GREMLIN Database
BIOF1 - 8-amino-7-oxononanoate synthase 1
UniProt: O31777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (361)
Sequences: 6420 (3899)
Seq/√Len: 205.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_Q68_Q4.1891.00
93_K285_D4.1331.00
303_Y376_D4.0211.00
160_E198_K3.9501.00
152_Q158_D3.8021.00
197_E230_R3.7791.00
343_R384_K3.6451.00
188_P191_D3.2031.00
158_D162_V3.1021.00
176_T180_F3.0661.00
93_K281_M2.8491.00
282_E285_D2.8341.00
303_Y372_K2.7861.00
174_I196_A2.7681.00
307_M379_L2.5971.00
160_E199_Y2.5791.00
296_R300_N2.5071.00
93_K288_L2.4431.00
251_G256_I2.3211.00
61_N65_E2.2921.00
106_F263_G2.2771.00
217_N223_N2.2731.00
160_E164_R2.2701.00
190_P225_F2.2511.00
251_G255_L2.2491.00
236_G248_Y2.2301.00
158_D161_R2.2261.00
156_M195_L2.1921.00
207_D210_A2.0931.00
101_E253_K2.0641.00
96_A288_L2.0451.00
290_E293_H2.0381.00
307_M376_D2.0351.00
58_R282_E1.9961.00
176_T205_V1.9941.00
311_M383_E1.9461.00
128_I162_V1.9031.00
60_I67_V1.8611.00
327_I336_F1.8551.00
191_D194_E1.8431.00
371_T374_E1.8391.00
121_L127_V1.8251.00
129_S133_N1.8031.00
58_R289_E1.7851.00
299_E372_K1.7781.00
307_M310_K1.7741.00
345_V377_Q1.7681.00
34_S41_K1.7571.00
56_H286_V1.7571.00
216_E223_N1.7271.00
117_L175_V1.7101.00
339_Q342_S1.6961.00
103_A250_A1.6961.00
42_V341_L1.6951.00
45_L370_H1.6831.00
131_E152_Q1.6651.00
61_N68_Q1.6611.00
45_L378_A1.6491.00
167_M172_R1.6231.00
303_Y307_M1.6151.00
86_M281_M1.5951.00
97_F219_R1.5841.00
127_V141_I1.5751.00
65_E69_Q1.5711.00
311_M379_L1.5661.00
139_D264_R1.5541.00
137_I175_V1.5541.00
141_I148_K1.5521.00
331_G335_Q1.5441.00
238_L280_C1.5411.00
304_F366_I1.5311.00
128_I172_R1.5131.00
115_G265_P1.5121.00
244_V280_C1.5061.00
95_A103_A1.5031.00
196_A203_V1.5001.00
245_L273_P1.4921.00
207_D221_T1.4731.00
164_R199_Y1.4691.00
336_F385_T1.4551.00
194_E230_R1.4531.00
66_A278_A1.4441.00
151_Y176_T1.4221.00
291_P295_E1.4201.00
339_Q343_R1.4121.00
347_A362_I1.4081.00
174_I201_A1.4061.00
126_I166_S1.4061.00
78_R83_T1.4041.00
94_L284_I1.3961.00
89_E281_M1.3901.00
211_S242_I1.3851.00
60_I64_Q1.3761.00
377_Q381_V1.3561.00
306_A310_K1.3461.00
34_S374_E1.3421.00
313_L386_A1.3421.00
173_L204_M1.3381.00
116_V249_A1.3351.00
303_Y375_L1.3131.00
253_K257_D1.3021.00
156_M188_P1.3001.00
64_Q67_V1.3001.00
149_K162_V1.2901.00
329_D332_V1.2871.00
300_N372_K1.2741.00
135_A264_R1.2721.00
102_A253_K1.2641.00
295_E299_E1.2581.00
338_D342_S1.2441.00
65_E68_Q1.2421.00
128_I166_S1.2391.00
195_L199_Y1.2381.00
74_T271_S1.2351.00
98_K250_A1.2281.00
159_L174_I1.2231.00
85_T89_E1.2201.00
126_I149_K1.2161.00
156_M191_D1.2091.00
88_Q92_K1.2021.00
178_G210_A1.1871.00
121_L173_L1.1851.00
330_E360_A1.1831.00
302_A306_A1.1811.00
178_G221_T1.1781.00
83_T88_Q1.1741.00
58_R286_V1.1681.00
352_F357_K1.1671.00
133_N137_I1.1661.00
116_V204_M1.1621.00
163_L195_L1.1591.00
304_F308_L1.1571.00
115_G263_G1.1431.00
193_V197_E1.1421.00
152_Q155_N1.1411.00
94_L238_L1.1401.00
98_K211_S1.1341.00
300_N303_Y1.1331.00
36_T41_K1.1311.00
286_V290_E1.1301.00
281_M285_D1.1291.00
183_D361_R1.1251.00
339_Q385_T1.1211.00
124_E170_R1.1211.00
154_V188_P1.1151.00
304_F364_T1.1121.00
174_I195_L1.1121.00
160_E195_L1.1101.00
300_N375_L1.1051.00
222_V227_L1.1041.00
193_V231_V1.1001.00
153_H185_N1.0941.00
92_K96_A1.0941.00
364_T378_A1.0931.00
163_L201_A1.0861.00
102_A256_I1.0861.00
151_Y180_F1.0811.00
193_V203_V1.0701.00
57_P61_N1.0701.00
192_I203_V1.0571.00
126_I170_R1.0501.00
86_M278_A1.0461.00
95_A250_A1.0451.00
62_A66_A1.0361.00
219_R223_N1.0341.00
121_L125_D1.0331.00
343_R381_V1.0301.00
305_K318_S1.0251.00
113_N136_S1.0251.00
28_E85_T1.0231.00
300_N368_A1.0161.00
70_Y85_T1.0111.00
108_S111_T1.0091.00
334_K349_S1.0071.00
298_W301_T1.0061.00
372_K376_D1.0051.00
176_T192_I0.9991.00
94_L248_Y0.9971.00
345_V378_A0.9961.00
336_F386_A0.9941.00
162_V165_K0.9911.00
100_T250_A0.9901.00
278_A282_E0.9871.00
252_S255_L0.9831.00
340_L381_V0.9831.00
100_T251_G0.9811.00
345_V381_V0.9751.00
334_K351_V0.9701.00
157_S161_R0.9671.00
111_T269_S0.9641.00
100_T234_Q0.9631.00
63_A279_A0.9580.99
352_F360_A0.9550.99
161_R165_K0.9510.99
129_S141_I0.9500.99
90_L277_T0.9490.99
155_N158_D0.9410.99
333_A360_A0.9410.99
275_A279_A0.9410.99
33_P374_E0.9380.99
86_M277_T0.9380.99
117_L121_L0.9340.99
87_H277_T0.9330.99
325_I364_T0.9320.99
173_L202_F0.9290.99
327_I332_V0.9290.99
61_N64_Q0.9250.99
102_A260_R0.9240.99
217_N288_L0.9240.99
186_I225_F0.9200.99
59_L279_A0.9200.99
292_E296_R0.9190.99
90_L280_C0.9190.99
182_M350_I0.9190.99
43_I374_E0.9170.99
52_G369_E0.9160.99
282_E286_V0.9150.99
126_I169_Y0.9110.99
204_M235_V0.9080.99
194_E198_K0.9070.99
88_Q102_A0.9070.99
366_I375_L0.9070.99
76_S80_I0.9040.99
132_L183_D0.9030.99
176_T189_L0.9010.99
273_P276_V0.8980.99
211_S248_Y0.8960.99
58_R61_N0.8950.99
242_I287_L0.8950.99
186_I214_L0.8930.99
78_R91_E0.8930.99
328_G360_A0.8890.99
296_R299_E0.8870.99
159_L192_I0.8870.99
135_A139_D0.8860.99
56_H59_L0.8830.99
333_A349_S0.8820.99
46_S348_Q0.8820.99
125_D170_R0.8820.99
335_Q338_D0.8810.99
307_M311_M0.8790.99
367_T370_H0.8790.99
97_F284_I0.8770.99
45_L375_L0.8760.99
196_A201_A0.8700.99
258_Y262_K0.8680.99
162_V166_S0.8670.99
132_L361_R0.8650.99
193_V230_R0.8630.99
187_A192_I0.8620.99
296_R372_K0.8610.99
129_S150_V0.8610.99
83_T87_H0.8590.99
374_E377_Q0.8580.99
223_N291_P0.8510.99
190_P224_H0.8480.99
221_T225_F0.8480.99
62_A278_A0.8480.99
125_D173_L0.8460.99
67_V275_A0.8420.99
107_Q245_L0.8400.99
239_S247_G0.8380.99
217_N291_P0.8370.99
89_E93_K0.8320.99
43_I345_V0.8290.99
214_L320_T0.8280.98
128_I159_L0.8280.98
178_G207_D0.8260.98
301_T323_L0.8250.98
245_L272_H0.8240.98
307_M380_D0.8240.98
63_A67_V0.8230.98
233_I255_L0.8220.98
380_D384_K0.8200.98
128_I192_I0.8190.98
222_V234_Q0.8170.98
131_E150_V0.8150.98
151_Y159_L0.8140.98
179_V186_I0.8130.98
122_S125_D0.8130.98
298_W302_A0.8120.98
186_I320_T0.8120.98
124_E147_D0.8110.98
157_S191_D0.8100.98
297_L301_T0.8080.98
62_A282_E0.8060.98
114_Q265_P0.8040.98
56_H293_H0.8040.98
249_A259_L0.8000.98
378_A382_I0.7980.98
222_V231_V0.7970.98
27_L35_V0.7970.98
186_I224_H0.7940.98
123_K145_K0.7930.98
66_A86_M0.7910.98
304_F323_L0.7910.98
156_M192_I0.7870.98
46_S81_A0.7860.98
166_S172_R0.7840.98
236_G250_A0.7840.98
296_R371_T0.7830.98
63_A72_A0.7810.98
117_L204_M0.7800.98
117_L173_L0.7800.98
377_Q380_D0.7780.98
154_V177_D0.7750.98
335_Q339_Q0.7690.98
53_F293_H0.7670.98
343_R385_T0.7650.97
372_K375_L0.7630.97
161_R164_R0.7590.97
138_I142_R0.7570.97
128_I149_K0.7550.97
325_I382_I0.7540.97
129_S138_I0.7530.97
129_S148_K0.7520.97
341_L346_F0.7490.97
58_R290_E0.7480.97
210_A221_T0.7450.97
133_N177_D0.7450.97
112_T116_V0.7420.97
215_G220_G0.7420.97
55_S60_I0.7410.97
78_R266_F0.7400.97
50_Y209_H0.7380.97
311_M380_D0.7380.97
110_F114_Q0.7370.97
211_S236_G0.7340.97
104_L256_I0.7320.97
293_H296_R0.7320.97
87_H105_V0.7310.97
90_L281_M0.7310.97
157_S160_E0.7290.97
28_E36_T0.7270.97
160_E191_D0.7260.97
294_M298_W0.7260.97
364_T382_I0.7250.97
154_V185_N0.7240.96
316_T326_L0.7240.96
112_T235_V0.7220.96
272_H277_T0.7180.96
309_V315_L0.7180.96
104_L260_R0.7160.96
380_D383_E0.7150.96
84_F87_H0.7050.96
215_G218_G0.7030.96
189_L205_V0.7020.96
114_Q118_S0.7000.96
305_K323_L0.6990.96
172_R201_A0.6950.96
86_M89_E0.6930.96
66_A70_Y0.6900.95
299_E303_Y0.6900.95
106_F115_G0.6900.95
116_V235_V0.6900.95
67_V72_A0.6850.95
156_M159_L0.6850.95
54_T75_G0.6840.95
106_F249_A0.6840.95
237_T247_G0.6820.95
154_V180_F0.6750.95
57_P60_I0.6720.95
34_S37_V0.6700.95
43_I377_Q0.6690.95
89_E285_D0.6690.95
80_I348_Q0.6690.95
308_L382_I0.6670.94
163_L199_Y0.6640.94
179_V210_A0.6590.94
98_K284_I0.6580.94
63_A278_A0.6520.94
314_T328_G0.6490.94
379_L383_E0.6480.94
196_A232_H0.6470.94
103_A248_Y0.6470.94
233_I251_G0.6460.94
283_A287_L0.6450.93
216_E291_P0.6450.93
336_F362_I0.6450.93
308_L364_T0.6430.93
147_D170_R0.6420.93
292_E295_E0.6420.93
54_T243_G0.6410.93
151_Y154_V0.6380.93
126_I172_R0.6350.93
214_L224_H0.6350.93
40_Q344_G0.6350.93
336_F340_L0.6290.93
313_L382_I0.6290.93
193_V227_L0.6290.93
125_D144_T0.6280.93
99_K228_D0.6270.92
285_D289_E0.6250.92
350_I354_T0.6250.92
212_G241_A0.6240.92
59_L283_A0.6220.92
104_L266_F0.6220.92
179_V320_T0.6220.92
97_F288_L0.6210.92
93_K284_I0.6190.92
245_L276_V0.6190.92
80_I350_I0.6180.92
121_L204_M0.6180.92
74_T274_P0.6180.92
52_G367_T0.6170.92
107_Q111_T0.6170.92
373_D377_Q0.6160.92
287_L294_M0.6160.92
205_V222_V0.6160.92
92_K102_A0.6150.92
97_F287_L0.6130.92
207_D234_Q0.6100.91
101_E252_S0.6100.91
151_Y174_I0.6100.91
129_S137_I0.6090.91
216_E224_H0.6090.91
300_N366_I0.6090.91
117_L137_I0.6080.91
49_N54_T0.6040.91
130_D153_H0.6030.91
98_K103_A0.6030.91
108_S245_L0.6020.91
376_D379_L0.6020.91
70_Y86_M0.6000.91
256_I260_R0.5990.91
219_R288_L0.5970.91
332_V335_Q0.5930.90
296_R368_A0.5930.90
149_K165_K0.5930.90
114_Q140_G0.5920.90
216_E295_E0.5910.90
78_R269_S0.5910.90
306_A309_V0.5910.90
172_R200_D0.5900.90
190_P194_E0.5890.90
163_L172_R0.5880.90
305_K319_E0.5870.90
179_V214_L0.5870.90
224_H319_E0.5870.90
270_T354_T0.5870.90
204_M233_I0.5860.90
87_H271_S0.5840.90
279_A283_A0.5840.90
337_S349_S0.5840.90
326_L361_R0.5820.89
100_T252_S0.5810.89
89_E92_K0.5810.89
307_M383_E0.5800.89
30_M33_P0.5780.89
131_E359_K0.5760.89
154_V176_T0.5760.89
209_H240_K0.5760.89
149_K166_S0.5750.89
239_S270_T0.5740.89
34_S377_Q0.5730.89
120_I233_I0.5720.89
71_G275_A0.5710.89
379_L382_I0.5710.89
194_E197_E0.5710.89
171_M202_F0.5710.89
131_E148_K0.5700.88
138_I150_V0.5660.88
222_V228_D0.5640.88
218_G294_M0.5630.88
303_Y379_L0.5630.88
43_I378_A0.5610.88
26_Q85_T0.5590.87
327_I333_A0.5580.87
304_F307_M0.5540.87
139_D142_R0.5540.87
98_K248_Y0.5530.87
30_M55_S0.5530.87
178_G214_L0.5520.87
305_K309_V0.5520.87
244_V279_A0.5520.87
169_Y172_R0.5510.87
133_N141_I0.5510.87
337_S341_L0.5510.87
134_H240_K0.5500.87
116_V233_I0.5490.87
152_Q161_R0.5480.86
156_M160_E0.5470.86
186_I221_T0.5460.86
133_N180_F0.5440.86
121_L146_A0.5420.86
97_F211_S0.5420.86
235_V247_G0.5410.86
330_E357_K0.5400.86
107_Q247_G0.5390.86
93_K96_A0.5380.85
166_S169_Y0.5380.85
268_F354_T0.5380.85
53_F286_V0.5370.85
53_F59_L0.5370.85
115_G119_S0.5360.85
308_L379_L0.5360.85
134_H209_H0.5360.85
244_V276_V0.5360.85
98_K234_Q0.5350.85
329_D333_A0.5350.85
63_A66_A0.5350.85
293_H300_N0.5350.85
193_V196_A0.5340.85
291_P294_M0.5340.85
213_V297_L0.5330.85
35_V44_Q0.5330.85
125_D171_M0.5320.85
63_A275_A0.5320.85
62_A65_E0.5310.85
334_K338_D0.5290.85
42_V346_F0.5270.84
318_S323_L0.5240.84
214_L221_T0.5240.84
313_L336_F0.5240.84
107_Q272_H0.5210.84
77_V109_G0.5190.83
167_M200_D0.5190.83
297_L300_N0.5170.83
40_Q342_S0.5150.83
127_V144_T0.5150.83
197_E232_H0.5150.83
299_E302_A0.5150.83
32_G55_S0.5140.83
69_Q89_E0.5130.83
151_Y177_D0.5130.83
336_F339_Q0.5120.83
185_N361_R0.5120.83
202_F232_H0.5120.83
197_E231_V0.5110.82
286_V293_H0.5110.82
203_V231_V0.5100.82
214_L298_W0.5090.82
351_V354_T0.5090.82
157_S164_R0.5090.82
340_L347_A0.5080.82
202_F255_L0.5080.82
29_S36_T0.5060.82
66_A69_Q0.5040.82
134_H181_S0.5020.81
328_G333_A0.5020.81
376_D380_D0.5010.81
304_F378_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w8tA 2 1 100 0.453 Contact Map
3wy7A 2 0.9439 100 0.469 Contact Map
2bwnA 2 0.9872 100 0.506 Contact Map
3kkiA 2 0.9668 100 0.508 Contact Map
1fc4A 2 1 100 0.514 Contact Map
1bs0A 2 0.9694 100 0.521 Contact Map
3tqxA 2 1 100 0.528 Contact Map
3a2bA 2 0.9898 100 0.532 Contact Map
4iw7A 2 0.8469 100 0.563 Contact Map
1vefA 2 0.8929 100 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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