GREMLIN Database
TDH - L-threonine 3-dehydrogenase
UniProt: O31776 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (304)
Sequences: 52764 (36364)
Seq/√Len: 2085.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_E330_K2.9881.00
38_K146_P2.9101.00
36_K75_E2.8111.00
38_K73_I2.7461.00
34_L75_E2.6561.00
33_V137_I2.6401.00
189_K215_T2.5551.00
145_D148_I2.5251.00
171_T195_Q2.5031.00
89_Y140_N2.4161.00
88_E139_R2.3951.00
85_K88_E2.3631.00
228_I231_A2.3241.00
70_F125_C2.3191.00
207_R211_Q2.2771.00
323_F334_L2.2661.00
167_P170_G2.2651.00
36_K73_I2.2571.00
25_I129_Y2.2011.00
195_Q216_C2.1851.00
36_K129_Y2.1801.00
147_S322_Q2.1301.00
206_L210_K2.0941.00
172_T188_A2.0791.00
10_M21_T2.0691.00
306_Q310_S2.0691.00
83_S134_A2.0481.00
321_H334_L2.0051.00
31_H80_N2.0011.00
30_K79_E1.9981.00
163_L191_A1.9841.00
185_V214_A1.9771.00
29_D32_E1.9591.00
324_P327_E1.9481.00
89_Y146_P1.9451.00
143_D309_S1.9311.00
70_F92_A1.9271.00
30_K80_N1.9141.00
71_S146_P1.8991.00
333_E337_S1.8571.00
170_G263_R1.8381.00
27_E76_G1.8331.00
207_R210_K1.7721.00
75_E129_Y1.7681.00
34_L131_K1.7671.00
173_A238_A1.7561.00
163_L303_Q1.7531.00
51_N336_R1.7461.00
173_A199_I1.7431.00
330_K333_E1.7401.00
203_E207_R1.7321.00
206_L217_T1.7191.00
323_F331_G1.6851.00
239_D259_A1.6851.00
190_A312_M1.6661.00
140_N146_P1.6531.00
334_L339_Q1.6521.00
197_I238_A1.6511.00
263_R288_T1.6461.00
200_D206_L1.6391.00
330_K334_L1.6231.00
258_A264_F1.6171.00
78_G81_V1.6111.00
175_I254_G1.5771.00
216_C232_L1.5531.00
203_E219_S1.5521.00
84_V139_R1.5501.00
223_E228_I1.5351.00
148_I316_A1.5341.00
140_N149_A1.5331.00
219_S222_K1.5231.00
224_D227_K1.5151.00
77_V86_V1.5101.00
195_Q215_T1.5081.00
9_L328_F1.5081.00
208_L211_Q1.5051.00
7_K22_E1.5001.00
32_E133_P1.5001.00
203_E222_K1.4851.00
263_R290_Q1.4831.00
258_A287_L1.4771.00
126_F332_F1.4661.00
34_L129_Y1.4651.00
76_G86_V1.4631.00
28_I131_K1.4561.00
37_V70_F1.4521.00
84_V88_E1.4521.00
89_Y142_A1.4451.00
258_A262_G1.4311.00
73_I89_Y1.4141.00
185_V198_A1.4091.00
7_K128_E1.3891.00
28_I34_L1.3881.00
31_H133_P1.3861.00
32_E131_K1.3761.00
241_V254_G1.3581.00
39_A147_S1.3561.00
241_V258_A1.3421.00
329_E333_E1.3381.00
50_Y332_F1.3371.00
74_V84_V1.3331.00
13_D19_V1.3311.00
177_C198_A1.3191.00
33_V84_V1.3061.00
34_L76_G1.2881.00
7_K326_E1.2851.00
320_T334_L1.2841.00
227_K231_A1.2731.00
171_T197_I1.2721.00
73_I146_P1.2611.00
184_A242_C1.2471.00
201_K206_L1.2431.00
201_K220_I1.2421.00
306_Q309_S1.2411.00
9_L20_L1.2281.00
152_Q308_I1.2241.00
175_I199_I1.2221.00
8_A23_V1.2041.00
190_A307_L1.2041.00
13_D17_G1.2041.00
165_S240_L1.2001.00
159_V163_L1.1841.00
38_K89_Y1.1671.00
84_V137_I1.1641.00
210_K217_T1.1481.00
14_G17_G1.1391.00
206_L219_S1.1371.00
228_I232_L1.1331.00
28_I32_E1.1311.00
25_I34_L1.1281.00
171_T239_D1.1231.00
31_H134_A1.1031.00
35_I72_G1.1021.00
203_E206_L1.0981.00
75_E86_V1.0971.00
303_Q306_Q1.0971.00
37_V130_V1.0971.00
198_A214_A1.0821.00
132_V137_I1.0731.00
170_G239_D1.0631.00
42_I331_G1.0471.00
9_L325_L1.0421.00
163_L300_T1.0421.00
39_A146_P1.0411.00
208_L340_C1.0361.00
50_Y336_R1.0341.00
328_F345_L1.0281.00
224_D228_I1.0171.00
156_G183_M1.0141.00
158_A187_V1.0101.00
256_A281_K1.0081.00
160_H300_T1.0071.00
302_R306_Q1.0071.00
245_S250_A1.0071.00
307_L312_M1.0051.00
210_K216_C1.0021.00
35_I90_V0.9981.00
20_L326_E0.9911.00
38_K71_S0.9901.00
43_C69_E0.9881.00
211_Q317_P0.9871.00
43_C68_H0.9841.00
40_A126_F0.9771.00
233_T237_G0.9691.00
222_K228_I0.9671.00
188_A193_A0.9641.00
158_A184_A0.9561.00
40_A125_C0.9501.00
144_M149_A0.9491.00
161_T267_L0.9481.00
126_F328_F0.9481.00
10_M65_V0.9441.00
77_V81_V0.9421.00
226_L256_A0.9411.00
174_V184_A0.9401.00
334_L343_V0.9321.00
10_M23_V0.9301.00
282_V289_I0.9301.00
185_V196_V0.9251.00
47_V335_M0.9171.00
25_I76_G0.9131.00
243_E246_G0.9121.00
174_V188_A0.9091.00
333_E336_R0.9091.00
177_C200_D0.9061.00
176_G198_A0.9011.00
252_A256_A0.8981.00
85_K139_R0.8921.00
197_I216_C0.8911.00
159_V303_Q0.8911.00
81_V134_A0.8911.00
229_V238_A0.8901.00
187_V304_V0.8881.00
64_Y123_A0.8841.00
27_E34_L0.8841.00
36_K128_E0.8821.00
199_I220_I0.8821.00
23_V123_A0.8791.00
253_Q256_A0.8771.00
202_N205_R0.8751.00
31_H78_G0.8731.00
201_K221_E0.8721.00
335_M343_V0.8721.00
226_L253_Q0.8711.00
82_S134_A0.8671.00
155_L183_M0.8661.00
41_S69_E0.8641.00
170_G240_L0.8621.00
197_I218_V0.8601.00
173_A257_M0.8591.00
126_F345_L0.8591.00
202_N219_S0.8561.00
200_D217_T0.8541.00
13_D16_F0.8531.00
175_I241_V0.8501.00
198_A209_A0.8501.00
171_T238_A0.8471.00
70_F130_V0.8451.00
25_I75_E0.8441.00
182_L208_L0.8441.00
39_A344_I0.8431.00
204_Y207_R0.8431.00
281_K285_K0.8421.00
323_F327_E0.8371.00
205_R340_C0.8281.00
303_Q307_L0.8261.00
8_A65_V0.8261.00
226_L230_S0.8211.00
161_T242_C0.8211.00
142_A309_S0.8161.00
299_S303_Q0.8151.00
91_S305_S0.8011.00
187_V307_L0.8001.00
31_H79_E0.7991.00
162_V188_A0.7971.00
261_G286_G0.7961.00
43_C46_D0.7961.00
227_K230_S0.7931.00
42_I335_M0.7891.00
9_L329_E0.7861.00
161_T184_A0.7811.00
172_T193_A0.7761.00
158_A183_M0.7731.00
90_V137_I0.7721.00
158_A180_I0.7691.00
7_K20_L0.7691.00
209_A214_A0.7661.00
323_F345_L0.7631.00
234_S237_G0.7611.00
9_L18_A0.7581.00
29_D131_K0.7561.00
197_I232_L0.7561.00
254_G264_F0.7561.00
224_D253_Q0.7561.00
42_I126_F0.7521.00
226_L257_M0.7511.00
177_C209_A0.7491.00
92_A132_V0.7461.00
201_K209_A0.7451.00
191_A303_Q0.7451.00
241_V264_F0.7441.00
20_L325_L0.7441.00
144_M308_I0.7401.00
196_V215_T0.7381.00
225_P253_Q0.7381.00
163_L187_V0.7381.00
282_V291_G0.7371.00
45_T68_H0.7341.00
316_A319_I0.7331.00
23_V65_V0.7331.00
299_S302_R0.7331.00
197_I229_V0.7311.00
249_S253_Q0.7301.00
77_V85_K0.7301.00
193_A240_L0.7271.00
334_L337_S0.7251.00
91_S140_N0.7251.00
43_C154_P0.7251.00
175_I250_A0.7241.00
307_L311_N0.7241.00
28_I76_G0.7231.00
165_S265_H0.7221.00
28_I78_G0.7171.00
188_A196_V0.7161.00
138_W302_R0.7161.00
282_V287_L0.7151.00
238_A241_V0.7141.00
240_L265_H0.7141.00
244_M267_L0.7121.00
33_V134_A0.7121.00
266_I289_I0.7111.00
71_S150_S0.7111.00
319_I322_Q0.7101.00
160_H286_G0.7081.00
307_L310_S0.7061.00
145_D149_A0.7031.00
193_A196_V0.6951.00
321_H330_K0.6941.00
323_F343_V0.6931.00
89_Y143_D0.6891.00
39_A322_Q0.6871.00
125_C130_V0.6831.00
177_C185_V0.6821.00
158_A162_V0.6791.00
138_W301_W0.6771.00
16_F333_E0.6751.00
174_V198_A0.6741.00
252_A275_T0.6691.00
260_N285_K0.6681.00
11_K17_G0.6661.00
157_N180_I0.6661.00
154_P179_P0.6641.00
305_S309_S0.6641.00
229_V257_M0.6631.00
88_E142_A0.6591.00
141_P309_S0.6581.00
44_G48_H0.6561.00
166_Q263_R0.6561.00
277_D281_K0.6551.00
230_S233_T0.6511.00
71_S140_N0.6511.00
138_W305_S0.6511.00
26_P131_K0.6471.00
159_V304_V0.6451.00
33_V74_V0.6451.00
83_S139_R0.6441.00
321_H343_V0.6361.00
39_A71_S0.6361.00
159_V307_L0.6351.00
31_H135_D0.6341.00
71_S89_Y0.6321.00
251_I264_F0.6301.00
189_K196_V0.6301.00
230_S237_G0.6291.00
35_I92_A0.6281.00
247_H250_A0.6281.00
164_E288_T0.6271.00
332_F336_R0.6241.00
243_E264_F0.6231.00
187_V191_A0.6221.00
83_S86_V0.6211.00
206_L220_I0.6201.00
91_S153_E0.6201.00
153_E157_N0.6191.00
161_T292_I0.6181.00
13_D21_T0.6161.00
208_L212_M0.6151.00
186_A212_M0.6151.00
200_D220_I0.6151.00
199_I218_V0.6141.00
185_V212_M0.6141.00
48_H53_D0.6131.00
240_L263_R0.6121.00
200_D219_S0.6121.00
238_A257_M0.6111.00
241_V257_M0.6111.00
206_L209_A0.6091.00
200_D209_A0.6091.00
93_E138_W0.6081.00
281_K284_F0.6071.00
45_T49_I0.6051.00
28_I80_N0.6031.00
152_Q304_V0.6031.00
26_P129_Y0.6011.00
148_I152_Q0.6001.00
15_A333_E0.6001.00
250_A254_G0.5941.00
184_A267_L0.5931.00
185_V209_A0.5921.00
155_L304_V0.5921.00
172_T240_L0.5921.00
37_V40_A0.5911.00
216_C228_I0.5871.00
92_A137_I0.5841.00
157_N267_L0.5841.00
281_K287_L0.5821.00
44_G178_G0.5811.00
24_P27_E0.5801.00
26_P34_L0.5801.00
159_V300_T0.5791.00
47_V336_R0.5721.00
35_I137_I0.5721.00
45_T48_H0.5721.00
298_F302_R0.5711.00
77_V88_E0.5701.00
252_A281_K0.5681.00
243_E268_S0.5661.00
60_I64_Y0.5661.00
209_A217_T0.5661.00
61_K64_Y0.5641.00
173_A241_V0.5631.00
67_G126_F0.5621.00
225_P229_V0.5611.00
82_S85_K0.5601.00
273_P277_D0.5591.00
265_H292_I0.5581.00
166_Q288_T0.5581.00
25_I131_K0.5571.00
283_V291_G0.5551.00
146_P149_A0.5481.00
164_E300_T0.5481.00
40_A345_L0.5471.00
168_A192_G0.5461.00
162_V187_V0.5451.00
218_V228_I0.5431.00
166_Q290_Q0.5431.00
218_V223_E0.5421.00
197_I233_T0.5401.00
71_S149_A0.5391.00
189_K214_A0.5391.00
84_V134_A0.5381.00
183_M187_V0.5381.00
25_I28_I0.5361.00
321_H327_E0.5351.00
287_L291_G0.5341.00
160_H164_E0.5341.00
168_A191_A0.5341.00
35_I70_F0.5331.00
183_M186_A0.5331.00
200_D205_R0.5321.00
92_A125_C0.5311.00
218_V232_L0.5311.00
37_V92_A0.5311.00
47_V51_N0.5311.00
210_K214_A0.5291.00
145_D322_Q0.5281.00
321_H340_C0.5271.00
153_E156_G0.5251.00
134_A137_I0.5251.00
201_K219_S0.5231.00
171_T233_T0.5221.00
183_M313_I0.5221.00
65_V124_G0.5201.00
151_I344_I0.5191.00
182_L318_V0.5161.00
175_I225_P0.5141.00
20_L328_F0.5131.00
26_P32_E0.5111.00
156_G304_V0.5101.00
278_L281_K0.5091.00
17_G50_Y0.5091.00
292_I295_R0.5071.00
308_I313_I0.5071.00
159_V191_A0.5061.00
140_N144_M0.5061.00
161_T265_H0.5051.00
173_A229_V0.5051.00
237_G259_A0.5031.00
77_V84_V0.5031.00
185_V189_K0.5021.00
43_C342_K0.5011.00
28_I31_H0.5011.00
249_S252_A0.5011.00
169_G193_A0.5001.00
320_T341_G0.5001.00
92_A130_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d8aA 3 0.9568 100 0.153 Contact Map
2dq4A 4 0.9798 100 0.162 Contact Map
1vj0A 4 0.9769 100 0.173 Contact Map
1h2bA 4 0.9654 100 0.174 Contact Map
4ej6A 1 0.9683 100 0.175 Contact Map
4ilkA 2 0.9625 100 0.175 Contact Map
3ukoA 4 0.9885 100 0.182 Contact Map
3ip1A 4 0.9741 100 0.188 Contact Map
1cdoA 2 0.9827 100 0.189 Contact Map
4rqtA 2 0.9885 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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