R1.0130.49
123_V127_L1.0060.49
119_W123_V1.0060.49
122_H160_I0.9920.48
156_W169_S0.9910.48
62_S77_S0.9910.48
94_Y103_P0.9880.47
51_A112_A0.9870.47
116_A120_L0.9810.47
30_K36_L0.9750.47
100_G103_P0.9710.46
22_G42_T0.9680.46
48_I52_A0.9600.46
72_V155_L0.9600.46
80_Y123_V0.9530.45
7_M77_S0.9520.45
168_A172_I0.9460.45
126_Y160_I0.9330.44
63_A146_T0.9320.44
91_K100_G0.9240.43
133_L137_I0.9230.43
158_V163_D0.9200.43
79_A125_A0.9070.42
119_W163_D0.9030.42
44_V144_S0.9010.41
126_Y156_W0.8910.41
79_A124_L0.8890.41
52_A93_Q0.8870.40
6_W143_S0.8690.39
68_G71_A0.8620.39
82_K96_V0.8570.38
169_S173_W0.8540.38
86_Q175_K0.8480.38
83_Q118_G0.8480.38
5_A106_R0.8460.38
4_I165_L0.8450.38
79_A121_R0.8400.37
164_F167_T0.8360.37
118_G122_H0.8280.37
9_V13_I0.8280.37
4_I85_I0.8260.36
80_Y85_I0.8170.36
119_W122_H0.8130.36
162_I166_I0.7980.35
53_T70_A0.7980.35
45_I77_S0.7970.35
112_A170_Y0.7950.34
5_A66_A0.7940.34
63_A148_A0.7900.34
73_Y85_I0.7780.33
53_T58_Y0.7770.33
126_Y153_L0.7730.33
164_F176_K0.7720.33
132_L135_G0.7710.33
25_V32_H0.7700.33
92_F97_T0.7650.33
7_M10_F0.7630.32
50_L131_G0.7590.32
32_H37_L0.7550.32
143_S146_T0.7540.32
42_T74_I0.7500.32
14_A18_V0.7470.31
74_I132_L0.7450.31
83_Q105_K0.7420.31
112_A116_A0.7370.31
104_L147_E0.7360.31
29_F176_K0.7320.31
157_T160_I0.7310.30
21_L36_L0.7300.30
168_A174_P0.7270.30
30_K85_I0.7250.30
24_A44_V0.7220.30
72_V122_H0.7220.30
20_V92_F0.7180.30
44_V47_L0.7150.30
112_A175_K0.7070.29
170_Y174_P0.7040.29
19_I77_S0.7030.29
22_G35_G0.7010.29
18_V41_L0.6970.28
102_K105_K0.6970.28
63_A85_I0.6840.28
9_V151_G0.6830.28
118_G129_G0.6790.27
127_L143_S0.6760.27
156_W160_I0.6760.27
109_M171_F0.6750.27
155_L163_D0.6670.27
109_M164_F0.6660.27
169_S172_I0.6660.27
109_M113_K0.6640.27
107_F112_A0.6640.27
133_L136_M0.6610.26
64_T153_L0.6610.26
38_F45_I0.6560.26
93_Q97_T0.6540.26
40_A45_I0.6520.26
10_F18_V0.6500.26
51_A143_S0.6480.26
63_A68_G0.6470.26
57_L63_A0.6450.26
43_P75_G0.6440.26
91_K102_K0.6440.26
163_D170_Y0.6440.26
141_N151_G0.6440.26
143_S151_G0.6430.26
97_T100_G0.6380.25
121_R138_Y0.6380.25
76_I163_D0.6380.25
126_Y130_A0.6360.25
17_V65_A0.6360.25
136_M141_N0.6340.25
65_A93_Q0.6340.25
34_L37_L0.6320.25
163_D174_P0.6320.25
78_I154_K0.6240.24
58_Y86_Q0.6200.24
85_I105_K0.6180.24
118_G156_W0.6170.24
11_C142_D0.6160.24
24_A147_E0.6140.24
91_K94_Y0.6120.24
61_A155_L0.6110.24
32_H66_A0.6070.24
16_W23_L0.6070.24
94_Y101_T0.6060.24
102_K177_E0.6000.23
123_V159_I0.5920.23
8_I73_Y0.5910.23
6_W10_F0.5880.23
91_K103_P0.5880.23
54_G58_Y0.5860.23
39_L43_P0.5850.23
116_A163_D0.5850.23
8_I96_V0.5820.22
20_V69_I0.5780.22
100_G105_K0.5770.22
16_W46_D0.5760.22
71_A133_L0.5750.22
124_L144_S0.5700.22
116_A122_H0.5650.22
65_A178_K0.5640.22
20_V61_A0.5610.21
87_W92_F0.5600.21
54_G115_G0.5590.21
90_E104_L0.5540.21
45_I173_W0.5530.21
129_G163_D0.5520.21
8_I87_W0.5510.21
55_V123_V0.5500.21
69_I99_K0.5470.21
168_A173_W0.5460.21
75_G121_R0.5430.21
156_W170_Y0.5430.21
53_T68_G0.5400.20
7_M14_A0.5400.20
79_A146_T0.5390.20
20_V140_I0.5380.20
66_A74_I0.5310.20
60_G87_W0.5300.20
104_L124_L0.5290.20
46_D92_F0.5280.20
126_Y167_T0.5270.20
158_V176_K0.5260.20
45_I136_M0.5260.20
39_L101_T0.5230.20
80_Y118_G0.5230.20
76_I156_W0.5220.20
134_A139_F0.5200.19
96_V99_K0.5120.19
40_A44_V0.5100.19
22_G77_S0.5080.19
84_M92_F0.5050.19
93_Q99_K0.5030.19
44_V166_I0.5030.19
123_V162_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.8216 72.5 0.938 Contact Map
3ne5A 3 0.9081 55.6 0.944 Contact Map
4k0jA 3 0.8162 35.8 0.951 Contact Map
4dx5A 3 0.8973 26.2 0.954 Contact Map
3w9iA 3 0.8595 25.7 0.954 Contact Map
4mt1A 3 0.8541 23.7 0.955 Contact Map
3h90A 3 0.7622 14.3 0.959 Contact Map
4mndA 2 0.7784 9.3 0.962 Contact Map
2a65A 2 0.9027 9.2 0.962 Contact Map
2mgyA 1 0.373 6.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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