GREMLIN Database
PBPX - Putative penicillin-binding protein PbpX
UniProt: O31773 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (306)
Sequences: 10341 (8185)
Seq/√Len: 467.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_E243_N3.7801.00
150_K244_H3.6681.00
242_K247_K3.3631.00
104_N362_Q3.3381.00
143_A240_Y3.2951.00
157_D161_T3.0001.00
146_Q244_H2.8651.00
124_N130_F2.8151.00
146_Q240_Y2.8041.00
154_Q157_D2.7041.00
149_E315_S2.7001.00
156_S175_K2.6921.00
83_N111_K2.6441.00
254_A296_M2.6301.00
236_P239_Q2.5671.00
240_Y244_H2.5631.00
132_V296_M2.5431.00
229_I240_Y2.4321.00
112_G126_P2.3911.00
117_D120_H2.3671.00
142_T304_F2.3411.00
157_D162_Y2.3071.00
149_E318_S2.2361.00
110_N299_I2.2351.00
233_S240_Y2.2301.00
315_S318_S2.1781.00
227_Y231_E2.1731.00
116_A122_I2.1681.00
128_T267_A2.1371.00
138_A304_F2.1201.00
115_Y121_Y2.1091.00
227_Y230_A1.9501.00
226_A290_G1.9501.00
144_I225_L1.9431.00
146_Q150_K1.8651.00
251_M254_A1.7821.00
165_H231_E1.7681.00
195_T198_D1.7601.00
134_S137_K1.7541.00
305_D364_I1.7371.00
143_A241_I1.7111.00
241_I246_F1.7041.00
144_I153_L1.6961.00
148_E155_T1.6941.00
316_Q320_E1.6921.00
109_T113_F1.6911.00
321_K324_T1.6881.00
235_E240_Y1.6781.00
305_D355_N1.6731.00
243_N247_K1.6731.00
87_S91_K1.6691.00
158_P161_T1.6571.00
235_E244_H1.6091.00
115_Y120_H1.5921.00
147_L229_I1.5911.00
83_N87_S1.5891.00
239_Q243_N1.5811.00
83_N113_F1.5741.00
237_Y290_G1.5581.00
358_S361_G1.5391.00
173_T176_N1.5341.00
88_N92_E1.5231.00
97_G124_N1.5101.00
235_E239_Q1.5051.00
102_V302_Y1.4711.00
246_F251_M1.4681.00
182_S221_N1.4661.00
127_L299_I1.4651.00
124_N128_T1.4471.00
133_G348_M1.4391.00
126_P299_I1.4361.00
308_L323_F1.4241.00
175_K333_M1.4151.00
176_N181_T1.4101.00
145_L155_T1.4031.00
102_V364_I1.4031.00
253_H265_Y1.4031.00
83_N109_T1.3961.00
147_L233_S1.3951.00
97_G130_F1.3891.00
99_A298_A1.3721.00
112_G124_N1.3691.00
197_D201_K1.3501.00
139_L294_I1.3501.00
176_N213_G1.3401.00
135_S355_N1.3341.00
141_A222_Y1.3311.00
148_E153_L1.3291.00
99_A124_N1.3271.00
246_F294_I1.3251.00
141_A178_L1.3221.00
171_T211_Q1.3171.00
237_Y241_I1.3111.00
174_L228_I1.3011.00
145_L148_E1.2871.00
144_I178_L1.2811.00
175_K321_K1.2731.00
254_A300_D1.2721.00
301_M368_F1.2581.00
116_A128_T1.2561.00
251_M300_D1.2431.00
103_R363_T1.2391.00
139_L304_F1.2381.00
148_E321_K1.2311.00
332_G337_V1.2161.00
125_N128_T1.2141.00
309_I357_F1.2051.00
137_K217_Y1.1981.00
152_K232_V1.1931.00
347_V352_N1.1851.00
84_Q88_N1.1831.00
135_S353_I1.1791.00
219_D291_A1.1691.00
103_R106_E1.1591.00
102_V107_I1.1571.00
134_S217_Y1.1471.00
256_F294_I1.1381.00
306_Q309_I1.1331.00
218_K221_N1.1311.00
146_Q313_L1.1281.00
158_P171_T1.1251.00
100_M367_L1.1211.00
305_D357_F1.1211.00
144_I229_I1.1201.00
139_L241_I1.1191.00
357_F364_I1.1151.00
145_L318_S1.1001.00
269_G351_F1.0971.00
110_N126_P1.0961.00
143_A229_I1.0961.00
238_E288_L1.0921.00
198_D201_K1.0891.00
143_A244_H1.0791.00
142_T314_Y1.0761.00
176_N179_T1.0761.00
249_A307_A1.0721.00
140_I237_Y1.0671.00
117_D122_I1.0661.00
301_M366_I1.0661.00
139_L251_M1.0631.00
135_S301_M1.0631.00
145_L322_M1.0541.00
136_Q294_I1.0521.00
222_Y225_L1.0441.00
298_A368_F1.0361.00
142_T308_L1.0331.00
96_S118_R1.0211.00
143_A233_S1.0161.00
299_I303_K1.0121.00
146_Q245_I1.0081.00
90_L113_F1.0001.00
211_Q214_V0.9991.00
86_I100_M0.9991.00
162_Y232_V0.9971.00
356_S365_V0.9931.00
157_D174_L0.9921.00
160_S170_Q0.9861.00
85_K89_Y0.9791.00
159_V228_I0.9781.00
210_R216_D0.9761.00
311_G320_E0.9731.00
153_L232_V0.9681.00
228_I232_V0.9681.00
99_A130_F0.9661.00
308_L335_F0.9661.00
132_V136_Q0.9641.00
147_L152_K0.9631.00
131_Y295_Y0.9601.00
86_I98_T0.9531.00
139_L246_F0.9491.00
246_F254_A0.9481.00
87_S113_F0.9481.00
251_M296_M0.9471.00
250_G303_K0.9461.00
84_Q87_S0.9321.00
99_A112_G0.9311.00
153_L174_L0.9261.00
159_V177_L0.9261.00
201_K205_L0.9251.00
140_I290_G0.9241.00
251_M304_F0.9201.00
273_E276_K0.9201.00
210_R214_V0.9171.00
131_Y348_M0.9151.00
107_I306_Q0.9141.00
331_Y336_Y0.9141.00
335_F357_F0.9111.00
303_K306_Q0.9091.00
242_K246_F0.9081.00
148_E318_S0.9001.00
229_I233_S0.8921.00
200_I227_Y0.8911.00
117_D268_V0.8861.00
239_Q242_K0.8821.00
311_G316_Q0.8781.00
118_R270_Y0.8771.00
229_I237_Y0.8761.00
226_A237_Y0.8741.00
129_S295_Y0.8711.00
180_H221_N0.8681.00
355_N366_I0.8641.00
233_S244_H0.8591.00
209_K216_D0.8581.00
87_S90_L0.8571.00
110_N298_A0.8471.00
251_M303_K0.8461.00
163_L231_E0.8451.00
129_S265_Y0.8431.00
115_Y123_Q0.8411.00
233_S236_P0.8391.00
302_Y364_I0.8381.00
237_Y256_F0.8361.00
87_S111_K0.8361.00
178_L225_L0.8351.00
129_S253_H0.8331.00
101_I365_V0.8331.00
162_Y174_L0.8311.00
344_N360_S0.8291.00
100_M111_K0.8291.00
132_V353_I0.8271.00
142_T146_Q0.8241.00
129_S255_G0.8231.00
139_L301_M0.8221.00
140_I226_A0.8201.00
241_I256_F0.8191.00
306_Q310_D0.8191.00
342_Y361_G0.8141.00
96_S371_I0.8131.00
279_T282_I0.8121.00
86_I90_L0.8111.00
162_Y228_I0.8111.00
253_H297_S0.8091.00
280_P284_D0.8021.00
215_W331_Y0.8011.00
174_L232_V0.8001.00
165_H201_K0.7951.00
201_K204_E0.7941.00
320_E324_T0.7931.00
98_T367_L0.7931.00
241_I254_A0.7901.00
117_D121_Y0.7901.00
181_T213_G0.7871.00
147_L150_K0.7861.00
196_P227_Y0.7861.00
192_G198_D0.7861.00
302_Y366_I0.7821.00
141_A334_G0.7791.00
159_V163_L0.7781.00
153_L228_I0.7771.00
308_L322_M0.7771.00
279_T284_D0.7771.00
331_Y335_F0.7751.00
259_T262_K0.7721.00
325_P330_T0.7721.00
319_Y323_F0.7721.00
155_T333_M0.7711.00
90_L98_T0.7701.00
143_A245_I0.7691.00
107_I110_N0.7661.00
176_N212_P0.7641.00
105_G306_Q0.7631.00
172_I182_S0.7621.00
135_S138_A0.7601.00
102_V306_Q0.7591.00
253_H300_D0.7541.00
319_Y322_M0.7531.00
230_A233_S0.7521.00
86_I113_F0.7521.00
280_P283_P0.7501.00
274_G277_T0.7491.00
311_G319_Y0.7451.00
196_P230_A0.7431.00
197_D227_Y0.7421.00
127_L253_H0.7411.00
175_K179_T0.7381.00
138_A355_N0.7371.00
138_A305_D0.7361.00
138_A335_F0.7351.00
172_I184_I0.7341.00
223_S291_A0.7321.00
103_R362_Q0.7291.00
115_Y122_I0.7251.00
296_M301_M0.7241.00
345_H354_L0.7231.00
115_Y118_R0.7161.00
323_F346_G0.7131.00
80_V84_Q0.7131.00
178_L222_Y0.7101.00
81_D84_Q0.7101.00
238_E242_K0.7091.00
309_I362_Q0.7061.00
309_I364_I0.7051.00
103_R108_V0.7031.00
323_F359_K0.6961.00
346_G357_F0.6921.00
146_Q149_E0.6901.00
314_Y319_Y0.6901.00
129_S297_S0.6901.00
163_L228_I0.6891.00
98_T369_S0.6891.00
137_K219_D0.6851.00
148_E154_Q0.6821.00
147_L240_Y0.6801.00
116_A125_N0.6801.00
187_H220_S0.6791.00
255_G295_Y0.6791.00
154_Q174_L0.6781.00
330_T337_V0.6781.00
222_Y334_G0.6771.00
144_I228_I0.6701.00
100_M109_T0.6701.00
289_Y292_G0.6691.00
230_A236_P0.6681.00
298_A366_I0.6671.00
341_S361_G0.6661.00
305_D366_I0.6641.00
142_T245_I0.6641.00
115_Y119_K0.6621.00
245_I313_L0.6591.00
89_Y95_F0.6581.00
154_Q175_K0.6551.00
166_F172_I0.6531.00
322_M335_F0.6521.00
184_I220_S0.6511.00
198_D202_D0.6511.00
219_D346_G0.6501.00
133_G351_F0.6491.00
307_A313_L0.6481.00
353_I368_F0.6471.00
317_K320_E0.6471.00
275_S278_V0.6471.00
318_S321_K0.6461.00
342_Y358_S0.6461.00
148_E157_D0.6451.00
131_Y136_Q0.6411.00
154_Q162_Y0.6391.00
147_L232_V0.6361.00
302_Y306_Q0.6321.00
132_V135_S0.6310.99
132_V368_F0.6310.99
163_L227_Y0.6290.99
323_F335_F0.6290.99
132_V301_M0.6270.99
133_G352_N0.6250.99
88_N91_K0.6250.99
298_A302_Y0.6250.99
95_F369_S0.6230.99
326_G329_S0.6230.99
320_E323_F0.6230.99
80_V83_N0.6220.99
160_S169_G0.6210.99
130_F368_F0.6200.99
308_L346_G0.6190.99
77_I80_V0.6170.99
267_A270_Y0.6130.99
182_S218_K0.6100.99
302_Y305_D0.6090.99
194_I198_D0.6080.99
78_K81_D0.6070.99
145_L335_F0.6060.99
342_Y346_G0.6050.99
156_S173_T0.6040.99
179_T333_M0.6040.99
132_V254_A0.6030.99
322_M332_G0.6000.99
263_E266_P0.6000.99
180_H222_Y0.5980.99
196_P199_L0.5980.99
174_L225_L0.5980.99
249_A303_K0.5970.99
256_F293_D0.5940.99
107_I302_Y0.5930.99
129_S262_K0.5900.99
95_F98_T0.5860.99
133_G292_G0.5800.99
186_G291_A0.5800.99
313_L318_S0.5790.99
316_Q319_Y0.5780.99
245_I248_P0.5770.99
112_G298_A0.5760.99
296_M300_D0.5740.99
318_S322_M0.5720.99
134_S219_D0.5720.99
181_T215_W0.5720.99
145_L149_E0.5710.99
254_A297_S0.5700.99
100_M113_F0.5700.99
125_N265_Y0.5690.99
158_P173_T0.5690.99
160_S164_P0.5660.99
241_I245_I0.5640.99
196_P200_I0.5630.99
159_V162_Y0.5630.99
159_V166_F0.5620.99
165_H204_E0.5580.99
97_G370_N0.5560.99
251_M307_A0.5550.99
168_N211_Q0.5540.99
297_S300_D0.5540.99
185_N206_Q0.5530.99
159_V224_V0.5520.99
159_V172_I0.5520.99
140_I241_I0.5510.99
301_M355_N0.5510.99
127_L265_Y0.5500.99
236_P240_Y0.5500.99
140_I225_L0.5480.99
307_A319_Y0.5460.99
170_Q176_N0.5460.99
186_G220_S0.5440.99
215_W336_Y0.5390.98
310_D362_Q0.5380.98
166_F224_V0.5380.98
281_Y284_D0.5370.98
177_L225_L0.5370.98
219_D344_N0.5370.98
122_I128_T0.5370.98
116_A124_N0.5350.98
144_I232_V0.5350.98
307_A312_K0.5340.98
202_D205_L0.5320.98
172_I176_N0.5310.98
346_G359_K0.5290.98
272_M277_T0.5280.98
237_Y246_F0.5260.98
279_T283_P0.5250.98
99_A102_V0.5250.98
144_I174_L0.5210.98
255_G259_T0.5210.98
358_S363_T0.5200.98
274_G278_V0.5200.98
238_E256_F0.5200.98
208_I212_P0.5200.98
166_F169_G0.5200.98
313_L319_Y0.5180.98
289_Y293_D0.5170.98
321_K325_P0.5160.98
337_V342_Y0.5160.98
90_L95_F0.5150.98
168_N171_T0.5140.98
86_I89_Y0.5130.98
118_R121_Y0.5120.98
240_Y243_N0.5120.98
79_T111_K0.5110.98
343_S346_G0.5110.98
379_Q382_N0.5100.98
247_K252_T0.5100.98
241_I294_I0.5070.98
140_I222_Y0.5070.98
138_A142_T0.5060.98
252_T300_D0.5050.98
312_K316_Q0.5050.98
166_F231_E0.5050.98
169_G172_I0.5030.98
303_K307_A0.5030.98
317_K321_K0.5030.98
177_L221_N0.5020.98
138_A141_A0.5000.97
139_L142_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tg9A 2 0.7724 100 0.291 Contact Map
1yqsA 1 0.8107 100 0.292 Contact Map
2qmiA 5 0.8005 100 0.301 Contact Map
4netA 1 0.8056 100 0.301 Contact Map
2qz6A 1 0.7724 100 0.302 Contact Map
3wrzA 1 0.798 100 0.302 Contact Map
2ffyA 1 0.7928 100 0.303 Contact Map
4gdnA 1 0.8056 100 0.305 Contact Map
4ivkA 4 0.8414 100 0.305 Contact Map
1ei5A 2 0.7928 100 0.305 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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