GREMLIN Database
YMFK - Uncharacterized protein YmfK
UniProt: O31769 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (247)
Sequences: 156 (52)
Seq/√Len: 3.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_R166_L3.5990.68
133_L233_D3.4620.65
158_R167_L2.5650.41
92_V104_D2.3870.37
160_L168_K2.3390.36
90_L247_V2.3260.35
168_K226_N2.3240.35
66_L193_S2.2940.35
80_K108_F2.2630.34
55_L186_F2.2510.34
81_L185_V2.2500.34
47_D99_Q2.1810.32
168_K225_Q2.1520.31
53_M183_E2.1440.31
160_L180_Y2.1310.31
173_S217_V2.0990.30
166_L188_V2.0430.29
191_I197_G2.0330.29
149_V187_I2.0210.28
41_V56_R2.0180.28
162_V186_F1.9110.26
62_Q72_T1.8970.26
86_L187_I1.8900.26
193_S217_V1.8760.25
62_Q185_V1.8400.25
17_E50_R1.8180.24
62_Q111_E1.8160.24
196_R222_I1.8110.24
30_S211_L1.8050.24
168_K195_R1.7540.23
9_K186_F1.7460.23
122_M175_L1.7220.23
166_L185_V1.7160.22
66_L196_R1.7110.22
206_R228_E1.7070.22
30_S180_Y1.6720.22
75_T128_K1.6450.21
97_Y154_C1.6410.21
19_Q77_K1.6380.21
123_A133_L1.6360.21
208_I226_N1.6010.20
242_N246_E1.5960.20
62_Q73_M1.5920.20
191_I222_I1.5910.20
115_L154_C1.5810.20
87_R187_I1.5740.20
70_L197_G1.5680.20
180_Y202_L1.5560.20
104_D117_L1.5540.20
72_T122_M1.5410.19
168_K255_E1.5380.19
66_L70_L1.5290.19
65_R132_K1.5280.19
30_S200_R1.5120.19
167_L227_T1.5050.19
160_L185_V1.5020.19
174_Q186_F1.4980.19
245_D251_E1.4790.18
69_I122_M1.4770.18
23_P156_S1.4750.18
64_K113_D1.4680.18
70_L196_R1.4530.18
58_R122_M1.4520.18
75_T202_L1.4290.18
18_I25_L1.4200.17
160_L176_I1.4180.17
167_L246_E1.4160.17
41_V69_I1.3800.17
57_C78_V1.3770.17
69_I72_T1.3720.17
70_L78_V1.3660.17
217_V244_P1.3560.16
123_A154_C1.3500.16
65_R80_K1.3480.16
168_K180_Y1.3380.16
62_Q75_T1.3320.16
136_I253_A1.3290.16
81_L186_F1.3010.16
193_S196_R1.2990.16
10_L117_L1.2760.15
162_V251_E1.2750.15
148_I187_I1.2730.15
101_D108_F1.2730.15
198_S203_Q1.2630.15
38_I89_R1.2610.15
62_Q103_D1.2530.15
80_K123_A1.2520.15
10_L60_I1.2520.15
103_D154_C1.2490.15
151_S156_S1.2350.15
160_L178_D1.2350.15
208_I252_H1.2280.15
87_R103_D1.2260.15
92_V126_F1.2240.15
126_F216_V1.2090.14
117_L188_V1.1960.14
167_L208_I1.1930.14
65_R69_I1.1870.14
171_I245_D1.1860.14
83_E225_Q1.1810.14
43_I104_D1.1800.14
162_V197_G1.1740.14
166_L240_L1.1650.14
158_R255_E1.1610.14
86_L211_L1.1540.14
12_W228_E1.1520.14
70_L242_N1.1480.14
92_V97_Y1.1300.13
10_L101_D1.1230.13
83_E185_V1.1220.13
126_F154_C1.1210.13
193_S205_V1.1130.13
183_E224_V1.1120.13
123_A217_V1.1020.13
21_N131_H1.1000.13
133_L217_V1.0920.13
12_W97_Y1.0860.13
199_E246_E1.0850.13
81_L243_D1.0840.13
14_F205_V1.0770.13
176_I180_Y1.0760.13
101_D117_L1.0740.13
19_Q132_K1.0610.13
126_F214_T1.0580.13
60_I191_I1.0500.12
158_R162_V1.0490.12
30_S57_C1.0470.12
181_S184_N1.0430.12
47_D186_F1.0410.12
70_L193_S1.0360.12
65_R73_M1.0190.12
154_C214_T1.0120.12
30_S38_I1.0100.12
115_L130_G1.0090.12
162_V168_K1.0080.12
18_I61_D1.0070.12
73_M111_E1.0030.12
193_S202_L0.9960.12
9_K81_L0.9890.12
29_I203_Q0.9820.12
61_D79_T0.9810.12
123_A236_Y0.9800.12
19_Q242_N0.9790.12
29_I78_V0.9770.12
57_C214_T0.9690.12
194_T225_Q0.9670.12
60_I185_V0.9650.12
70_L202_L0.9640.12
48_L104_D0.9610.12
108_F154_C0.9460.11
61_D115_L0.9450.11
55_L85_R0.9440.11
57_C244_P0.9420.11
92_V154_C0.9380.11
37_S72_T0.9340.11
87_R111_E0.9330.11
132_K205_V0.9280.11
80_K111_E0.9220.11
85_R103_D0.9180.11
74_E175_L0.9150.11
17_E92_V0.9140.11
63_I191_I0.9120.11
19_Q176_I0.9070.11
108_F214_T0.9040.11
15_E215_K0.9030.11
183_E244_P0.9010.11
167_L196_R0.8960.11
167_L176_I0.8860.11
174_Q197_G0.8800.11
69_I209_M0.8780.11
123_A233_D0.8770.11
158_R249_T0.8740.11
107_T151_S0.8730.11
53_M85_R0.8720.11
180_Y198_S0.8580.10
186_F251_E0.8570.10
74_E173_S0.8560.10
190_G216_V0.8510.10
117_L200_R0.8500.10
174_Q178_D0.8490.10
74_E216_V0.8490.10
154_C251_E0.8470.10
69_I149_V0.8460.10
49_S128_K0.8460.10
66_L73_M0.8460.10
65_R217_V0.8450.10
117_L134_I0.8390.10
56_R73_M0.8370.10
44_N131_H0.8330.10
80_K87_R0.8310.10
193_S246_E0.8310.10
73_M244_P0.8300.10
11_E102_A0.8280.10
208_I213_A0.8220.10
14_F193_S0.8200.10
37_S149_V0.8150.10
178_D222_I0.8150.10
122_M151_S0.8150.10
114_E246_E0.8140.10
18_I174_Q0.8130.10
148_I254_E0.8130.10
53_M60_I0.8130.10
21_N44_N0.8090.10
19_Q227_T0.8030.10
229_Y233_D0.8020.10
58_R75_T0.7970.10
82_R88_D0.7950.10
9_K92_V0.7940.10
195_R217_V0.7930.10
43_I53_M0.7920.10
66_L194_T0.7900.10
178_D191_I0.7840.10
17_E98_I0.7780.10
154_C187_I0.7770.10
55_L111_E0.7770.10
81_L193_S0.7740.10
15_E139_M0.7730.10
65_R209_M0.7710.10
53_M200_R0.7690.10
85_R154_C0.7680.10
87_R149_V0.7680.10
80_K98_I0.7650.10
38_I194_T0.7570.09
225_Q254_E0.7460.09
92_V123_A0.7450.09
156_S178_D0.7450.09
178_D214_T0.7440.09
67_E128_K0.7410.09
160_L226_N0.7400.09
104_D173_S0.7390.09
90_L101_D0.7380.09
73_M85_R0.7370.09
47_D188_V0.7360.09
92_V109_R0.7350.09
73_M193_S0.7320.09
123_A149_V0.7290.09
73_M205_V0.7290.09
56_R176_I0.7280.09
64_K67_E0.7240.09
122_M173_S0.7210.09
149_V205_V0.7140.09
64_K128_K0.7130.09
59_H214_T0.7130.09
158_R184_N0.7080.09
75_T242_N0.7080.09
39_N79_T0.7070.09
86_L107_T0.7070.09
12_W215_K0.7050.09
81_L244_P0.7040.09
74_E245_D0.7030.09
62_Q83_E0.7020.09
17_E212_P0.7010.09
77_K226_N0.7010.09
158_R188_V0.7000.09
38_I166_L0.6940.09
92_V107_T0.6940.09
134_I208_I0.6940.09
160_L191_I0.6910.09
132_K185_V0.6900.09
39_N222_I0.6890.09
47_D206_R0.6890.09
19_Q184_N0.6880.09
132_K198_S0.6880.09
62_Q80_K0.6850.09
179_E215_K0.6850.09
22_R28_D0.6810.09
177_A208_I0.6770.09
37_S208_I0.6730.09
83_E245_D0.6730.09
87_R109_R0.6700.09
15_E43_I0.6660.09
152_S187_I0.6620.09
56_R202_L0.6610.09
50_R123_A0.6610.09
97_Y101_D0.6610.09
225_Q255_E0.6600.09
62_Q87_R0.6580.09
196_R255_E0.6570.09
199_E228_E0.6550.09
22_R124_E0.6520.09
122_M182_T0.6470.09
36_L52_G0.6450.09
167_L213_A0.6450.09
22_R31_S0.6390.08
109_R233_D0.6390.08
86_L115_L0.6360.08
217_V233_D0.6340.08
168_K191_I0.6300.08
74_E109_R0.6280.08
81_L160_L0.6270.08
124_E240_L0.6110.08
117_L125_L0.6100.08
73_M202_L0.6090.08
78_V92_V0.6070.08
37_S58_R0.6030.08
202_L205_V0.6020.08
62_Q202_L0.5980.08
29_I32_L0.5970.08
68_S183_E0.5970.08
227_T244_P0.5930.08
83_E132_K0.5930.08
117_L207_E0.5920.08
38_I215_K0.5910.08
14_F49_S0.5900.08
101_D105_K0.5890.08
131_H209_M0.5870.08
30_S53_M0.5840.08
17_E123_A0.5830.08
74_E208_I0.5830.08
41_V205_V0.5830.08
117_L209_M0.5820.08
11_E131_H0.5820.08
65_R214_T0.5810.08
39_N174_Q0.5810.08
12_W63_I0.5800.08
56_R205_V0.5800.08
56_R252_H0.5780.08
102_A253_A0.5760.08
99_Q195_R0.5740.08
42_T172_R0.5730.08
37_S63_I0.5720.08
191_I194_T0.5660.08
128_K136_I0.5660.08
61_D198_S0.5640.08
174_Q191_I0.5630.08
62_Q104_D0.5630.08
58_R62_Q0.5610.08
20_V193_S0.5600.08
43_I108_F0.5590.08
100_R199_E0.5570.08
89_R213_A0.5540.08
60_I101_D0.5540.08
37_S191_I0.5490.08
193_S232_D0.5450.08
177_A222_I0.5440.08
111_E151_S0.5420.08
174_Q242_N0.5400.08
60_I173_S0.5400.08
87_R98_I0.5390.08
133_L154_C0.5390.08
39_N196_R0.5380.08
229_Y249_T0.5370.08
100_R167_L0.5320.08
55_L222_I0.5310.08
154_C236_Y0.5310.08
11_E78_V0.5280.08
57_C103_D0.5270.08
162_V233_D0.5260.08
17_E108_F0.5250.08
75_T162_V0.5210.08
43_I154_C0.5210.08
65_R108_F0.5210.08
139_M215_K0.5170.08
108_F236_Y0.5170.08
83_E160_L0.5160.08
132_K180_Y0.5160.08
61_D213_A0.5140.08
180_Y225_Q0.5130.07
126_F231_L0.5130.07
9_K200_R0.5110.07
55_L217_V0.5110.07
56_R125_L0.5100.07
162_V210_R0.5090.07
74_E252_H0.5090.07
53_M73_M0.5060.07
9_K18_I0.5050.07
19_Q177_A0.5050.07
41_V254_E0.5040.07
92_V101_D0.5010.07
148_I180_Y0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lw7A 2 0.4387 95.7 0.956 Contact Map
1qf9A 1 0.487 94.3 0.959 Contact Map
2lvwA 2 0.3457 94.2 0.96 Contact Map
4nu0A 1 0.4164 93.8 0.96 Contact Map
4qbgB 1 0.4164 93.3 0.961 Contact Map
1nksA 5 0.4684 93.1 0.961 Contact Map
2xb4A 4 0.4164 93.1 0.961 Contact Map
4xrpA 2 0.4981 93.1 0.961 Contact Map
2ko1A 2 0.3048 91.8 0.963 Contact Map
1ly1A 2 0.4349 91.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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