GREMLIN Database
YMCA - Uncharacterized protein YmcA
UniProt: O31779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (119)
Sequences: 267 (181)
Seq/√Len: 16.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_E69_K3.4720.99
31_R35_Q3.2380.99
76_D79_Q2.8320.98
39_N87_V2.7870.98
45_I85_I2.7490.97
12_Q15_N2.6420.97
18_K22_E2.4770.95
49_I61_H2.4270.94
29_F122_G2.3560.93
85_I90_E2.2200.91
64_K67_A2.1380.89
27_D31_R2.0850.88
76_D80_E2.0780.88
79_Q83_E2.0680.88
45_I81_E1.9840.85
52_L74_K1.7830.79
104_L108_T1.7730.78
42_V87_V1.7610.78
36_I88_I1.6560.73
59_L81_E1.5400.67
40_D44_T1.5270.67
26_V112_Q1.5200.66
58_N67_A1.5140.66
56_A68_L1.5060.66
23_T32_A1.4910.65
46_V49_I1.4900.65
8_D11_Q1.4420.62
88_I102_L1.4220.61
73_A105_V1.4030.60
33_E46_V1.3950.59
93_D97_E1.3750.58
29_F117_I1.3740.58
80_E84_E1.3610.57
26_V98_V1.3440.56
28_F32_A1.3410.56
60_K108_T1.3230.55
55_Q63_E1.3170.55
60_K68_L1.3090.54
34_A80_E1.3050.54
30_K121_T1.2920.53
73_A77_A1.2380.50
57_V81_E1.2350.50
116_E119_T1.2340.50
18_K116_E1.2280.50
5_S21_S1.1960.48
83_E92_R1.1930.48
68_L72_E1.1760.47
21_S30_K1.1750.47
8_D100_D1.1690.46
7_K11_Q1.1490.45
95_Q99_N1.1240.44
39_N109_I1.1040.42
20_I111_N1.0750.41
48_Q59_L1.0740.41
51_A59_L1.0730.41
26_V55_Q1.0610.40
91_F95_Q1.0540.40
36_I93_D1.0530.39
49_I76_D1.0480.39
58_N64_K1.0450.39
77_A107_H1.0340.38
10_V107_H1.0320.38
38_E44_T1.0300.38
49_I78_L1.0200.38
105_V109_I1.0160.37
70_Q77_A1.0110.37
13_A72_E0.9800.35
58_N62_Y0.9770.35
20_I101_L0.9680.35
5_S64_K0.9660.35
70_Q112_Q0.9610.34
50_K57_V0.9480.34
18_K44_T0.9410.33
36_I60_K0.9290.33
24_E82_L0.9010.31
66_E73_A0.8960.31
44_T48_Q0.8850.31
70_Q74_K0.8800.30
7_K48_Q0.8430.28
44_T117_I0.8290.28
31_R90_E0.8280.28
48_Q80_E0.8200.27
33_E87_V0.8130.27
34_A40_D0.8040.27
33_E36_I0.7920.26
92_R98_V0.7910.26
67_A71_V0.7890.26
62_Y67_A0.7880.26
25_E98_V0.7870.26
6_K111_N0.7860.26
77_A101_L0.7770.25
4_Y19_M0.7760.25
12_Q71_V0.7730.25
77_A81_E0.7730.25
72_E81_E0.7670.25
37_N106_A0.7460.24
90_E95_Q0.7410.24
23_T98_V0.7410.24
31_R73_A0.7370.24
7_K119_T0.7300.23
49_I56_A0.7260.23
114_T122_G0.7220.23
97_E100_D0.7190.23
59_L65_H0.7160.23
12_Q106_A0.7150.23
103_Q109_I0.7030.22
11_Q116_E0.6940.22
38_E84_E0.6910.22
29_F118_I0.6890.22
6_K122_G0.6880.22
33_E82_L0.6860.22
13_A32_A0.6800.21
37_N76_D0.6770.21
62_Y97_E0.6760.21
108_T116_E0.6730.21
20_I97_E0.6700.21
29_F105_V0.6660.21
109_I113_V0.6650.21
54_K57_V0.6630.21
54_K99_N0.6620.21
25_E32_A0.6600.21
13_A33_E0.6530.20
39_N121_T0.6420.20
24_E36_I0.6380.20
48_Q113_V0.6350.20
19_M23_T0.6250.19
63_E93_D0.6180.19
75_I102_L0.6150.19
26_V74_K0.6120.19
30_K117_I0.6110.19
80_E96_M0.6100.19
6_K22_E0.6090.19
43_S79_Q0.6030.18
34_A121_T0.5990.18
21_S92_R0.5920.18
50_K54_K0.5910.18
100_D111_N0.5910.18
37_N90_E0.5880.18
43_S66_E0.5870.18
28_F69_K0.5860.18
85_I95_Q0.5830.18
54_K75_I0.5820.18
31_R101_L0.5790.18
65_H82_L0.5770.18
22_E42_V0.5750.17
89_Q94_S0.5730.17
16_L90_E0.5690.17
96_M100_D0.5670.17
24_E107_H0.5670.17
26_V48_Q0.5660.17
26_V101_L0.5640.17
61_H97_E0.5560.17
30_K56_A0.5540.17
36_I46_V0.5540.17
88_I93_D0.5530.17
62_Y100_D0.5480.17
68_L108_T0.5470.17
32_A109_I0.5470.17
35_Q113_V0.5400.16
16_L115_N0.5370.16
43_S73_A0.5370.16
15_N20_I0.5320.16
4_Y35_Q0.5260.16
42_V81_E0.5230.16
59_L120_S0.5210.16
25_E46_V0.5200.16
36_I97_E0.5190.16
40_D66_E0.5180.16
32_A101_L0.5180.16
100_D107_H0.5130.15
61_H87_V0.5120.15
97_E108_T0.5110.15
72_E95_Q0.5090.15
52_L55_Q0.5090.15
44_T59_L0.5080.15
40_D48_Q0.5070.15
66_E76_D0.5060.15
19_M105_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pihA 2 0.8601 100 0.423 Contact Map
2oeeA 2 0.6503 99.8 0.607 Contact Map
2oeqA 4 0.8252 99.8 0.62 Contact Map
2iazA 4 0.7832 99.7 0.629 Contact Map
4f01A 2 0.7063 16 0.943 Contact Map
4jneA 2 0.7063 12.7 0.946 Contact Map
3ghgA 2 0.5804 11.1 0.947 Contact Map
4po2A 4 0.7343 7.8 0.951 Contact Map
1j1vA 1 0.3846 7.8 0.951 Contact Map
3epzA 1 0.3846 6.9 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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