GREMLIN Database
YMDB - Uncharacterized protein ymdB
UniProt: O31775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (256)
Sequences: 1232 (884)
Seq/√Len: 55.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_M69_T4.6351.00
191_A248_A3.5821.00
6_I199_T3.5221.00
183_N253_R3.2301.00
2_R240_D2.9281.00
38_G63_I2.8941.00
132_D167_R2.8111.00
132_D163_Y2.7021.00
36_I60_A2.7001.00
35_I146_F2.4651.00
33_F110_L2.4271.00
9_V36_I2.3891.00
5_F196_V2.3741.00
181_A253_R2.3501.00
160_L164_T2.3471.00
130_K133_E2.2621.00
31_P238_V2.2621.00
168_A171_V2.1901.00
89_A134_L2.1291.00
144_Y241_I2.1001.00
113_I131_A2.0841.00
196_V236_G2.0421.00
42_A48_T2.0381.00
131_A160_L1.9921.00
116_Q124_L1.9801.00
165_D187_P1.9651.00
115_L149_F1.9361.00
111_A138_A1.9321.00
9_V55_L1.9311.00
117_G151_A1.8740.99
242_D245_T1.8230.99
111_A142_T1.8150.99
52_Y56_I1.8030.99
52_Y63_I1.7660.99
170_A239_I1.7430.99
62_A112_V1.7060.99
131_A164_T1.7020.99
115_L131_A1.7000.99
126_D129_L1.6850.99
19_K54_S1.6510.99
56_I84_N1.6310.99
170_A237_V1.6230.99
100_I134_L1.6200.98
65_M86_V1.6160.98
89_A115_L1.5940.98
193_I237_V1.5850.98
18_V36_I1.5840.98
89_A131_A1.5720.98
42_A51_I1.5650.98
102_Y142_T1.5410.98
104_K109_E1.5380.98
146_F172_V1.5170.98
242_D249_V1.5020.98
62_A86_V1.4990.97
93_E129_L1.4870.97
158_L184_R1.4770.97
161_G192_Y1.4670.97
119_T153_A1.4600.97
239_I251_I1.4370.97
110_L144_Y1.4300.97
12_S15_R1.4140.96
6_I236_G1.4070.96
6_I36_I1.4000.96
169_S241_I1.3980.96
131_A135_I1.3810.96
15_R54_S1.3810.96
31_P34_T1.3590.95
237_V251_I1.3570.95
102_Y111_A1.3470.95
162_W184_R1.3460.95
41_A47_L1.3380.95
213_I225_F1.3310.95
146_F170_A1.3310.95
18_V22_V1.3300.95
165_D189_G1.3280.95
109_E141_R1.3260.95
45_K208_M1.3210.95
172_V196_V1.3140.95
203_D231_K1.3140.95
17_M232_T1.3120.95
52_Y85_L1.2910.94
172_V237_V1.2910.94
89_A130_K1.2880.94
15_R43_H1.2830.94
100_I111_A1.2670.93
33_F103_V1.2650.93
38_G47_L1.2650.93
147_I164_T1.2630.93
10_V206_L1.2620.93
172_V239_I1.2420.93
5_F172_V1.2380.93
5_F174_T1.2310.92
111_A145_I1.2310.92
149_F160_L1.2230.92
143_P246_K1.2230.92
108_K243_D1.2220.92
100_I138_A1.2190.92
160_L163_Y1.2170.92
62_A101_T1.2150.92
34_T60_A1.2040.92
10_V208_M1.2030.92
79_I85_L1.2030.92
159_A217_F1.1990.91
209_D226_T1.1950.91
62_A103_V1.1920.91
179_Q193_I1.1920.91
147_I160_L1.1900.91
29_Y238_V1.1770.91
18_V199_T1.1710.90
204_G210_R1.1370.89
169_S246_K1.1370.89
162_W210_R1.1340.89
135_I140_K1.1330.89
239_I248_A1.1230.88
118_R125_D1.1130.88
158_L192_Y1.1080.88
161_G186_L1.1060.88
56_I82_V1.0860.87
13_P227_V1.0860.87
52_Y82_V1.0790.86
45_K72_K1.0760.86
185_I250_K1.0730.86
6_I234_L1.0720.86
49_E81_D1.0720.86
33_F62_A1.0700.86
118_R127_P1.0700.86
159_A205_I1.0650.86
29_Y252_E1.0650.86
209_D212_T1.0510.85
240_D250_K1.0430.84
164_T168_A1.0410.84
191_A239_I1.0400.84
118_R126_D1.0390.84
26_K34_T1.0360.84
139_A167_R1.0240.83
110_L146_F1.0080.82
155_S217_F1.0070.82
86_V103_V0.9900.81
135_I145_I0.9870.81
142_T145_I0.9830.81
204_G228_A0.9750.80
113_I147_I0.9730.80
49_E75_I0.9570.79
114_N148_D0.9510.78
183_N193_I0.9500.78
240_D249_V0.9480.78
184_R203_D0.9460.78
145_I168_A0.9390.78
16_D20_E0.9270.77
165_D188_K0.9270.77
87_R99_G0.9120.75
6_I18_V0.9100.75
154_T206_L0.9060.75
183_N251_I0.9050.75
125_D129_L0.9050.75
11_G227_V0.9030.75
235_S255_L0.8960.74
104_K107_G0.8960.74
163_Y167_R0.8960.74
166_G190_T0.8890.74
215_K223_V0.8860.73
102_Y138_A0.8810.73
199_T234_L0.8740.72
113_I145_I0.8600.71
47_L51_I0.8590.71
26_K61_D0.8580.71
135_I168_A0.8560.71
162_W187_P0.8530.70
165_D186_L0.8510.70
17_M21_Y0.8500.70
171_V190_T0.8490.70
43_H229_E0.8470.70
18_V55_L0.8460.70
49_E53_H0.8450.70
61_D105_A0.8430.70
3_I146_F0.8420.69
86_V101_T0.8380.69
155_S213_I0.8340.69
100_I113_I0.8270.68
75_I85_L0.8250.68
42_A47_L0.8200.67
98_K101_T0.8200.67
67_N208_M0.8190.67
53_H57_Q0.8170.67
65_M114_N0.8140.67
86_V98_K0.8130.67
5_F146_F0.8090.66
45_K67_N0.8070.66
109_E143_P0.8010.66
185_I191_A0.8000.65
134_L137_E0.8000.65
135_I167_R0.7990.65
19_K58_S0.7990.65
75_I78_F0.7960.65
92_P124_L0.7940.65
49_E79_I0.7920.65
26_K29_Y0.7920.65
138_A142_T0.7910.65
41_A51_I0.7860.64
5_F237_V0.7790.63
115_L160_L0.7790.63
210_R214_I0.7740.63
17_M234_L0.7730.63
55_L58_S0.7730.63
147_I168_A0.7720.63
25_L234_L0.7710.63
18_V58_S0.7680.62
92_P125_D0.7660.62
76_F79_I0.7650.62
91_F124_L0.7640.62
36_I55_L0.7640.62
2_R30_K0.7600.61
47_L75_I0.7580.61
55_L63_I0.7560.61
92_P126_D0.7510.61
161_G214_I0.7490.60
1_M243_D0.7460.60
184_R192_Y0.7450.60
172_V193_I0.7390.59
163_Y218_K0.7350.59
34_T61_D0.7340.59
48_T51_I0.7320.59
67_N114_N0.7270.58
55_L60_A0.7270.58
132_D164_T0.7250.58
143_P169_S0.7250.58
108_K144_Y0.7240.58
62_A224_R0.7240.58
202_Y233_T0.7230.58
208_M225_F0.7200.57
71_D122_P0.7180.57
132_D147_I0.7150.57
45_K71_D0.7150.57
136_A140_K0.7090.56
80_D98_K0.7030.56
129_L218_K0.7020.55
6_I60_A0.6990.55
102_Y109_E0.6980.55
179_Q183_N0.6980.55
9_V18_V0.6970.55
125_D130_K0.6970.55
202_Y231_K0.6960.55
212_T223_V0.6950.55
65_M79_I0.6910.54
128_F217_F0.6900.54
3_I241_I0.6880.54
135_I139_A0.6870.54
162_W203_D0.6860.54
25_L238_V0.6840.54
109_E137_E0.6790.53
119_T225_F0.6770.53
201_P228_A0.6760.53
146_F239_I0.6760.53
68_H177_H0.6740.52
5_F114_N0.6700.52
205_I214_I0.6680.52
132_D135_I0.6680.52
85_L143_P0.6660.52
208_M212_T0.6630.51
74_E77_D0.6630.51
51_I54_S0.6630.51
43_H54_S0.6620.51
25_L29_Y0.6610.51
20_E24_K0.6610.51
33_F101_T0.6610.51
126_D130_K0.6570.51
91_F116_Q0.6550.50
25_L31_P0.6540.50
13_P232_T0.6540.50
92_P220_N0.6530.50
238_V252_E0.6530.50
18_V21_Y0.6530.50
53_H56_I0.6520.50
134_L138_A0.6510.50
113_I134_L0.6510.50
203_D210_R0.6480.50
158_L178_V0.6470.50
2_R252_E0.6440.49
204_G232_T0.6440.49
67_N122_P0.6420.49
92_P222_P0.6410.49
169_S248_A0.6400.49
215_K219_T0.6400.49
213_I223_V0.6380.49
116_Q220_N0.6370.48
153_A256_I0.6360.48
4_L254_I0.6340.48
209_D229_E0.6330.48
40_N68_H0.6260.47
72_K76_F0.6240.47
40_N177_H0.6240.47
199_T236_G0.6190.47
228_A232_T0.6160.46
131_A168_A0.6130.46
211_E215_K0.6130.46
158_L162_W0.6080.45
139_A142_T0.6070.45
135_I138_A0.6050.45
8_D40_N0.6010.45
78_F81_D0.6010.45
161_G164_T0.6000.44
161_G168_A0.5990.44
26_K77_D0.5990.44
208_M227_V0.5970.44
82_V85_L0.5970.44
124_L220_N0.5950.44
37_N44_G0.5900.43
128_F155_S0.5870.43
24_K27_T0.5860.43
238_V250_K0.5840.43
24_K28_K0.5830.43
91_F95_T0.5830.43
36_I236_G0.5820.43
151_A160_L0.5810.42
133_E136_A0.5800.42
130_K134_L0.5760.42
233_T255_L0.5760.42
96_P221_L0.5760.42
53_H181_A0.5750.42
45_K213_I0.5750.42
122_P220_N0.5730.42
8_D177_H0.5710.41
164_T167_R0.5700.41
34_T62_A0.5690.41
116_Q122_P0.5650.41
113_I138_A0.5630.41
26_K244_Q0.5600.40
241_I245_T0.5600.40
9_V19_K0.5590.40
105_A108_K0.5580.40
2_R238_V0.5580.40
4_L238_V0.5570.40
56_I78_F0.5560.40
47_L85_L0.5550.40
114_N174_T0.5550.40
158_L205_I0.5530.40
2_R31_P0.5500.39
13_P201_P0.5490.39
13_P233_T0.5470.39
32_H105_A0.5460.39
115_L147_I0.5440.39
100_I145_I0.5420.38
8_D68_H0.5420.38
185_I237_V0.5400.38
89_A167_R0.5370.38
32_H61_D0.5360.38
144_Y247_K0.5340.38
120_F213_I0.5330.38
151_A164_T0.5320.37
201_P230_G0.5310.37
56_I63_I0.5310.37
15_R48_T0.5310.37
25_L254_I0.5310.37
95_T129_L0.5290.37
21_Y24_K0.5290.37
181_A193_I0.5270.37
135_I164_T0.5270.37
26_K31_P0.5260.37
68_H175_H0.5260.37
22_V34_T0.5250.37
47_L69_T0.5250.37
15_R71_D0.5240.37
3_I35_I0.5200.36
39_E177_H0.5190.36
120_F153_A0.5190.36
12_S50_K0.5160.36
31_P240_D0.5160.36
121_L206_L0.5150.36
39_E175_H0.5140.36
9_V60_A0.5130.36
86_V112_V0.5130.36
212_T226_T0.5130.36
39_E68_H0.5130.36
102_Y145_I0.5100.35
184_R202_Y0.5070.35
70_W222_P0.5070.35
108_K143_P0.5060.35
100_I137_E0.5050.35
114_N149_F0.5040.35
183_N252_E0.5040.35
12_S229_E0.5040.35
191_A243_D0.5000.34
86_V124_L0.5000.34
166_G189_G0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t70A 2 0.9583 100 0.413 Contact Map
4b2oA 4 1 100 0.421 Contact Map
2z06A 4 0.9545 100 0.426 Contact Map
1t71A 2 0.9924 100 0.444 Contact Map
3c9fA 2 0.9773 99.8 0.827 Contact Map
2z1aA 1 0.9318 99.8 0.837 Contact Map
2wdcA 1 0.9735 99.7 0.849 Contact Map
3jyfA 2 0.9205 99.7 0.856 Contact Map
4h2gA 2 0.9773 99.6 0.86 Contact Map
3gveA 2 0.9356 99.6 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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