GREMLIN Database
YMFM - Uncharacterized membrane protein YmfM
UniProt: O31771 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (248)
Sequences: 2153 (1928)
Seq/√Len: 122.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_A228_L4.3221.00
3_L17_L4.2901.00
209_D253_N4.0771.00
212_W249_G3.9681.00
24_N27_I3.6661.00
6_L44_A3.4921.00
214_R225_E3.4811.00
210_S229_K3.2681.00
208_S255_K3.2501.00
48_D51_Q2.9111.00
6_L41_Y2.8971.00
18_T22_E2.8581.00
206_K233_T2.7261.00
250_Y253_N2.6891.00
255_K262_V2.4961.00
229_K232_E2.4761.00
3_L14_K2.3621.00
20_L45_V2.3461.00
20_L38_I2.2411.00
16_Y37_F2.2001.00
210_S227_T2.1561.00
12_I16_Y2.1541.00
35_R57_K2.1371.00
224_K234_Y2.1081.00
13_Q16_Y2.0981.00
10_T44_A2.0671.00
216_R222_S2.0611.00
32_F36_A2.0261.00
201_I259_N2.0171.00
211_S248_T2.0031.00
204_E257_K1.9741.00
36_A40_Q1.9621.00
204_E235_K1.9041.00
202_E235_K1.9001.00
247_R276_T1.8591.00
9_A44_A1.8551.00
11_K40_Q1.8261.00
108_V112_I1.8181.00
211_S254_L1.7991.00
207_A254_L1.7941.00
214_R247_R1.7871.00
43_E49_A1.7401.00
14_K18_T1.7291.00
206_K255_K1.7091.00
203_L258_I1.6851.00
15_R37_F1.6621.00
10_T243_Q1.6601.00
217_D223_L1.6011.00
105_I109_Y1.5981.00
53_F56_H1.5841.00
12_I37_F1.5671.00
251_A270_K1.5411.00
160_T165_K1.4911.00
252_P270_K1.4801.00
240_D244_V1.4791.00
209_D250_Y1.4751.00
19_A28_I1.4691.00
35_R53_F1.4671.00
99_L103_V1.4401.00
42_A52_L1.4301.00
51_Q54_E1.4011.00
49_A52_L1.3991.00
69_S73_S1.3971.00
38_I52_L1.3971.00
4_D14_K1.3821.00
169_D175_D1.3691.00
30_G40_Q1.3521.00
36_A39_K1.3451.00
226_G232_E1.3161.00
248_T254_L1.2991.00
106_A110_A1.2891.00
3_L18_T1.2871.00
172_K176_S1.2611.00
205_L215_V1.2340.99
13_Q40_Q1.2320.99
107_I111_I1.2260.99
159_D165_K1.2220.99
216_R220_S1.2090.99
19_A24_N1.1960.99
218_E243_Q1.1930.99
164_T171_K1.1890.99
11_K15_R1.1790.99
228_L232_E1.1780.99
29_P37_F1.1750.99
72_I76_N1.1740.99
70_E73_S1.1680.99
226_G234_Y1.1650.99
202_E237_D1.1510.99
204_E233_T1.1510.99
206_K257_K1.1500.99
207_A214_R1.1490.99
164_T169_D1.1410.99
257_K262_V1.1320.99
41_Y44_A1.1310.99
136_S166_E1.1170.99
6_L17_L1.1170.99
218_E223_L1.1130.99
188_G191_T1.1070.99
98_I101_V1.1020.99
207_A211_S1.1000.99
4_D17_L1.0910.99
161_K165_K1.0870.99
267_L270_K1.0650.98
217_D240_D1.0590.98
34_V56_H1.0580.98
93_P96_L1.0490.98
17_L44_A1.0470.98
16_Y19_A1.0390.98
52_L55_E1.0300.98
130_A133_Q1.0180.98
11_K228_L1.0000.98
7_Q14_K0.9970.97
28_I34_V0.9970.97
202_E259_N0.9930.97
69_S75_M0.9890.97
134_S138_Y0.9880.97
4_D8_A0.9840.97
72_I75_M0.9840.97
49_A53_F0.9810.97
214_R222_S0.9770.97
246_I277_I0.9730.97
30_G37_F0.9720.97
273_M277_I0.9710.97
252_P267_L0.9620.97
13_Q28_I0.9500.97
162_K169_D0.9470.97
250_Y274_A0.9420.96
160_T163_E0.9420.96
161_K164_T0.9420.96
50_D54_E0.9380.96
11_K37_F0.9380.96
164_T170_K0.9340.96
170_K174_N0.9330.96
93_P97_V0.9330.96
222_S225_E0.9270.96
13_Q37_F0.9240.96
205_L254_L0.9240.96
204_E260_G0.9160.96
133_Q138_Y0.9130.96
174_N194_E0.9000.95
19_A29_P0.9000.95
163_E174_N0.8990.95
181_I184_A0.8970.95
270_K273_M0.8890.95
168_E173_E0.8850.95
167_N181_I0.8850.95
39_K43_E0.8740.95
19_A33_Y0.8690.94
89_L92_L0.8680.94
218_E240_D0.8630.94
131_I136_S0.8570.94
91_L95_I0.8540.94
160_T172_K0.8530.94
228_L234_Y0.8510.94
98_I102_I0.8370.93
97_V101_V0.8360.93
209_D230_K0.8340.93
2_S5_D0.8330.93
7_Q20_L0.8300.93
173_E177_E0.8290.93
251_A273_M0.8280.93
37_F41_Y0.8270.93
168_E174_N0.8260.93
200_K237_D0.8250.93
248_T265_Y0.8240.93
20_L32_F0.8230.93
90_E93_P0.8190.93
71_K75_M0.8140.92
165_K170_K0.8120.92
236_K240_D0.8100.92
245_D278_K0.7990.92
189_S193_Y0.7970.91
118_K127_S0.7950.91
173_E181_I0.7950.91
264_S267_L0.7910.91
181_I189_S0.7840.91
131_I135_E0.7820.91
215_V246_I0.7780.90
132_T135_E0.7750.90
203_L246_I0.7740.90
30_G52_L0.7640.90
123_H128_E0.7620.90
275_Q279_I0.7610.89
39_K53_F0.7610.89
253_N270_K0.7610.89
165_K171_K0.7600.89
218_E242_K0.7580.89
160_T164_T0.7550.89
73_S76_N0.7540.89
32_F35_R0.7530.89
248_T275_Q0.7470.89
137_K165_K0.7440.88
28_I37_F0.7440.88
216_R221_S0.7420.88
38_I93_P0.7340.88
165_K173_E0.7330.88
182_K186_T0.7300.87
251_A267_L0.7290.87
159_D162_K0.7230.87
37_F207_A0.7220.87
169_D173_E0.7180.87
132_T137_K0.7180.87
31_K34_V0.7160.86
35_R259_N0.7150.86
179_L197_G0.7080.86
187_E193_Y0.7070.86
70_E74_G0.7060.86
161_K169_D0.7040.86
36_A231_D0.7040.86
212_W247_R0.7040.86
60_I66_D0.6990.85
215_V220_S0.6990.85
96_L111_I0.6970.85
247_R274_A0.6940.85
25_Y56_H0.6930.85
6_L45_V0.6930.85
163_E169_D0.6930.85
7_Q10_T0.6920.85
7_Q16_Y0.6920.85
16_Y33_Y0.6920.85
92_L97_V0.6920.85
7_Q11_K0.6900.84
164_T180_E0.6830.84
111_I115_A0.6820.84
5_D9_A0.6810.84
124_N128_E0.6760.83
15_R30_G0.6750.83
100_G111_I0.6750.83
57_K60_I0.6740.83
43_E258_I0.6730.83
167_N173_E0.6720.83
240_D243_Q0.6700.83
23_G29_P0.6650.82
171_K177_E0.6650.82
170_K181_I0.6640.82
207_A213_I0.6620.82
205_L256_I0.6610.82
213_I248_T0.6610.82
133_Q137_K0.6600.82
203_L248_T0.6590.82
130_A137_K0.6590.82
167_N178_K0.6570.81
243_Q278_K0.6560.81
45_V56_H0.6550.81
166_E172_K0.6530.81
135_E164_T0.6530.81
172_K185_G0.6490.81
38_I56_H0.6470.80
203_L279_I0.6450.80
173_E176_S0.6430.80
168_E172_K0.6390.80
66_D72_I0.6370.79
6_L37_F0.6360.79
99_L277_I0.6330.79
35_R234_Y0.6300.79
92_L96_L0.6290.78
121_D164_T0.6270.78
70_E75_M0.6270.78
31_K56_H0.6250.78
7_Q12_I0.6250.78
216_R271_K0.6240.78
2_S249_G0.6220.78
5_D8_A0.6210.78
201_I237_D0.6190.77
35_R61_P0.6150.77
190_L193_Y0.6130.77
161_K170_K0.6090.76
16_Y29_P0.6090.76
163_E189_S0.6080.76
180_E184_A0.6080.76
47_L52_L0.6060.76
212_W215_V0.6010.75
223_L227_T0.6000.75
17_L29_P0.5990.75
137_K159_D0.5980.75
13_Q39_K0.5950.75
86_S91_L0.5950.75
159_D164_T0.5950.75
36_A41_Y0.5940.74
103_V108_V0.5930.74
175_D178_K0.5910.74
12_I207_A0.5870.74
184_A187_E0.5870.74
252_P273_M0.5860.73
125_A128_E0.5860.73
172_K178_K0.5830.73
264_S268_D0.5830.73
173_E186_T0.5830.73
271_K275_Q0.5820.73
253_N273_M0.5810.73
10_T40_Q0.5810.73
217_D236_K0.5780.72
132_T136_S0.5770.72
107_I114_F0.5760.72
252_P269_P0.5760.72
16_Y41_Y0.5750.72
102_I105_I0.5750.72
169_D196_S0.5730.72
92_L95_I0.5710.72
188_G193_Y0.5710.72
131_I134_S0.5700.71
30_G53_F0.5690.71
6_L36_A0.5690.71
160_T178_K0.5670.71
128_E137_K0.5640.71
256_I263_L0.5630.71
71_K74_G0.5630.71
265_Y274_A0.5610.70
216_R229_K0.5600.70
73_S90_E0.5600.70
10_T14_K0.5590.70
5_D249_G0.5570.70
13_Q36_A0.5560.70
216_R245_D0.5550.69
163_E175_D0.5550.69
175_D180_E0.5540.69
236_K279_I0.5540.69
256_I265_Y0.5520.69
159_D175_D0.5510.69
163_E167_N0.5510.69
87_K99_L0.5510.69
225_E248_T0.5510.69
204_E227_T0.5510.69
187_E192_T0.5510.69
130_A167_N0.5490.69
251_A265_Y0.5480.68
167_N192_T0.5470.68
12_I17_L0.5470.68
217_D242_K0.5460.68
224_K228_L0.5450.68
64_Y68_V0.5440.68
39_K279_I0.5440.68
162_K168_E0.5370.67
169_D177_E0.5370.67
40_Q43_E0.5350.67
65_H75_M0.5340.66
71_K205_L0.5340.66
167_N171_K0.5330.66
89_L97_V0.5320.66
266_E275_Q0.5310.66
160_T176_S0.5310.66
35_R223_L0.5300.66
163_E172_K0.5260.65
88_A96_L0.5250.65
96_L110_A0.5240.65
181_I186_T0.5230.65
226_G278_K0.5230.65
29_P34_V0.5220.65
159_D163_E0.5220.65
90_E94_T0.5170.64
166_E184_A0.5170.64
134_S137_K0.5160.64
181_I185_G0.5130.63
7_Q13_Q0.5130.63
2_S65_H0.5130.63
211_S249_G0.5130.63
201_I258_I0.5120.63
172_K183_A0.5100.63
97_V108_V0.5090.63
3_L7_Q0.5090.63
2_S91_L0.5090.63
220_S226_G0.5080.63
47_L109_Y0.5080.63
39_K102_I0.5070.63
66_D69_S0.5070.63
168_E175_D0.5050.62
15_R19_A0.5050.62
265_Y275_Q0.5040.62
175_D185_G0.5030.62
17_L36_A0.5020.62
205_L212_W0.5020.62
137_K173_E0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fymA 1 0.2326 99.3 0.753 Contact Map
2wusR 1 0.2361 98.5 0.823 Contact Map
4gqmA 2 0.2743 98.3 0.831 Contact Map
3kz3A 2 0.191 95.7 0.887 Contact Map
2ef8A 2 0.2118 95.5 0.889 Contact Map
2ofyA 2 0.1979 95.4 0.889 Contact Map
3f6wA 2 0.1944 95.4 0.889 Contact Map
1lmb3 2 0.2153 94.8 0.893 Contact Map
1y7yA 2 0.1632 94.7 0.894 Contact Map
3kxaA 4 0.2014 94.6 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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